NAD(P)+ transhydrogenase (ferredoxin);
NADH-dependent reduced ferredoxin:NADP+ oxidoreductase;
nfnAB (gene names)
Acting on NADH or NADPH;
With NAD+ or NADP+ as acceptor
NADH:NADP+, ferredoxin oxidoreductase
NADH + H+ + 2 NADP+ + 2 reduced ferredoxin [iron-sulfur] cluster = NAD+ + 2 NADPH + 2 oxidized ferredoxin [iron-sulfur] cluster
oxidized ferredoxin [iron-sulfur] cluster [CPD:
The iron-sulfur flavoprotein complex, originally isolated from the bacterium Clostridium kluyveri, couples the exergonic reduction of NADP+ with reduced ferredoxin and the endergonic reduction of NADP+ with NADH.
EC 22.214.171.124 created 2015
Wang S, Huang H, Moll J, Thauer RK
NADP+ reduction with reduced ferredoxin and NADP+ reduction with NADH are coupled via an electron-bifurcating enzyme complex in Clostridium kluyveri.
Demmer JK, Huang H, Wang S, Demmer U, Thauer RK, Ermler U
Insights into Flavin-based Electron Bifurcation via the NADH-dependent Reduced Ferredoxin:NADP Oxidoreductase Structure.
Lubner CE, Jennings DP, Mulder DW, Schut GJ, Zadvornyy OA, Hoben JP, Tokmina-Lukaszewska M, Berry L, Nguyen DM, Lipscomb GL, Bothner B, Jones AK, Miller AF, King PW, Adams MWW, Peters JW
Mechanistic insights into energy conservation by flavin-based electron bifurcation.
ExplorEnz - The Enzyme Database: 126.96.36.199
ExPASy - ENZYME nomenclature database: 188.8.131.52
BRENDA, the Enzyme Database: 184.108.40.206