KEGG   ENZYME: 1.8.1.18
Entry
EC 1.8.1.18                 Enzyme                                 
Name
NAD(P)H sulfur oxidoreductase (CoA-dependent);
NADPH NSR;
S0 reductase;
coenzyme A-dependent NADPH sulfur oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
Sysname
hydrogen sulfide:NAD(P)+ oxidoreductase (CoA-dependent)
Reaction(IUBMB)
hydrogen sulfide + NAD(P)+ = sulfur + NAD(P)H + H+ [RN:R10419 R10438]
Reaction(KEGG)
R10419 R10438
Substrate
hydrogen sulfide [CPD:C00283];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
sulfur [CPD:C00087];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This FAD-dependent enzyme, characterized from the archaeon Pyrococcus furiosus, is responsible for NAD(P)H-linked sulfur reduction. The activity with NADH is about half of that with NADPH. The reaction is dependent on CoA, although the nature of this dependency is not well understood.
History
EC 1.8.1.18 created 2013
Orthology
K18367  CoA-dependent NAD(P)H sulfur oxidoreductase
Genes
DMLDmul_13050
DALDalk_1083
DATHRM2_42160
DOVDSCO28_39810
DWDDSCW_42240
DALKDSCA_40950
DLIdnl_15590
DMMdnm_038310
CLTCM240_1008
PDCCDIF630_02792
CDCCD196_2380(nox)
CDLCDR20291_2427(nox)
PDFCD630DERM_25400
PSORRSJ16_03165
ROCHF520_02975
NTHNther_0427
NCDACONDI_02759(cdr_2)
MFWmflW37_6990
MENTCS528_03630
SDISDIMI_v3c02700(nox)
SAPISAPIS_v1c03240(nox2)
SCQSCULI_v1c03440(nox2)
SCJSCANT_v1c02780(nox)
SHJSHELI_v1c02820(nox)
SFZSFLOR_v1c03380(nox)
SCLASCLARK_001466(nox)
SPRNS100390_v1c00280(nox)
SPITSTU14_v1c00280(nox)
SCHISCHIN_v1c04520(nox)
MSAMycsm_01876
MCBMycch_5453 Mycch_5967
MRHMycrhN_2935
RKOJWS14_41295
NCANoca_4815 Noca_4840
RXYRxyl_2921
TTSThthe16_1852
TTLTtJL18_1933
TSCTSC_c03950(cdr)
THCTCCBUS3UF1_19370
TOSTheos_0116
TAQTO73_0296
TPARAV541_01545
TBCA0O31_01275
BGBKK9_0762(nox)
BGNBgCN_0755
BGSX921_00595
BGCBLA33_00590
BMAYA7X70_03670
BHDBHYOB78_06050
BRMBmur_1346
BPOBP951000_1623
BPJB2904_orf2348(nox)
BPWWESB_0452(nox)
BIPBint_2689(nox)
FHWRN87_08440
FPDCTM68_09425
FPEIC4N17_02555
FCII6I83_06120
LBALebu_1121
LOTAXF11_09665
LEQBCB68_08255
LHFJCM16775_1492
LSZJCM16776_0912
LHGJMUB5056_1214
LTEJMUB4039_1251
LWDJCM16777_1347(cdr)
SMFSmon_1004
TAMTheam_1321
AFUAF_0254 AF_0395
AFGAFULGI_00002410
AVEArcve_0623
ASTAsulf_00763 Asulf_00806
FPLFerp_0243 Ferp_1513
GACGACE_0171 GACE_1887
GAHGAH_00177 GAH_00543
PFUPF1186
PFIPFC_05150
PHOPH0572(PH0572)
PABPAB0936(noxA-1)
PYNPNA2_1248
PYAPYCH_07890
PYSPy04_1126
PYCTQ32_04610
TKOTK1299
TONTON_0305
TGATGAM_1050
TSITSIB_0263
TBATERMP_02185
THEGQS_04305
THATAM4_984
THMCL1_0500
TLTOCC_09741
THSTES1_0076
TNUBD01_0098
TEUTEU_06045
TGYX802_09060
THVADU37_CDS01970
TCHCHITON_0620
TPEPA0127_08345
TPIEA7C91_06865
TGGA3K92_02810
TCEA3L02_00375
TBSA3L01_01625
THHCDI07_01600(cdr)
TSLA3L11_05395
TTDA3L14_03115
TPRFA3L09_04710
TRLA3L10_04955
TPAFA3L08_05385
THYA3L12_01910
TICFH039_03805(cdr)
TCQTIRI35C_0553
THEMFPV09_05465(cdr)
THEIK1720_04445(cdr)
PPACPAP_01275
HSUHLASF_1265
HSFHLASA_1253
SALIL593_10585
HHIHAH_5054(noxA1)
HHNHISP_18435
HABSG26_17795
HTABVU17_15620
HSINKDQ40_20540
HALAHrd1104_00415
HALLLC1Hm_2910
HALIBV210_10285 BV210_17075
HSNDV733_09040 DV733_09080
HPELHZS54_07350
HWAHQ_1120A
HWCHqrw_1150
HMEHFX_6281(noxA1)
HALEG3A49_06145
HLMDV707_14315
HALQHrr1229_017775
SRUBC2R22_18425
HDFAArcSl_1934
HAHHalar_2195
HALYHYG82_05820
HJTDVR14_16540 DVR14_20660
NAJB1756_15865
NAGAArcMg_2670
NANAArc1_1034
NBGDV706_01875
NASGCU68_11875
TACTa0837
TVOTVG0846070(TVG0846070)
PTOPTO1479
FACFACI_IFERC01G0306
FAIFAD_1225
CDIVCPM_1150
IHOIgni_0671
IISEYM_06280
IPCIPA_07550
IAGIgag_0286
HBUHbut_0802
PFMPyrfu_1068
PDLPyrde_1518
STOSTK_22470(nox)
SOHD1869_12355
SSOSSO2283
SOLSsol_0100
SSOASULA_0096(cdr)
SSOLSULB_0097(cdr)
SSOFSULC_0096(cdr)
SSHIJ5U23_01088
SCASSACC_19940
SAISaci_0149(npx)
SACNSacN8_00710
SACRSacRon12I_00710
SACSSUSAZ_00750
SISLS215_0094
SIAM1425_0094
SIMM1627_0094
SIDM164_0094
SIYYG5714_0096
SINYN1551_0094
SIILD85_0095
SIHSiH_0095
SIRSiRe_0093
SICSiL_0093
SULABFU36_10050
SULEGFS03_02015(cdr)
SULOGFS33_09210(cdr)
SULLEWF20_13420
MSEMsed_2080
MEMJMJ1HA_2351
MCNMcup_0209
MHKDFR87_08085
MPRUDFR88_07755
MTENGWK48_04075
MJNMjAS7_0383
AHOAhos_0488
AMANB6F84_06115
ABRIDFR85_08505
ASULDFR86_05170
AAMBD1866_10130
ACIHHS5_18540
SACDHS1genome_2156
SAZOD1868_08100
CSTYKN1_07880
STEPIC006_2715
SAHSHS7_03670
PAIPAE2371
PISPisl_0245 Pisl_0611
PCLPcal_1390 Pcal_1700
PASPars_1572
PYRP186_0499 P186_0715
POGPogu_0642 Pogu_1301
TNETneu_0425 Tneu_1510
PYWPYWP30_00443 PYWP30_01601
CMACmaq_1123 Cmaq_1604
TTNTTX_1426(noxA)
TUZTUZN_2129
VDIVdis_0029 Vdis_1321
VMOVMUT_0916 VMUT_2147
VSOVsou_00310 Vsou_24490
TPETpen_0143
THBN186_01640
TCBTCARB_1412
THFMA03_00805
THELIG193_06880
ASCASAC_1028 ASAC_1401
ACIASE86_04135 SE86_06260
CLGCalag_0508 Calag_0624
CCAINAS2_0463
 » show all
Reference
1  [PMID:17449625]
  Authors
Schut GJ, Bridger SL, Adams MW
  Title
Insights into the metabolism of elemental sulfur by the hyperthermophilic archaeon Pyrococcus furiosus: characterization of a coenzyme A- dependent NAD(P)H sulfur oxidoreductase.
  Journal
J Bacteriol 189:4431-41 (2007)
DOI:10.1128/JB.00031-07
  Sequence
[pfu:PF1186]
Reference
2  [PMID:21965560]
  Authors
Bridger SL, Clarkson SM, Stirrett K, DeBarry MB, Lipscomb GL, Schut GJ, Westpheling J, Scott RA, Adams MW
  Title
Deletion strains reveal metabolic roles for key elemental sulfur-responsive proteins in Pyrococcus furiosus.
  Journal
J Bacteriol 193:6498-504 (2011)
DOI:10.1128/JB.05445-11
Reference
3  [PMID:15720393]
  Authors
Harris DR, Ward DE, Feasel JM, Lancaster KM, Murphy RD, Mallet TC, Crane EJ 3rd
  Title
Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii. Implications for this disulfide metabolism of anaerobic hyperthermophiles.
  Journal
FEBS J 272:1189-200 (2005)
DOI:10.1111/j.1742-4658.2005.04555.x
  Sequence
[pho:PH0572]
Other DBs
ExplorEnz - The Enzyme Database: 1.8.1.18
IUBMB Enzyme Nomenclature: 1.8.1.18
ExPASy - ENZYME nomenclature database: 1.8.1.18
BRENDA, the Enzyme Database: 1.8.1.18

DBGET integrated database retrieval system