KEGG   ENZYME: 1.6.5.11Help
Entry
EC 1.6.5.11                 Enzyme                                 

Name
NADH dehydrogenase (quinone);
reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase;
NADH-quinone oxidoreductase;
DPNH-menadione reductase;
D-diaphorase;
NADH2 dehydrogenase (quinone)
Class
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
NADH:(quinone-acceptor) oxidoreductase
Reaction(IUBMB)
NADH + H+ + a quinone = NAD+ + a quinol [RN:R07358]
Reaction(KEGG)
Substrate
NADH [CPD:C00004];
H+ [CPD:C00080];
quinone [CPD:C00472]
Product
NAD+ [CPD:C00003];
quinol [CPD:C00530]
Comment
Menaquinone can act as acceptor. Inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives.
History
EC 1.6.5.11 created 1972 as EC 1.6.99.5, transferred 2015 to EC 1.6.5.11
Pathway
ec00190  Oxidative phosphorylation
ec01100  Metabolic pathways
Reference
1  [PMID:4388793]
  Authors
Koli AK, Yearby C, Scott W, Donaldson KO.
  Title
Purification and properties of three separate menadione reductases from hog liver.
  Journal
J Biol Chem 244:621-9 (1969)
Other DBs
ExplorEnz - The Enzyme Database: 1.6.5.11
IUBMB Enzyme Nomenclature: 1.6.5.11
ExPASy - ENZYME nomenclature database: 1.6.5.11
BRENDA, the Enzyme Database: 1.6.5.11
CAS: 37256-36-3

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