KEGG   ENZYME: 1.8.1.15
Entry
EC 1.8.1.15                 Enzyme                                 
Name
mycothione reductase;
mycothiol-disulfide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
Sysname
mycothiol:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2 mycothiol + NAD(P)+ = mycothione + NAD(P)H + H+ [RN:R05715 R05716 R06289 R06290]
Reaction(KEGG)
R05715 R05716 R06289(G) R06290(G)
Substrate
mycothiol [CPD:C06717];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
mycothione [CPD:C11502];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Contains FAD. No activity with glutathione, trypanothione or coenzyme A as substrate.
History
EC 1.8.1.15 created 2002
Orthology
K17883  mycothione reductase
Genes
ACANACA1_062090
NGRNAEGRDRAFT_59476
ANTArnit_1994
AVPAVENP_1239
ALKALEK_2221
ALPLPB137_09085
AHSAHALO_1673
AMARAMRN_1698
ACAAACAN_1722
AMOLAMOL_1721
PACOAACT_2085
DAKDaAHT2_2612
OVAOBV_20500
FAAHMPREF0389_00598
AMIJEQM06_05810
AMICAmi3637_16965
ABUTAmi103574_08370
VPRVpar_0470
VATB7L28_02405
VRM44547418_00485(lpd)
VDNNCTC11831_00445(lpd)
VNKVEIT17_04490
MEDMELS_2028
MHWACT01_12905
MEGDKB62_01625
MMAXLCQ47_00495
AINAcin_2175(pdhD)
MTURv2855(mtr)
MTVRVBD_2855
MTCMT2922
MRAMRA_2878(mtr)
MTFTBFG_12870
MTBTBMG_01117
MTKTBSG_01126
MTZTBXG_001107
MTGMRGA327_17500
MTECCDC5079_2617
MTURCFBS_3010(mtr)
MTLCCDC5180_2585
MTOMTCTRI2_2912(mtr)
MTDUDA_2855(mtr)
MTNERDMAN_3130(mtr)
MTJJ112_15285
MTUBMT7199_2887
MTUCJ113_19785
MTUEJ114_15220
MTXM943_14735
MTUHI917_19935
MTULTBHG_02785
MTUTHKBT1_2998(mtr)
MTUUHKBT2_3003(mtr)
MTQHKBS1_3005(mtr)
MBOBQ2027_MB2880(mtr)
MBBBCG_2875(mtr)
MBTJTY_2870(mtr)
MBMBCGMEX_2869(mtr)
MBKK60_029540
MBXBCGT_2687
MAFMAF_28600(mtr)
MMICRN08_3147
MCEMCAN_28771(mtr)
MCQBN44_60322(mtr)
MCVBN43_40546(mtr)
MCXBN42_40843(mtr)
MCZBN45_51251(mtr)
MPAMAP_2923(gorA)
MAOMAP4_0882
MAVIRC58_04335
MAVURE97_04335
MAVMAV_3710
MITOCO_35370
MIAOCU_35420
MIDMIP_05321
MYOOEM_35810
MCHIAN480_18710
MIROCQ_36580
MMALCKJ54_16635(mtr)
MMANMMAN_02600(mtr)
MSAMycsm_02462
MMCMmcs_2067
MKMMkms_2113
MJLMjls_2050
MMIMMAR_1875(mtr)
MMAEMMARE11_18030(mtr)
MMMW7S_17690
MLIMULP_02043(mtr)
MKNMKAN_24710
MYVG155_12260
MYEAB431_11245
MGOAFA91_26455
MHADB586_15095
MDXBTO20_22595
MSHGMSG_01713(mtr)
MFJMFLOJ_15740(mtr)
MSTOMSTO_17200(mtr)
MSIMMSIM_06470(mtr)
MSAKMSAS_54590(mtr)
MKUI2456_09340(mtr)
MGROFZ046_08815 FZ046_16515(mtr)
MXEMYXE_32450(mtr)
MNVMNVI_32680(mtr)
MPAGC0J29_10850(mtr)
MNMMNVM_34740(mtr)
MGORH0P51_10485(mtr)
MCOOMCOO_01040(mtr)
MBAIMB901379_01702(mtr)
MSEOMSEO_05220(mtr)
MPSEMPSD_18850(mtr)
MSHOMSHO_53290(mtr)
MHEKJMUB5695_03243(mtr)
MGAUMGALJ_07840
MLJMLAC_27740(mtr)
MBRDMBRA_46570(mtr)
MSHJMSHI_22040(mtr)
MKRMKOR_16320(mtr)
MDFK0O62_11770(mtr)
MMAMK3U93_08370(mtr)
MHOLK3U96_16285(mtr)
MHERK3U94_14680(mtr)
MSENK3U95_17540(mtr)
MPAEK0O64_10895(mtr)
MSPGF6B93_07595(mtr)
MOTLTS72_15380(mtr)
MSMMSMEG_2611
MSGMSMEI_2549(gorA)
MSBLJ00_12995
MSNLI99_12995
MSHLI98_13000
MVAMvan_2298
MGIMflv_0265 Mflv_4054
MSPMspyr1_05110 Mspyr1_33990
MCBMycch_0410 Mycch_2032
MNED174_11380
MYNMyAD_11165
MFTXA26_25200
MPHLMPHLCCUG_03215(mtr)
MVQMYVA_2206
MLLB1R94_17955
MRHMycrhN_5688
MTHN4412656_01680(mtr)
MHASMHAS_02439(mtr)
MDUMDUV_22330
MCHTMCHIJ_44880
MDRMDOR_14310
MAUUNCTC10437_00464(mtr_1) NCTC10437_02160(mtr_2)
MMAGMMAD_06940(gor) MMAD_22460
MMORMMOR_41270
MAICMAIC_19420
MALVMALV_14030
MTYMTOK_18780(gor) MTOK_40710
MPSCMPSYJ_43770(mtr)
MARZMARA_17680 MARA_33210(gor)
MGADMGAD_16280
MHEVMHEL_44510
MSARMSAR_32240
MANYMANY_05890
MAUBMAUB_55500
MPOFMPOR_09680(mtr) MPOR_26230
MPHUMPHO_13640
MMUCC1S78_011545(mtr)
MMATMMAGJ_55990
MBOKMBOE_49650
MFGK6L26_19960(mtr)
MSEIMSEDJ_18050(gor) MSEDJ_34720
MFLVNCTC10271_03223(mtr)
MABMAB_0062
MMVMYCMA_0038
MABBMASS_0064
MABLMMASJCM_0065
MCHEBB28_00305
MIZBAB75_00595
MSTEMSTE_00062
MSAOMYCSP_00330
MSALDSM43276_00053(mtr)
MJDJDM601_2573(mtr)
MTER4434518_02522(mtr)
MMINMMIN_02800(mtr)
MHIBMHIB_20190(mtr)
ASDAS9A_1606
MPAKMIU77_12210(mtr)
CGLCgl2003(Cgl2003)
CGBcg2194(gor)
CGUWA5_1928(Mtr)
CGTcgR_1832
CGSC624_09690
CGGC629_09700
CGMcgp_2194(mtr)
CGJAR0_09455
CGQCGLAR1_09305
CGXSB89_09145
CEFCE1896
CDIDIP1494
CDPCD241_1439(mtr)
CDHCDB402_1403(mtr)
CDTCDHC01_1438(mtr)
CDECDHC02_1391(mtr)
CDRCDHC03_1415(mtr)
CDACDHC04_1415(mtr)
CDZCD31A_1511(mtr)
CDBCDBH8_1491(mtr)
CDSCDC7B_1496(mtr)
CDDCDCE8392_1413(mtr)
CDWCDPW8_1484(mtr)
CDVCDVA01_1377(mtr)
CDIPERS451417_01519(mtr)
CJKjk1153(gorA)
CURcu0840(mtr)
CUACU7111_0826(mtr)
CARcauri_1543(mtr)
CKPckrop_1156
CPUCPFRC_06540(mtr)
CPLCp3995_1329
CPGCP316_06700(mtr)
CPPCpP54B96_1317
CPKCP1002_06605(mtr)
CPQCPC231_06545(mtr)
CPXCPI19_04975(mtr)
CPZCpPAT10_1292
CORCp267_1351
COPCP31_06930(mtr)
CODCp106_1274
COSCp4202_1284
COICPCIP5297_06715(mtr)
COECP258_06715(mtr)
COUCP162_04590(mtr)
CPSECPTA_01874
CPSUCPTB_01888
CPSFCPTC_01868
CRDCRES_1244(mtr)
CULCULC22_01405(mtr)
CUCCULC809_01391(mtr)
CUECULC0102_1522(mtr)
CUNCul210932_1475
CUSCulFRC11_1379
CUQCul210931_1362(mtr)
CUZCul05146_1442
CUJCUL131002_1396
CVACVAR_1654(mtr)
CHNA605_08755
CCNH924_08445
CTERA606_06650
CMDB841_08085
CAZCARG_05950
CFNCFAL_06430
CCGCCASEI_06120
CVTB843_08335
CGYCGLY_07630(mtr)
CAXCATYP_04120
CIICIMIT_07660
CUVCUREI_07430
COADR71_2013(mtr)
CDOCDOO_08790
CHMB842_08110
CSXCSING_08415(mtr)
CMQB840_07730(mtr)
CKUUL82_06460(mtr)
CCJUL81_07260(mtr)
CMVCMUST_09435(mtr)
CEICEPID_07715(mtr)
CTEDCTEST_08190(mtr)
CUTCUTER_06770(mtr)
CLWCLAC_05260
CDXCDES_08985(mtr)
CSPWM42_2407(mtr)
CSTACSTAT_05420
CCJZccrud_08710
CFKCFRA_07345
CPHOCPHO_04855
CFCCFLV_07675
CGVCGLAU_07810(mtr)
CSTRCBE89_05695
CAQUCAQU_07775
CSPHCSPHI_05390
CAMGCAMM_05655
CMINNCTC10288_00936(mtr)
CPEGCPELA_04300(mtr)
CXEFOB82_10940(mtr)
CEECENDO_07060(mtr)
CSANE3227_08150(mtr)
CGKCGERO_06835(mtr)
CRFFRC0190_01530
CRLNCTC7448_02132(mtr)
CCHOCCHOA_07240(mtr)
CPRECsp1_11950(mtr)
CPSOCPPEL_04495(mtr)
CSURN24_2075
CCYSSAMEA4530656_0840(mtr)
CMATHBA49_01660(mtr)
CYZC3B44_04405(mtr)
CKFI6I12_05310(mtr)
CANSGP473_05355(mtr)
CLIAC3E79_06890(mtr)
CPRPI6I69_01010(mtr)
CAMCI6I65_01480(mtr)
CGLUI6J20_02260(mtr)
CUOCUROG_05910(mtr)
CLIZG7Y31_07455(mtr)
CSILCBE74_07535
CTUBI6I74_00750(mtr)
CLUJIAU68_07475(mtr)
CQNG7Y29_06760(mtr)
CKWCKALI_07060(mtr)
CCOECETAM_08160(mtr)
COKCOCCU_08775(mtr)
CZOIAU67_05285(mtr)
CORYFQV43_06310(mtr)
CMFGWO64_004825(mtr)
BFVC628_09675
RHARHA1_ro06610
RERRER_26020(mtr)
REYO5Y_11935
REBXU06_12135
RQIC1M55_13175(mtr)
ROPROP_66450(mtr)
ROAPd630_LPD03269
REQREQ_18700(mtr)
RPYY013_01215
RBYCEJ39_11970(mtr)
RHBNY08_1407
RAVAAT18_11585
RFAA3L23_04639(mtr)
RHSA3Q41_03631(mtr)
RHWBFN03_05885
RRZCS378_01335(mtr)
RHUA3Q40_01396(mtr)
RHQIM25_15275
RHODAOT96_23375
RRT4535765_01950(mtr)
RCRNCTC10994_00912(mtr)
RTMG4H71_19315(mtr)
RKOJWS14_35770(mtr)
RGOKYT97_00595(mtr)
GBRGbro_2130
GPOGPOL_c20300
GORKTR9_2057
GOQACH46_08650
GTABCM27_11040
GOCCXX93_14195
GITC6V83_09155
GRUGCWB2_14675(mtr)
GOMD7316_00649(mtr)
GAVC5O27_13455(mtr)
GODGKZ92_13495(mtr)
GAMGII34_09880
GPDGII33_09430
GJIH1R19_10250
GOILK459_00075
TPRTpau_1696
TSMASU32_09190
SRTSrot_2976
DTMBJL86_1837
DITC3V38_14920(mtr)
DIZCT688_09015(mtr)
DPCA6048_09240
DLUA6035_08800
CBQAL705_01085
TOYFO059_10515
SGBWQO_27985
SVESVEN_0154
SALSSLNWT_6734
SCADDN051_04450
SVUB1H20_32185
SFYGFH48_34580
SSEOD0Z67_02865
SSUBCP968_30515
SNFJYK04_00433(mtr)
SLIAHA039_20795
SCALI6J39_31995
TWHTWT_629
TWSTW646(pdhD)
CMICMM_1879
CMSCMS1352
CMCCMN_01857
CMHVO01_08675
CCAPAES38_09145
CZHH9X71_09465
RTNA6122_1101
RRYC1O28_04785
RIAC7V51_02290
RFSC1I64_08975
RTEGSU10_06300
LEULeucomu_03930
LTREVS81_04260
LLUTK1X41_12525
AGGC1N71_08830
PSEVUSB125703_02024(mtr)
ARRARUE_c20740(gor)
ARMART_0441
ARLAFL94_13920
AREAL755_10875
AAQAOC05_06260
ARWMB46_05940
ARYATC04_04040
ARZAUT26_18445
ARNCGK93_11545(mtr)
ARXARZXY2_4202(mtr1)
ACRYAC20117_17210
AAGINCTC2676_1_01065(mtr)
AJGKKR91_06445
AAUAAur_1942
PUEFV140_20215(mtr)
ACHAchl_1643
PSULAU252_02160
PSEYGU243_02695
AAIAARI_10940(lpdA)
GARAOZ07_05795
GCRGcLGCM259_2761
GLUF0M17_05455(mtr)
GPRJQN66_13875
RSARSal33209_2968
KRHKRH_15030(mtr)
KPLKPaMU14_07340
KFVAS188_08885
KIIKocCE7_07905
KRSEQG70_11335
KODHBK84_07945
KVRCIB50_0001618(mtr)
MLUMlut_13800
MICKB1A86_00006860
RMURMDY18_13730
RDNHMPREF0733_11652
RAJRA11412_1375
RTERIDM49_07640
RAMAIDM48_07305
RKRI6G21_07865
NAEBHE16_03395
AULDCC27_004735
PAEYKUF55_06165
BFABfae_09170
BRXBH708_18395
BRVCFK39_12610
BGGCFK41_12335
BRZCFK38_14905
BSAUDWV08_01860
BRRC1N80_14305
DVADAD186_17580
DJJCOP05_02450
KSEKsed_08580
DNIHX89_10205
DAYFV141_09275(mtr)
LMOIVV02_10750
YIMJ5M86_04485(mtr)
ALXLVQ62_16165
SKESked_05900
PSEIGCE65_00655
ARSADJ73_05625
JTEASJ30_11135
JLIEXU32_03220
JMEEEW87_004020
PHWG7075_00210
SERJSGUI_1021
SERWFY030_04130
ORNDV701_06540
ORZFNH13_13605
BLYA2T55_08960
BLINBLSMQ_1948
BRIFDF13_10785
BLUTEW640_03770
BCAUI6G59_12455
DCOSAMEA4475696_1308(mtr)
AUSIPK37_14495
HALTIM660_11345
PACPPA0333
PAKHMPREF0675_3374
PAVTIA2EST22_01675
PAXTIA2EST36_01660
PAZTIA2EST2_01595
PAWPAZ_c03510(mtr)
PCNTIB1ST10_01705
PACCPAC1_01715
PACHPAGK_0354
PACNTIA1EST1_01665
PRAPALO_08900
PRLBCB70_04825
CGRN4412665_00185(mtr)
PFRPFREUD_20050
PFRERM25_1912
PACDEGX94_08550
PAUSNCTC13651_02145(mtr)
PPCHMPREF9154_0446
ARUBJ5A65_02540
PBOPACID_27840
AACIASQ49_08165
ACIJJS278_00727(mtr)
AJIC0Z10_02220
MPHMLP_47800(mtr)
MIKFOE78_22215
MICGGJV80_14315
TFLRPIT_01740
TFABW733_04555
TESBW730_00110
TEZBKM78_11015
TLATLA_TLA_02219(mtr)
RAINRai3103_10060
BRTJ4N02_14095
NDKI601_3199(mtr)
NOOFE634_19115
NANOG5V58_11775
NMESH9L09_07090
NAQUENKNEFLB_00495(mtr)
MGGMPLG2_3694(mtr)
KFLKfla_5911
KQIF1D05_02210 F1D05_14150
NGVCDO52_26195
NMLNamu_2195
NAKEH165_08115
SENSACE_5978(mtr)
SACGFDZ84_04905
SVISvir_10080
SACCEYD13_05495(mtr)
AMDAMED_2053(gor)
AMNRAM_10420
AMMAMES_2037(gor)
AMZB737_2038(gor)
AOIAORI_5853(gor)
AJAAJAP_10190(mtr)
AMQAMETH_1660(gor)
AMYCCU254_08395
AMYBBKN51_22785
AABA4R43_18255
AMYYYIM_11805(mtr)
AORISD37_28665
AACDLWP59_08365
PDXPsed_2506 Psed_4694
PSEAWY02_08770 WY02_24285
PSEEFRP1_18525
PSEHXF36_05735 XF36_07385
PSEQAD006_25975
PECQAD017_05570
PHHAFB00_03410 AFB00_20845
PAUTPdca_19280 Pdca_48760
PBROHOP40_32395 HOP40_33875
APRECNX65_28845
AMIAmir_5878
SESPBN6_70400(mtr)
SSYIEKG83_39470
KALKALB_7270
KPHYAOZ06_44450
LEDBBK82_22275
AHMTL08_09015
ACTIUA75_09045
ACADUA74_09075
AHGAHOG_08535(mtr)
ACTAC1701_19555
ALOCRK58580
PMADBAY61_07180
SACEGIY23_16965
CAICaci_3488
SNASnas_5390
TPECHLG82_08675
ACTTDDD63_10550
FSLEJO69_02640
FLHEJ997_03585
AEYCDG81_07350
EKEEK0264_19010
AYMYM304_00190(mtr)
EUZDVS28_a2551
DLYDehly_0886
DEWDGWBC_0646
DFODform_01203(lpd|pdhD)
SNGSNE_A15700(merA)
VBSEGM51_14485
LILLA_2115(lpd)
LIELIF_A1717(lpd)
LICLIC_11803
LISLIL_11929(lpd2)
LBJLBJ_1895(lpdA-3)
LBLLBL_1389(lpdA-3)
LSTLSS_09369
LAJA0128_09105
LMAYDPV73_13575
LKMEFP84_01200
LWLFHG68_09335
LKBLPTSP3_g19860(lpd_3)
SCORJ3U87_11600
FGOC4N16_06235
FNFBSQ88_05455
FPLFerp_0777
GACGACE_0381
MBAMbar_A2696
MBYMSBRM_1149
MBWMSBRW_2032
MBARMSBR2_1262
MBAKMSBR3_0219
MACMA_1652
MMAMM_3279
MMAZMmTuc01_3376
MMJMSMAS_1407
MMACMSMAC_2768
MVCMSVAZ_1797
MEKMSKOL_1774
MLSMSLAZ_1895
METMMSMTP_1275
MEFMSWH1_1795
MEQMSWHS_1524
MSJMSSAC_1913
MSZMSSIH_2328
MSWMSSIT_2357
MTHRMSTHT_0784
MTHEMSTHC_2486
MHORMSHOH_2040
MFZAOB57_012570
MBUMbur_1783
MMETMCMEM_0038
MELOJ7W08_10260
MMHMmah_1936
MHAZBHR79_03955
MEVMetev_0133
MZHMzhil_1970
MPYMpsy_1813
MZIHWN40_13065
MHZMetho_2396
MTPMthe_0903
MCJMCON_0536
MHIMhar_2119
MPDMCP_0970
RCIRCIX79(lpd)
HDLHALDL1_04520 HALDL1_05415
HNOLT974_05460
HLULT972_02405
SALRFQU85_00215
HALREFA46_008550 EFA46_013340
HAADMW046_18045
HALXM0R89_02910 M0R89_20810 M0R89_20870
HALJG9465_10855
HSINKDQ40_17735 KDQ40_17810
NMONmlp_1828(lpdA2)
NHOHWV23_11885
NSALHWV07_13510
HUTHuta_0842
HTIHTIA_0139
HALLLC1Hm_3043(lpd3) LC1Hm_3061(lpd4)
HSNDV733_10690 DV733_10730
HPELHZS54_21730
HARCHARCEL1_08020
HDOMUK72_04880
HMEHFX_6465(pdhD)
HBOHbor_32240
HAQDU484_12040 DU484_12320
HAJDU500_12480
HRAEI982_03555 EI982_03630
HLMDV707_09990
HLAHlac_1256
HALBEKH57_01435
HALQHrr1229_012550
HSAIHPS36_15100
HALNB4589_006635
HALGHUG10_10660
HALUHUG12_01085 HUG12_05495
HMPK6T50_17720
HREK6T36_16985
HACBHbl1158_06245
HAHHalar_1057 Halar_1161
HTUHtur_0256 Htur_2738
HDABB347_12730
HJTDVR14_08650 DVR14_16810 DVR14_20930
HALYHYG82_03630 HYG82_14725
HSALJMJ58_07930 JMJ58_15190
HLOJ0X27_07630 J0X27_14835
HAKZJ0X25_01865 J0X25_07730
NMGNmag_1804(lpdA2) Nmag_3630(lpdA3)
HXAHalxa_0173 Halxa_1341 Halxa_1962
NATNJ7G_0841
NPENatpe_1515 Natpe_3719
NVRFEJ81_07800 FEJ81_17820
NPLFGF80_02510
NAYHYG81_02785 HYG81_11315
NGENatgr_1559
HRUHalru_2923
NOUNatoc_0124
SALIL593_05465 L593_05495
SAIMK0C01_09920
HLRHALLA_05360 HALLA_20465
HLCCHINAEXTREME04785 CHINAEXTREME18355
NAJB1756_08780 B1756_15825
NBGDV706_17530 DV706_17560
NASGCU68_18870 GCU68_19630
NACAQV86_04690
MEAMMU439_04860
ABIAboo_0496
ACFAciM339_0547
TPETpen_1824
THBN186_00730
TCBTCARB_1233
THFMA03_01505
THELIG193_07670
NGANgar_c26660
NVNNVIE_008480
NEVNTE_02192
CCAINAS2_1173
NCONLC1Nh_0693(lpd2)
LOKILokiarch_14060(mtr_1) Lokiarch_51530(mtr_2)
PSYTDSAG12_01083(lpdA_1)
 » show all
Reference
1  [PMID:10512639]
  Authors
Patel MP, Blanchard JS
  Title
Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase.
  Journal
Biochemistry 38:11827-33 (1999)
DOI:10.1021/bi991025h
  Sequence
[mtu:Rv2855]
Reference
2  [PMID:11318633]
  Authors
Patel MP, Blanchard JS.
  Title
Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects.
  Journal
Biochemistry 40:5119-26 (2001)
DOI:10.1021/bi0029144
  Sequence
[mtu:Rv2855]
Other DBs
ExplorEnz - The Enzyme Database: 1.8.1.15
IUBMB Enzyme Nomenclature: 1.8.1.15
ExPASy - ENZYME nomenclature database: 1.8.1.15
BRENDA, the Enzyme Database: 1.8.1.15
CAS: 252212-92-3

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