KEGG ENZYME: 1.8.3.6

ENZYME: 1.8.3.6

Entry

EC 1.8.3.6                  Enzyme

Name

farnesylcysteine lyase;
FC lyase;
FCLY

Class

Oxidoreductases;
Acting on a sulfur group of donors;
With oxygen as acceptor

Sysname

S-(2E,6E)-farnesyl-L-cysteine oxidase

Reaction(IUBMB)

S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2 [RN:R09562]

Reaction(KEGG)

R09562

Substrate

S-(2E,6E)-farnesyl-L-cysteine [CPD:C19691];
O2 [CPD:C00007];
H2O [CPD:C00001]

Product

(2E,6E)-farnesal [CPD:C03461];
L-cysteine [CPD:C00097];
H2O2 [CPD:C00027]

Comment

A flavoprotein (FAD). In contrast to mammalian EC 1.8.3.5 (prenylcysteine oxidase) the farnesylcysteine lyase from Arabidopsis is specific for S-farnesyl-L-cysteine and shows no activity with S-geranylgeranyl-L-cysteine.

History

EC 1.8.3.6 created 2011

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K05906

prenylcysteine oxidase / farnesylcysteine lyase

Genes

HSA:	51449(PCYOX1)

PTR:	470398(PCYOX1)

PPS:	100971101(PCYOX1)

GGO:	101138892(PCYOX1)

PON:	100457284(PCYOX1)

NLE:	100606095(PCYOX1)

MCC:	710068(PCYOX1)

MCF:	101926201(PCYOX1)

CSAB:

103220094(PCYOX1)

CATY:

105576534(PCYOX1)

PANU:

101022266(PCYOX1)

TGE:	112605329(PCYOX1)

RRO:	104659273 104661318(PCYOX1)

RBB:	108516355(PCYOX1)

TFN:	117061975(PCYOX1)

PTEH:

111550486(PCYOX1)

CJC:	100404939(PCYOX1)

SBQ:	101047105(PCYOX1)

CSYR:

103264662(PCYOX1)

MMUR:

105863272 105863282(PCYOX1)

OGA:	100954104(PCYOX1)

MMU:	66881(Pcyox1)

MCAL:

110295686(Pcyox1)

MPAH:

110316366(Pcyox1)

RNO:	246302(Pcyox1)

MCOC:

116099179(Pcyox1)

MUN:	110547181(Pcyox1)

CGE:	100774789(Pcyox1)

MAUA:

101824525(Pcyox1)

PLEU:

114680827(Pcyox1)

MORG:

121437787(Pcyox1)

NGI:	103725906(Pcyox1)

HGL:	101725032(Pcyox1)

CPOC:

100725382(Pcyox1)

CCAN:

109698768(Pcyox1)

DORD:

105990225(Pcyox1)

DSP:	122110515(Pcyox1)

NCAR:

124963527

OCU:	100354763(PCYOX1)

OPI:	101532356(PCYOX1)

TUP:	102492977(PCYOX1)

CFA:	481418(PCYOX1)

VVP:	112934410(PCYOX1)

VLG:	121490816(PCYOX1)

AML:	100468481(PCYOX1)

UMR:	103671811(PCYOX1)

UAH:	113244236(PCYOX1)

UAR:	123786032(PCYOX1)

ELK:

111148173

LLV:

125108533

MPUF:

101676752(PCYOX1)

ORO:	101383182(PCYOX1)

EJU:	114218922(PCYOX1)

ZCA:	113937570(PCYOX1)

MLX:	118007999(PCYOX1)

FCA:	101096467(PCYOX1)

PYU:	121019288(PCYOX1)

PBG:	122496968(PCYOX1)

PTG:	102955992(PCYOX1)

PPAD:

109262459(PCYOX1)

AJU:	106967763(PCYOX1)

HHV:	120236635(PCYOX1)

BTA:	100125835(PCYOX1)

BOM:	102279554(PCYOX1)

BIU:	109566249(PCYOX1)

BBUB:

102399126(PCYOX1)

CHX:	102176973(PCYOX1)

OAS:	101105397(PCYOX1)

ODA:	120851393(PCYOX1)

CCAD:

122441876(PCYOX1)

SSC:	100624596(PCYOX1)

CFR:	102511924(PCYOX1)

CBAI:

105075789(PCYOX1)

CDK:	105088901(PCYOX1)

VPC:	102546040(PCYOX1)

BACU:

103010853(PCYOX1)

LVE:	103091374(PCYOX1)

OOR:	101280418(PCYOX1)

DLE:	111167878(PCYOX1)

PCAD:

102993678(PCYOX1)

PSIU:

116764285(PCYOX1)

ECB:	100060594(PCYOX1)

EPZ:	103547599(PCYOX1)

EAI:	106828313(PCYOX1)

MYB:	102262695(PCYOX1)

MYD:	102755614(PCYOX1)

MMYO:

118668888(PCYOX1)

MLF:	102436365(PCYOX1)

MNA:	107529289(PCYOX1)

PKL:	118717482(PCYOX1)

HAI:	109385413(PCYOX1)

DRO:	112303075(PCYOX1)

SHON:

118988494(PCYOX1)

AJM:	119035785(PCYOX1)

PDIC:

114499268(PCYOX1)

PHAS:

123811846(PCYOX1)

MMF:	118630835(PCYOX1)

RFQ:	117033026(PCYOX1)

PALE:

102888402(PCYOX1)

PGIG:

120594429(PCYOX1)

PVP:	105295760(PCYOX1)

RAY:	107519108(PCYOX1)

MJV:

108402540

TOD:	119259044(PCYOX1)

SARA:

101543825(PCYOX1)

LAV:	100674445(PCYOX1)

TMU:

101360021

DNM:	101416984(PCYOX1)

MDO:	100032803(PCYOX1)

GAS:	123236997(PCYOX1)

SHR:	100929029(PCYOX1)

PCW:	110207621(PCYOX1)

OAA:	100088724(PCYOX1L) 100091365(PCYOX1)

GGA:	426297(PCYOX1)

PCOC:

116231312(PCYOX1)

MGP:	100545768(PCYOX1)

CJO:	107323602(PCYOX1)

NMEL:

110387147(PCYOX1)

APLA:

101804304(PCYOX1L)

ACYG:

106046247(PCYOX1)

AFUL:

116499319(PCYOX1)

TGU:	100226181(PCYOX1L) 115498183(PCYOX1)

LSR:	110478629(PCYOX1)

SCAN:

103824661(PCYOX1) 103824662

PMOA:

120499138(PCYOX1)

OTC:	121336006(PCYOX1)

PRUF:

121352744(PCYOX1)

GFR:	102032195(PCYOX1)

FAB:	101808104(PCYOX1)

PHI:	102109379(PCYOX1)

PMAJ:

107213988(PCYOX1)

CCAE:

111938747(PCYOX1)

CCW:	104694867(PCYOX1)

ETL:	114066448(PCYOX1)

FPG:	101917041(PCYOX1)

FCH:	102057230(PCYOX1)

CLV:	102097250(PCYOX1)

EGZ:	104123772(PCYOX1)

NNI:	104019025(PCYOX1L)

ACUN:

113488068(PCYOX1)

PADL:

103914322(PCYOX1)

ACHC:

115349954(PCYOX1)

AAM:	106490249(PCYOX1)

AROW:

112973628(PCYOX1)

NPD:	112949768(PCYOX1)

DNE:	112996703(PCYOX1)

ASN:	102379956(PCYOX1)

AMJ:	102574611(PCYOX1)

CPOO:

109317286(PCYOX1)

PSS:	102452243(PCYOX1)

CMY:	102947169(PCYOX1)

CPIC:

101941069(PCYOX1)

TST:	117872906(PCYOX1)

CABI:

116833381

MRV:	120399585(PCYOX1)

ACS:	100563966(pcyox1)

PVT:	110072210(PCYOX1) 110075841

SUND:

121932951(PCYOX1)

PBI:	103055758(PCYOX1)

PMUR:

107283235(PCYOX1)

TSR:	106542621(PCYOX1)

PGUT:

117673340(PCYOX1)

VKO:	123016770(PCYOX1)

PMUA:

114602675(PCYOX1)

ZVI:	118086407(PCYOX1)

GJA:	107118770 107118771

STOW:

125442035(PCYOX1)

XLA:	108711539(pcyox1.L)

XTR:	549056(pcyox1)

NPR:	108785358(PCYOX1)

RTEM:

120932969 120932970(PCYOX1)

BBUF:

120986091(PCYOX1)

BGAR:

122927443(PCYOX1) 122927444

DRE:	550289(pcyox1)

SRX:	107713365 107744114

SANH:

107686458 107688072

SGH:	107562568 107569400 107581983

CCAR:

109045315 109052061 109092885

CAUA:

113038184(pcyox1l) 113054126 113075381 113110395

PPRM:

120482582(pcyox1)

MAMB:

125256584(pcyox1)

IPU:	100304900 108276731(pcyox1)

PHYP:

113543127(pcyox1l) 113544142

SMEO:

124393874(pcyox1)

TFD:	113661294(pcyox1)

AMEX:

103021813(pcyox1l) 103023969 103044269

EEE:	113575162 113585763(pcyox1l)

TRU:	101065828(pcyox1l) 101067237(pcyox1)

TNG:	GSTEN00003251G001 GSTEN00017330G001

LCO:	104923352(pcyox1)

NCC:	104950632(pcyox1l) 104961020(pcyox1)

CGOB:

115017104 115019279(pcyox1l)

ELY:	117262769 117269681(pcyox1)

PLEP:

121952973 121959547(pcyox1)

SLUC:

116035072(pcyox1) 116037040

ECRA:

117955713 117959305(pcyox1)

PFLV:

114566340(pcyox1l) 114570624(pcyox1)

GAT:	120821779 120832249(pcyox1)

PPUG:

119215256 119226526(pcyox1)

MSAM:

119894904 119918692(pcyox1)

CUD:	121518342 121525634(pcyox1)

ALAT:

119029752(pcyox1) 119031978

MZE:	101483866(pcyox1l) 101485660

ONL:	100689931(pcyox1l) 100704244(pcyox1)

OAU:	116319707 116322403(pcyox1)

OLA:	101155871(pcyox1l) 101172915(pcyox1)

OML:	112142954 112163513(pcyox1)

XMA:	102229017(pcyox1) 102235232(pcyox1l)

XCO:	114149713(pcyox1) 114153555(pcyox1l)

XHE:	116724427(pcyox1) 116728776(pcyox1l)

PRET:

103473683(pcyox1)

PFOR:

103139082(pcyox1l) 103148439(pcyox1)

PLAI:

106955705(pcyox1l) 106958396(pcyox1)

PMEI:

106907593(pcyox1l) 106927958(pcyox1)

GAF:	122844561 122846896(pcyox1)

CVG:	107084167(pcyox1l) 107092669(pcyox1)

CTUL:

119771586(pcyox1) 119792693

GMU:	124872403(pcyox1) 124876542

NFU:	107372848(pcyox1) 107386753(pcyox1l)

KMR:	108232575(pcyox1) 108238884

ALIM:

106514514(pcyox1) 106524041(pcyox1l)

NWH:	119420742 119424694(pcyox1)

AOCE:

111568369(pcyox1) 111584671(pcyox1l)

CSEM:

103390492(pcyox1) 103395449(pcyox1l)

POV:	109626079(pcyox1) 109643089(pcyox1l)

SSEN:

122779949 122781775(pcyox1)

HHIP:

117772032(pcyox1) 117774242

HSP:	118121924 118125623(pcyox1)

LCF:	108879214(pcyox1) 108893957(pcyox1l)

SDU:	111217056(pcyox1l) 111234251(pcyox1)

SLAL:

111647482(pcyox1l) 111668094(pcyox1)

XGL:	120802841 120806268(pcyox1)

HCQ:	109513148(pcyox1)

BPEC:

110155903(pcyox1l) 110160541(pcyox1)

MALB:

109960018(pcyox1l) 109963438(pcyox1)

BSPL:

114866797(pcyox1) 114869696

SASA:

106564891

OTW:	112219406(pcyox1)

OMY:	110523690(pcyox1) 110537783

OGO:

124048853

ONE:	115124212(pcyox1)

SALP:

111961511(pcyox1) 111981600(pcyox1l)

SNH:

120026318

ELS:

105014988

SFM:	108934092(pcyox1l) 108935642(pcyox1)

PKI:	111836976(pcyox1l) 111849890(pcyox1)

AANG:

118212864(pcyox1)

LOC:	102682350(pcyox1)

PSPA:

121302340 121303146 121324023

ARUT:

117397725 117962552

LCM:	102366651(PCYOX1)

CMK:	103188150 103190257(pcyox1)

BFO:	118414937 118419608

CIN:

100186242

SCLV:

120330559 120340686

SPU:	115918874 577359 582165 592408

APLC:

110989094

SKO:	100370797 102805603

BCOO:

119074618

AME:

412611

ACER:

107998886

ALAB:

122720980

BIM:

100743723

BBIF:

117211066

BVK:

117232243

BVAN:

117157814

BTER:

100649389

BPYO:

122573885

CCAL:

108626446

OBB:

114875502

MGEN:

117223232

NMEA:

116424831

CGIG:

122396007

SOC:	105193102 105198266 105206662

MPHA:

105831429

AEC:

105146005

ACEP:

105623574

PBAR:

105431014

VEM:

105560811

HST:

105192368

DQU:

106746985

CFO:

105249342

FEX:

115244363

LHU:

105678694

PGC:

109852538

OBO:

105280562

PCF:

106788841

PFUC:

122525219

VPS:

122627819

CSOL:

105364959

TPRE:

106651310

MDL:

103580178

CGLO:

123260709

FAS:

105265393

DAM:

107036125

AGIF:

122851958

CCIN:

107263592

API:

100160471

DNX:

107163506

AGS:

114127115

RMD:

113559222

BTAB:

109031110

DCI:

103506991

CLEC:

106672112

NLU:	111049375 120354361

PHU:	Phum_PHUM389870

ZNE:

110832717

FCD:

110846125

DPX:	DAPPUDRAFT_269767 DAPPUDRAFT_304769 DAPPUDRAFT_95738

PVM:

113802630

PJA:

122253278

PCHN:

125028337

PCLA:

123756431

HAZT:

108678704

EAF:

111701761

LSM:

121114065

PPOI:

119095101 119095948

DPTE:

113792744

CSCU:

111615199

PTEP:

107451756

SDM:

118205609

LOA:	LOAG_06248

TSP:

Tsp_01052

LGI:	LOTGIDRAFT_236715

PCAN:

112560113

BGT:

106056814

GAE:

121381029

CRG:

105323619

MYI:

110462099

PMAX:

117335498

OBI:

106883316

OSN:

115224350

LAK:

106171255

SMM:	Smp_125500

SHX:	MS3_0017856

OVI:	T265_00458

EGL:

EGR_06057

NVE:

5512734

EPA:

110254130

ATEN:

116302930

ADF:

107343001

AMIL:

114976187

PDAM:

113684316

SPIS:

111340782

DGT:

114523253

XEN:

124452467

HMG:

100200423

AQU:

100641107

ATH:	AT5G63910(FCLY)

ALY:

9302655

CRB:

17875809

CSAT:

104727020 104741908 104762535

EUS:	EUTSA_v10004131mg

BRP:

103873809

BNA:	106347946 106348069

BOE:

106336305

RSZ:

108856168

THJ:	104818420 104819345

CPAP:

110816574

CIT:

102619140

CIC:	CICLE_v10000962mg

PVY:

116118145

MINC:

123199441

TCC:

18611918

GRA:

105763575

GHI:	107925476 107945423

GAB:

108483661

DZI:	111292606 111300977

EGR:	104418080 104418081

GMX:

100819877

GSJ:

114415804

PVU:	PHAVU_009G154600g

VRA:

106779708

VAR:

108330593

VUN:

114164811

CCAJ:

109814849

APRC:

113849182

MTR:	MTR_3g096675

CAM:

101495143

LJA:	Lj1g3v1355770.1(Lj1g3v1355770.1)

ADU:

107463306

AIP:

107613822

AHF:	112707944 112771151

LANG:

109339143

FVE:

101303553

RCN:

112188298

PPER:

18780160

PMUM:

103327053

PAVI:

110754263

PDUL:

117626550

MDM:

103400276

PXB:

103946782

ZJU:

107425615

MNT:

21393162

CSV:

101215055

CMO:

103486051

BHJ:

120073321

MCHA:

111025661

CMAX:

111467195

CMOS:

111435563

CPEP:

111804493

RCU:

8270275

JCU:

105641920

HBR:

110666793

MESC:

110628401

POP:	18100924 7466760

PEU:	105119050 105119051 105124535

PALZ:

118043479 118043487

JRE:

108996352

QSU:	112013734 112028612 112029314 112029316

QLO:

115965681

TWL:

119991679

VVI:

100268071

VRI:

117918625

SLY:

101250000

SPEN:

107006015

SOT:

102583614

CANN:

107850614

NTA:	107795977 107826766

NSY:

104243491

NTO:	104115921 104118441

NAU:

109237424

INI:

109172521

ITR:

116019000

SIND:

105178024

OEU:

111401093

EGT:

105976860

SSPL:

121769750

ECAD:

122581291

LSV:

111899421

CCAV:

112519116

DCR:

108226355

CSIN:

114256721 114256754 114285854

BVG:

104890578

SOE:	110779740 110798959

CQI:	110701286 110736618

NNU:	104605839 104606672

MING:

122056992

TSS:	122660313 122670028

PSOM:

113356270

NCOL:

116266860

OBR:

102720704

BDI:

100821994

ATS:

109768343

TDC:	119357246 119366537

TAES:

123047537 123055345 123161600 123191158

TUA:	125540353 125540355

SBI:

8064304

ZMA:

103642227

SITA:

101780490

SVS:

117848456

PVIR:

120642230 120683689

PHAI:

112899569

PDA:

103702607

EGU:

105037230

MUS:

103971814

DCT:

110098590

PEQ:

110021299

AOF:

109826352

ATR:

18432903

SMO:	SELMODRAFT_170018 SELMODRAFT_443023

PPP:

112279627

CSL:	COCSUDRAFT_47763

CVR:	CHLNCDRAFT_142455

APRO:

F751_1899

CCP:	CHC_T00001248001

SLB:	AWJ20_3123

OPA:	HPODL_00208

NCR:

NCU09710

NTE:	NEUTE1DRAFT131085(NEUTE1DRAFT_131085)

SMP:	SMAC_06050

PAN:	PODANSg1272

TTT:	THITE_2145487

MTM:	MYCTH_2308190

MGR:

MGG_03858

TMN:	UCRPA7_7168

SSCK:

SPSK_04174

FGR:	FGSG_06053

FPU:	FPSE_04205

FVR:	FVEG_04685

FOX:	FOXG_07758

NHE:	NECHADRAFT_78887

TRE:	TRIREDRAFT_47814

TRR:	M419DRAFT_55662

MAW:

MAC_01917

MAJ:

MAA_04674

PLJ:	VFPFJ_02124

VAL:	VDBG_03079

VDA:	VDAG_03987

CFJ:	CFIO01_06455

CHIG:

CH63R_01393

SAPO:

SAPIO_CDS4414

ELA:	UCREL1_4173

PFY:	PFICI_03485

SSL:	SS1G_07921 SS1G_13940

BFU:	BCIN_15g00860 BCIN_15g04470

MBE:

MBM_07457

PSCO:

LY89DRAFT_686416 LY89DRAFT_786734

GLZ:	GLAREA_07174 GLAREA_12356

ANI:

AN3057.2

AFM:	AFUA_3G09330

ACT:	ACLA_037250

NFI:	NFIA_067810

ANG:	ANI_1_1612144(An16g02960)

AFV:	AFLA_004128

ALUC:

AKAW2_70257S

ACHE:

ACHE_20881S

APUU:

APUU_12387S APUU_30472A

PCS:	Pc12g16150

PDP:	PDIP_75960

TMF:	PMAA_045370

CIM:	CIMG_01871

CPW:	CPC735_046370

URE:	UREG_06824

PBL:	PAAG_07424

PBN:	PADG_05122

ABE:

ARB_01153

TVE:

TRV_03271

AJE:	HCAG_05398

BGH:	BDBG_00461

PNO:	SNOG_11973

PTE:

PTT_12890

BZE:	COCCADRAFT_80711

BSC:	COCSADRAFT_157070

BOR:	COCMIDRAFT_83964

AALT:

CC77DRAFT_1028353

ZTR:	MYCGRDRAFT_23211

PFJ:	MYCFIDRAFT_87304

FFU:	CLAFUR5_12645

BCOM:

BAUCODRAFT_371035

TML:	GSTUM_00006317001 GSTUM_00011429001

CNE:

CNK01940

CNB:

CNBK1600

CNG:	CNAG_02708

CGI:	CGB_K2060C

TMS:	TREMEDRAFT_73026

TASA:

A1Q1_03762

TVS:	TRAVEDRAFT_172083

DSQ:	DICSQDRAFT_155080

PCO:	PHACADRAFT_259228

SHS:	STEHIDRAFT_89550

HIR:	HETIRDRAFT_308119

PSQ:	PUNSTDRAFT_94528 PUNSTDRAFT_94532

ADL:	AURDEDRAFT_109626

FME:	FOMMEDRAFT_146234

GTR:	GLOTRDRAFT_69176

LBC:	LACBIDRAFT_300931

MRR:

Moror_288

E1B28_001607

CCI:	CC1G_01677

SCM:	SCHCODRAFT_46910

ABP:	AGABI1DRAFT117116(AGABI1DRAFT_117116)

ABV:	AGABI2DRAFT214837(AGABI2DRAFT_214837)

CPUT:

CONPUDRAFT_68904

SLA:	SERLADRAFT_445942

WSE:	WALSEDRAFT_33355

WIC:	J056_001304

UMA:	UMAG_04318

PFP:	PFL1_04520

MRT:

MRET_1718

PGR:	PGTG_03244

MLR:	MELLADRAFT_79816

MBR:	MONBRDRAFT_26319

SRE:	PTSG_07160 PTSG_10804

DDI:	DDB_G0287201

DPP:	DICPUDRAFT_94966

DFA:

DFA_01059

ACAN:

ACA1_031620 ACA1_108260

TGO:	TGME49_236010

TET:	TTHERM_00158490

PTM:	GSPATT00000286001 PTMB.231c

SMIN:

v1.2.010012.t1(symbB.v1.2.010012.t1) v1.2.035027.t1(symbB.v1.2.035027.t1)

PTI:	PHATRDRAFT_47005

TPS:	THAPSDRAFT_5586

SPAR:

SPRG_14908

EHX:	EMIHUDRAFT_109080

GTT:	GUITHDRAFT_162871

NGR:	NAEGRDRAFT_62621

HSU:	HLASF_1152

HSF:	HLASA_1140

» show all

Reference

1 [PMID:19969520]

Authors

Huizinga DH, Denton R, Koehler KG, Tomasello A, Wood L, Sen SE, Crowell DN

Title

Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis.

Journal

Mol Plant 3:143-55 (2010)
DOI:10.1093/mp/ssp091

Sequence

[ath:AT5G63910]

Reference

2 [PMID:17425716]

Authors

Crowell DN, Huizinga DH, Deem AK, Trobaugh C, Denton R, Sen SE

Title

Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine.

Journal

Plant J 50:839-47 (2007)
DOI:10.1111/j.1365-313X.2007.03091.x

Sequence

[ath:AT5G63910]

Other DBs

ExplorEnz - The Enzyme Database:

1.8.3.6

IUBMB Enzyme Nomenclature:

1.8.3.6

ExPASy - ENZYME nomenclature database:

1.8.3.6

BRENDA, the Enzyme Database:

1.8.3.6

DBGET integrated database retrieval system