EC                  Enzyme                                 

NAD(P)H oxidase (H2O2-forming);
dual oxidase;
thyroid NADPH oxidase;
thyroid oxidase;
thyroid oxidase 2;
NADPH oxidase;
NAD(P)H:oxygen oxidoreductase;
NAD(P)H oxidase
Acting on NADH or NADPH;
With oxygen as acceptor
BRITE hierarchy
NAD(P)H:oxygen oxidoreductase (H2O2-forming)
NAD(P)H + H+ + O2 = NAD(P)+ + H2O2 [RN:R07171 R07172]
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O2 [CPD:C00027]
Requires FAD, heme and calcium. When calcium is present, this transmembrane glycoprotein generates H2O2 by transfering electrons from intracellular NAD(P)H to extracellular molecular oxygen. The electron bridge within the enzyme contains one molecule of FAD and probably two heme groups. This flavoprotein is expressed at the apical membrane of thyrocytes, and provides H2O2 for the thyroid peroxidase-catalysed biosynthesis of thyroid hormones.
EC created 2003, modified 2013
K13411  dual oxidase
HSA: 50506(DUOX2) 53905(DUOX1)
PTR: 453395(DUOX2) 467673(DUOX1)
PPS: 100974723(DUOX1) 100978429(DUOX2)
GGO: 101137548(DUOX1) 101139037(DUOX2)
PON: 100445893(DUOX2) 100447745(DUOX1)
NLE: 100588618(DUOX1) 100595406(DUOX2)
MCC: 713126(DUOX1) 713906(DUOX2)
MCF: 102131806(DUOX2) 102133834(DUOX1)
CSAB: 103245704(DUOX2) 103245708(DUOX1)
RRO: 104653891(DUOX2) 104653893(DUOX1)
RBB: 108530131(DUOX1) 108530134(DUOX2)
CJC: 100387872(DUOX2) 100406741(DUOX1)
SBQ: 101043225(DUOX1) 101045049(DUOX2)
MMU: 214593(Duox2) 99439(Duox1)
MCAL: 110289528(Duox2) 110289597(Duox1)
MPAH: 110318871(Duox2) 110318947(Duox1)
RNO: 266807(Duox1) 79107(Duox2)
MUN: 110553262(Duox2) 110553266(Duox1)
CGE: 100764526(Duox2) 100774391(Duox1)
NGI: 103746898(Duox2) 103746936(Duox1)
HGL: 101698133(Duox1) 101698889(Duox2)
CCAN: 109692712(Duox2) 109692713(Duox1)
OCU: 100344845(DUOX1) 100345610(DUOX2)
TUP: 102471164(DUOX2) 102496442(DUOX1)
CFA: 403719(DUOX2) 403720(DUOX1)
VVP: 112913033 112919876(DUOX2) 112919877(DUOX1)
AML: 100469477(DUOX2)
UMR: 103656587(DUOX2) 103656588(DUOX1)
ORO: 101365122(DUOX2) 101365433(DUOX1)
FCA: 101087408(DUOX2) 101091374(DUOX1)
PTG: 102968075(DUOX2) 102968369(DUOX1)
AJU: 106986276(DUOX1) 106986277
BTA: 510409(DUOX1) 785698(DUOX2)
BOM: 102272102(DUOX2) 102277170(DUOX1)
BIU: 109564555(DUOX1) 109565168(DUOX2)
BBUB: 102403106(DUOX1) 102405152(DUOX2)
PHD: 102333965(DUOX1) 102334675(DUOX2)
CHX: 102179569(DUOX1) 106502554(DUOX2)
OAS: 100462743(DUOX2) 101111972(DUOX1)
SSC: 397060(DUOX2) 397177(DUOX1)
CFR: 102510558(DUOX1) 102510795(DUOX2)
CDK: 105101748(DUOX1) 105101749(DUOX2)
BACU: 103001055(DUOX2) 103001339(DUOX1)
LVE: 103071982(DUOX2) 103076766(DUOX1)
ECB: 100070541(DUOX1) 100070566(DUOX2)
EPZ: 103546007 103554035(DUOX1) 103554037(DUOX2)
EAI: 106834993(DUOX1) 106834997(DUOX2)
MYB: 102242003(DUOX2) 102252627(DUOX1) 106728032
MYD: 102771512(DUOX1) 102771797(DUOX2)
MNA: 107536153(DUOX1) 107536249(DUOX2)
RSS: 109444262(DUOX2) 109460862(DUOX1)
DRO: 112311051(DUOX2) 112311507(DUOX1)
PALE: 102894515(DUOX1) 102895435(DUOX2)
LAV: 100661484(DUOX2) 100677682(DUOX1)
MDO: 100012658(DUOX2) 100012836(DUOX1)
SHR: 100931267(DUOX2) 100932050(DUOX1)
PCW: 110223647(DUOX1) 110223721
OAA: 100089154(DUOX2) 100093104
GGA: 427482(DUOX2)
MGP: 100538948(DUOX2)
CJO: 107318475(DUOX2)
APLA: 101800626(DUOX2)
ACYG: 106047419(DUOX2)
TGU: 100218721(DUOX2)
LSR: 110483946(DUOX2)
SCAN: 103816154(DUOX2)
GFR: 102037063(DUOX2)
FAB: 101805677(DUOX2)
PHI: 102105296(DUOX2)
PMAJ: 107209583
CCAE: 111934317
CCW: 104697496
ETL: 114060481(DUOX2)
FPG: 101914675(DUOX2)
FCH: 102054788
CLV: 102097710(DUOX2)
EGZ: 104130687(DUOX2)
NNI: 104016775(DUOX2)
ACUN: 113483989
AAM: 106487968
ASN: 102372872
AMJ: 102573689(DUOX2)
PSS: 102461565(DUOX2)
CMY: 102933380(DUOX2)
CPIC: 101942492(DUOX2)
ACS: 100562649
PVT: 110091655
PBI: 103059551(DUOX2)
PMUR: 107294062(DUOX2)
GJA: 107106710
XLA: 108710292(duox2.L) 108711340 108712328(duox2.S)
XTR: 100486050(duox2) 100486194(duox1)
DRE: 565097(duox)
IPU: 108275020(duox1)
PHYP: 113529691(duox1)
AMEX: 103026091(duox1)
EEE: 113584048
TRU: 100124426(duox)
LCO: 104937849(duox1)
NCC: 104960088(duox1)
MZE: 101470770
OLA: 101160477(duox1)
XMA: 102217295(duox1)
XCO: 114151766(duox1)
PRET: 103466440(duox1)
NFU: 107388507
KMR: 108229956(duox1)
CSEM: 103380468(duox1)
LCF: 108876727(duox1)
SDU: 111229749(duox1)
HCQ: 109507657(duox1)
BPEC: 110169429
MALB: 109973835
ELS: 105018355(duox1)
PKI: 111835096(duox1)
LCM: 102354060
CIN: 100170036(duox-d) 100170037(duox-c) 100170038(duox-b) 100170039(duox-a)
SPU: 100893745 588656(duox1)
APLC: 110980995
DME: Dmel_CG3131(Duox)
DER: 6542143
DPE: 6603391
DSI: Dsimw501_GD22800(Dsim_GD22800)
DWI: 6644426
DAZ: 108610468
DHE: 111592500
MDE: 101898456
AGA: AgaP_AGAP009978(DUOX)
AAG: 5569378
AME: 551970
BIM: 100742890
BTER: 100646100
AEC: 105143353
ACEP: 105623067
NVI: 100123854
DPA: 109541703
BMOR: 101742234
PMAC: 106717948
PRAP: 110992372
HAW: 110372854
TNL: 113498966
PXY: 105389437
API: 100160850
DNX: 107163754
AGS: 114128657
CLEC: 106669322
CEL: CELE_F53G12.3(duox-2) CELE_F56C11.1(bli-3)
CBR: CBG05103(Cbr-bli-3)
BMY: Bm1_45640
TSP: Tsp_00940
OBI: 106882005
AQU: 100637823
EGR: 104451914
GMX: 100791701
VRA: 106754540
VAR: 108328293
ADU: 107484734
AIP: 107636666
LANG: 109338475
PPER: 18773495
PMUM: 103323741
PAVI: 110752794
ZJU: 107411138
CSV: 101207699
CMOS: 111451080
JRE: 108993958
VVI: 100265669
NTA: 107787778
NTO: 104110382
LSV: 111886578
CCAV: 112505645
DCR: 108221739
BVG: 104900197
PDA: 103702834
MGR: MGG_08299
PTE: PTT_09646
SMIN: v1.2.034563.t1(symbB.v1.2.034563.t1) v1.2.036935.t1(symbB.v1.2.036935.t1)
 » show all
1  [PMID:12110737]
Moreno JC, Bikker H, Kempers MJ, van Trotsenburg AS, Baas F, de Vijlder JJ, Vulsma T, Ris-Stalpers C.
Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism.
N Engl J Med 347:95-102 (2002)
2  [PMID:11822874]
De Deken X, Wang D, Dumont JE, Miot F.
Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.
Exp Cell Res 273:187-96 (2002)
[hsa:53905 50506]
3  [PMID:10806195]
De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F.
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.
J Biol Chem 275:23227-33 (2000)
[hsa:53905 50506]
4  [PMID:10601291]
Dupuy C, Ohayon R, Valent A, Noel-Hudson MS, Deme D, Virion A.
Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.
J Biol Chem 274:37265-9 (1999)
[hsa:50506] [ssc:397060]
5  [PMID:10401672]
Leseney AM, Deme D, Legue O, Ohayon R, Chanson P, Sales JP, Pires de Carvalho D, Dupuy C, Virion A.
Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue.
Biochimie 81:373-80 (1999)
6  [PMID:1995628]
Dupuy C, Virion A, Ohayon R, Kaniewski J, Deme D, Pommier J.
Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane.
J Biol Chem 266:3739-43 (1991)
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CAS: 77106-92-4

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