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Entry
EC 1.6.3.4                  Enzyme                                 

Name
NADH oxidase (H2O-forming);
H2O-forming NADH oxidase;
Nox-2
Class
Oxidoreductases;
Acting on NADH or NADPH;
With oxygen as acceptor
BRITE hierarchy
Sysname
NADH:oxygen oxidoreductase (H2O-forming)
Reaction(IUBMB)
2 NADH + 2 H+ + O2 = 2 NAD+ + 2 H2O [RN:R10517]
Reaction(KEGG)
Substrate
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). The bacterium Streptococcus mutans contains two distinct NADH oxidases, a H2O-forming enzyme and a H2O2-forming enzyme (cf. EC 1.6.3.3, NADH oxidase (H2O2-forming)) [1].
History
EC 1.6.3.4 created 2013
Orthology
K17869  NADH oxidase (H2O-forming)
K22405  NADH oxidase (H2O-forming)
Genes
MMT: Metme_1624
MDN: JT25_005995
MDH: AYM39_16345
MKO: MKLM6_3358
METL: U737_04005
MPSY: CEK71_14720
TIG: THII_3128
BLEP: AL038_16445
TVI: Thivi_2130
TMB: Thimo_3250
DAR: Daro_1451
AZO: azo0526(fprA)
AOA: dqs_0536
WSU: WS0163
ARC: ABLL_0060
SMUL: SMUL_1215
SHAL: SHALO_1200
SULJ: SJPD1_1233
GUR: Gura_0371
GLO: Glov_0399
GBM: Gbem_0186(roo)
GEO: Geob_1311(roo)
GEM: GM21_0168
GEB: GM18_0199
DES: DSOUD_0965(roo)
DEU: DBW_1080
RSP: RSP_3191(fprA)
RCP: RCAP_rcc03286(norV)
RHC: RGUI_2055
LCA: LSEI_0285
LCB: LCABL_02800(nox)
LCS: LCBD_0278
LCE: LC2W_0269
LCW: BN194_02850(nox_2)
LRH: LGG_00325(nox)
LRG: LRHM_0312
LRL: LC705_00311(nox)
LRA: LRHK_319(nox)
CAE: SMB_G1045(fprA) SMB_G2484(fprA)
CPE: CPE1014
CTC: CTC_01004
CBO: CBO2619
CBA: CLB_2561
CBH: CLC_2492
CBY: CLM_2982
CBL: CLK_2005
CBB: CLD_1946
CBI: CLJ_B2849
CBN: CbC4_0837
CBF: CLI_2683
CBM: CBF_2675
CKL: CKL_3321(fprA)
CKR: CKR_2929
CSR: Cspa_c08450(fprA1) Cspa_c08470(fprA2)
CPAT: CLPA_c10580(fprA2)
CPAE: CPAST_c10580(fprA2)
CLT: CM240_0358 CM240_1207(fprA1)
CBV: U729_2924(fprA2)
CSQ: CSCA_1492
CLD: CLSPO_c26930(fprA1)
ASF: SFBM_0059
CCEL: CCDG5_0978(fprA2)
BPRO: PMF13cell1_01797(fprA1)
CSO: CLS_09940
CPRO: CPRO_00260(fprA1)
PDC: CDIF630_01304(fprA) CDIF630_01800(fprAnorR)
SLP: Slip_1536
DAE: Dtox_2294
CTHM: CFE_0293
BPRM: CL3_22630
CSC: Csac_1982
ATE: Athe_1435
TTM: Tthe_1029
TSH: Tsac_1486
MGJ: MGM1_5040
KST: KSMBR1_2772(fprA)
APS: CFPG_262
CTE: CT2285
CPC: Cpar_0005
CCH: Cag_2008
CLI: Clim_0005
PVI: Cvib_0005
PLT: Plut_0004
PPH: Ppha_0005
PAA: Paes_0005
PROC: Ptc2401_00005(fprA1)
 » show all
Taxonomy
Reference
1  [PMID:3082630]
  Authors
Schmidt HL, Stocklein W, Danzer J, Kirch P, Limbach B
  Title
Isolation and properties of an H2O-forming NADH oxidase from Streptococcus faecalis.
  Journal
Eur J Biochem 156:149-55 (1986)
DOI:10.1111/j.1432-1033.1986.tb09560.x
Reference
2  [PMID:8254304]
  Authors
Higuchi M, Shimada M, Yamamoto Y, Hayashi T, Koga T, Kamio Y
  Title
Identification of two distinct NADH oxidases corresponding to H2O2-forming oxidase and H2O-forming oxidase induced in Streptococcus mutans.
  Journal
J Gen Microbiol 139:2343-51 (1993)
DOI:10.1099/00221287-139-10-2343
  Sequence
[smu:SMU_1117]
Reference
3  [PMID:8824824]
  Authors
Matsumoto J, Higuchi M, Shimada M, Yamamoto Y, Kamio Y
  Title
Molecular cloning and sequence analysis of the gene encoding the H2O-forming NADH oxidase from Streptococcus mutans.
  Journal
Biosci Biotechnol Biochem 60:39-43 (1996)
DOI:10.1271/bbb.60.39
  Sequence
[smu:SMU_1117]
Reference
4  [PMID:15014929]
  Authors
Kawasaki S, Ishikura J, Chiba D, Nishino T, Niimura Y
  Title
Purification and characterization of an H2O-forming NADH oxidase from Clostridium aminovalericum: existence of an oxygen-detoxifying enzyme in an obligate anaerobic bacteria.
  Journal
Arch Microbiol 181:324-30 (2004)
DOI:10.1007/s00203-004-0659-3
Reference
5  [PMID:22418266]
  Authors
Zhang YW, Tiwari MK, Gao H, Dhiman SS, Jeya M, Lee JK
  Title
Cloning and characterization of a thermostable H2O-forming NADH oxidase from Lactobacillus rhamnosus.
  Journal
Enzyme Microb Technol 50:255-62 (2012)
DOI:10.1016/j.enzmictec.2012.01.009
  Sequence
[lrg:LRHM_0312]
Other DBs
ExplorEnz - The Enzyme Database: 1.6.3.4
IUBMB Enzyme Nomenclature: 1.6.3.4
ExPASy - ENZYME nomenclature database: 1.6.3.4
BRENDA, the Enzyme Database: 1.6.3.4

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