KEGG ENZYME: 1.6.3.1

ENZYME: 1.6.3.1

Entry

EC 1.6.3.1                  Enzyme

Name

NAD(P)H oxidase (H2O2-forming);
THOX2;
ThOX;
dual oxidase;
p138tox;
thyroid NADPH oxidase;
thyroid oxidase;
thyroid oxidase 2;
NADPH oxidase;
NAD(P)H:oxygen oxidoreductase;
NAD(P)H oxidase

Class

Oxidoreductases;
Acting on NADH or NADPH;
With oxygen as acceptor

Sysname

NAD(P)H:oxygen oxidoreductase (H2O2-forming)

Reaction(IUBMB)

NAD(P)H + H+ + O2 = NAD(P)+ + H2O2 [RN:R07171 R07172]

Reaction(KEGG)

R07171 R07172

Substrate

NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O2 [CPD:C00027]

Comment

Requires FAD, heme and calcium. When calcium is present, this transmembrane glycoprotein generates H2O2 by transfering electrons from intracellular NAD(P)H to extracellular molecular oxygen. The electron bridge within the enzyme contains one molecule of FAD and probably two heme groups. This flavoprotein is expressed at the apical membrane of thyrocytes, and provides H2O2 for the thyroid peroxidase-catalysed biosynthesis of thyroid hormones.

History

EC 1.6.3.1 created 2003, modified 2013

Orthology

K13411

dual oxidase

Genes

HSA:	50506(DUOX2) 53905(DUOX1)

PTR:	453395(DUOX2) 467673(DUOX1)

PPS:	100974723(DUOX1) 100978429(DUOX2)

GGO:	101137548(DUOX1) 101139037(DUOX2)

PON:	100445893(DUOX2) 100447745(DUOX1)

PPYG:

129014080(DUOX1) 129014091(DUOX2)

NLE:	100588618(DUOX1) 100595406(DUOX2)

HMH:	116481630(DUOX2) 116481634(DUOX1)

SSYN:

129482715(DUOX2) 129482716(DUOX1)

MCC:	713126(DUOX1) 713906(DUOX2)

MCF:	102131806(DUOX2) 102133834(DUOX1)

MTHB:

126959003 126959006

MNI:	105491060(DUOX1) 105491076(DUOX2)

CSAB:

103245704(DUOX2) 103245708(DUOX1)

CATY:

105588180(DUOX2) 105588237(DUOX1)

PANU:

101001178(DUOX1) 101003630(DUOX2)

TGE:	112627574(DUOX2) 112627626(DUOX1)

MLEU:

105548205(DUOX2) 105548207(DUOX1)

RRO:	104653891(DUOX2) 104653893(DUOX1)

RBB:	108530131(DUOX1) 108530134(DUOX2)

TFN:	117070727(DUOX1) 117070728(DUOX2)

PTEH:

111552779(DUOX2) 111552783(DUOX1)

CANG:

105502161(DUOX1) 105502244(DUOX2)

CJC:	100387872(DUOX2) 100406741(DUOX1)

SBQ:	101043225(DUOX1) 101045049(DUOX2)

CIMI:

108315882(DUOX1) 108315930(DUOX2)

ANAN:

105709960(DUOX1) 105710120(DUOX2)

CSYR:

103264964(DUOX1) 103264967(DUOX2)

MMUR:

105872553(DUOX2) 105872556(DUOX1)

LCAT:

123622110(DUOX2) 123622143(DUOX1)

PCOQ:

105814270(DUOX1) 105814287(DUOX2)

OGA:	100944838(DUOX2) 100951355(DUOX1)

MMU:	214593(Duox2) 99439(Duox1)

MCAL:

110289528(Duox2) 110289597(Duox1)

MPAH:

110318871(Duox2) 110318947(Duox1)

RNO:	266807(Duox1) 79107(Duox2)

MCOC:

116091779(Duox2) 116091780(Duox1)

ANU:	117702979(Duox1) 117703645

MUN:	110553262(Duox2) 110553266(Duox1)

CGE:	100764526(Duox2) 100774391(Duox1)

MAUA:

101839193(Duox2) 101839454(Duox1)

PROB:

127221539(Duox1) 127221542(Duox2)

PLEU:

114699556(Duox2) 114699606(Duox1)

MORG:

121465728(Duox1) 121465787(Duox2)

MFOT:

126496594 126496822

AAMP:

119814681(Duox1) 119815006(Duox2)

NGI:	103746898(Duox2) 103746936(Duox1)

HGL:	101698133(Duox1) 101698889(Duox2)

CPOC:

100712930(Duox2) 100713662(Duox1)

CCAN:

109692712(Duox2) 109692713(Duox1)

DORD:

105980984(Duox1) 105980986(Duox2)

DSP:	122114489(Duox2) 122114688(Duox1)

PLOP:

125340532(Duox2) 125340795(Duox1)

NCAR:

124976018 124976951

MMMA:

107138131(Duox1) 107138136(Duox2)

OCU:	100344845 100345610

OPI:	101518356(DUOX1) 101527435(DUOX2)

TUP:	102471164(DUOX2) 102496442(DUOX1)

GVR:	103599021(DUOX2) 103599027(DUOX1)

CFA:	403719(DUOX2) 403720(DUOX1)

CLUD:

112676001(DUOX1) 112676004(DUOX2)

VVP:	112919876(DUOX2) 112919877(DUOX1)

VLG:	121480469(DUOX1) 121485693(DUOX2)

NPO:	129504180(DUOX2) 129504193(DUOX1)

AML:

100469477

UMR:	103656587(DUOX2) 103656588(DUOX1)

UAH:	113246795 113249136(DUOX1) 113250192 113269715(DUOX2) 125280908 125281381 125281384 125281397 125281422 125281937 125281939 125281946 125281993 125282078 125282213 130543918

UAR:	123775598 123801946(DUOX1) 123801956(DUOX2)

ELK:	111159740 111161962

LLV:	125104903 125105521

MPUF:

101675593(DUOX2) 101677288

MNP:	131999714(DUOX2) 131999717(DUOX1)

MLK:	131836227 131836230(DUOX1)

NVS:	122893437(DUOX1) 122893611(DUOX2)

ORO:	101365122(DUOX2) 101365433(DUOX1)

EJU:	114226548(DUOX1) 114226550(DUOX2)

ZCA:	113908521(DUOX2) 113909575(DUOX1)

MLX:	118003552(DUOX2) 118003553

NSU:	110585577(DUOX1) 110585599(DUOX2)

LWW:	102736507(DUOX1) 102745755(DUOX2)

FCA:	101087408(DUOX2) 101091374(DUOX1)

PYU:	121041635(DUOX2) 121041640(DUOX1)

PCOO:

112855594 112855595(DUOX2)

PBG:	122468696(DUOX1) 122468698(DUOX2)

PVIV:

125167834(DUOX1) 125167835(DUOX2)

LRUF:

124508067 124508070

PTG:	102968075(DUOX2) 102968369(DUOX1)

PPAD:

109263047(DUOX1) 109263048(DUOX2)

PUC:	125909963 125910376

AJU:	106986276 106986277

HHV:	120243824(DUOX1) 120243827(DUOX2)

BTA:	510409(DUOX1) 785698(DUOX2)

BOM:	102272102(DUOX2) 102277170(DUOX1)

BIU:	109564555(DUOX1) 109565168(DUOX2)

BBUB:

102403106(DUOX1) 102405152(DUOX2)

BBIS:

104994233(DUOX2) 104994265(DUOX1)

CHX:	102179569(DUOX1) 106502554(DUOX2)

OAS:	100462743(DUOX2) 101111972(DUOX1)

BTAX:

128054038(DUOX1) 128054063(DUOX2)

ODA:	120852935(DUOX2) 120852937(DUOX1)

CCAD:

122443648(DUOX1) 122443649(DUOX2)

MBEZ:

129562620(DUOX1) 129563165(DUOX2)

SSC:	397060(DUOX2) 397177(DUOX1)

CFR:	102510558(DUOX1) 102510795(DUOX2)

CBAI:

105076985(DUOX2) 105077066(DUOX1)

CDK:	105101748(DUOX1) 105101749(DUOX2)

VPC:	102537541(DUOX2) 102537792(DUOX1)

BACU:

103001055(DUOX2) 103001339(DUOX1)

BMUS:

118889680(DUOX1) 118890546(DUOX2)

LVE:	103071982(DUOX2) 103076766(DUOX1)

OOR:	101269659(DUOX1) 101280015(DUOX2)

DLE:	111181555 111181567

PCAD:

102980878(DUOX2) 102993288(DUOX1)

PSIU:

116748576 116749048(DUOX2)

NASI:

112410647

ECB:	100070541(DUOX1) 100070566(DUOX2)

EPZ:	103554035(DUOX1) 103554037(DUOX2)

EAI:	106834993(DUOX1) 106834997(DUOX2)

MYB:	102242003(DUOX2) 102252627(DUOX1)

MYD:	102771512(DUOX1) 102771797(DUOX2)

MMYO:

118651162(DUOX2) 118651210(DUOX1)

MLF:	102431860(DUOX2) 102435194(DUOX1)

MDT:	132237894(DUOX1) 132238003(DUOX2)

PKL:	118721941(DUOX1) 118722118(DUOX2)

EFUS:

103287540(DUOX2) 103287541(DUOX1)

MNA:	107536153(DUOX1) 107536249(DUOX2)

DRO:	112311051(DUOX2) 112311507(DUOX1)

SHON:

118992575(DUOX2) 118992576(DUOX1)

AJM:	119053965(DUOX1) 119054202(DUOX2)

PDIC:

114493099(DUOX2) 114493372(DUOX1)

PHAS:

123808383(DUOX2) 123808384(DUOX1)

MMF:	118634032(DUOX2) 118643623(DUOX1)

PPAM:

129063884(DUOX1) 129063909(DUOX2)

HAI:	109396658(DUOX1) 109396662

RFQ:	117022873(DUOX2) 117022930(DUOX1)

PALE:

102894515(DUOX1) 102895435(DUOX2)

PGIG:

120622692(DUOX1) 120622695(DUOX2)

PVP:	105288716(DUOX1) 105288802(DUOX2)

RAY:	107514952(DUOX2) 107514968(DUOX1)

MJV:	108400250(DUOX2) 108400257(DUOX1)

TOD:	119238574 119238578(DUOX1)

SARA:

101538188(DUOX2) 101544879(DUOX1)

SETR:

126020877 126020922

LAV:	100661484(DUOX2) 100677682(DUOX1)

TMU:	101345381 101356645

ETF:	101649942(DUOX1) 101654000

DNM:	101412118(DUOX2) 101412552

MDO:	100012658(DUOX2) 100012836(DUOX1)

GAS:	123234061 123235930(DUOX1)

SHR:	100931267(DUOX2) 100932050(DUOX1)

AFZ:	127546640 127549323

PCW:	110223647(DUOX1) 110223721

TVP:	118829117 118829832(DUOX2)

OAA:	100089154(DUOX2) 100093104

GGA:	427482(DUOX2)

PCOC:

116244490(DUOX2)

MGP:	100538948(DUOX2)

CJO:	107318475(DUOX2)

TPAI:

128075553(DUOX2)

LMUT:

125698129(DUOX2)

NMEL:

110403879(DUOX2)

APLA:

101800626

ACYG:

106047419(DUOX2)

CATA:

118258122(DUOX2)

AFUL:

116493480

TGU:

100218721

LSR:

110483946

SCAN:

103816154

PMOA:

120508906

OTC:

121343480

PRUF:

121354438

GFR:	102037063(DUOX2)

FAB:	101805677(DUOX2)

OMA:

130257185

PHI:

102105296

PMAJ:

107209583

CCAE:

111934317

CCW:

104697496

CBRC:

103613492

ETL:	114060481(DUOX2)

ZAB:	102073652(DUOX2)

ZLE:	135452058(DUOX2)

ACHL:

103803619

SVG:	106861562(DUOX2)

MMEA:

130582049(DUOX2)

HRT:	120758814(DUOX2)

SATI:

136366799(DUOX2)

FPG:	101914675(DUOX2)

FCH:

102054788

CCRI:

104161059(DUOX2)

NNT:

104404842

SHAB:

115612850

ACUN:

113483989

TALA:

104369414

ACHC:

115341551

HALD:

104314108

HLE:	104834669(DUOX2)

AGEN:

126043498

GCL:

127020504

CSTI:

104554504

LDI:

104355052

MNB:

103773474

AVIT:

104275030(DUOX2)

BRHI:

104491634

EGZ:	104130687(DUOX2)

NNI:	104016775(DUOX2)

PCRI:

104035098

PCAO:

104045946

PADL:

103916812(DUOX2)

AFOR:

103896475

FGA:	104069584(DUOX2)

GSTE:

104261232

CLV:	102097710(DUOX2)

MUI:

104546897

PGUU:

104468825

PLET:

104623027

EHS:

104510797

CMAC:

104476107(DUOX2)

CUCA:

104064857(DUOX2)

TEO:	104381060(DUOX2)

BREG:

104629205(DUOX1)

OHA:

104330638

ACAR:

104517945

CPEA:

104396143(DUOX2)

CVF:

104293626

RTD:	128914814(DUOX2)

AAM:

106487968

AROW:

112967264

NPD:	112951292(DUOX2)

TGT:	104580189(DUOX2)

DNE:	112993048(DUOX2)

SCAM:

104139038(DUOX2)

ASN:

102372872

AMJ:	102573689(DUOX2)

CPOO:

109308805

GGN:

109288798

PSS:	102461565(DUOX2)

CMY:

102933380

CCAY:

125644070

DCC:

119862561

CPIC:

101942492(DUOX2)

TST:	117884303(DUOX2)

CABI:

116827174

MRV:

120373615

ACS:

100562649

ASAO:

132762396(DUOX2)

PVT:

110091655

SUND:

121934790(DUOX2)

PBI:	103059551(DUOX2)

PMUR:

107294062(DUOX2)

CTIG:

120306363

PGUT:

117674550(DUOX2)

APRI:

131184833(DUOX2)

PTEX:

113442373(DUOX2)

NSS:	113422914(DUOX2)

VKO:

123033744

PMUA:

114584565(DUOX2)

PRAF:

128401762(DUOX2)

ZVI:

118092463

HCG:

128335217

GJA:

107106710

STOW:

125424641

EMC:	129345260(DUOX2)

XLA:	108710292(duox2.L) 108711340 108712328(duox2.S)

XTR:	100486050(duox2) 100486194(duox1)

NPR:	108801818 108804829

RTEM:

120931421 120931423

BBUF:

120985726(DUOX1) 120986322

BGAR:

122923413 122927672

MUO:	115458066 115458080

GSH:	117348294 117348540

DRE:	565097(duox)

SRX:	107712499 107739096

SANH:

107662471 107688941

SGH:	107557982 107589348

CCAR:

109059806

CAUA:

113043483 113043896 113067050

CGIB:

127946775 128013932

PTET:

122330495(duox)

LROH:

127157149(duox)

OMC:	131534476(duox)

PPRM:

120495536(duox)

RKG:	130099345(duox)

MAMB:

125247766(duox)

CIDE:

127507635

CERY:

137014962(duox)

MASI:

127435739

TROS:

130551643(duox)

TDW:	130414330(duox)

MANU:

129433482(duox)

IPU:	108275020(duox)

IFU:	128618319(duox)

PHYP:

113529691(duox1)

SMEO:

124392773(duox)

TFD:	113660148(duox)

TVC:	132856860(duox)

TRN:	134320764(duox)

AMEX:

103026091(duox)

CMAO:

118811708(duox)

EEE:

113584048

CHAR:

105892344(duox)

TRU:	100124426(duox)

TFS:	130535906(duox)

TNG:	GSTEN00025605G001

LCO:	104937849(duox1)

NCC:	104960088(duox1)

TBEN:

117491690(duox)

CGOB:

115009999

PGEO:

117448565(duox)

GACU:

117538906(duox)

EMAC:

134881758(duox)

ELY:	117262773(duox)

EFO:	125887379(duox)

PLEP:

121950646(duox)

SLUC:

116038809(duox)

ECRA:

117949674(duox)

ESP:	116693897(duox1)

PFLV:

114559718(duox1)

GAT:	120809557(duox)

PPUG:

119195784(duox)

AFB:	129108597(duox)

CLUM:

117731992(duox)

PSWI:

130195347(duox)

MSAM:

119894233(duox)

SCHU:

122874546(duox)

CUD:	121515362(duox)

ALAT:

119024169(duox)

MZE:

101470770

ONL:	100696790(duox1)

OAU:	116326693(duox)

OLA:	101160477(duox1)

OML:	112152210(duox)

CSAI:

133444724(duox)

XMA:	102217295(duox1)

XCO:	114151766(duox1)

XHE:	116710584 116711046

PRET:

103466440(duox1)

PFOR:

103155698

PLAI:

106958144

PMEI:

106919349

GAF:	122834984(duox)

PPRL:

129359358(duox)

CVG:

107087399

CTUL:

119775040(duox)

GMU:	124882361(duox)

NFU:

107388507

KMR:	108229956(duox)

ALIM:

106526813(duox1)

NWH:	119416339(duox)

AOCE:

111577711

MCEP:

125014956(duoX)

CSEM:

103380468(duox1)

POV:	109624285(duox1)

SSEN:

122761368(duox)

HHIP:

117763804(duox)

HSP:	118110158(duox)

PPLT:

128444541(duox)

SMAU:

118314714(duox)

LCF:	108876727(duox)

SDU:	111229749(duox1)

SLAL:

111658523(duox1)

XGL:	120793840(duox)

HCQ:	109507657(duox1)

SSCV:

125971362

SBIA:

133502387(duox)

PEE:	133402813(duox)

PTAO:

133478562(duox)

BPEC:

110169429

MALB:

109973835

BSPL:

114857408(duox)

SJO:	128359313(duox)

SASA:

106561775 106584698

STRU:

115192881 115197710

OTW:	112257697(duox)

OMY:	110502555(duox) 110521216

OGO:	124031608 124037496

ONE:

115144669

OKI:	109885757 109898227

OKE:	118378263 118378457

SALP:

112068471 112070024

SNH:	120051672 120065946

CCLU:

121540085 121568188

ELS:	105018355(duox1)

SFM:	108926713 108931140

PKI:	111835096(duox1)

AANG:

118214827(duox) 118227745

LOC:

102686607

PSPA:

121294413 121299078

ARUT:

117427637 117429209

PSEX:

120541780(duox)

LCM:

102354060

CMK:	103188862(duox) 103189631

RTP:	109915384 109929142

CPLA:

122542470 122542494(duox)

HOC:	132834712(duox) 132834849

LERI:

129713461(duox) 129713673

PMRN:

116939211 116939218 116941785

LRJ:

133346585

BFO:	118405238 118410062 118410673

BBEL:

109478520 109484726 109485115

CIN:	100170036(duox-d) 100170037(duox-c) 100170038(duox-b) 100170039(duox-a)

SCLV:

120342587

SPU:	100893745 588656(duox1)

LPIC:

129262287 129262288

APLC:

110980995

ARUN:

117296152

AJC:

117119778

SKO:	100378968 102804119 102808835

DME:	Dmel_CG3131(Duox)

DER:

6542143

DSE:

6613156

DSI:	Dsimw501_GD22800(Dsim_GD22800)

DYA:	Dyak_GE15013

DAN:

6497732

DSR:

110185672

DPO:

4816533

DPE:

6603391

DMN:

108163035

DWI:

6644426

DGR:

6570040

DMO:	Dmoj_GI12101

DAZ:

108610468

DNV:

115564315

DHE:

111592500

CCAT:

101460810

BOD:

106625065

BDR:

105225675

RZE:	108361967 108372158

AOQ:

129247091

TDA:

119687726

MDE:

101898456

SCAC:

106088128

LCQ:

111691057

LSQ:

119602199

GFS:

119642325

ECOE:

129938951

CLON:

129609482

HIS:

119652329

AGA:

1279399

ACOZ:

120957353

AARA:

120901491

AMER:

121595666

ASTE:

118512226

AFUN:

125775114

AMOU:

128302188

AALI:

118460842

AAG:

5569378

AALB:

109622897 115258596

ASUA:

134212016

CQU:	CpipJ_CPIJ003117

CPII:

120422785

CNS:

116343935

BCOO:

119081949

AME:

551970

ACER:

107993848

ALAB:

122712686

ADR:

102679095

AFLR:

100869014

BIM:

100742890

BBIF:

117206993

BVK:

117235941

BVAN:

117154209

BTER:

100646100

BAFF:

126916062

BPYO:

122566024

BPAS:

132905008

FVI:

122537563

CCAL:

108628573

OBB:

114871314

OLG:

117605491

MGEN:

117217339 117223205

NMEA:

116428719 116432216

CGIG:

122398578 122399477

SOC:	105193293 105198516

MPHA:

105832768 105839999

AEC:

105143353

ACEP:

105623067

PBAR:

105425537 105433753

VEM:	105561934 105565430

HST:	105180870 105189824 105191215

DQU:	106745647 106748066

CFO:	105249651 105253135

FEX:	115238324 115238334 115243603

LHU:	105674245 105674838(Duox)

PGC:	109853998 109861167

OBO:	105277837 105283516

PCF:	106787395 106787604

PFUC:

122514344 122522295

VPS:	122626888 122632224

VCRB:

124431389

VVE:

124946379

NVI:

100123854

CSOL:

105360056

TPRE:

106654602

LHT:

122502121

LBD:

127287382

MDL:	103568521 103578043

CGLO:

123258500 123265286

FAS:	105271402 105271872

DAM:	107039719 107045559

AGIF:

122857152

CINS:

118071263

VCAN:

122414533

CCIN:

107264776 107268015 107268261

DSM:	124404959 124411074

NPT:	124211416 124220322

NFB:	124175046 124183629

NLO:	107224630 107226508

NVG:	124297468 124306051

AROA:

105689367 105690261

TCA:	659451 660520

DPA:

109541703

SOY:

115891745

AGRG:

126735493

ATD:	109594881 109594882 109596781

CSET:

123316127 123322151

AGB:	108905028 108907487

LDC:	111502526 111510352

DVV:	114325141 114326347

NVL:	108556323 108568369

APLN:

108735923

PPYR:

116165495 116181099

OTU:	111425098 111429313

BMOR:

101742234

BMAN:

114249899

MSEX:

115447638

DPL:	KGM_207783

BANY:

112051693

MJU:

123872626

NIQ:

126773546

VCD:

124534246

MCIX:

123656610

PMAC:

106717948

PPOT:

106108434

PXU:

106115869

PRAP:

110992372

PBX:

123709947

PNAP:

125053715

ZCE:

119830708

CCRC:

123696144

LSIN:

126975823

AAGE:

121733075

HAW:	110372854(duoX)

HZE:

124637464

TNL:

113498966

SLIU:

111347853

OFU:

114364584

ATRA:

106131398

GMW:

113520780

PXY:

105389437

PGW:

126371855

LGLY:

125230299

CFEL:

113386970

CCRN:

123291727 123294128

API:

100160850

DNX:

107163754

AGS:

114128657

RMD:

113556351

ACOO:

126833243

DVT:

126908066

BTAB:

109040851

DCI:

103506134

CLEC:

106669322

HHAL:

106678549(Duox)

NLU:	111058714 120354282

HVI:	124366471 124371953

MQU:	129001946 129002045

PHU:	Phum_PHUM454140

FOC:

113214828

TPAL:

117640823

ZNE:	110836218 110836302

CSEC:

111862142 111873871

SGRE:

126355596

BROR:

134538839 134543307

IEL:	124159382 124167279

FCD:	110845799 110847047

DPX:	DAPPUDRAFT_115264 DAPPUDRAFT_320872 DAPPUDRAFT_329115

DMK:

116936030

DPZ:	124344465 124344476

PVM:	113809368 113821689

PJA:	122247237 122250160

PCHN:

125029410 125043153

PMOO:

119580595 119585016

HAME:

121856691 121876182

PCLA:

123765441 123768988

CQD:	128686120 128694942

PTRU:

123502638 123516038

ESN:	127003819 127005734

MNZ:	135197901 135209655

HAZT:

108668232 108674360

EAF:	111699344 111712072

LSM:	121126652 121132081

TCF:	131882251 131882785

PPOI:

119096881 119097515 119109308

ISC:	115322793 8031895

DSV:	119434619 119442650

RSAN:

119386466 119387297

RMP:	119178146 119188292

VDE:

111248894

VJA:

111269827

TUT:	107362746 107366415

DPTE:

113794004 113795926

DFR:	124490589 124491423

CSCU:

111612592 111619848 111625119

CVS:	136979215 136984174 136989508

PTEP:

107441689 107445505 107451888

ABRU:

129955181 129958731 129961582

UDV:	129216752 129217818 129223755

SDM:	118182489 118187761 118195019

LPOL:

106457545 106464290 106475085 106477616

PMEO:

129586240

CEL:	CELE_F53G12.3(duox-2) CELE_F56C11.1(bli-3)

CBR:	CBG_05103(Cbr-duox-2)

CRQ:	GCK72_001329

NAI:	NECAME_02527

BMY:	BM_BM4466(Bm4466)

LOA:	LOAG_18205

TSP:

Tsp_00940

LGI:	LOTGIDRAFT_112352 LOTGIDRAFT_235056 LOTGIDRAFT_235234

PVUL:

126817982 126818032 126822318

PCAN:

112553786 112554429 112554430 112558393

BGT:	106070912 106078268

GAE:	121385129 121388454

HRF:	124112180 124122507 124122515

HRJ:	124278674 124291869 124291870

CRG:	105325327 105331097 105334568

CANU:

128175759 128176036 128179806

CVN:	111128315 111128630 111129986 111129994 111136982

OED:	125645917 125649060 125650048

MYI:	110445627 110445731 110453652 110456222

PMAX:

117314677 117334185 117334744

MCAF:

127730076 127734067 127734992

MMER:

123560845 123565534 123566150 123566602

RPHI:

132724237 132757527

DPOL:

127859436 127877225 127879739 127879740 127879741

MAEA:

128227146 128227690 128234775

OBI:

106882005

OSN:

115213405

LJP:	135462115 135464009 135473364

LAK:	106150451 106151065 106178827

LLON:

135497866

DGT:	114531756 114531757

XEN:	124439533 124439535

AQU:

100637823

CCP:	CHC_T00004536001

PAN:	PODANSg09756

MGR:

MGG_08299

PPEI:

PpBr36_02127

FPU:	FPSE_02823

FVR:	FVEG_12250

FOX:	FOXG_13287

VAL:	VDBG_00422

VDA:	VDAG_00032

CFJ:	CFIO01_04415

CHIG:

CH63R_09213

PFY:	PFICI_13149

SRE:	PTSG_06098

» show all

Reference

1 [PMID:12110737]

Authors

Moreno JC, Bikker H, Kempers MJ, van Trotsenburg AS, Baas F, de Vijlder JJ, Vulsma T, Ris-Stalpers C

Title

Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism.

Journal

N Engl J Med 347:95-102 (2002)
DOI:10.1056/NEJMoa012752

Sequence

[hsa:50506]

Reference

2 [PMID:11822874]

Authors

De Deken X, Wang D, Dumont JE, Miot F

Title

Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.

Journal

Exp Cell Res 273:187-96 (2002)
DOI:10.1006/excr.2001.5444

Sequence

[hsa:53905 50506]

Reference

3 [PMID:10806195]

Authors

De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F

Title

Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.

Journal

J Biol Chem 275:23227-33 (2000)
DOI:10.1074/jbc.M000916200

Sequence

[hsa:53905 50506]

Reference

4 [PMID:10601291]

Authors

Dupuy C, Ohayon R, Valent A, Noel-Hudson MS, Deme D, Virion A.

Title

Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.

Journal

J Biol Chem 274:37265-9 (1999)
DOI:10.1074/jbc.274.52.37265

Sequence

[hsa:50506] [ssc:397060]

Reference

5 [PMID:10401672]

Authors

Leseney AM, Deme D, Legue O, Ohayon R, Chanson P, Sales JP, Pires de Carvalho D, Dupuy C, Virion A.

Title

Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue.

Journal

Biochimie 81:373-80 (1999)
DOI:10.1016/S0300-9084(99)80084-4

Reference

6 [PMID:1995628]

Authors

Dupuy C, Virion A, Ohayon R, Kaniewski J, Deme D, Pommier J.

Title

Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane.

Journal

J Biol Chem 266:3739-43 (1991)

Other DBs

ExplorEnz - The Enzyme Database:

1.6.3.1

IUBMB Enzyme Nomenclature:

1.6.3.1

ExPASy - ENZYME nomenclature database:

1.6.3.1

BRENDA, the Enzyme Database:

1.6.3.1

CAS:	77106-92-4

DBGET integrated database retrieval system