KEGG   ENZYME: 1.6.5.10Help
Entry
EC 1.6.5.10                 Enzyme                                 

Name
NADPH dehydrogenase (quinone);
reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase;
NADPH oxidase;
NADPH2 dehydrogenase (quinone)
Class
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
NADPH:(quinone-acceptor) oxidoreductase
Reaction(IUBMB)
NADPH + H+ + a quinone = NADP+ + a quinol [RN:R07359]
Reaction(KEGG)
Substrate
NADPH [CPD:C00005];
H+ [CPD:C00080];
quinone [CPD:C15602]
Product
NADP+ [CPD:C00006];
quinol [CPD:C15603]
Comment
A flavoprotein [1, 2]. The enzyme from Escherichia coli is specific for NADPH and is most active with quinone derivatives and ferricyanide as electron acceptors [3].
Menaquinone can act as acceptor. The enzyme from hog liver is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol [1].
History
EC 1.6.5.10 created 1972 as EC 1.6.99.6, transferred 2011 to EC 1.6.5.10
Reference
1  [PMID:4388793]
  Authors
Koli AK, Yearby C, Scott W, Donaldson KO.
  Title
Purification and properties of three separate menadione reductases from hog liver.
  Journal
J Biol Chem 244:621-9 (1969)
Reference
2  [PMID:2118386]
  Authors
Hayashi M, Hasegawa K, Oguni Y, Unemoto T
  Title
Characterization of FMN-dependent NADH-quinone reductase induced by menadione in  Escherichia coli.
  Journal
Biochim Biophys Acta 1035:230-6 (1990)
DOI:10.1016/0304-4165(90)90122-D
Reference
3  [PMID:8611590]
  Authors
Hayashi M, Ohzeki H, Shimada H, Unemoto T
  Title
NADPH-specific quinone reductase is induced by 2-methylene-4-butyrolactone in Escherichia coli.
  Journal
Biochim Biophys Acta 1273:165-70 (1996)
DOI:10.1016/0005-2728(95)00138-7
Other DBs
ExplorEnz - The Enzyme Database: 1.6.5.10
IUBMB Enzyme Nomenclature: 1.6.5.10
ExPASy - ENZYME nomenclature database: 1.6.5.10
BRENDA, the Enzyme Database: 1.6.5.10
CAS: 37256-37-4

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