Entry
Name
hydroxylamine dehydrogenase;
HAO (ambiguous);
hydroxylamine oxidoreductase (ambiguous);
hydroxylamine oxidase (misleading)
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
hydroxylamine:ferricytochrome-c oxidoreductase (nitrite-forming)
Reaction(IUBMB)
hydroxylamine + H2O + 4 ferricytochrome c = nitrite + 4 ferrocytochrome c + 5 H+ [RN:
R10164 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzymes from the nitrifying bacterium Nitrosomonas europaea [1,4] and the methylotrophic bacterium Methylococcus capsulatus [5] are hemoproteins with seven c-type hemes and one specialized P-460-type heme per subunit. The enzyme converts hydroxylamine to nitrite via an enzyme-bound nitroxyl intermediate [3]. While nitrite is the main product, the enzyme from Nitrosomonas europaea can also produce nitric oxide by catalysing the activity of EC
1.7.2.9 , hydroxylamine oxidase [2].
History
EC 1.7.2.6 created 1972 as EC 1.7.3.4, part transferred 2012 to EC 1.7.2.6, modifed 2021, modified 2021
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K10535 hydroxylamine dehydrogenase
Genes
TVI : Thivi_1285 Thivi_1727
TBOG : LT988_06870 LT988_19330
TLR : Thiosp_01677(hao1_1)
EPS : L0Y14_05540 L0Y14_06805 L0Y14_09955
NEU : NE0962(hao2) NE2044(hao1) NE2339(hao3)
NET : Neut_1672 Neut_1793 Neut_2335
NIT : NAL212_1807 NAL212_2138 NAL212_2750
NII : Nit79A3_0807 Nit79A3_0822 Nit79A3_2942
NCO : AAW31_01285 AAW31_16290 AAW31_18275
NUR : ATY38_00070 ATY38_06640 ATY38_10080 ATY38_15220
NST : Nstercoris_00693 Nstercoris_01409 Nstercoris_02225
NMU : Nmul_A0805 Nmul_A1082 Nmul_A2662
NLC : EBAPG3_003140 EBAPG3_006260 EBAPG3_012560
NIZ : NNRS527_00826 NNRS527_01109 NNRS527_02973
GEB : GM18_0233 GM18_1834 GM18_2729
GER : KP004_04185 KP004_20970
DMS : E8L03_02115 E8L03_18435 E8L03_19655
DAF : Desaf_0946 Desaf_1748
DEJ : AWY79_06255 AWY79_08845
PPRF : DPRO_1839 DPRO_2651
PSEL : GM415_07795 GM415_15315
DBK : DGMP_05910 DGMP_39400
DAL : Dalk_2369 Dalk_2563 Dalk_3570
DAT : HRM2_00870 HRM2_07570
DOV : DSCO28_29230 DSCO28_72600
DWD : DSCW_06220 DSCW_34050 DSCW_34270 DSCW_58830
DALK : DSCA_52000 DSCA_52610
DML : Dmul_03220 Dmul_30760
DTI : Desti_4134 Desti_4281
DAX : FDQ92_05200 FDQ92_07200
TID : Thein_0424 Thein_2217
TOP : TOPB45_0384 TOPB45_0551
TAV : G4V39_02595 G4V39_10675
TMAI : FVE67_00020 FVE67_02225 FVE67_08170
ACP : A2cp1_0959 A2cp1_2170
ANK : AnaeK_0956 AnaeK_2076
DAI : Desaci_0102 Desaci_0818
LCRE : Pla8534_10350(hao1)
KST : KSMBR1_1764(hao_1) KSMBR1_2163(hao_2) KSMBR1_3397(hao_5) KSMBR1_3422(hao_6) KSMBR1_3442(hao_7) KSMBR1_3792(hao_8)
BROC : IPI25_04955 IPI25_06490 IPI25_07420 IPI25_09825 IPI25_11795 IPI25_13695
BPIT : BPIT_04170 BPIT_07980 BPIT_13210 BPIT_14680 BPIT_19600 BPIT_21190 BPIT_21780
JET : L3J17_01580 L3J17_03290 L3J17_04875 L3J17_06450
THYD : TTHT_0107 TTHT_1535
CABY : Cabys_2203 Cabys_2556
NKF : Nkreftii_001662 Nkreftii_003177
MOX : DAMO_2285 DAMO_2473(hao)
FSH : Q2T83_13455 Q2T83_17735
FPL : Ferp_0649 Ferp_0711 Ferp_1198
» show all
Taxonomy
Reference
Authors
Rees MK.
Title
Studies of the hydroxylamine metabolism of Nitrosomonas europaea. I. Purification of hydroxylamine oxidase.
Journal
Reference
Authors
Hooper AB, Terry KR
Title
Hydroxylamine oxidoreductase of Nitrosomonas. Production of nitric oxide from hydroxylamine.
Journal
Reference
Authors
Hooper AB, Balny C.
Title
Reaction of oxygen with hydroxylamine oxidoreductase of Nitrosomonas: fast kinetics.
Journal
Reference
Authors
Lipscomb JD, Hooper AB.
Title
Resolution of multiple heme centers of hydroxylamine oxidoreductase from Nitrosomonas. 1. Electron paramagnetic resonance spectroscopy.
Journal
Reference
Authors
Poret-Peterson AT, Graham JE, Gulledge J, Klotz MG
Title
Transcription of nitrification genes by the methane-oxidizing bacterium, Methylococcus capsulatus strain Bath.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.7.2.6
ExPASy - ENZYME nomenclature database: 1.7.2.6
BRENDA, the Enzyme Database: 1.7.2.6