KEGG   ENZYME: 1.6.3.1
Entry
EC 1.6.3.1                  Enzyme                                 
Name
NAD(P)H oxidase (H2O2-forming);
THOX2;
ThOX;
dual oxidase;
p138tox;
thyroid NADPH oxidase;
thyroid oxidase;
thyroid oxidase 2;
NADPH oxidase;
NAD(P)H:oxygen oxidoreductase;
NAD(P)H oxidase
Class
Oxidoreductases;
Acting on NADH or NADPH;
With oxygen as acceptor
Sysname
NAD(P)H:oxygen oxidoreductase (H2O2-forming)
Reaction(IUBMB)
NAD(P)H + H+ + O2 = NAD(P)+ + H2O2 [RN:R07171 R07172]
Reaction(KEGG)
R07171 R07172
Substrate
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O2 [CPD:C00027]
Comment
Requires FAD, heme and calcium. When calcium is present, this transmembrane glycoprotein generates H2O2 by transfering electrons from intracellular NAD(P)H to extracellular molecular oxygen. The electron bridge within the enzyme contains one molecule of FAD and probably two heme groups. This flavoprotein is expressed at the apical membrane of thyrocytes, and provides H2O2 for the thyroid peroxidase-catalysed biosynthesis of thyroid hormones.
History
EC 1.6.3.1 created 2003, modified 2013
Orthology
K13411  dual oxidase
Genes
HSA50506(DUOX2) 53905(DUOX1)
PTR453395(DUOX2) 467673(DUOX1)
PPS100974723(DUOX1) 100978429(DUOX2)
GGO101137548(DUOX1) 101139037(DUOX2)
PON100445893(DUOX2) 100447745(DUOX1)
NLE100588618(DUOX1) 100595406(DUOX2)
MCC713126(DUOX1) 713906(DUOX2)
MCF102131806(DUOX2) 102133834(DUOX1)
CSAB103245704(DUOX2) 103245708(DUOX1)
CATY105588180(DUOX2) 105588237(DUOX1)
PANU101001178(DUOX1) 101003630(DUOX2)
TGE112627574(DUOX2) 112627626(DUOX1)
RRO104653891(DUOX2) 104653893(DUOX1)
RBB108530131(DUOX1) 108530134(DUOX2)
TFN117070727(DUOX1) 117070728(DUOX2)
PTEH111552779(DUOX2) 111552783(DUOX1)
CJC100387872(DUOX2) 100406741(DUOX1)
SBQ101043225(DUOX1) 101045049(DUOX2)
CSYR103264964(DUOX1) 103264967(DUOX2)
MMUR105872553(DUOX2) 105872556(DUOX1)
OGA100944838(DUOX2) 100951355(DUOX1)
MMU214593(Duox2) 99439(Duox1)
MCAL110289528(Duox2) 110289597(Duox1)
MPAH110318871(Duox2) 110318947(Duox1)
RNO266807(Duox1) 79107(Duox2)
MCOC116091779(Duox2) 116091780(Duox1)
MUN110553262(Duox2) 110553266(Duox1)
CGE100764526(Duox2) 100774391(Duox1)
PLEU114699556(Duox2) 114699606(Duox1)
NGI103746898(Duox2) 103746936(Duox1)
HGL101698133(Duox1) 101698889(Duox2)
CPOC100712930(Duox2) 100713662(Duox1)
CCAN109692712(Duox2) 109692713(Duox1)
DORD105980984(Duox1) 105980986(Duox2)
DSP122114489(Duox2) 122114688(Duox1)
NCAR124976018 124976951
OCU100344845(DUOX1) 100345610(DUOX2)
OPI101518356(DUOX1) 101527435(DUOX2)
TUP102471164(DUOX2) 102496442(DUOX1)
CFA403719(DUOX2) 403720(DUOX1)
VVP112919876(DUOX2) 112919877(DUOX1)
VLG121480469(DUOX1) 121485693(DUOX2)
AML100469477
UMR103656587(DUOX2) 103656588(DUOX1)
UAH113246795 113249136 113269715
UAR123775598 123801946(DUOX1) 123801956(DUOX2)
ELK111159740 111161962
LLV125104903 125105521
MPUF101675593(DUOX2) 101677288
ORO101365122(DUOX2) 101365433(DUOX1)
EJU114226548(DUOX1) 114226550(DUOX2)
ZCA113908521(DUOX2) 113909575(DUOX1)
MLX118003552(DUOX2) 118003553
FCA101087408(DUOX2) 101091374(DUOX1)
PYU121041635(DUOX2) 121041640(DUOX1)
PBG122468696(DUOX1) 122468698(DUOX2)
PTG102968075(DUOX2) 102968369(DUOX1)
PPAD109263047(DUOX1) 109263048(DUOX2)
AJU106986276(DUOX1) 106986277
HHV120243824(DUOX1) 120243827(DUOX2)
BTA510409(DUOX1) 785698(DUOX2)
BOM102272102(DUOX2) 102277170(DUOX1)
BIU109564555(DUOX1) 109565168(DUOX2)
BBUB102403106(DUOX1) 102405152(DUOX2)
CHX102179569(DUOX1) 106502554(DUOX2)
OAS100462743(DUOX2) 101111972(DUOX1)
ODA120852935(DUOX2) 120852937(DUOX1)
CCAD122443648(DUOX1) 122443649(DUOX2)
SSC397060(DUOX2) 397177(DUOX1)
CFR102510558(DUOX1) 102510795(DUOX2)
CBAI105076985(DUOX2) 105077066(DUOX1)
CDK105101748(DUOX1) 105101749(DUOX2)
VPC102537541(DUOX2) 102537792(DUOX1)
BACU103001055(DUOX2) 103001339(DUOX1)
LVE103071982(DUOX2) 103076766(DUOX1)
OOR101269659 101280015
DLE111181555 111181567
PCAD102980878(DUOX2) 102993288(DUOX1)
PSIU116748576 116749048(DUOX2)
ECB100070541(DUOX1) 100070566(DUOX2)
EPZ103554035(DUOX1) 103554037(DUOX2)
EAI106834993(DUOX1) 106834997(DUOX2)
MYB102242003(DUOX2) 102252627(DUOX1)
MYD102771512(DUOX1) 102771797(DUOX2)
MMYO118651162(DUOX2) 118651210(DUOX1)
MLF102431860(DUOX2) 102435194(DUOX1)
MNA107536153(DUOX1) 107536249(DUOX2)
PKL118721941(DUOX1) 118722118(DUOX2)
HAI109396658(DUOX1) 109396662
DRO112311051(DUOX2) 112311507(DUOX1)
SHON118992575(DUOX2) 118992576(DUOX1)
AJM119053965(DUOX1) 119054202(DUOX2)
PDIC114493099(DUOX2) 114493372(DUOX1)
PHAS123808383(DUOX2) 123808384(DUOX1)
MMF118634032(DUOX2) 118643623(DUOX1)
RFQ117022873(DUOX2) 117022930(DUOX1)
PALE102894515(DUOX1) 102895435(DUOX2)
PGIG120622692(DUOX1) 120622695(DUOX2)
PVP105288716(DUOX1) 105288802(DUOX2)
RAY107514952(DUOX2) 107514968(DUOX1)
MJV108400250 108400257(DUOX1)
TOD119238574(DUOX2) 119238578(DUOX1)
SARA101538188(DUOX2) 101544879(DUOX1)
LAV100661484(DUOX2) 100677682(DUOX1)
TMU101345381 101356645
DNM101412118(DUOX2) 101412552
MDO100012658(DUOX2) 100012836(DUOX1)
GAS123234061 123235930(DUOX1)
SHR100931267(DUOX2) 100932050(DUOX1)
PCW110223647(DUOX1) 110223721
OAA100089154(DUOX2) 100093104
GGA427482(DUOX2)
PCOC116244490(DUOX2)
MGP100538948(DUOX2)
CJO107318475(DUOX2)
NMEL110403879(DUOX2)
APLA101800626(DUOX2)
ACYG106047419(DUOX2)
AFUL116493480
TGU100218721
LSR110483946
SCAN103816154
PMOA120508906
OTC121343480
PRUF121354438
GFR102037063(DUOX2)
FAB101805677(DUOX2)
PHI102105296(DUOX2)
PMAJ107209583
CCAE111934317
CCW104697496
ETL114060481(DUOX2)
ZAB102073652(DUOX2)
FPG101914675(DUOX2)
FCH102054788
CLV102097710(DUOX2)
EGZ104130687(DUOX2)
NNI104016775(DUOX2)
ACUN113483989
TALA104369414
PADL103916812(DUOX2)
ACHC115341551
AAM106487968
AROW112967264
NPD112951292(DUOX2)
DNE112993048(DUOX2)
ASN102372872
AMJ102573689(DUOX2)
CPOO109308805
GGN109288798
PSS102461565(DUOX2)
CMY102933380
CPIC101942492(DUOX2)
TST117884303(DUOX2)
CABI116827174
MRV120373615
ACS100562649
PVT110091655
SUND121934790(DUOX2)
PBI103059551(DUOX2)
PMUR107294062(DUOX2)
PGUT117674550(DUOX2)
VKO123033744
PMUA114584565(DUOX2)
ZVI118092463
GJA107106710
XLA108710292(duox2.L) 108711340 108712328(duox2.S)
XTR100486050(duox2) 100486194(duox1)
NPR108801818 108804829
RTEM120931421 120931423
BBUF120985726(DUOX1) 120986322
BGAR122923413 122927672
DRE565097(duox)
SRX107712499 107739096
SANH107662471 107688941
SGH107557982 107589348
CCAR109059806
CAUA113043483 113043896 113067050
IPU108275020(duox)
PHYP113529691(duox1)
SMEO124392773(duox)
TFD113660148(duox)
AMEX103026091(duox1)
EEE113584048
TRU100124426(duox)
TNGGSTEN00025605G001
LCO104937849(duox1)
NCC104960088(duox1)
CGOB115009999
ELY117262773(duox)
PLEP121950646(duox)
SLUC116038809(duox)
ECRA117949674(duox)
PFLV114559718(duox1)
GAT120809557(duox)
PPUG119195784(duox)
MSAM119894233(duox)
CUD121515362(duox)
MZE101470770
ONL100696790(duox1)
OAU116326693(duox)
OLA101160477(duox1)
OML112152210(duox)
XMA102217295(duox1)
XCO114151766(duox1)
XHE116710584 116711046
PRET103466440(duox1)
PFOR103155698
PLAI106958144
PMEI106919349
GAF122834984(duox)
CVG107087399
CTUL119775040(duox)
GMU124882361(duox)
NFU107388507
KMR108229956(duox)
ALIM106526813(duox1)
NWH119416339(duox)
AOCE111577711
CSEM103380468(duox1)
POV109624285(duox1)
SSEN122761368(duox)
HHIP117763804(duox)
LCF108876727(duox1)
SDU111229749(duox1)
SLAL111658523(duox1)
XGL120793840(duox)
HCQ109507657(duox1)
BPEC110169429
MALB109973835
SASA106561775 106584698
OTW112257697(duox)
OMY110502555(duox) 110521216
OGO124031608 124037496
ONE115144669
SALP112068471 112070024
SNH120051672 120065946
ELS105018355(duox1)
SFM108926713 108931140
PKI111835096(duox1)
AANG118214827(duox) 118227745
LOC102686607
PSPA121294413 121299078
ARUT117427637 117429209
LCM102354060
CMK103188862(duox) 103189631
RTP109915384 109929142
BFO118405238 118410062 118410673
BBEL109478520 109484726 109485115
CIN100170036(duox-d) 100170037(duox-c) 100170038(duox-b) 100170039(duox-a)
SCLV120342587
SPU100893745 588656(duox1)
APLC110980995
SKO100378968 102804119 102808835
DMEDmel_CG3131(Duox)
DER6542143
DSE6613156
DSIDsimw501_GD22800(Dsim_GD22800)
DYADyak_GE15013
DAN6497732
DSR110185672
DPODpse_GA16169
DPE6603391
DMN108163035
DWI6644426
DGR6570040
DMODmoj_GI12101
DAZ108610468
DNV115564315
DHE111592500
CCAT101460810
BOD106625065
MDE101898456
SCAC106088128
LCQ111691057
AGAAgaP_AGAP009978(DUOX)
ACOZ120957353
AARA120901491
AAG5569378
AALB109622897 115258596
CQUCpipJ_CPIJ003117
CPII120422785
CNS116343935
AME551970
ACER107993848
ALAB122712686
BIM100742890
BBIF117206993
BVK117235941
BVAN117154209
BTER100646100
BPYO122566024
CCAL108628573
OBB114871314
MGEN117217339 117223205
NMEA116428719 116432216
CGIG122398578 122399477
SOC105193293 105198516
MPHA105832768 105839999
AEC105143353
ACEP105623067
PBAR105425537 105433753
VEM105561934 105565430
HST105180870 105189824 105191215
DQU106745647 106748066
CFO105249651 105253135
FEX115238324 115238334 115243603
LHU105674245 105674838
PGC109853998 109861167
OBO105277837 105283516
PCF106787395 106787604
PFUC122514344 122522295
VPS122626888 122632224
NVI100123854
CSOL105360056
TPRE106654602
MDL103568521 103578043
CGLO123258500 123265286
FAS105271402 105271872
DAM107039719 107045559
AGIF122857152
CCIN107264776 107268015 107268261
TCA659451 660520
DPA109541703
SOY115891745
ATD109594881 109594882 109596781
CSET123316127 123322151
AGB108905028 108907487
LDC111502526 111510352
NVL108556323 108568369
APLN108735923
PPYR116165495 116181099
OTU111425098 111429313
BMOR101742234
BMAN114249899
MSEX115447638
DPLKGM_207783
BANY112051693
PMAC106717948
PPOT106108434
PXU106115869
PRAP110992372
ZCE119830708
HAW110372854
TNL113498966
OFU114364584
PXY105389437
API100160850
DNX107163754
AGS114128657
RMD113556351
BTAB109040851
DCI103506134
CLEC106669322
HHAL106678549
NLU111058714 120354282
PHUPhum_PHUM454140
FOC113214828
ZNE110836218 110836302
CSEC111862142 111873871
FCD110845799 110847047
DPXDAPPUDRAFT_115264 DAPPUDRAFT_320872 DAPPUDRAFT_329115
DMK116936030
PVM113809368 113821689
PJA122247237 122250160
PCHN125029410 125043153
HAME121856691 121876182
PCLA123765441 123768988
PTRU123502638 123516038
HAZT108668232 108674360
EAF111699344 111712072
ISCIscW_ISCW007865
DSV119434619 119442650
RSAN119386466 119387297
RMP119178146 119188292
VDE111248894
VJA111269827
TUT107362746 107366415
DPTE113794004 113795926
DFR124490589 124491423
CSCU111612592 111619848 111625119
PTEP107441689 107445505 107451888
SDM118182489 118187761 118195019
CELCELE_F53G12.3(duox-2) CELE_F56C11.1(bli-3)
CBRCBG_05103(Cbr-duox-2)
BMYBM_BM4466(Bm4466)
LOALOAG_18205
NAINECAME_02527
TSPTsp_00940
LGILOTGIDRAFT_112352 LOTGIDRAFT_235056 LOTGIDRAFT_235234
PCAN112553786 112554429 112554430 112558393
BGT106070912 106078268
GAE121385129 121388454
HRF124112180 124122507 124122515
HRJ124278674 124291869 124291870
CRG105325327 105331097 105334568
MYI110445627 110445731 110453652 110456222
PMAX117314677 117334185 117334744
MMER123560845 123565534 123566150 123566602
OBI106882005
OSN115213405
LAK106150451 106151065 106178827
DGT114531756 114531757
XEN124439533 124439535
AQU100637823
CCPCHC_T00004536001
PANPODANSg09756
MGRMGG_08299
FPUFPSE_02823
FVRFVEG_12250
FOXFOXG_13287
VALVDBG_00422
VDAVDAG_00032
CFJCFIO01_04415
PFYPFICI_13149
SREPTSG_06098
 » show all
Reference
1  [PMID:12110737]
  Authors
Moreno JC, Bikker H, Kempers MJ, van Trotsenburg AS, Baas F, de Vijlder JJ, Vulsma T, Ris-Stalpers C
  Title
Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism.
  Journal
N Engl J Med 347:95-102 (2002)
DOI:10.1056/NEJMoa012752
  Sequence
[hsa:50506]
Reference
2  [PMID:11822874]
  Authors
De Deken X, Wang D, Dumont JE, Miot F
  Title
Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.
  Journal
Exp Cell Res 273:187-96 (2002)
DOI:10.1006/excr.2001.5444
  Sequence
[hsa:53905 50506]
Reference
3  [PMID:10806195]
  Authors
De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F
  Title
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.
  Journal
J Biol Chem 275:23227-33 (2000)
DOI:10.1074/jbc.M000916200
  Sequence
[hsa:53905 50506]
Reference
4  [PMID:10601291]
  Authors
Dupuy C, Ohayon R, Valent A, Noel-Hudson MS, Deme D, Virion A.
  Title
Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.
  Journal
J Biol Chem 274:37265-9 (1999)
DOI:10.1074/jbc.274.52.37265
  Sequence
[hsa:50506] [ssc:397060]
Reference
5  [PMID:10401672]
  Authors
Leseney AM, Deme D, Legue O, Ohayon R, Chanson P, Sales JP, Pires de Carvalho D, Dupuy C, Virion A.
  Title
Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue.
  Journal
Biochimie 81:373-80 (1999)
DOI:10.1016/S0300-9084(99)80084-4
Reference
6  [PMID:1995628]
  Authors
Dupuy C, Virion A, Ohayon R, Kaniewski J, Deme D, Pommier J.
  Title
Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane.
  Journal
J Biol Chem 266:3739-43 (1991)
Other DBs
ExplorEnz - The Enzyme Database: 1.6.3.1
IUBMB Enzyme Nomenclature: 1.6.3.1
ExPASy - ENZYME nomenclature database: 1.6.3.1
BRENDA, the Enzyme Database: 1.6.3.1
CAS: 77106-92-4

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