Entry
Name
nitrite reductase (cytochrome; ammonia-forming);
cytochrome c nitrite reductase;
multiheme nitrite reductase
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
ammonia:ferricytochrome-c oxidoreductase
Reaction(IUBMB)
NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+ [RN:
R05712 ]
Reaction(KEGG)
Substrate
Product
Comment
Found as a multiheme cytochrome in many bacteria. The enzyme from Escherichia coli contains five hemes c and requires Ca2+. It also reduces nitric oxide and hydroxylamine to ammonia, and sulfite to sulfide.
History
EC 1.7.2.2 created 2001
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K03385 nitrite reductase (cytochrome c-552)
Genes
ECOO : ECRM13514_5279(nrfA)
ECOH : ECRM13516_4947(nrfA)
ELR : ECO55CA74_23445(nrfA)
ECW : EcE24377A_4626(nrfA)
EDJ : ECDH1ME8569_3928(nrfA)
ECOI : ECOPMV1_04523(nrfA)
SEM : STMDT12_C44120(nrfA)
SETC : CFSAN001921_19035(nrfA)
SEEN : SE451236_04415(nrfA)
SENH : CFSAN002069_10715(nrfA)
SEEH : SEEH1578_07550(nrfA)
SENJ : CFSAN001992_12495(nrfA)
SEEC : CFSAN002050_04620(nrfA)
SEEB : SEEB0189_021065(nrfA)
SENC : SEET0819_05200(nrfA)
AHN : NCTC12129_00045(nrfA_1)
PSHI : SAMEA2665130_1554(nrfA)
PAQU : DMB82_0009480(nrfA)
PHEI : NCTC12003_01160(nrfA)
PRJ : NCTC6933_02836(nrfA)
LRI : NCTC12151_03528(nrfA)
HIC : NTHIC486_01724(nrfA)
HPIT : NCTC13334_00029(nrfA)
HHZ : NCTC10839_00746(nrfA)
HAEG : NCTC8502_01203(nrfA)
PDAG : 4362423_01343(nrfA)
ADP : NCTC12871_01194(nrfA)
ALIG : NCTC10568_00118(nrfA)
ASEG : NCTC10977_00890(nrfA)
AVT : NCTC3438_00862(nrfA)
RPNE : NCTC8284_03424(nrfA)
PAET : NCTC13378_02172(nrfA)
SPC : Sputcn32_0685 Sputcn32_3604
SHP : Sput200_0617 Sput200_2562 Sput200_3617
SSE : Ssed_0688 Ssed_0931 Ssed_3653 Ssed_3744
SPL : Spea_0831 Spea_1228 Spea_2812
SHN : Shewana3_0658 Shewana3_2363
SHW : Sputw3181_3486 Sputw3181_3743
SHL : Shal_0886 Shal_1262 Shal_2918 Shal_2920
SWP : swp_0613 swp_0614 swp_0919 swp_3403 swp_3958
SHF : CEQ32_00830 CEQ32_00870 CEQ32_19730(nrfA)
SJA : SJ2017_0852 SJ2017_1167 SJ2017_3429
SPSW : Sps_02599 Sps_04168 Sps_05255
SMAV : CFF01_02425 CFF01_03375 CFF01_15285(nrfA)
SHEW : CKQ84_04245(nrfA) CKQ84_13345
SALG : BS332_12335 BS332_17250
SLJ : EGC82_17345 EGC82_18490(nrfA)
SMAI : EXU30_04765 EXU30_08365 EXU30_13680(nrfA)
SPOL : FH971_04610 FH971_16800(nrfA)
SBK : SHEWBE_1531(nrfA) SHEWBE_1743(nrfA)
SAES : HBH39_13245 HBH39_14550(nrfA) HBH39_16715
SCAA : TUM17387_21640(nrfA_1) TUM17387_30060(nrfA_2)
SPSH : FM037_05555(nrfA) FM037_07170
SEUR : FM038_004655(nrfA) FM038_006710 FM038_019770 FM038_022095(nrfA)
SYK : KDN34_03655(nrfA) KDN34_12890
SAVI : JYB87_00590 JYB87_04065(nrfA)
SGLA : FJ709_14935 FJ709_15710(nrfA)
SINV : K8B83_18715 K8B83_19765(nrfA)
SVM : KDH10_003836(nrfA) KDH10_004009
SHEJ : MZ182_03095(nrfA) MZ182_12855 MZ182_18730
SCHK : GII14_04355(nrfA) GII14_10350
FBL : Fbal_1273 Fbal_2153 Fbal_3133 Fbal_3383
FES : HER31_01295 HER31_05330(nrfA) HER31_06195 HER31_13675(nrfA)
AEL : NCTC12917_02305(nrfA)
UPL : DSM104440_02438(nrfA)
HCL : NCTC13205_01273(nrfA)
HPUL : NCTC13154_00484(nrfA)
CJV : MTVDSCj20_1338(nrfA)
CFV : CFVI03293_1296(nrfA)
CAMP : CFT03427_1221(nrfA)
CLR : UPTC16701_0993(nrfA)
CLM : UPTC16712_1023(nrfA)
CAMR : CAQ16704_1011(nrfA)
CHV : CHELV3228_0627(nrfA)
CAMZ : CVIC12175_0145(nrfA)
CRX : CRECT_0784 CRECT_2101(nrfA)
SMUL : SMUL_0890(nrfA) SMUL_2170
GSU : GSU0357 GSU3154(nrfA)
GSK : KN400_0325 KN400_3092(nrfA)
GME : Gmet_0294(nrfA-1) Gmet_0296(nrfA-2)
GPI : GPICK_01735 GPICK_01875 GPICK_01890
GAO : A2G06_01575 A2G06_14850
GBZ : JZM60_07310 JZM60_07320 JZM60_14585
GEM : GM21_1277 GM21_1296 GM21_2150
GEB : GM18_2144 GM18_2814 GM18_2827
GLO : Glov_0211 Glov_1042 Glov_1061
GBM : Gbem_2070(nrfA-1) Gbem_2929(nrfA-2) Gbem_2946
GBN : GEOBRER4_12440 GEOBRER4_12670(nrfA_1) GEOBRER4_18970(nrfA_2)
GER : KP004_05915 KP004_06080 KP004_09325
GSUB : KP001_05850 KP001_09460 KP001_09575
GNT : KP003_05505 KP003_05605 KP003_08735
GPL : M1B72_11440 M1B72_14820 M1B72_14940
PPD : Ppro_1200 Ppro_2999 Ppro_3705
DVE : DESUT3_23710(nrfA_1) DESUT3_40720(nrfA_2)
DSB : LN040_02765 LN040_09785
DESU : NLA06_01885 NLA06_02525
ACP : A2cp1_0963 A2cp1_3092
AFW : Anae109_0955 Anae109_0964
ANK : AnaeK_0960 AnaeK_2987
AIA : AWH56_002325 AWH56_007315 AWH56_007325
CACE : CACET_c22020(nrfA1) CACET_c22150(nrfA2)
CFM : BJL90_17280 BJL90_17385
DSY : DSY2472(nrfA) DSY3065(nrfA)
DDH : Desde_3046 Desde_3613
DDL : Desdi_1519 Desdi_2944
DFG : B0537_03960 B0537_07535 B0537_08415
HCV : FTV88_0091 FTV88_3259(nrfA)
CHY : CHY_0243(nrfA) CHY_0608
CUN : Cul210932_2053(nrfA)
CUQ : Cul210931_2000(nrfA)
CUJ : CUL131002_1963c(nrfA)
PAUS : NCTC13651_01013(nrfA)
PPC : HMPREF9154_1959(nrfA)
ASLA : NCTC11923_00168(nrfA)
EGD : GS424_006330 GS424_009160 GS424_014915
AHAT : ADCFC_15670 ADCFC_18330 ADCFC_24140
OBG : Verru16b_00354(nrfA)
RML : FF011L_29380(nrfA_2)
BTHO : Btheta7330_01801(nrfA)
BCEL : BcellWH2_04867(nrfA)
BFC : BacF7301_21820(nrfA) BacF7301_21980(nrfA)
PCAG : NCTC12856_01291(nrfA)
PSOE : CE91St14_02120(nrfA)
PARC : CI960_03655 CI960_07325
PGOL : K6V26_02905(nrfA) K6V26_05190(nrfA)
PFAI : NXY11_01645(nrfA) NXY11_12155(nrfA)
PMZ : HMPREF0659_A5771(nrfA)
PDN : HMPREF9137_1264(nrfA)
POC : NCTC13071_01845(nrfA)
FLL : EI427_11935 EI427_20705
FKA : KM029_17535(nrfA) KM029_21275(nrfA)
FBT : D770_00875(nrfA) D770_09995(nrfA)
» show all
Taxonomy
Reference
Authors
Einsle O, Messerschmidt A, Stach P, Bourenkov GP, Bartunik HD, Huber R, Kroneck PM
Title
Structure of cytochrome c nitrite reductase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.7.2.2
ExPASy - ENZYME nomenclature database: 1.7.2.2
UM-BBD (Biocatalysis/Biodegradation Database): 1.7.2.2
BRENDA, the Enzyme Database: 1.7.2.2