KEGG   ENZYME: 1.8.1.15Help
Entry
EC 1.8.1.15                 Enzyme                                 

Name
mycothione reductase;
mycothiol-disulfide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
mycothiol:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2 mycothiol + NAD(P)+ = mycothione + NAD(P)H + H+ [RN:R05715 R05716 R06289 R06290]
Reaction(KEGG)
Substrate
mycothiol [CPD:C06717];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
mycothione [CPD:C11502];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Contains FAD. No activity with glutathione, trypanothione or coenzyme A as substrate.
History
EC 1.8.1.15 created 2002
Orthology
K17883  mycothione reductase
Genes
MTU: Rv2855(mtr)
MTV: RVBD_2855
MTC: MT2922
MRA: MRA_2878(mtr)
MTF: TBFG_12870
MTB: TBMG_01117
MTK: TBSG_01126
MTZ: TBXG_001107
MTG: MRGA327_17500
MTE: CCDC5079_2617
MTUR: CFBS_3010(mtr)
MTO: MTCTRI2_2912(mtr)
MTD: UDA_2855(mtr)
MTN: ERDMAN_3130(mtr)
MTUE: J114_15220
MTUH: I917_19935
MTUL: TBHG_02785
MTUT: HKBT1_2998(mtr)
MTUU: HKBT2_3003(mtr)
MTQ: HKBS1_3005(mtr)
MBO: BQ2027_MB2880(mtr)
MBB: BCG_2875(mtr)
MBT: JTY_2870(mtr)
MBM: BCGMEX_2869(mtr)
MBX: BCGT_2687
MAF: MAF_28600(mtr)
MMIC: RN08_3147
MCE: MCAN_28771(mtr)
MCQ: BN44_60322(mtr)
MCV: BN43_40546(mtr)
MCX: BN42_40843(mtr)
MCZ: BN45_51251(mtr)
MPA: MAP_2923(gorA)
MAO: MAP4_0882
MAVI: RC58_04335
MAVU: RE97_04335
MAV: MAV_3710
MIT: OCO_35370
MIA: OCU_35420
MID: MIP_05321
MYO: OEM_35810
MIR: OCQ_36580
MMAL: CKJ54_16635(mtr)
MMC: Mmcs_2067
MKM: Mkms_2113
MJL: Mjls_2050
MMI: MMAR_1875(mtr)
MMAE: MMARE11_18030(mtr)
MMM: W7S_17690
MLI: MULP_02043(mtr)
MHAD: B586_15095
MSG: MSMEI_2549(gorA)
MVA: Mvan_2298
MPHL: MPHLCCUG_03215(mtr)
MVQ: MYVA_2206
MTHN: 4412656_01680(mtr)
MAB: MAB_0062
MABB: MASS_0064
MCHE: BB28_00305
MSTE: MSTE_00062
MJD: JDM601_2573(mtr)
MTER: 4434518_02522(mtr)
ASD: AS9A_1606
CGL: NCgl1928(Cgl2003)
CGB: cg2194(gor)
CGU: WA5_1928(Mtr)
CGT: cgR_1832
CGM: cgp_2194(mtr)
CGJ: AR0_09455
CEF: CE1896
CDI: DIP1494
CDP: CD241_1439(mtr)
CDH: CDB402_1403(mtr)
CDT: CDHC01_1438(mtr)
CDE: CDHC02_1391(mtr)
CDR: CDHC03_1415(mtr)
CDA: CDHC04_1415(mtr)
CDZ: CD31A_1511(mtr)
CDB: CDBH8_1491(mtr)
CDS: CDC7B_1496(mtr)
CDD: CDCE8392_1413(mtr)
CDW: CDPW8_1484(mtr)
CDV: CDVA01_1377(mtr)
CDIP: ERS451417_01519(mtr)
CJK: jk1153(gorA)
CUR: cu0840(mtr)
CUA: CU7111_0826(mtr)
CAR: cauri_1543(mtr)
CPU: cpfrc_01298(mtr)
COP: Cp31_1312
CPSE: CPTA_01874
CPSU: CPTB_01888
CPSF: CPTC_01868
CRD: CRES_1244(mtr)
CUL: CULC22_01405(mtr)
CUC: CULC809_01391(mtr)
CUE: CULC0102_1522(mtr)
CUQ: Cul210931_1362(mtr)
CVA: CVAR_1654(mtr)
CTER: A606_06650
CGY: CGLY_07630(mtr)
COA: DR71_2013(mtr)
CSX: CSING_08415(mtr)
CMQ: B840_07730(mtr)
CKU: UL82_06460(mtr)
CCJ: UL81_07260(mtr)
CMV: CMUST_09435(mtr)
CEI: CEPID_07715(mtr)
CTED: CTEST_08190(mtr)
CUT: CUTER_06770(mtr)
CDX: CDES_08985(mtr)
CSP: WM42_2407(mtr)
CPHO: CPHO_04855
CGV: CGLAU_07810(mtr)
CAQU: CAQU_07775
CAMG: CAMM_05655
CMIN: NCTC10288_00936(mtr)
RER: RER_26020(mtr)
REY: O5Y_11935
ROP: ROP_66450(mtr)
REQ: REQ_18700(mtr)
RHB: NY08_1407
RFA: A3L23_04639(mtr)
RHS: A3Q41_03631(mtr)
RRZ: CS378_01335(mtr)
RHU: A3Q40_01396(mtr)
RQI: C1M55_13175(mtr)
RRT: 4535765_01950(mtr)
GBR: Gbro_2130
GOR: KTR9_2057
GRU: GCWB2_14675(mtr)
TPR: Tpau_1696
SRT: Srot_2976
DIT: C3V38_14920(mtr)
DIZ: CT688_09015(mtr)
SGB: WQO_27985
SVE: SVEN_0154
SALS: SLNWT_6734
SLX: SLAV_31880(mtr)
TWH: TWT_629
TWS: TW646(pdhD)
CMI: CMM_1879
CMS: CMS1352
CMC: CMN_01857
ARR: ARUE_c20740(gor)
ARM: ART_0441
ARN: CGK93_11545(mtr)
ARX: ARZXY2_4202(mtr1)
AAU: AAur_1942
ACH: Achl_1643
AAI: AARI_10940(lpdA)
KRH: KRH_15030(mtr)
LMOI: VV02_10750
SERJ: SGUI_1021
BLIN: BLSMQ_1948
PAC: PPA0333
PAW: PAZ_c03510(mtr)
PACC: PAC1_01715
PACH: PAGK_0354
CGRN: 4412665_00185(mtr)
PFRE: RM25_1912
ACIJ: JS278_00727(mtr)
MPH: MLP_47800(mtr)
NDK: I601_3199(mtr)
KFL: Kfla_5911
MGG: MPLG2_3694(mtr)
NML: Namu_2195
SEN: SACE_5978(mtr)
AMD: AMED_2053(gor)
AMN: RAM_10420
AMM: AMES_2037(gor)
AMZ: B737_2038(gor)
AOI: AORI_5853(gor)
AJA: AJAP_10190(mtr)
AMQ: AMETH_1660(gor)
PSEE: FRP1_18525
AMI: Amir_5878
SESP: BN6_70400(mtr)
KAL: KALB_7270
ACTI: UA75_09045
ACAD: UA74_09075
AHG: AHOG_08535(mtr)
ALO: CRK58580
CAI: Caci_3488
SNA: Snas_5390
AYM: YM304_00190(mtr)
 » show all
Taxonomy
Reference
1  [PMID:10512639]
  Authors
Patel MP, Blanchard JS.
  Title
Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase.
  Journal
Biochemistry 38:11827-33 (1999)
DOI:10.1021/bi991025h
  Sequence
[mtu:Rv2855]
Reference
2  [PMID:11318633]
  Authors
Patel MP, Blanchard JS.
  Title
Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects.
  Journal
Biochemistry 40:5119-26 (2001)
DOI:10.1021/bi0029144
  Sequence
[mtu:Rv2855]
Other DBs
ExplorEnz - The Enzyme Database: 1.8.1.15
IUBMB Enzyme Nomenclature: 1.8.1.15
ExPASy - ENZYME nomenclature database: 1.8.1.15
BRENDA, the Enzyme Database: 1.8.1.15
CAS: 252212-92-3

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