KEGG   ENZYME: 1.6.5.7
Entry
EC 1.6.5.7                  Enzyme                                 
Name
2-hydroxy-1,4-benzoquinone reductase;
hydroxybenzoquinone reductase;
1,2,4-trihydroxybenzene:NAD oxidoreductase
Class
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor
Sysname
NADH:2-hydroxy-1,4-benzoquinone oxidoreductase
Reaction(IUBMB)
2-hydroxy-1,4-benzoquinone + NADH + H+ = hydroxyquinol + NAD+ [RN:R05399]
Reaction(KEGG)
R05399
Substrate
2-hydroxy-1,4-benzoquinone [CPD:C07103];
NADH [CPD:C00004];
H+ [CPD:C00080]
Product
hydroxyquinol [CPD:C02814];
NAD+ [CPD:C00003]
Comment
A flavoprotein (FMN) that differs in substrate specificity from other quinone reductases. The enzyme in Burkholderia cepacia is inducible by 2,4,5-trichlorophenoxyacetate.
History
EC 1.6.5.7 created 2000, modified 2004
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K23529  2-hydroxy-1,4-benzoquinone reductase
Genes
IGNMMG00_06180
BYIBYI23_B013640
BUEBRPE67_BCDS00600
BUMAXG89_19320
BUIAX768_29085
BUOBRPE64_BCDS00690
RTSCE91St31_14040
FEIK9M53_03830
FLPLK994_08340
Reference
1  [PMID:9721310]
  Authors
Zaborina O, Daubaras DL, Zago A, Xun L, Saido K, Klem T, Nikolic D, Chakrabarty AM.
  Title
Novel pathway for conversion of chlorohydroxyquinol to maleylacetate in Burkholderia cepacia AC1100.
  Journal
J Bacteriol 180:4667-75 (1998)
DOI:10.1128/JB.180.17.4667-4675.1998
Other DBs
ExplorEnz - The Enzyme Database: 1.6.5.7
IUBMB Enzyme Nomenclature: 1.6.5.7
ExPASy - ENZYME nomenclature database: 1.6.5.7
UM-BBD (Biocatalysis/Biodegradation Database): 1.6.5.7
BRENDA, the Enzyme Database: 1.6.5.7
CAS: 214466-94-1

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