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Entry
EC 1.8.2.5                  Enzyme                                 

Name
thiosulfate reductase (cytochrome)
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
sulfite,hydrogen sulfide:ferricytochrome-c3 oxidoreductase (thiosulfate-forming)
Reaction(IUBMB)
sulfite + hydrogen sulfide + 2 ferricytochrome c3 = thiosulfate + 2 ferrocytochrome c3 [RN:R11606]
Reaction(KEGG)
Substrate
sulfite [CPD:C00094];
hydrogen sulfide [CPD:C00283];
ferricytochrome c3 [CPD:C02682]
Product
thiosulfate [CPD:C00320];
ferrocytochrome c3 [CPD:C02684]
Comment
The enzyme is found in sulfate-reducing bacteria. The source of the electrons is molecular hydrogen, via EC 1.12.2.1, cytochrome-c3 hydrogenase. The organisms utilize the sulfite that is produced for energy generation by EC 1.8.99.5, dissimilatory sulfite reductase.
History
EC 1.8.2.5 created 2017
Reference
1
  Authors
Ishimoto, M. and Koyama, J.
  Title
On the role of a cytochrome in the thiosulfate reduction by sulfate-reducing bacterium.
  Journal
B Chem Soc Jpn 28:231b-232 (1955)
Reference
2
  Authors
Ishimoto, M., Toyama, J.
  Title
Biochemical studies on sulfate reducing bacteria. VI. Separation of hydrogenase and thiosulfate reductase and partial purification of cytochrome and green pigment.
  Journal
J Biochem (Tokyo) 44:233-242 (1957)
Reference
3  [PMID:5784203]
  Authors
Nakatsukasa W, Akagi JM
  Title
Thiosulfate reductase isolated from Desulfotomaculum nigrificans.
  Journal
J Bacteriol 98:429-33 (1969)
Reference
4  [PMID:5573735]
  Authors
Haschke RH, Campbell LL
  Title
Thiosulfate reductase of Desulfovibrio vulgaris.
  Journal
J Bacteriol 106:603-7 (1971)
Reference
5  [PMID:242299]
  Authors
Hatchikian EC
  Title
Purification and properties of thiosulfate reductase from Desulfovibrio gigas.
  Journal
Arch Microbiol 105:249-56 (1975)
Reference
6  [PMID:2993256]
  Authors
Aketagawa J, Kobayashi K, Ishimoto M
  Title
Purification and properties of thiosulfate reductase from Desulfovibrio vulgaris, Miyazaki F.
  Journal
J Biochem 97:1025-32 (1985)
Other DBs
ExplorEnz - The Enzyme Database: 1.8.2.5
IUBMB Enzyme Nomenclature: 1.8.2.5
ExPASy - ENZYME nomenclature database: 1.8.2.5
BRENDA, the Enzyme Database: 1.8.2.5

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