KEGG   ENZYME: 1.7.2.6
Entry
EC 1.7.2.6                  Enzyme                                 
Name
hydroxylamine dehydrogenase;
HAO (ambiguous);
hydroxylamine oxidoreductase (ambiguous);
hydroxylamine oxidase (misleading)
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
Sysname
hydroxylamine:ferricytochrome-c oxidoreductase (nitrite-forming)
Reaction(IUBMB)
hydroxylamine + H2O + 4 ferricytochrome c = nitrite + 4 ferrocytochrome c + 5 H+ [RN:R10164]
Reaction(KEGG)
R10164
Substrate
hydroxylamine [CPD:C00192];
H2O [CPD:C00001];
ferricytochrome c [CPD:C00125]
Product
nitrite [CPD:C00088];
ferrocytochrome c [CPD:C00126];
H+ [CPD:C00080]
Comment
The enzymes from the nitrifying bacterium Nitrosomonas europaea [1,4] and the methylotrophic bacterium Methylococcus capsulatus [5] are hemoproteins with seven c-type hemes and one specialized P-460-type heme per subunit. The enzyme converts hydroxylamine to nitrite via an enzyme-bound nitroxyl intermediate [3]. While nitrite is the main product, the enzyme from Nitrosomonas europaea can also produce nitric oxide by catalysing the activity of EC 1.7.2.9, hydroxylamine oxidase [2].
History
EC 1.7.2.6 created 1972 as EC 1.7.3.4, part transferred 2012 to EC 1.7.2.6, modifed 2021, modified 2021
Pathway
ec00910  Nitrogen metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10535  hydroxylamine dehydrogenase
Genes
VFLAL536_13820
PGHFH974_09640
GHOAL542_00990
SSESsed_3758 Ssed_4366
SHLShal_1091
SWDSwoo_4755
SKHSTH12_01223(hao1)
SCYPJYB88_10420
SSEMJYB85_07405
HALCEY643_14770
MCAMCA0956
METUGNH96_08475
MAHMEALZ_1830(hao)
MBUREQU24_08350
MMAIsS8_3996
MMOBF6R98_20735
MOZMoryE10_01020
NOCNoc_0892
NHLNhal_1085
NWANwat_0758
NWRE3U44_17775
TVIThivi_1285 Thivi_1727
TMBThimo_1376
NTTTAO_0474(haoA)
TTPE6P07_00340
NTGNSCAC_1127(hao)
THIPN838_23495
THIMKFB96_23910
TBOGLT988_06870 LT988_19330
MGEOCFI10_15045
MSECLN244_03125
GSNYC6258_02023
SVASVA_2722
THOSP60_06870
REVHUE57_17855
RFRRfer_0059
COFFOZ74_14370
NEUNE0962(hao2) NE2044(hao1) NE2339(hao3)
NETNeut_1672 Neut_1793 Neut_2335
NITNAL212_1807 NAL212_2138 NAL212_2750
NIINit79A3_0807 Nit79A3_0822 Nit79A3_2942
NCOAAW31_01285 AAW31_16290 AAW31_18275
NURATY38_00070 ATY38_06640 ATY38_10080 ATY38_15220
NSTNstercoris_00693 Nstercoris_01409 Nstercoris_02225
NMUNmul_A0805 Nmul_A1082 Nmul_A2662
NLCEBAPG3_003140 EBAPG3_006260 EBAPG3_012560
NIVJY500_20665
DDZDSYM_27790
HFEHFELIS_07960
HBIHBZC1_10550
HCEHCW_02425
HCMHCD_03625
HHMBN341_2930
HSHNHP194022_13670
CFFCFF8240_0800
CFTCFF04554_0806
CFVCFVI03293_0949
CFXCFV97608_0865
CFZCSG_11900
CAMPCFT03427_0792
CFPCR44_04030
CCVCCV52592_0434
CCOCCC13826_1552
CCOCCCON33237_0583
CAJCIG1485E_1075
CGRACGRAC_2027
CHYOCHH_0728
CPINCPIN18020_1239
CGEOCGEO_1057
CBLACBLAS_1476
CMUCCMCT_0574
ANTArnit_1867
AMOLAMOL_1575
HEBRAEBR_2203
AANAAANAER_2174
NAMNAMH_1280
NAPC3L23_06730
CMEDFE773_03965
CPAFC6V80_06735
GMEGmet_0142
GEMGM21_0983
GEBGM18_0233 GM18_1834 GM18_2729
GPIGPICK_00415
GURGura_1628
GLOGlov_1044
GBMGbem_3667
GBNGEOBRER4_35680
GSBGSUB_01230
GERKP004_04185 KP004_20970
DESDSOUD_1989
DEUDBW_1324
DVEDESUT3_15840
DFLDFE_0004
DDEDde_0300
DMSE8L03_02115 E8L03_18435 E8L03_19655
DHYDESAM_20150
DAFDesaf_0946 Desaf_1748
DPIBN4_11252 BN4_12791
DEJAWY79_06255 AWY79_08845
PPRFDPRO_1839 DPRO_2651
PSELGM415_07795 GM415_15315
DDNDND132_1554
DSXGD604_02500
PBIZLWC08_15290
DBADbac_0217
DRTDret_1248 Dret_2383
DSFUWK_00763 UWK_02292
DBKDGMP_05910 DGMP_39400
DOLDole_1634
DMLDmul_03220 Dmul_30760
DALDalk_2369 Dalk_2563 Dalk_3570
DATHRM2_00870 HRM2_07570
DTOTOL2_C02850
DOVDSCO28_29230 DSCO28_72600
DWDDSCW_06220 DSCW_34050 DSCW_34270 DSCW_58830
DALKDSCA_52000 DSCA_52610
DLIdnl_39220 dnl_50430
DMMdnm_030860
DEKDSLASN_29050
ADEAdeh_1764
ACPA2cp1_0959 A2cp1_2170
AFWAnae109_0953
ANKAnaeK_0956 AnaeK_2076
CFUSCYFUS_008857
LLUAKJ09_07040
MRMA7982_01893
DTIDesti_4134 Desti_4281
SFUSfum_2550
DAXFDQ92_05200 FDQ92_07200
DBRDeba_1332 Deba_1630
DAVDESACE_06540
DHRLGS26_01085
MSCBN69_3242
MROSEHO51_04010
MHEYH2LOC_009200
MPARF7D14_18670
SILSPOA0201
MAGQMGMAQ_1797
MGMMmc1_0550 Mmc1_3025
CALKHUE98_14995
DORDesor_3789
DAIDesaci_0102 Desaci_0818
DMIDesmer_0501
OPROcepr_0853
MINMinf_2434(cccA)
MKCkam1_2135
LCREPla8534_10350(hao1)
PLHVT85_05655(hao1)
PBORBSF38_05477(hao1)
AGVOJF2_56510(hao1)
KSTKSMBR1_1764(hao_1) KSMBR1_2163(hao_2) KSMBR1_3397(hao_5) KSMBR1_3422(hao_6) KSMBR1_3442(hao_7) KSMBR1_3792(hao_8)
BROCIPI25_04955 IPI25_06490 IPI25_07420 IPI25_09825 IPI25_11795 IPI25_13695
BPITBPIT_04170 BPIT_07980 BPIT_13210 BPIT_14680 BPIT_19600 BPIT_21190 BPIT_21780
JETL3J17_01580 L3J17_03290 L3J17_04875 L3J17_06450
PCORKS4_29250(hao1)
ALUSSTSP2_00683(hao1)
THYDTTHT_0107 TTHT_1535
IALIALB_0863
MROMROS_1112
TTKTST_0960 TST_1228
TAMTheam_0418
DDFDEFDS_1818
DAPDacet_1014
FSIFlexsi_0284
CABYCabys_2203 Cabys_2556
DTPJZK55_10500
NMVNITMOv2_1281
NIONITINOP_0065(hao)
NJANSJP_2412
NKFNkreftii_001662 Nkreftii_003177
TIDThein_0424 Thein_2217
TOPTOPB45_0384 TOPB45_0551
TAVG4V39_02595 G4V39_10675
TMAIFVE67_00020 FVE67_02225 FVE67_08170
MOXDAMO_2285 DAMO_2473(hao)
FPLFerp_0649 Ferp_0711 Ferp_1198
GACGACE_0430 GACE_1826
GAHGAH_00817 GAH_01297
MBUMbur_0467
IHOIgni_0955
IISEYM_05715
PFMPyrfu_1339
 » show all
Reference
1  [PMID:5758552]
  Authors
Rees MK.
  Title
Studies of the hydroxylamine metabolism of Nitrosomonas europaea. I. Purification of hydroxylamine oxidase.
  Journal
Biochemistry 7:353-66 (1968)
DOI:10.1021/bi00841a045
Reference
2  [PMID:497235]
  Authors
Hooper AB, Terry KR
  Title
Hydroxylamine oxidoreductase of Nitrosomonas. Production of nitric oxide from hydroxylamine.
  Journal
Biochim Biophys Acta 571:12-20 (1979)
DOI:10.1016/0005-2744(79)90220-1
Reference
3  [PMID:7117545]
  Authors
Hooper AB, Balny C.
  Title
Reaction of oxygen with hydroxylamine oxidoreductase of Nitrosomonas: fast kinetics.
  Journal
FEBS Lett 144:299-303 (1982)
DOI:10.1016/0014-5793(82)80658-3
Reference
4  [PMID:6289867]
  Authors
Lipscomb JD, Hooper AB.
  Title
Resolution of multiple heme centers of hydroxylamine oxidoreductase from Nitrosomonas. 1. Electron paramagnetic resonance spectroscopy.
  Journal
Biochemistry 21:3965-72 (1982)
DOI:10.1021/bi00260a010
Reference
5  [PMID:18650926]
  Authors
Poret-Peterson AT, Graham JE, Gulledge J, Klotz MG
  Title
Transcription of nitrification genes by the methane-oxidizing bacterium, Methylococcus capsulatus strain Bath.
  Journal
ISME J 2:1213-20 (2008)
DOI:10.1038/ismej.2008.71
Other DBs
ExplorEnz - The Enzyme Database: 1.7.2.6
IUBMB Enzyme Nomenclature: 1.7.2.6
ExPASy - ENZYME nomenclature database: 1.7.2.6
BRENDA, the Enzyme Database: 1.7.2.6
CAS: 9075-43-8

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