KEGG   ENZYME: 1.6.3.4
Entry
EC 1.6.3.4                  Enzyme                                 

Name
NADH oxidase (H2O-forming);
H2O-forming NADH oxidase;
Nox-2
Class
Oxidoreductases;
Acting on NADH or NADPH;
With oxygen as acceptor
Sysname
NADH:oxygen oxidoreductase (H2O-forming)
Reaction(IUBMB)
2 NADH + 2 H+ + O2 = 2 NAD+ + 2 H2O [RN:R10517]
Reaction(KEGG)
R10517
Substrate
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). The bacterium Streptococcus mutans contains two distinct NADH oxidases, a H2O-forming enzyme and a H2O2-forming enzyme (cf. EC 1.6.3.3, NADH oxidase (H2O2-forming)) [1].
History
EC 1.6.3.4 created 2013
Orthology
K17869  NADH oxidase (H2O-forming)
K22405  NADH oxidase (H2O-forming)
Genes
MSX: AU14_10195
MMT: Metme_1624
MDN: JT25_005995
MDH: AYM39_16345
MKO: MKLM6_3358
METL: U737_04005
MBUR: EQU24_17220
MPSY: CEK71_14720
MMOB: F6R98_01550
TIG: THII_3128
BVE: AK36_3321
BCEN: DM39_5503
BCEW: DM40_3035
BAM: Bamb_4522
BCT: GEM_3332
BLAT: WK25_27745
BTEI: WS51_08830
BPSL: WS57_02405
BMEC: WJ16_30115
BUK: MYA_3063
BPH: Bphy_5452
DAR: Daro_1451
AZO: azo0526(fprA)
AOA: dqs_0536
WSU: WS0163
AELL: AELL_0048
HEBR: AEBR_0103
PACO: AACT_0052
ARC: ABLL_0060
SMUL: SMUL_1215
SHAL: SHALO_1200
SULJ: SJPD1_1233
GUR: Gura_0371
GLO: Glov_0399
GBM: Gbem_0186(roo)
GEO: Geob_1311(roo)
GEM: GM21_0168
GEB: GM18_0199
DES: DSOUD_0965(roo)
DEU: DBW_1080
DMA: DMR_05120
DAS: Daes_2620
DBA: Dbac_1920
DML: Dmul_16820(roo2)
DAL: Dalk_3568
DALK: DSCA_17110
SCL: sce8342
AMIH: CO731_03434(dfa3)
SNO: Snov_3274
BLAG: BLTE_07140
HDI: HDIA_3186(dfa3)
PZU: PHZ_c2748
RSP: RSP_3191(fprA)
RCP: RCAP_rcc03286(norV)
RHC: RGUI_2055
SAL: Sala_0594
MAG: amb3260
MAGN: WV31_14750
BTM: MC28_F053
BMYC: DJ92_2201
PRI: PRIO_3639
LCA: LSEI_0285
LCS: LCBD_0278
LCE: LC2W_0269
LPAP: LBPC_0268
LCB: LCABL_02800(nox)
LCW: BN194_02850(nox_2)
LRH: LGG_00325(nox)
LRG: LRHM_0312
LRL: LC705_00311(nox)
LRA: LRHK_319(nox)
CAE: SMB_G1045(fprA) SMB_G2484(fprA)
CPE: CPE1014
CTC: CTC_01004
CBO: CBO2619
CBA: CLB_2561
CBH: CLC_2492
CBY: CLM_2982
CBL: CLK_2005
CBB: CLD_1946
CBI: CLJ_B2849
CBN: CbC4_0837
CBF: CLI_2683
CBM: CBF_2675
CKL: CKL_3321(fprA)
CKR: CKR_2929
CSR: Cspa_c08450(fprA1) Cspa_c08470(fprA2)
CPAT: CLPA_c05590(norV) CLPA_c10580(fprA2)
CPAE: CPAST_c05590(norV) CPAST_c10580(fprA2)
CLT: CM240_1207(fprA1)
CBV: U729_2924(fprA2)
CSQ: CSCA_1492
CLD: CLSPO_c26930(fprA1)
AOE: Clos_2179
ASF: SFBM_0059
HHW: NCTC503_00298(fprA1_1) NCTC503_01057(fprA1_2)
CTH: Cthe_1485
CSS: Cst_c18460(norV)
CSD: Clst_1775
ESR: ES1_11490
ESU: EUS_05340
CCEL: CCDG5_0978(fprA2)
RUM: CK1_29410
FPR: FP2_18650
BFI: CIY_07580
COO: CCU_21010
CCT: CC1_25240
BPRO: PMF13cell1_00512(norV_2) PMF13cell1_01797(fprA1)
CSO: CLS_09940
BPRL: CL2_06530
CPRO: CPRO_00260(fprA1) CPRO_12360(norV_1) CPRO_17980(norV_2)
EHL: EHLA_1253
RTO: RTO_09930
ERT: EUR_05840
ERA: ERE_13660
PDC: CDIF630_01304(fprA) CDIF630_01800(fprAnorR)
SLP: Slip_1536
DAE: Dtox_2294
CTHM: CFE_0293
BPRM: CL3_22630
BPRS: CK3_14570
TTE: TTE1000
THX: Thet_1489
TIT: Thit_0961
CSC: Csac_1982
ATE: Athe_1435
TOC: Toce_0215
TACI: TDSAC_0087
MED: MELS_0566
MGJ: MGM1_5040
MMC: Mmcs_0461
MKM: Mkms_0472
MJL: Mjls_0448
MSAL: DSM43276_04166(dfa3)
SVE: SVEN_1312
SALU: DC74_2914
SALL: SAZ_15950
STRE: GZL_06060
SPRI: SPRI_0799
KFL: Kfla_5650
PDX: Psed_2042
ASE: ACPL_3778
ACTS: ACWT_3650
CAI: Caci_5304
OLS: Olsu_1651
BVO: Pan97_20650(roo)
KST: KSMBR1_2772(fprA)
PBU: L21SP3_01535(fprA)
PBP: STSP1_01291(fprA)
PBAS: SMSP2_01831(fprA)
ALUS: STSP2_02687(fprA)
ABAC: LuPra_00160(fprA2)
BVU: BVU_1993
APS: CFPG_262
PRU: PRU_1697
CTE: CT2285
CPC: Cpar_0005
CCH: Cag_2008
CLI: Clim_0005
PVI: Cvib_0005
PLT: Plut_0004
PPH: Ppha_0005
PAA: Paes_0005
PROC: Ptc2401_00005(fprA1)
TMW: THMA_0774
TMQ: THMB_0774
TMX: THMC_0774
TPT: Tpet_0174
TRQ: TRQ2_0172
TNA: CTN_1826
TNP: Tnap_0553
TLE: Tlet_1499
TME: Tmel_1198
CEX: CSE_12410
DTU: Dtur_1770
BANA: BARAN1_0466(fprA)
MMG: MTBMA_c06080(fprA1)
METC: MTCT_0123
METE: tca_00141(fprA_1)
ABI: Aboo_0876
PHO: PH1085(PH1085)
PAB: PAB0596(fprA)
PYN: PNA2_1596
PYS: Py04_1397
TON: TON_0863
TGA: TGAM_1223(fprA)
TSI: TSIB_1899
THE: GQS_00705
THA: TAM4_2128
THM: CL1_1843
TLT: OCC_12396
THS: TES1_0423
TNU: BD01_0676
TEU: TEU_08950
PPAC: PAP_03315
MBAR: MSBR2_0152
MBAK: MSBR3_1061
MAC: MA_3381(fprA)
METM: MSMTP_1855
MTHR: MSTHT_0681
MTHE: MSTHC_0039
MHOR: MSHOH_1573
MTP: Mthe_0320
MCJ: MCON_0035
MHI: Mhar_1594
MHU: Mhun_0795
MLA: Mlab_0174
MEMA: MMAB1_0411
MPI: Mpet_2110
MBN: Mboo_2086
MPL: Mpal_0614
IHO: Igni_1186
IIS: EYM_06500
DKA: DKAM_0602
TAG: Tagg_0559
HBU: Hbut_1540
TUZ: TUZN_2162
VMO: VMUT_0280
TPE: Tpen_0503
ASC: ASAC_0531
NEV: NTE_02077
TAA: NMY3_03442(fprA1)
NFN: NFRAN_1121(fprA)
KCR: Kcr_0197
 » show all
Reference
1  [PMID:3082630]
  Authors
Schmidt HL, Stocklein W, Danzer J, Kirch P, Limbach B
  Title
Isolation and properties of an H2O-forming NADH oxidase from Streptococcus faecalis.
  Journal
Eur J Biochem 156:149-55 (1986)
DOI:10.1111/j.1432-1033.1986.tb09560.x
Reference
2  [PMID:8254304]
  Authors
Higuchi M, Shimada M, Yamamoto Y, Hayashi T, Koga T, Kamio Y
  Title
Identification of two distinct NADH oxidases corresponding to H2O2-forming oxidase and H2O-forming oxidase induced in Streptococcus mutans.
  Journal
J Gen Microbiol 139:2343-51 (1993)
DOI:10.1099/00221287-139-10-2343
  Sequence
[smu:SMU_1117]
Reference
3  [PMID:8824824]
  Authors
Matsumoto J, Higuchi M, Shimada M, Yamamoto Y, Kamio Y
  Title
Molecular cloning and sequence analysis of the gene encoding the H2O-forming NADH oxidase from Streptococcus mutans.
  Journal
Biosci Biotechnol Biochem 60:39-43 (1996)
DOI:10.1271/bbb.60.39
  Sequence
[smu:SMU_1117]
Reference
4  [PMID:15014929]
  Authors
Kawasaki S, Ishikura J, Chiba D, Nishino T, Niimura Y
  Title
Purification and characterization of an H2O-forming NADH oxidase from Clostridium aminovalericum: existence of an oxygen-detoxifying enzyme in an obligate anaerobic bacteria.
  Journal
Arch Microbiol 181:324-30 (2004)
DOI:10.1007/s00203-004-0659-3
Reference
5  [PMID:22418266]
  Authors
Zhang YW, Tiwari MK, Gao H, Dhiman SS, Jeya M, Lee JK
  Title
Cloning and characterization of a thermostable H2O-forming NADH oxidase from Lactobacillus rhamnosus.
  Journal
Enzyme Microb Technol 50:255-62 (2012)
DOI:10.1016/j.enzmictec.2012.01.009
  Sequence
[lrg:LRHM_0312]
Other DBs
ExplorEnz - The Enzyme Database: 1.6.3.4
IUBMB Enzyme Nomenclature: 1.6.3.4
ExPASy - ENZYME nomenclature database: 1.6.3.4
BRENDA, the Enzyme Database: 1.6.3.4

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