KEGG ENZYME: 1.7.1.2

ENZYME: 1.7.1.2

Entry

EC 1.7.1.2                  Enzyme

Name

nitrate reductase [NAD(P)H];
assimilatory nitrate reductase ( ambiguous);
assimilatory NAD(P)H-nitrate reductase;
NAD(P)H bispecific nitrate reductase;
nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate));
nitrate reductase NAD(P)H;
NAD(P)H-nitrate reductase;
nitrate reductase [NAD(P)H2];
NAD(P)H2:nitrate oxidoreductase

Class

Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor

Sysname

nitrite:NAD(P)+ oxidoreductase

Reaction(IUBMB)

nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+ [RN:R00794 R00796]

Reaction(KEGG)

R00794 R00796

Substrate

nitrite [CPD:C00088];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

nitrate [CPD:C00244];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

An iron-sulfur molybdenum flavoprotein.

History

EC 1.7.1.2 created 1961 as EC 1.6.6.2, transferred 2002 to EC 1.7.1.2

Pathway

ec00910

Nitrogen metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

ec01310

Nitrogen cycle

Orthology

K10534

nitrate reductase (NAD(P)H)

Genes

ATH:	AT1G37130(NIA2) AT1G77760(NIA1)

ALY:	9325221 9329985

CRB:	17895831 17897387

CSAT:

104702559 104713453 104742100 104743831 104751674 104757885 104777515

EUS:	EUTSA_v10003628mg EUTSA_v10018092mg

BRP:	103830551 103832206 103853097

BNA:	106353470 106354597 106368948 106397776 106400358 106411852 125574763 125589173

BOE:	106300064 106300202 106327343

RSZ:	108817773 108827738 108832026 130506291

THJ:	104813138 104813644 104817024

CPAP:

110815200

CIT:

102610866

CIC:	CICLE_v10000220mg

PVY:

116131487

MINC:

123202651 123206115

TCC:

18592259

GRA:	105786148 105790558 105797192

GHI:	107908387 107910262 107922292 107951439 121229423

GAB:	108458123 108460813

HSYR:

120139827 120155842 120203105

DZI:	111297320 111312332 111315611

EGR:

104450466

GMX:	100813471 100818103 100818642 732634(INR2)

GSJ:	114381160 114383053 114383521 114415374

PVU:	PHAVU_008G168000g PHAVU_009G121000g

VRA:	106761747 106764856

VAR:	108320980 108329915

VUN:	114164208 114195673

VUM:	124819673 124819674 124821823

CCAJ:

109787973 109793868

APRC:

113848520 113853291

MTR:	11410374 11415881 11428809

TPRA:

123896899 123896900 123907835

CAM:	101498580 101509314

PSAT:

127088207 127118871

VVO:	131620604 131627342

LJA:

130734287

ADU:

107460801

AIP:

107606095

AHF:	112706114 112764569

LANG:

109328054 109360020

PCIN:

129302892 129302893

QSA:	O6P43_015229

FVE:

101295234

RCN:

112176179

PPER:

18790070

PMUM:

103332932

PAVI:

110753196

PDUL:

117637123

MDM:	103401883 103439424

MSYL:

126603903 126632297

PXB:	103956697 103956979

ZJU:

107435000

MNT:

21403045

CSAV:

115713111

CSV:	101216001(NR1) 101219000(NR2) 101219242(NR3)

CMO:	103487560 103499266

BHJ:	120068130 120085245 120093002

MCHA:

111011766 111011787

CMAX:

111476969 111487583 111489182 111489275 111489277

CMOS:

111442711 111444943 111444944 111444945 111445293 111460569

CPEP:

111797396 111802114 111809152 111809170 111809173

RCU:

8274143

MEAN:

126681606

JCU:

105638879

HBR:

110647032

MESC:

110608013 110608420

POP:	7463180 7469126

PEU:	105116456 105120308 105127858

PALZ:

118041743

PNZ:	133692617 133693426

JRE:	109006417 109012439

CILL:

122310369 122313651

CAVE:

132167094

QSU:

112035904

QLO:

115959748

TWL:

120009223

VVI:

100264320

VRI:	117906287 117906574

SLY:	100736473(NR)

SPEN:

107004448

SOT:	102577728(NR3)

SSTN:

125843745

SDUL:

129902062

CANN:

107867964

LBB:	132627089 132627095

NTA:	107785409(NIA2) 107820848 107823732(NIA1)

NSY:	104210745 104248549

NTO:

104097998

NAU:

109206453

INI:

109176053

ITR:

116001570

SIND:

105171134 105176500

OEU:	111383770 111383771 111389106 111403601

EGT:

105974302

SSPL:

121779804 121782505 121786517 121811379

SMIL:

131002710

SHIS:

125204949 125219112

APAN:

127246988 127257112

HAN:	110878571 110912275

ECAD:

122588863

LSV:	111893654 111902813

CCAV:

112504364

DCR:	108215759 108216720 108218952

CSIN:

114286364

RVL:

131329574

AEW:	130759058 130776397

BVG:

104887841

SOE:

110786500

CQI:	110714182 110725315

ATRI:

130810316

MOF:

131161797

NNU:	104589330 104589753

MING:

122077224 122083851

TSS:	122656769 122663398

PSOM:

113346441 113356231

OSA:	4330867 4345795(NIA1) 4345798

OBR:	102716852 102717821

OGL:	127761523 127782425 127782574

BDI:	100827784 100829419

ATS:	109742560 109757553 109768384

TDC:	119318041 119319271 119325320 119333024 119342786

TAES:

123084198 123128536 123131635 123135422 123138401 123143006 123145655 123152955 123170733

TUA:	125521818 125528475

LPER:

127305997 127318565

LRD:	124673418 124673724 124688457

SBI:	8055422 8078943 8083522

ZMA:	100383210 103643134 103654219 109939975 542278

MFLO:

136467840 136467841 136474023 136474063 136477131 136498981

SITA:

101754380 101760744

SVS:	117839581 117855530 117860413

PVIR:

120655163 120657317 120678409 120712604 120712605

PHAI:

112892413 112896561 112897841 112898311

PDA:	103710540 120108364

EGU:

105035363

MUS:	103977556 103995477 103998006

ZOF:	121971533 121976120 122010408 122016977

DCT:

110097032

PEQ:

110019783

MSIN:

131236478

NCOL:

116262783

ATR:

18423189

SMO:	SELMODRAFT_231924 SELMODRAFT_234494

PPP:	112287210 112287872 112291496

CRE:	CHLRE_09g410950v5

VCN:	VOLCADRAFT_76569(nitA)

MNG:

MNEG_1964

CSL:	COCSUDRAFT_29226 COCSUDRAFT_37154

CVR:	CHLNCDRAFT_56304

OLU:	OSTLU_37938

OTA:	OT_ostta10g00920

BPG:	Bathy02g01530 Bathy02g01540

MIS:	MICPUN_113975(nia)

MPP:	MICPUCDRAFT_57689(NIA) MICPUCDRAFT_70878(NIA1)

CME:	CYME_CMG019C

CCP:	CHC_T00003369001 CHC_T00008899001

BBRX:

BRETT_005343

OPA:	HPODL_02384

NCR:	NCU05298(nit-3)

NTE:	NEUTE1DRAFT80350(NEUTE1DRAFT_80350)

SMP:	10806136(SMAC4_01692) 10809034(SMAC4_07620)

PAN:	PODANSg6246

PBEL:

QC761_304260

PPSD:

QC762_304260

PPSP:

QC763_304260

PPSA:

QC764_304260

TTT:	THITE_2115738 THITE_52692

MTM:	MYCTH_2299273

CTHR:

CTHT_0029850

MGR:

MGG_06062

PPEI:

PpBr36_02883

PGRI:

PgNI_01819

TMN:	UCRPA7_7933

SSCK:

SPSK_02996 SPSK_08411

FGR:	FGSG_01947

FPU:	FPSE_09169

FPOA:

FPOAC1_002064

FVN:	FVRRES_02307

FVR:	FVEG_07298 FVEG_12090

FOX:	FOXG_03770 FOXG_04181

NHE:	NECHADRAFT_105480

FFC:	NCS54_00464900 NCS54_01268400

FKR:	NCS57_01241100

FMU:	J7337_007215 J7337_010693

TRE:	TRIREDRAFT_81955

TRR:	M419DRAFT_93515

TATV:

25780107(TrAtP1_010554)

MAW:	19252935(J3458_004091)

MAJ:	MAA_01097 MAA_07503

MBRN:

26239197(NIA) 26247596(NIA1)

PCHM:

VFPPC_03535 VFPPC_04406 VFPPC_06382

CMT:	CCM_02951 CCM_08736

AMUS:

LMH87_002129 LMH87_006987 LMH87_009946

PLJ:	28882782(PLICBS_001215) 28891066(PLICBS_004620)

PTKZ:

JDV02_007993 JDV02_009483

VAL:	VDBG_00766 VDBG_06582

VDA:	VDAG_00378 VDAG_05123

CFJ:	CFIO01_10398

CLUP:

CLUP02_14889

CHIG:

CH63R_03809 CH63R_04539

CDET:

87940842(CDEST_04339) 87941600(CDEST_05097)

SAPO:

SAPIO_CDS10293

ELA:	UCREL1_11259

PFY:	PFICI_05019

SSL:	SS1G_01885

BFU:	BCIN_07g01270(BcniaD)

MBE:

MBM_01744

PSCO:

LY89DRAFT_596669 LY89DRAFT_709030

GLZ:	GLAREA_01730

ANI:	ANIA_01006(niaD) ANIA_08449

AFM:	AFUA_1G12830 AFUA_5G10420

ACT:	ACLA_013480 ACLA_022640

NFI:	NFIA_012730 NFIA_076810

ANG:	An07g08910 An07g08920 An08g05610(niaD)

AFV:	AFLA_002348

ALUC:

AKAW2_30508S

ACHE:

ACHE_30392A ACHE_41045A

APUU:

APUU_50780S

PCS:	N7525_003048 N7525_008242

PDP:	PDIP_28120

POU:	POX_c03828 POX_e06483

TMF:	EYB26_002968

TRG:	TRUGW13939_05030 TRUGW13939_09494

CIM:	CIMG_08017

CPW:	CPC735_020560

URE:	UREG_02306

ABE:	ARB_00118 ARB_06695

TVE:	TRV_04039 TRV_06659

PBL:	PAAG_03766 PAAG_12411(PAAG_07727)

PBN:	PADG_02807 PADG_03269

AJE:	HCAG_07200

BGH:	BDBG_00707 BDBG_00910

PNO:	SNOG_02336 SNOG_06022

PTE:

PTT_08192

PTRR:

6343217(PtrM4_119670)

BZE:	COCCADRAFT_6546

BSC:	COCSADRAFT_28067

BOR:	COCMIDRAFT_27058

AALT:

CC77DRAFT_937944 CC77DRAFT_993138

ARAB:

EKO05_0000744 EKO05_0006947

ZTR:	MYCGRDRAFT_111003

PFJ:	MYCFIDRAFT_206926

FFU:	CLAFUR5_02627 CLAFUR5_03244 CLAFUR5_05579

CBET:

CB0940_03119

BCOM:

BAUCODRAFT_108920 BAUCODRAFT_70791

NPA:	UCRNP2_1295 UCRNP2_9098

TML:	GSTUM_00010228001

TVS:	TRAVEDRAFT_47429 TRAVEDRAFT_47550

DSQ:	DICSQDRAFT_101612 DICSQDRAFT_167737

PCO:	PHACADRAFT_170854

SHS:	STEHIDRAFT_134312

HIR:	HETIRDRAFT_383634

PSQ:	PUNSTDRAFT_121467 PUNSTDRAFT_98106

ADL:	AURDEDRAFT_158237 AURDEDRAFT_174664 AURDEDRAFT_177759

GTR:	GLOTRDRAFT_107246 GLOTRDRAFT_116849 GLOTRDRAFT_80932

RSX:	RhiXN_02365

LBC:	LACBIDRAFT_254066

CCI:	CC1G_07230

PCUB:

JR316_0009414

MRR:	Moror_15986

CPUT:

CONPUDRAFT_47108

SLA:	SERLADRAFT_437856(NR)

UMA:	UMAG_03847

PFP:	PFL1_06433

SGRA:

EX895_001277

MLR:	MELLADRAFT_33600

RIE:	OCT59_008910 OCT59_021674

ACAN:

ACA1_054310

PTI:	PHATRDRAFT_54983

FCY:	FRACYDRAFT_197330 FRACYDRAFT_206583

TPS:	THAPSDRAFT_25299

AAF:	AURANDRAFT_53391(NIA1) AURANDRAFT_55689

PIF:	PITG_13012

PSOJ:

PHYSODRAFT_337236

» show all

Reference

Authors

Nason A.

Title

Nitrate reductases.

Journal

In: Boyer PD, Lardy H, Myrback K (eds). The Enzymes. 2nd ed. Vol. 7. New York: Academic Press; 1963. p. 587-607.

Reference

2 [PMID:5864033]

Authors

Paneque A, Del Campo FF, Ramirez JM, Losada M.

Title

Flavin nucleotide nitrate reductase from spinach.

Journal

Biochim Biophys Acta 109:79-85 (1965)
DOI:10.1016/0926-6585(65)90092-0

Reference

3 [PMID:11289301]

Authors

Campbell WH.

Title

Structure and function of eukaryotic NAD(P)H:nitrate reductase.

Journal

Cell Mol Life Sci 58:194-204 (2001)
DOI:10.1007/PL00000847

Reference

4 [PMID:8534676]

Authors

Berks BC, Ferguson SJ, Moir JW, Richardson DJ

Title

Enzymes and associated electron transport systems that catalyse the respiratory reduction of nitrogen oxides and oxyanions.

Journal

Biochim Biophys Acta 1232:97-173 (1995)
DOI:10.1016/0005-2728(95)00092-5

Other DBs

ExplorEnz - The Enzyme Database:

1.7.1.2

IUBMB Enzyme Nomenclature:

1.7.1.2

ExPASy - ENZYME nomenclature database:

1.7.1.2

BRENDA, the Enzyme Database:

1.7.1.2

CAS:

9029-27-0

DBGET integrated database retrieval system