KEGG   ENZYME: 1.7.2.7
Entry
EC 1.7.2.7                  Enzyme                                 
Name
hydrazine synthase;
HZS
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
Sysname
hydrazine:ferricytochrome-c oxidoreductase
Reaction(IUBMB)
hydrazine + H2O + 3 ferricytochrome c = nitric oxide + ammonium + 3 ferrocytochrome c [RN:R09799]
Reaction(KEGG)
R09799
Substrate
hydrazine [CPD:C05361];
H2O [CPD:C00001];
ferricytochrome c [CPD:C00125]
Product
nitric oxide [CPD:C00533];
ammonium;
ferrocytochrome c [CPD:C00126]
Comment
The enzyme, characterized from anaerobic ammonia oxidizers (anammox bacteria), is one of only a few enzymes that are known to form an N-N bond (other examples include EC 1.7.1.14, nitric oxide reductase [NAD(P)+, nitrous oxide-forming] and EC 4.8.1.1, L-piperazate synthase). The enzyme from the bacterium Candidatus Kuenenia stuttgartiensis is a dimer of heterotrimers and contains multiple c-type cytochromes.
History
EC 1.7.2.7 created 2016, modified 2021
Pathway
ec00910  Nitrogen metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K20932  hydrazine synthase subunit
K20933  hydrazine synthase subunit
K20934  hydrazine synthase subunit
Genes
PAUUE8A73_021295
KSTKSMBR1_2703(hzsC_3) KSMBR1_2704(hzsB_3) KSMBR1_2713(hzsA_1)
BROCIPI25_10105 IPI25_10120
BPITBPIT_07240 BPIT_07250 BPIT_07260 BPIT_07540 BPIT_26620 BPIT_26630 BPIT_26640
JETL3J17_02470 L3J17_02475 L3J17_02480 L3J17_08105 L3J17_08110 L3J17_09005
Reference
1  [PMID:21964329]
  Authors
Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M
  Title
Molecular mechanism of anaerobic ammonium oxidation.
  Journal
Nature 479:127-30 (2011)
DOI:10.1038/nature10453
  Sequence
Reference
2  [PMID:26479033]
  Authors
Dietl A, Ferousi C, Maalcke WJ, Menzel A, de Vries S, Keltjens JT, Jetten MS, Kartal B, Barends TR.
  Title
The inner workings of the hydrazine synthase multiprotein complex.
  Journal
Nature 527:394-7 (2015)
DOI:10.1038/nature15517
Other DBs
ExplorEnz - The Enzyme Database: 1.7.2.7
IUBMB Enzyme Nomenclature: 1.7.2.7
ExPASy - ENZYME nomenclature database: 1.7.2.7
BRENDA, the Enzyme Database: 1.7.2.7

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