KEGG   ENZYME: 1.8.1.15
Entry
EC 1.8.1.15                 Enzyme                                 

Name
mycothione reductase;
mycothiol-disulfide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
Sysname
mycothiol:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2 mycothiol + NAD(P)+ = mycothione + NAD(P)H + H+ [RN:R05715 R05716 R06289 R06290]
Reaction(KEGG)
R05715 R05716 R06289(G) R06290(G)
Substrate
mycothiol [CPD:C06717];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
mycothione [CPD:C11502];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Contains FAD. No activity with glutathione, trypanothione or coenzyme A as substrate.
History
EC 1.8.1.15 created 2002
Orthology
K17883  mycothione reductase
Genes
ANT: Arnit_1994
AVP: AVENP_1239
ALK: ALEK_2221
AHS: AHALO_1673
AMAR: AMRN_1698
ACAA: ACAN_1722
AMOL: AMOL_1721
PACO: AACT_2085
ALP: LPB137_09085
DAK: DaAHT2_2612
OVA: OBV_20500
VPR: Vpar_0470
VRM: 44547418_00485(lpd)
VDN: NCTC11831_00445(lpd)
MED: MELS_2028
AIN: Acin_2175(pdhD)
MTU: Rv2855(mtr)
MTV: RVBD_2855
MTC: MT2922
MRA: MRA_2878(mtr)
MTUR: CFBS_3010(mtr)
MTO: MTCTRI2_2912(mtr)
MTD: UDA_2855(mtr)
MTN: ERDMAN_3130(mtr)
MTUC: J113_19785
MTUE: J114_15220
MTUH: I917_19935
MTUL: TBHG_02785
MTUT: HKBT1_2998(mtr)
MTUU: HKBT2_3003(mtr)
MTQ: HKBS1_3005(mtr)
MBO: BQ2027_MB2880(mtr)
MBB: BCG_2875(mtr)
MBT: JTY_2870(mtr)
MBM: BCGMEX_2869(mtr)
MBX: BCGT_2687
MAF: MAF_28600(mtr)
MMIC: RN08_3147
MCE: MCAN_28771(mtr)
MCQ: BN44_60322(mtr)
MCV: BN43_40546(mtr)
MCX: BN42_40843(mtr)
MCZ: BN45_51251(mtr)
MPA: MAP_2923(gorA)
MAO: MAP4_0882
MAVI: RC58_04335
MAVU: RE97_04335
MAV: MAV_3710
MIT: OCO_35370
MIA: OCU_35420
MID: MIP_05321
MYO: OEM_35810
MIR: OCQ_36580
MMAL: CKJ54_16635(mtr)
MMC: Mmcs_2067
MKM: Mkms_2113
MJL: Mjls_2050
MMI: MMAR_1875(mtr)
MMAE: MMARE11_18030(mtr)
MMM: W7S_17690
MLI: MULP_02043(mtr)
MHAD: B586_15095
MSHG: MSG_01713(mtr)
MFJ: MFLOJ_15740(mtr)
MXE: MYXE_32450(mtr)
MNV: MNVI_32680(mtr)
MPAG: C0J29_10850(mtr)
MSG: MSMEI_2549(gorA)
MVA: Mvan_2298
MPHL: MPHLCCUG_03215(mtr)
MVQ: MYVA_2206
MTHN: 4412656_01680(mtr)
MHAS: MHAS_02439(mtr)
MAUU: NCTC10437_00464(mtr_1) NCTC10437_02160(mtr_2)
MMOR: MMOR_41270
MAIC: MAIC_19420
MAB: MAB_0062
MABB: MASS_0064
MCHE: BB28_00305
MSTE: MSTE_00062
MSAL: DSM43276_00053(mtr)
MJD: JDM601_2573(mtr)
MTER: 4434518_02522(mtr)
MMIN: MMIN_02800(mtr)
MHIB: MHIB_20190(mtr)
ASD: AS9A_1606
MKR: MKOR_16320(mtr)
CGL: NCgl1928(Cgl2003)
CGB: cg2194(gor)
CGU: WA5_1928(Mtr)
CGT: cgR_1832
CGM: cgp_2194(mtr)
CGJ: AR0_09455
CEF: CE1896
CDI: DIP1494
CDP: CD241_1439(mtr)
CDH: CDB402_1403(mtr)
CDT: CDHC01_1438(mtr)
CDE: CDHC02_1391(mtr)
CDR: CDHC03_1415(mtr)
CDA: CDHC04_1415(mtr)
CDZ: CD31A_1511(mtr)
CDB: CDBH8_1491(mtr)
CDS: CDC7B_1496(mtr)
CDD: CDCE8392_1413(mtr)
CDW: CDPW8_1484(mtr)
CDV: CDVA01_1377(mtr)
CDIP: ERS451417_01519(mtr)
CJK: jk1153(gorA)
CUR: cu0840(mtr)
CUA: CU7111_0826(mtr)
CAR: cauri_1543(mtr)
CPG: CP316_06700(mtr)
CPK: CP1002_06605(mtr)
CPQ: CPC231_06545(mtr)
CPX: CPI19_04975(mtr)
COP: CP31_06930(mtr)
COI: CPCIP5297_06715(mtr)
COE: CP258_06715(mtr)
COU: CP162_04590(mtr)
CPSE: CPTA_01874
CPSU: CPTB_01888
CPSF: CPTC_01868
CRD: CRES_1244(mtr)
CUL: CULC22_01405(mtr)
CUC: CULC809_01391(mtr)
CUE: CULC0102_1522(mtr)
CUQ: Cul210931_1362(mtr)
CVA: CVAR_1654(mtr)
CTER: A606_06650
CGY: CGLY_07630(mtr)
COA: DR71_2013(mtr)
CSX: CSING_08415(mtr)
CMQ: B840_07730(mtr)
CKU: UL82_06460(mtr)
CCJ: UL81_07260(mtr)
CMV: CMUST_09435(mtr)
CEI: CEPID_07715(mtr)
CTED: CTEST_08190(mtr)
CUT: CUTER_06770(mtr)
CDX: CDES_08985(mtr)
CSP: WM42_2407(mtr)
CPHO: CPHO_04855
CGV: CGLAU_07810(mtr)
CAQU: CAQU_07775
CAMG: CAMM_05655
CMIN: NCTC10288_00936(mtr)
CPEG: CPELA_04300(mtr)
CXE: FOB82_10940(mtr)
CEE: CENDO_07060(mtr)
CSAN: E3227_08150(mtr)
CGK: CGERO_06835(mtr)
CRL: NCTC7448_02132(mtr)
RER: RER_26020(mtr)
REY: O5Y_11935
ROP: ROP_66450(mtr)
REQ: REQ_18700(mtr)
RHB: NY08_1407
RFA: A3L23_04639(mtr)
RHS: A3Q41_03631(mtr)
RRZ: CS378_01335(mtr)
RHU: A3Q40_01396(mtr)
RQI: C1M55_13175(mtr)
RRT: 4535765_01950(mtr)
RBY: CEJ39_11970(mtr)
RCR: NCTC10994_00912(mtr)
RTM: G4H71_19315(mtr)
GBR: Gbro_2130
GOR: KTR9_2057
GRU: GCWB2_14675(mtr)
GOM: D7316_00649(mtr)
GAV: C5O27_13455(mtr)
GOD: GKZ92_13495(mtr)
TPR: Tpau_1696
SRT: Srot_2976
DIT: C3V38_14920(mtr)
DIZ: CT688_09015(mtr)
SGB: WQO_27985
SVE: SVEN_0154
SALS: SLNWT_6734
TWH: TWT_629
TWS: TW646(pdhD)
CMI: CMM_1879
CMS: CMS1352
CMC: CMN_01857
ARR: ARUE_c20740(gor)
ARM: ART_0441
ARN: CGK93_11545(mtr)
ARX: ARZXY2_4202(mtr1)
AAU: AAur_1942
PUE: FV140_20215(mtr)
ACH: Achl_1643
AAI: AARI_10940(lpdA)
GLU: F0M17_05455(mtr)
KRH: KRH_15030(mtr)
KVR: CIB50_0001618(mtr)
DAY: FV141_09275(mtr)
LMOI: VV02_10750
SERJ: SGUI_1021
BLIN: BLSMQ_1948
PAC: PPA0333
PAW: PAZ_c03510(mtr)
PACC: PAC1_01715
PACH: PAGK_0354
CGRN: 4412665_00185(mtr)
PFRE: RM25_1912
PAUS: NCTC13651_02145(mtr)
ACIJ: JS278_00727(mtr)
MPH: MLP_47800(mtr)
NDK: I601_3199(mtr)
KFL: Kfla_5911
MGG: MPLG2_3694(mtr)
NML: Namu_2195
SEN: SACE_5978(mtr)
SACC: EYD13_05495(mtr)
AMD: AMED_2053(gor)
AMN: RAM_10420
AMM: AMES_2037(gor)
AMZ: B737_2038(gor)
AOI: AORI_5853(gor)
AJA: AJAP_10190(mtr)
AMQ: AMETH_1660(gor)
AMYY: YIM_11805(mtr)
AORI: SD37_28665
PSEE: FRP1_18525
AMI: Amir_5878
SESP: BN6_70400(mtr)
KAL: KALB_7270
ACTI: UA75_09045
ACAD: UA74_09075
AHG: AHOG_08535(mtr)
ALO: CRK58580
CAI: Caci_3488
SNA: Snas_5390
AYM: YM304_00190(mtr)
DFO: Dform_01203(lpd|pdhD)
SNG: SNE_A15700(merA)
LIE: LIF_A1717(lpd)
LIS: LIL_11929(lpd2)
LBJ: LBJ_1895(lpdA-3)
LST: LSS_09369
GAC: GACE_0381
ABI: Aboo_0496
MBAR: MSBR2_1262
MBAK: MSBR3_0219
MMA: MM_3279
MMAC: MSMAC_2768
METM: MSMTP_1275
MTHR: MSTHT_0784
MTHE: MSTHC_2486
MHOR: MSHOH_2040
MBU: Mbur_1783
MMET: MCMEM_0038
MMH: Mmah_1936
MPY: Mpsy_1813
MTP: Mthe_0903
MCJ: MCON_0536
MHI: Mhar_2119
MPD: MCP_0970
RCI: RCIX79(lpd)
NMO: Nmlp_1828(lpdA2)
HUT: Huta_0842
HTI: HTIA_0139
HALL: LC1Hm_3043(lpd3) LC1Hm_3061(lpd4)
HME: HFX_6465(pdhD)
HLA: Hlac_1256
NMG: Nmag_1804(lpdA2) Nmag_3630(lpdA3)
NAT: NJ7G_0841
NEV: NTE_02192
CCAI: NAS2_1173
LOKI: Lokiarch_14060(mtr_1) Lokiarch_51530(mtr_2)
PSYT: DSAG12_01083(lpdA_1)
 » show all
Reference
1  [PMID:10512639]
  Authors
Patel MP, Blanchard JS
  Title
Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase.
  Journal
Biochemistry 38:11827-33 (1999)
DOI:10.1021/bi991025h
  Sequence
[mtu:Rv2855]
Reference
2  [PMID:11318633]
  Authors
Patel MP, Blanchard JS.
  Title
Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects.
  Journal
Biochemistry 40:5119-26 (2001)
DOI:10.1021/bi0029144
  Sequence
[mtu:Rv2855]
Other DBs
ExplorEnz - The Enzyme Database: 1.8.1.15
IUBMB Enzyme Nomenclature: 1.8.1.15
ExPASy - ENZYME nomenclature database: 1.8.1.15
BRENDA, the Enzyme Database: 1.8.1.15
CAS: 252212-92-3

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