Entry |
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Name |
N-hydroxy-2-acetamidofluorene reductase;
N-hydroxy-2-acetylaminofluorene reductase;
NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase
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Class |
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor
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Sysname |
2-acetamidofluorene:NAD(P)+ oxidoreductase
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Reaction(IUBMB) |
2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+ [RN: R04046 R04047]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Also acts, more slowly, on N-hydroxy-4-acetamidobiphenyl.
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History |
EC 1.7.1.12 created 1989 as EC 1.6.6.13, transferred 2002 to EC 1.7.1.12
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Reference |
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Authors |
Gutmann HR, Erickson RR. |
Title |
The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction. |
Journal |
J Biol Chem 244:1729-40 (1969) |
Reference |
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Authors |
Kitamura S, Tatsumi K. |
Title |
Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.7.1.12 |
ExPASy - ENZYME nomenclature database: | 1.7.1.12 |
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