KEGG   ENZYME: 1.6.3.4
Entry
EC 1.6.3.4                  Enzyme                                 
Name
NADH oxidase (H2O-forming);
H2O-forming NADH oxidase;
Nox-2
Class
Oxidoreductases;
Acting on NADH or NADPH;
With oxygen as acceptor
Sysname
NADH:oxygen oxidoreductase (H2O-forming)
Reaction(IUBMB)
2 NADH + 2 H+ + O2 = 2 NAD+ + 2 H2O [RN:R10517]
Reaction(KEGG)
R10517
Substrate
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). The bacterium Streptococcus mutans contains two distinct NADH oxidases, a H2O-forming enzyme and a H2O2-forming enzyme (cf. EC 1.6.3.3, NADH oxidase (H2O2-forming)) [1].
History
EC 1.6.3.4 created 2013
Orthology
K17869  NADH oxidase (H2O-forming)
K22405  NADH oxidase (H2O-forming)
Genes
MMTMetme_1624
MDNJT25_005995
MDHAYM39_16345
MKOMKLM6_3358
METLU737_04005
MPADKEF85_00880
MELLIVG45_12825
MMOTQZJ86_04550
MBUREQU24_17220
MPSYCEK71_14720
MMOBF6R98_01550
MOZMoryE10_26400(fprA)
MESLKKZ03_21000
TIGTHII_3128
BLEPAL038_16445
THISHZT40_09015
TUNJ9260_05615
TLOJ9253_07425
TSBHMY34_12970
TSJL3K52_17600
TVIThivi_2130
TMBThimo_3250
TSYTHSYN_03990
THIPN838_15565
CJAPGWK36_11795
THIMKFB96_17595
TBOGLT988_12130
TLRThiosp_01216(fprA)
TFRIThiofri_01529(fprA_1)
EBSECTOBSL9_2540
AQLBXU06_13035
SNIVSFSGTM_04400(fprA)
DARDaro_1451
DEYHYN24_06790
DDENKI615_08700
QAUKI612_04970
FLEKI610_08875
AZOazo0526(fprA)
AOAdqs_0536
AZRCJ010_03500
AZQG3580_18960
ACOMCEW83_10515
APPCAP2UW1_4425
RSPRSP_3191(fprA)
RSHRsph17029_3930
RSQRsph17025_3191
RSKRSKD131_3367
CAZTLV780_15550
RCPRCAP_rcc03286(norV)
RHCRGUI_2055
DAAAKL17_1541
WSUWS0163
SBALHUE88_05590
SMAXFJR03_02795
SKUSulku_1316
SBASulba_0996
SMULSMUL_1215
SHALSHALO_1200
SULSSdiek1_1284
SULJSJPD1_1233
SULTFA592_12375
ANTArnit_0077
AELLAELL_0048
ASUIASUIS_0050
AVPAVENP_0064
ADZADFLV_0072
ARCABLL_0060
PACOAACT_0052
HEBRAEBR_0103
AANAAANAER_0109
SMABLN246_08390
DAVDESACE_01655
GPIGPICK_15220
GEMGM21_0168
GEBGM18_0199
GEFFO488_18975
GURGura_0371
GEOGeob_1311(roo)
GLOGlov_0399
TAMMGEAMG1_0121(fprA)
GBMGbem_0186(roo)
GBNGEOBRER4_01720(norV)
GERKP004_20755
GSUBKP001_15575
GNTKP003_20680
GPLM1B72_21175
GSBGSUB_03650
GHCL9S41_05505
DEUDBW_1080
DVEDESUT3_31850(fprA)
DEPAOP6_0617(fprA)
DESDSOUD_0965(roo)
LCALSEI_0285
LCZLCAZH_0305
LCSLCBD_0278
LCELC2W_0269
LCWBN194_02850(nox_2)
LCLLOCK919_0299
LPQAF91_00725
LPILBPG_02448
LPAPLBPC_0268
LCBLCABL_02800(nox)
LCXLCA12A_2517
LRHLGG_00325(nox)
LRGLRHM_0312
LRLLC705_00311(nox)
LRALRHK_319(nox)
LROLOCK900_0301
LRCLOCK908_0315
LCHIKG086_01195
LZEKG087_01400
LHNLHUE1_001367
LMAEFGL90_01365
LROSLROSL1_2334
LHBD1010_01590
WDIH9L19_07180
XAKKIMC2_04430
XAPXA3_14520
CACCA_C1027 CA_C2449
CAESMB_G1045(fprA) SMB_G2484(fprA)
CAYCEA_G1039 CEA_G2463
CPECPE0288 CPE1014
CPFCPF_0284 CPF_1269
CPRCPR_0275 CPR_1091
CTCCTC_01004
CTETBN906_01067
CNONT01CX_1654
CBOCBO2619
CBACLB_2561
CBHCLC_2492
CBYCLM_2982
CBLCLK_2005
CBBCLD_1946
CBICLJ_B2849
CBNCbC4_0837
CBFCLI_2683
CBMCBF_2675
CBJH04402_02712
CBECbei_4481 Cbei_4483
CBZCbs_4481 Cbs_4483
CBEILF65_05014 LF65_05016
CKLCKL_3321(fprA)
CKRCKR_2929
CLJCLJU_c21940
CCBClocel_1666
CSRCspa_c08450(fprA1) Cspa_c08470(fprA2)
CPASClopa_1032 Clopa_1671
CPATCLPA_c10580(fprA2)
CPAECPAST_c10580(fprA2)
CAHCAETHG_0291
CLTCM240_1207(fprA1)
CBVU729_2924(fprA2)
CSQCSCA_1492
CLDCLSPO_c26930(fprA1)
CACECACET_c35310
CCKCcar_07240
CEUA7L45_15690
CFMBJL90_03480
CCHVBTM20_01910
CARGRSJ17_05515 RSJ17_11705
CDRKB9W14_11805
CIABEN51_09430 BEN51_12645
CSEPCP523_06540 CP523_13435
CDYF3K33_22940 F3K33_22950
CCOHSAMEA4530647_0828(fprA1)
CGASJ1C67_07255 J1C67_12525
CLOSDMR38_11295
CCAAKQH81_02920
CMAHC1I91_21805 C1I91_27065
CRWCROST_015780(fprA1)
CFBCLFE_016500(fprA1)
CAUNCLAUR_013280(fprA1)
CGELpsyc5s11_38240
CTAGLL095_16140 LL095_19740
CINTHZF06_02400
CLODC820_001542(norV)
ASFSFBM_0059
ASMMOUSESFB_0059
ASOSFBmNL_00074
ASBRATSFB_0060
HHWNCTC503_00298(fprA1_1) NCTC503_01057(fprA1_2)
CALEFDN13_04340
CRSFQB35_11305
CPRFK7H06_03520 K7H06_16880
SARJHH195_05345
OCWOW730_00410 OW730_20300
CCELCCDG5_0978(fprA2)
EHAEthha_1061
ACOLK5I23_16800
PETRQKW49_16275
PALMRBG61_01660
CAPREQM14_01055
CFEMHCR03_15400
SWOSwol_2054 Swol_2363
SLPSlip_1536
DAIDesaci_0640
DAEDtox_2294
ACAEHYG86_10775
CTHMCFE_0293
IBUIB211_02921
BPRMCL3_22630
BYLA4V09_16140
BHANCGC63_03185
BLAUDQQ01_03010
BPROPMF13cell1_01797(fprA1)
BLIQINP51_00335
BLARLC508_14805
BCOCBLCOC_08460(norV)
BHVBLHYD_05110(norV)
LACYA4V08_25210
CSOCLS_09940
ACHTbsdcttw_07790
RGNRGna_17470
CBOLCGC65_05545
SINTK5I26_04275
QDOH9Q78_14125
WHJH9Q79_12870
LBXlbkm_1425
CPROCPRO_00260(fprA1)
ANVRBQ60_00160
CLEClole_2026
CEWEKH84_12250
VGUHYG85_08030 HYG85_16400
VPYHZI73_04160 HZI73_20765
CSPOQNI18_01720
PBIFKXZ80_03170 KXZ80_06615
PSORRSJ16_03120 RSJ16_07995
CDFCD630_11570(norV) CD630_16230
PDCCDIF630_01304(fprA) CDIF630_01800(fprAnorR)
CDCCD196_1016(norV) CD196_1546
CDLCDR20291_0994(norV) CDR20291_1521
PDFCD630DERM_11570(norV) CD630DERM_16230
ROCHF520_02930
RILCRIB_409
PHXKGNDJEFE_01933(fprA1)
TEMJW646_07820 JW646_12860
TGCL0P85_00705 L0P85_14815
TMYTEMA_22400(fprA1) TEMA_32640(norV)
TEBT8CH_2350(fprA)
THYRP4S50_05435
IBRNQ514_11530
TTMTthe_1029
TTOThethe_00986
TXYThexy_1693
TSHTsac_1486
MASMahau_2344
HPRFHLPR_23730
CSCCsac_1982
ATEAthe_1435
COBCOB47_1119
CHDCalhy_1301
COWCalow_1214
CKICalkr_1420
CLCCalla_0805
CKNCalkro_1275
CCHAELD05_06245
CDIACaldiYA01_10840
CNAGOTJ99_001287
CMOROTK00_001121
CDANSOJ16_001392
CAZOG3A45_11855
TISP3962_11580
TURAT726_01520 AT726_05065
TSGHLK68_03790 HLK68_14320
TBBJ0J69_04240 J0J69_07985
TFCT23_14120 T23_19390
ETTAZF37_06205
MYGASO20_00625
MGJMGM1_5040
TBKHF295_04280
KSTKSMBR1_2772(fprA)
BROCIPI25_12290
BPITBPIT_27170
JETL3J17_10755
FHOH9Q81_05250
CSOMMKD34_07280
APSCFPG_262
SHYRLA303_07220
CTECT2285
CPCCpar_0005
CLZBIU88_00020
CCHCag_2008
CPHCpha266_0026
CPBCphamn1_0006
CLIClim_0005
PVICvib_0005
PLTPlut_0004
PPHPpha_0005
PAAPaes_0005
PROCPtc2401_00005(fprA1)
PRSB9H02_00025
PROSCHL67_00030
PROWOO006_00035
PROIOO005_00035
OCYOSSY52_13870
DINSelin_0989
DDFDEFDS_0572
DAPDacet_1865
GTLEP073_09040
CNICalni_0057
FSIFlexsi_1655
 » show all
Reference
1  [PMID:3082630]
  Authors
Schmidt HL, Stocklein W, Danzer J, Kirch P, Limbach B
  Title
Isolation and properties of an H2O-forming NADH oxidase from Streptococcus faecalis.
  Journal
Eur J Biochem 156:149-55 (1986)
DOI:10.1111/j.1432-1033.1986.tb09560.x
Reference
2  [PMID:8254304]
  Authors
Higuchi M, Shimada M, Yamamoto Y, Hayashi T, Koga T, Kamio Y
  Title
Identification of two distinct NADH oxidases corresponding to H2O2-forming oxidase and H2O-forming oxidase induced in Streptococcus mutans.
  Journal
J Gen Microbiol 139:2343-51 (1993)
DOI:10.1099/00221287-139-10-2343
  Sequence
[smu:SMU_1117]
Reference
3  [PMID:8824824]
  Authors
Matsumoto J, Higuchi M, Shimada M, Yamamoto Y, Kamio Y
  Title
Molecular cloning and sequence analysis of the gene encoding the H2O-forming NADH oxidase from Streptococcus mutans.
  Journal
Biosci Biotechnol Biochem 60:39-43 (1996)
DOI:10.1271/bbb.60.39
  Sequence
[smu:SMU_1117]
Reference
4  [PMID:15014929]
  Authors
Kawasaki S, Ishikura J, Chiba D, Nishino T, Niimura Y
  Title
Purification and characterization of an H2O-forming NADH oxidase from Clostridium aminovalericum: existence of an oxygen-detoxifying enzyme in an obligate anaerobic bacteria.
  Journal
Arch Microbiol 181:324-30 (2004)
DOI:10.1007/s00203-004-0659-3
Reference
5  [PMID:22418266]
  Authors
Zhang YW, Tiwari MK, Gao H, Dhiman SS, Jeya M, Lee JK
  Title
Cloning and characterization of a thermostable H2O-forming NADH oxidase from Lactobacillus rhamnosus.
  Journal
Enzyme Microb Technol 50:255-62 (2012)
DOI:10.1016/j.enzmictec.2012.01.009
  Sequence
[lrg:LRHM_0312]
Other DBs
ExplorEnz - The Enzyme Database: 1.6.3.4
IUBMB Enzyme Nomenclature: 1.6.3.4
ExPASy - ENZYME nomenclature database: 1.6.3.4
BRENDA, the Enzyme Database: 1.6.3.4

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