KEGG   ENZYME: 1.6.5.12Help
Entry
EC 1.6.5.12                 Enzyme                                 

Name
demethylphylloquinone reductase;
ndbB (gene name);
NDC1 (gene name);
demethylphylloquinone:NADPH oxidoreductase
Class
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
NADPH:demethylphylloquinone oxidoreductase
Reaction(IUBMB)
demethylphylloquinone + NADPH + H+ = demethylphylloquinol + NADP+ [RN:R11061]
Reaction(KEGG)
Substrate
demethylphylloquinone [CPD:C13309];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
demethylphylloquinol [CPD:C21084];
NADP+ [CPD:C00006]
Comment
The enzyme, found in plants and cyanobacteria, is involved in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is a type II NADPH dehydrogenase and requires a flavine adenine dinucleotide cofactor.
History
EC 1.6.5.12 created 2015
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17872  demethylphylloquinone reductase
Genes
ATH: AT5G08740(NDC1)
ALY: ARALYDRAFT_908854
CRB: 17882848
CSAT: 104708204 104734909 104769096
EUS: EUTSA_v10013258mg
BRP: 103847188
BNA: 106419271 111212609
BOE: 106319430
RSZ: 108817949
THJ: 104819353
CPAP: 110816571
CIT: 102618551
TCC: 18611964
GRA: 105762580
GAB: 108476577
DZI: 111316878
GMX: 100795521
GSJ: 114413256
VRA: 106769327
VAR: 108323929
VUN: 114174969
CCAJ: 109789425
CAM: 101503757
LJA: Lj4g3v2827910.1(Lj4g3v2827910.1) Lj4g3v2827910.2(Lj4g3v2827910.2)
ADU: 107480195
AIP: 107630920
LANG: 109358669
FVE: 101308875
RCN: 112176025
PPER: 18777173
PMUM: 103337243
PAVI: 110753675
MDM: 103433086
PXB: 103952273
CSV: 101223053
CMO: 103486095
MCHA: 111017844
CMAX: 111465980
CMOS: 111432564
CPEP: 111782254
RCU: 8282114
JCU: 105639437
MESC: 110624194
POP: 7490188
PEU: 105124511
JRE: 108996371
VVI: 100264660
SLY: 101263978
SPEN: 107015022
SOT: 102581506
CANN: 107868106
NSY: 104238606
NTO: 104085114
NAU: 109225159
INI: 109179495
HAN: 110873719
LSV: 111879295
CCAV: 112519684
DCR: 108219442
BVG: 104890540
SOE: 110800407
NNU: 104587537
OSA: 4340478
DOSA: Os06t0214900-01(Os06g0214900)
OBR: 102715487
BDI: 100823745
ATS: 109746764(LOC109746764)
SBI: 8080027
ZMA: 100282489(si618008g06(715))
SITA: 101767448
PDA: 103723780
EGU: 105034423
MUS: 103986928
DCT: 110115656
PEQ: 110035971
AOF: 109832866
ATR: 18429029
PPP: 112277043
CRE: CHLREDRAFT_189359(NDA5)
MNG: MNEG_6066
APRO: F751_3208
SYN: slr1743(ndh)
SYZ: MYO_112180(ndh)
SYY: SYNGTS_1207(ndh)
SYT: SYNGTI_1207(ndh)
SYS: SYNPCCN_1206(ndh)
SYQ: SYNPCCP_1206(ndh)
SYJ: D082_23110(ndbB)
SYW: SYNW2165
SYC: syc1598_c(ndbB)
SYG: sync_2511
SYR: SynRCC307_0389(ndh)
SYX: SynWH7803_2175(ndh)
SYP: SYNPCC7002_A2120(ndbB)
CYA: CYA_0862
CYB: CYB_1748
SYNR: KR49_07070
SYND: KR52_04635
TEL: tlr1136(ndbB)
THN: NK55_02985(ndbB)
TVN: NIES2134_101430(ndbB)
LET: O77CONTIG1_02936(ndh)
PMA: Pro_0096(ndh)
PMM: PMM0082
PMT: PMT_1625
PRC: EW14_0102
PRM: EW15_0164
AMR: AM1_2697
MAR: MAE_42940(ndbB2) MAE_62400(ndbB1)
MVZ: myaer102_17350(ndbB2) myaer102_34460(ndbB1)
CYL: AA637_13705(ndh-2)
CYT: cce_0154(ndbB) cce_4052
ARP: NIES39_C03210(ndbB)
PAGH: NIES204_19420(ndbB)
GVI: glr3503
GLJ: GKIL_1185(ndh)
ANA: alr4094
AVA: Ava_0810
NAZ: Aazo_4817
ANB: ANA_C11689(ndh)
CALH: IJ00_11250
DOU: BMF77_01764(ndh)
CTHE: Chro_5076
CEO: ETSB_0596(ndbB)
CER: RGRSB_0558(ndbB)
 » show all
Taxonomy
Reference
1  [PMID:26023160]
  Authors
Fatihi A, Latimer S, Schmollinger S, Block A, Dussault PH, Vermaas WF, Merchant SS, Basset GJ
  Title
A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1 in Synechocystis and Arabidopsis.
  Journal
Plant Cell 27:1730-41 (2015)
DOI:10.1105/tpc.15.00103
  Sequence
[ath:AT5G08740] [syn:slr1743]
Other DBs
ExplorEnz - The Enzyme Database: 1.6.5.12
IUBMB Enzyme Nomenclature: 1.6.5.12
ExPASy - ENZYME nomenclature database: 1.6.5.12
BRENDA, the Enzyme Database: 1.6.5.12

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