Entry
Name
renalase;
alphaNAD(P)H oxidase/anomerase (incorrect);
NAD(P)H:oxygen oxidoreductase (H2O2-forming, epimerising) (incorrect)
Class
Oxidoreductases;
Acting on NADH or NADPH;
With oxygen as acceptor
BRITE hierarchy
Sysname
dihydro-NAD(P):oxygen oxidoreductase (H2O2-forming)
Reaction(IUBMB)
(1) 1,2-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2 [RN:
R11504 ];
(2) 1,6-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2 [RN:
R11505 ]
Reaction(KEGG)
Substrate
Product
Comment
Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta-NAD(P)+. These isomeric forms, generated by nonspecific reduction of beta-NAD(P)+ or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.
History
EC 1.6.3.5 created 2014, modified 2015
Orthology
Genes
PANU : 101018358 116268633
CANG : 105501741 105515946(RNLS)
MUN : 110559537 110565226(Rnls)
CCAN : 109701757 109701762
HHV : 120225112 120235954(RNLS)
RAY : 107501768(RNLS) 107502207
SRX : 107753429 107758426(rnls)
SANH : 107669231 107680274
PPRM : 120488721 120490787
MASI : 127423446 127427189
MSAM : 119884417 119896736
STRU : 115157124(rnls) 115201166
OTW : 112223443(rnls) 112224276
OMY : 110491377(rnls) 110498987
ONE : 115106360(rnls) 115144453
OKI : 109865892(rnls) 109869981
CCLU : 121533453 121547335
ARUT : 117415306 117418595
PTEP : 107441860 107444555
DPOL : 127867637 127867654
CSAT : 104743043 104758891 104778472
BNA : 106406798(BNAC06G11190D) 106412247(BNAA05G13480D) 125601986
CCAJ : 109793988 109806166
LJA : Lj3g3v0966670.1(Lj3g3v0966670.1)
PSOM : 113312534 113324200
TAES : 123107942 123113563 123123092
PVIR : 120649548 120688319
MNG : MNEG_16171 MNEG_7620
MPP : MICPUCDRAFT_49755 MICPUCDRAFT_50900
SMIN : v1.2.038250.t1(symbB.v1.2.038250.t1)
FCY : FRACYDRAFT_228835 FRACYDRAFT_232556 FRACYDRAFT_260361
EHX : EMIHUDRAFT_104009 EMIHUDRAFT_194464 EMIHUDRAFT_232377
XPH : XppCFBP6546_04775(XppCFBP6546P_04775)
PTAE : NCTC10697_03669(crtN)
PPHN : HU825_13715 HU825_17560
SDEG : GOM96_00715 GOM96_04565
LWA : SAMEA4504053_2871(crtN)
PLG : NCTC10937_04379(crtN)
ACK : C380_11080 C380_16345
ACRA : BSY15_328 BSY15_3704
ATEM : PQV96_07830 PQV96_10865
DEL : DelCs14_2552 DelCs14_2753
DHK : BO996_18555 BO996_19170
DLA : I6G47_02865 I6G47_03875
CTT : CtCNB1_1909 CtCNB1_1991 CtCNB1_2397
CTES : O987_07835 O987_09365 O987_15475
CTEZ : CT3_18340 CT3_26810
LIM : L103DPR2_02243(mnmC_2)
LIH : L63ED372_01579(mnmC_1)
NCB : C0V82_09720 C0V82_11585
SYY : SYNGTS_0942(sll1135)
SYT : SYNGTI_0942(sll1135)
SYS : SYNPCCN_0941(sll1135)
SYQ : SYNPCCP_0941(sll1135)
LCRE : Pla8534_67200 Pla8534_71630(vioA_2)
AAGG : ETAA8_44230(hemY_2)
HALA : Hrd1104_00660 Hrd1104_05790 Hrd1104_09175
HASV : SVXHr_1492 SVXHr_1790 SVXHr_1994
HALZ : E5139_13205 E5139_14090
HALL : LC1Hm_1339 LC1Hm_1637
HAZP : GBQ70_13220 GBQ70_14105
HDS : HSR122_0075 HSR122_1672
HARC : HARCEL1_04190 HARCEL1_04400
» show all
Taxonomy
Reference
Authors
Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV
Title
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.
Journal
Sequence
Reference
Authors
Beaupre BA, Hoag MR, Roman J, Forsterling FH, Moran GR
Title
Metabolic function for human renalase: oxidation of isomeric forms of beta-NAD(P)H that are inhibitory to primary metabolism.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.6.3.5
ExPASy - ENZYME nomenclature database: 1.6.3.5
BRENDA, the Enzyme Database: 1.6.3.5