KEGG   ENZYME: 1.8.1.20
Entry
EC 1.8.1.20                 Enzyme                                 
Name
4,4'-dithiodibutanoate disulfide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
Sysname
4-sulfanylbutanoate:NAD+ oxidoreductase
Reaction(IUBMB)
2 4-sulfanylbutanoate + NAD+ = 4,4'-disulfanediyldibutanoate + NADH + H+ [RN:R11876]
Reaction(KEGG)
R11876
Substrate
4-sulfanylbutanoate [CPD:C21736];
NAD+ [CPD:C00003]
Product
4,4'-disulfanediyldibutanoate [CPD:C21737];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Rhodococcus erythropolis MI2, contains an FMN cofator.
History
EC 1.8.1.20 created 2017
Orthology
K22347  4,4'-dithiodibutanoate disulfide reductase
Genes
MITOCO_00550
MIAOCU_00560
MIDMIP_00074
MYOOEM_00550
MCHIAN480_00300
MIROCQ_00550
MMALCKJ54_00265
MMMW7S_00270
MYEAB431_25170
MKUI2456_00375
MRFMJO55_06525
MNED174_24100
MYNMyAD_23640
MFTXA26_09370
MRHMycrhN_2327
MAUUNCTC10437_01289
MALVMALV_43100
MPSCMPSYJ_51650
MARZMARA_41720
RHARHA1_ro03649
RERRER_60190
REYO5Y_28900
REBXU06_29215
RQIC1M55_30700
ROPROP_34690
ROAPd630_LPD08040
RPYY013_16435
RBYCEJ39_02880
RAVAAT18_26630
RHWBFN03_18040
RRZCS378_16005
RHQIM25_06325
RHODAOT96_10340
RRT4535765_00001
RCRNCTC10994_02629
RKOJWS14_19735(nox)
RGOKYT97_19400(nox)
ROZCBI38_30455
RPSKJWS13_25170(nox)
RGORNMQ04_20905
IAMHC251_06655
 » show all
Reference
1  [PMID:26407888]
  Authors
Khairy H, Wubbeler JH, Steinbuchel A
  Title
Biodegradation of the organic disulfide 4,4'-dithiodibutyric acid by Rhodococcus spp.
  Journal
Appl Environ Microbiol 81:8294-306 (2015)
DOI:10.1128/AEM.02059-15
  Sequence
[rer:RER_60190]
Reference
2  [PMID:27564089]
  Authors
Khairy H, Wubbeler JH, Steinbuchel A
  Title
The NADH:flavin oxidoreductase Nox from Rhodococcus erythropolis MI2 is the key enzyme of 4,4'-dithiodibutyric acid degradation.
  Journal
Lett Appl Microbiol 63:434-441 (2016)
DOI:10.1111/lam.12662
Other DBs
ExplorEnz - The Enzyme Database: 1.8.1.20
IUBMB Enzyme Nomenclature: 1.8.1.20
ExPASy - ENZYME nomenclature database: 1.8.1.20
BRENDA, the Enzyme Database: 1.8.1.20

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