Acting on NADH or NADPH;
With unknown physiological acceptors
Deleted entry: aquacobalamin reductase (NADPH). This entry has been deleted since the enzyme the entry was based on was later shown to be EC 188.8.131.52, pyruvate dehydrogenase (NADP+). On the other hand, it has been shown that non-enzymatic reduction of cob(III)alamin to cob(II)alamin occurs efficiently in the presence of free dihydroflavins or non-specific reduced flavoproteins.