KEGG   ENZYME: 1.6.99.1Help
Entry
EC 1.6.99.1                 Enzyme                                 

Name
NADPH dehydrogenase;
NADPH2 diaphorase;
NADPH diaphorase;
OYE;
diaphorase;
dihydronicotinamide adenine dinucleotide phosphate dehydrogenase;
NADPH-dehydrogenase;
NADPH-diaphorase;
NADPH2-dehydrogenase;
old yellow enzyme;
reduced nicotinamide adenine dinucleotide phosphate dehydrogenase;
TPNH dehydrogenase;
TPNH-diaphorase;
triphosphopyridine diaphorase;
triphosphopyridine nucleotide diaphorase;
NADPH2 dehydrogenase;
NADPH:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on NADH or NADPH;
With unknown physiological acceptors
BRITE hierarchy
Sysname
NADPH:acceptor oxidoreductase
Reaction(IUBMB)
NADPH + H+ + acceptor = NADP+ + reduced acceptor [RN:R00282]
Reaction(KEGG)
Substrate
NADPH [CPD:C00005];
H+ [CPD:C00080];
acceptor [CPD:C00028]
Product
NADP+ [CPD:C00006];
reduced acceptor [CPD:C00030]
Comment
A flavoprotein (FMN in yeast, FAD in plants).
History
EC 1.6.99.1 created 1961, modified 1976
Orthology
K00354  NADPH2 dehydrogenase
Genes
QSU: 112022069 112029128
SCE: YHR179W(OYE2) YPL171C(OYE3)
AGO: AGOS_AGR329C
KLA: KLLA0_A09075g
KMX: KLMA_10458(KYE1) KLMA_10592(KYE1)
LTH: KLTH0E07898g KLTH0E07920g KLTH0G01584g
VPO: Kpol_1018p121 Kpol_1054p16 Kpol_370p3 Kpol_370p4
ZRO: ZYRO0C11902g ZYRO0C11924g ZYRO0F12144g ZYRO0F13618g ZYRO0F16852g ZYRO0G15444g
CGR: CAGL0I02024g CAGL0I02574g CAGL0K10890g CAGL0L09537g
NCS: NCAS_0B00730(NCAS0B00730) NCAS_0B01090(NCAS0B01090) NCAS_0C02260(NCAS0C02260) NCAS_0C04110(NCAS0C04110) NCAS_0D01280(NCAS0D01280) NCAS_0D04260(NCAS0D04260) NCAS_0E03890(NCAS0E03890) NCAS_0J01750(NCAS0J01750)
NDI: NDAI_0A00330(NDAI0A00330) NDAI_0A08130(NDAI0A08130) NDAI_0B00920(NDAI0B00920) NDAI_0C03460(NDAI0C03460) NDAI_0E00850(NDAI0E00850) NDAI_0E01890(NDAI0E01890)
TPF: TPHA_0A02230(TPHA0A02230) TPHA_0H02440(TPHA0H02440) TPHA_0P01030(TPHA0P01030)
TBL: TBLA_0A04730(TBLA0A04730) TBLA_0A10550(TBLA0A10550) TBLA_0B02130(TBLA0B02130) TBLA_0C01370(TBLA0C01370) TBLA_0C07300(TBLA0C07300) TBLA_0D00160(TBLA0D00160) TBLA_0D03290(TBLA0D03290) TBLA_0D03340(TBLA0D03340) TBLA_0E00660(TBLA0E00660) TBLA_0E03220(TBLA0E03220) TBLA_0G00610(TBLA0G00610) TBLA_0G03670(TBLA0G03670) TBLA_0I03570(TBLA0I03570) TBLA_0J00530(TBLA0J00530)
TDL: TDEL_0E00270(TDEL0E00270) TDEL_0G00820(TDEL0G00820)
KAF: KAFR_0B04485(KAFR0B04485) KAFR_0B07070(KAFR0B07070) KAFR_0E00120(KAFR0E00120) KAFR_0E02340(KAFR0E02340) KAFR_0F03530(KAFR0F03530) KAFR_0F03540(KAFR0F03540) KAFR_0F03550(KAFR0F03550) KAFR_0I00110(KAFR0I00110)
PIC: PICST_31316(OYE2.8) PICST_31957(OYE2.9) PICST_31958(OYE2.4) PICST_43720(OYE2.2) PICST_44456(OYE2.5) PICST_44613(OYE2.7) PICST_44614(OYE2.6) PICST_52325(OYE3.3) PICST_55621(OYE2.3) PICST_89722(OYE2.1)
SLB: AWJ20_1214(OYE2) AWJ20_2660(OYE3) AWJ20_4128(OYE3) AWJ20_4314(OYE2)
NCR: NCU04452(mig-3)
NTE: NEUTE1DRAFT116490(NEUTE1DRAFT_116490)
MGR: MGG_08297
MAW: MAC_03660
MBE: MBM_00173
ANI: AN5228.2
ANG: ANI_1_1086064(An07g08760) ANI_1_2326074(An08g09330) ANI_1_2358094(An11g08510)
CNE: CNI02360
CNB: CNBH2240
KLW: DA718_17990(namA)
SPLY: Q5A_005085(namA_1)
PVA: Pvag_pPag20187(yqjM) Pvag_pPag30075(yqjM)
MMK: MU9_1262
LRI: NCTC12151_03132(namA_2)
PAET: NCTC13378_00105(namA)
MSU: MS2012(nemA)
MHQ: D650_3240
MHAT: B824_5550
MHX: MHH_c02620(namA)
MHAE: F382_06425
MHAM: J450_05780
MHAO: J451_06660
MHAL: N220_12580
MHAQ: WC39_01670
MHAY: VK67_01675
MVE: X875_2550
APJ: APJL_1211
APA: APP7_1248(namA)
BTO: WQG_2410
BTRE: F542_19550
BTRH: F543_21450
BTRA: F544_1970
PFS: PFLU_3184
MCT: MCR_0569
MCS: DR90_1348
MCAT: MC25239_00568(namA)
SFR: Sfri_1304
HCE: HCW_00035
CFZ: CSG_6460
CIS: CINS_0085
CLX: CLAN_1066
CAMY: CSUIS_1154
ABU: Abu_1060
ABT: ABED_1011
HBV: ABIV_1099
ARC: ABLL_1655
SMUL: SMUL_0825(namA)
SHAL: SHALO_0827
SULJ: SJPD1_0752
DAL: Dalk_4705
ZMC: A265_01763(namA)
ZMR: A254_01787(namA)
BOMB: GT348_07330(namA)
TMO: TMO_a0397(namA)
BSU: BSU23820(yqjM)
BSR: I33_2457
BSL: A7A1_3662
BSH: BSU6051_23820(yqjM)
BSUT: BSUB_02555(yqjM)
BSUL: BSUA_02555(yqjM)
BSUS: Q433_13015
BSS: BSUW23_11750(yqjM)
BSO: BSNT_08808(namA)
BSQ: B657_23820(yqjM)
BSX: C663_2262(namA)
BLI: BL00797(yqjM)
BLD: BLi02551(yqjM)
BLH: BaLi_c26370(yqjM)
BAY: RBAM_022120(namA)
BAQ: BACAU_2225(yqjM)
BYA: BANAU_2365(yqjM)
BAMP: B938_11430
BAML: BAM5036_2136(yqjM)
BAMA: RBAU_2349(yqjM)
BAMN: BASU_2138(yqjM)
BAMB: BAPNAU_1373(yqjM)
BAMT: AJ82_12540
BAMY: V529_24840(yqjM)
BMP: NG74_02317(namA)
BAO: BAMF_2280(yqjM1)
BAZ: BAMTA208_12210(yqjM)
BQL: LL3_02570(yqjM)
BXH: BAXH7_02491(yqjM)
BQY: MUS_2674(yqjM)
BAMI: KSO_008335
BAMC: U471_22870
BAMF: U722_12050
BHA: BH1481
BAN: BA_2038
BAR: GBAA_2038
BAT: BAS1891
BAI: BAA_2105
BANT: A16_20740
BANR: A16R_21010
BANS: BAPAT_1947
BANV: DJ46_842(namA)
BCE: BC2023
BCA: BCE_2106
BCQ: BCQ_2023
BCX: BCA_2110
BNC: BCN_1953
BCF: bcf_09990
BCER: BCK_24450
BTL: BALH_1798
BTT: HD73_2200
BTHI: BTK_11110
BTM: MC28_1248(namA)
BTG: BTB_c20930(namA)
BTI: BTG_09820
BTW: BF38_3250(namA)
BWW: bwei_2988(namA)
BMYO: BG05_3954
BMYC: DJ92_4589(namA)
BCL: ABC2441
BPUM: BW16_11480
BPUS: UP12_10735
BPF: BpOF4_14350(namA)
BMQ: BMQ_4415
BMD: BMD_4401
BMH: BMWSH_0817(yqjM)
BMEG: BG04_1332(namA) BG04_5903
BAG: Bcoa_2324
BCOA: BF29_1245
BJS: MY9_2400
BMET: BMMGA3_11225(namA)
BACW: QR42_10685
BACP: SB24_17665
BACB: OY17_14330
BACO: OXB_2718
BACY: QF06_10095
BACL: BS34A_26170(yqjM)
BALM: BsLM_2335
BGY: BGLY_2827(namA)
BBEV: BBEV_1345(namA)
BALT: CFN77_11330(namA)
OIH: OB0028
GKA: GK2332
GTN: GTNG_2262
GGH: GHH_c24190(namA)
GEA: GARCT_02318(namA)
AFL: Aflv_0981
ANM: GFC28_24(namA)
AAMY: GFC30_2528(namA)
ANL: GFC29_1601(namA)
AND: GRQ40_12395(namA)
LSP: Bsph_3418
LPAK: GDS87_14410(namA)
VIM: GWK91_06740(namA)
PSYO: PB01_10150
PRD: F7984_12785(namA)
BSE: Bsel_2230
MCL: MCCL_1670
MCAK: MCCS_21340(namA)
LMO: lmo2471
LMOD: LMON_2482
LMOQ: LM6179_1733(yqjM)
LMR: LMR479A_2596(yqjM)
LMOM: IJ09_12450
LMOG: BN389_24340(namA)
LMP: MUO_12335
LMOZ: LM1816_14667(namA)
LMOX: AX24_10280
LMQ: LMM7_2513(namA)
LMS: LMLG_1819
LMOK: CQ02_12545
LMV: Y193_03360(namA)
LIN: lin2614
LWE: lwe2419
LSG: lse_2371
LIV: LIV_2378
LGZ: NCTC10812_02447(namA)
ESI: Exig_0686
EAN: Eab7_0660(namA)
BBE: BBR47_04320(yqjM)
PPM: PPSC2_12070(yqjM1) PPSC2_13425(yqjM3) PPSC2_24490(yqjM5)
PPO: PPM_2310(yqjM1) PPM_2574(yqjM3) PPM_4865(yqjM5)
PLV: ERIC2_c33860(namA)
PSAB: PSAB_21090
PRI: PRIO_3787(namA1) PRIO_4753(namA3)
PSWU: SY83_03020
PLEN: EIM92_16970(namA)
ASOC: CB4_02460(namA)
AAC: Aaci_1968
AAD: TC41_2077
BTS: Btus_0686
JEO: JMA_20580
SPAE: E2C16_05835(namA)
PAEK: D3873_06290(namA)
PANC: E2636_07650(namA)
PGQ: FK545_16315(namA)
PLAY: DNR44_012645(namA)
TVU: AB849_003090(namA)
ECAS: ECBG_00187
CML: BN424_1945(namA)
CAC: CA_C3229
CAE: SMB_G0201 SMB_G3265(namA)
CPAS: Clopa_3649
CPAT: CLPA_c29460(namA)
CPAE: CPAST_c29460(namA)
AMT: Amet_4335
CCE: Ccel_1107
BPB: bpr_I0740
CPY: Cphy_1660
EAC: EAL2_808p05050(namA)
DSY: DSY3515
DHD: Dhaf_1893
SAY: TPY_3793
CBAR: PATL70BA_1167(namA)
TTE: TTE0012(NemA)
THX: Thet_0012
TIT: Thit_0012
TOC: Toce_0258
TTM: Tthe_1998
TSH: Tsac_2462
FMA: FMG_1365
PMIC: NW74_07120
MED: MELS_1651
PFT: JBW_00787
MPE: MYPE8990(MYPE8990)
MMO: MMOB0680(nemA)
ACL: ACL_1096
ABRA: BN85309220(namA)
APAL: BN85403720
CAG: Cagg_0995
HAU: Haur_0586
CTA: pCTA_0006
CRA: CTO_p0006
CTRQ: A363_p4
CTRX: A5291_p4
CTRZ: A7249_p4
CTCT: CTW3_04955
RBA: RB1274
TPED: TPE_2430
OCK: EXM22_15550(namA)
BRM: Bmur_0472
BPW: WESB_1412
BIP: Bint_1767
SMF: Smon_1392
TAI: Taci_0533
TLI: Tlie_1530
SLI: Slin_2837
FAE: FAES_3345
CHZ: CHSO_3857(namA)
CTAK: 4412677_00999(namA)
CHRS: EAG08_05540(namA)
CARH: EGY05_15730(namA)
CNK: EG343_07735(namA)
CNR: EB819_04270(namA)
FBA: FIC_02082
TAL: Thal_1054
PMO: Pmob_0870
ASAC: ATHSA_0037
MRU: mru_2164
MOL: YLM1_1652
 » show all
Taxonomy
Reference
1
  Authors
Akesson, A., Ehrenberg, A. and Theorell, H.
  Title
Old yellow enzyme.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 477-494.
Reference
2  [PMID:13471057]
  Authors
AVRON M, JAGENDORF AT.
  Title
Some further investigations on chloroplast TPNH diaphorase.
  Journal
Arch Biochem Biophys 72:17-24 (1957)
DOI:10.1016/0003-9861(57)90169-8
Reference
3
  Authors
Jagendorf, A.T.
  Title
Chloroplast TPNH diaphorase.
  Journal
Methods Enzymol 6:430-434 (1963)
Reference
4
  Authors
Theorell, H.
  Title
Das gelbe Oxydationsferment.
  Journal
Biochem Z 278:263-290 (1935)
Reference
5  [PMID:13373435]
  Authors
AKESON A, THEORELL H.
  Title
Molecular weight and FMN content of crystallin old yellow enzyme.
  Journal
Arch Biochem Biophys 65:439-48 (1956)
DOI:10.1016/0003-9861(56)90204-1
Other DBs
ExplorEnz - The Enzyme Database: 1.6.99.1
IUBMB Enzyme Nomenclature: 1.6.99.1
ExPASy - ENZYME nomenclature database: 1.6.99.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.6.99.1
BRENDA, the Enzyme Database: 1.6.99.1
CAS: 9001-68-7

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