KEGG ENZYME: 1.8.3.6

ENZYME: 1.8.3.6

Entry

EC 1.8.3.6 Enzyme

Name

farnesylcysteine lyase;
FC lyase;
FCLY

Class

Oxidoreductases;
Acting on a sulfur group of donors;
With oxygen as acceptor

Sysname

S-(2E,6E)-farnesyl-L-cysteine oxidase

Reaction(IUBMB)

S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2 [RN:R09562]

Reaction(KEGG)

R09562

Substrate

S-(2E,6E)-farnesyl-L-cysteine [CPD:C19691];
O2 [CPD:C00007];
H2O [CPD:C00001]

Product

(2E,6E)-farnesal [CPD:C03461];
L-cysteine [CPD:C00097];
H2O2 [CPD:C00027]

Comment

A flavoprotein (FAD). In contrast to mammalian EC 1.8.3.5 (prenylcysteine oxidase) the farnesylcysteine lyase from Arabidopsis is specific for S-farnesyl-L-cysteine and shows no activity with S-geranylgeranyl-L-cysteine.

History

EC 1.8.3.6 created 2011

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01130

Biosynthesis of antibiotics

Orthology

K05906

prenylcysteine oxidase / farnesylcysteine lyase

Genes

HSA:	51449(PCYOX1)

PTR:	470398(PCYOX1)

PPS:	100971101(PCYOX1)

GGO:	101138892(PCYOX1)

PON:	100457284(PCYOX1)

NLE:	100606095(PCYOX1)

MCC:	710068(PCYOX1)

MCF:	101926201(PCYOX1)

CSAB:

103220094(PCYOX1)

RRO:	104659273 104661318(PCYOX1)

RBB:	108516355(PCYOX1)

CJC:	100404939(PCYOX1)

SBQ:	101047105(PCYOX1)

MMU:	66881(Pcyox1)

MCAL:

110295686(Pcyox1)

MPAH:

110316366(Pcyox1)

RNO:	246302(Pcyox1)

MUN:	110547181(Pcyox1)

CGE:	100774789(Pcyox1)

NGI:	103725906(Pcyox1)

HGL:	101725032(Pcyox1)

CCAN:

109698768(Pcyox1)

OCU:	100354763(PCYOX1)

TUP:	102492977(PCYOX1)

CFA:	481418(PCYOX1)

VVP:	112934410(PCYOX1)

AML:	100468481(PCYOX1)

UMR:	103671811(PCYOX1)

UAH:	113244236(PCYOX1)

ORO:	101383182(PCYOX1)

FCA:	101096467(PCYOX1)

PTG:	102955992(PCYOX1)

PPAD:

109262459(PCYOX1)

AJU:	106967763(PCYOX1)

BTA:	100125835(PCYOX1)

BOM:	102279554(PCYOX1)

BIU:	109566249(PCYOX1)

BBUB:

102399126(PCYOX1)

CHX:	102176973(PCYOX1)

OAS:	101105397(PCYOX1)

SSC:	100624596(PCYOX1)

CFR:	102511924(PCYOX1)

CDK:	105088901(PCYOX1)

BACU:

103010853(PCYOX1)

LVE:	103091374(PCYOX1)

OOR:	101280418(PCYOX1)

DLE:	111167878(PCYOX1)

PCAD:

102993678(PCYOX1)

ECB:	100060594(PCYOX1) 100060629(PCYOX1L)

EPZ:	103547599(PCYOX1)

EAI:	106828313(PCYOX1)

MYB:	102262695(PCYOX1)

MYD:	102755614(PCYOX1)

MNA:	107529289(PCYOX1)

HAI:	109385413(PCYOX1)

DRO:	112303075(PCYOX1)

PALE:

102888402(PCYOX1)

RAY:	107519108(PCYOX1)

MJV:	108390156 108402540

LAV:	100674445(PCYOX1)

TMU:

101360021

MDO:	100032803(PCYOX1)

SHR:	100929029(PCYOX1) 111718937

PCW:	110207621(PCYOX1)

OAA:	100088724(PCYOX1L)

GGA:	426297(PCYOX1)

MGP:	100545768(PCYOX1)

CJO:	107323602(PCYOX1)

NMEL:

110387147(PCYOX1)

ACYG:

106046247(PCYOX1)

TGU:	100222230 100226181(PCYOX1L)

LSR:	110478629(PCYOX1)

SCAN:

103824661(PCYOX1) 103824662

GFR:	102032195(PCYOX1) 106632220

FAB:	101808104(PCYOX1)

PHI:	102109379(PCYOX1)

PMAJ:

107213988(PCYOX1)

CCAE:

111938747(PCYOX1)

CCW:	104694867(PCYOX1)

ETL:	114066448(PCYOX1)

FPG:	101917041(PCYOX1)

FCH:	102057230(PCYOX1)

CLV:	102097250(PCYOX1)

EGZ:	104123772(PCYOX1)

NNI:

104017280

ACUN:

113488068(PCYOX1)

PADL:

103914322(PCYOX1)

AAM:	106490249(PCYOX1)

ASN:	102379956(PCYOX1)

AMJ:	102574611(PCYOX1)

PSS:	102452243(PCYOX1)

CMY:

102947169

CPIC:

101941069(PCYOX1)

ACS:	100563966(pcyox1)

PVT:	110072210(PCYOX1) 110075841

PBI:	103055758(PCYOX1)

PMUR:

107283235(PCYOX1)

TSR:	106542621(PCYOX1)

PMUA:

114602675(PCYOX1)

GJA:	107118770 107118771

XLA:	108711539(pcyox1.L)

XTR:	549056(pcyox1)

NPR:	108785358(PCYOX1)

DRE:	550289(pcyox1)

SRX:	107713365 107744114

SANH:

107686458 107688072

SGH:	107562568 107569400

CCAR:

109052061

IPU:	108276731(pcyox1)

PHYP:

113544142

AMEX:

103023969 103044269

EEE:

113575162

TRU:	101067237(pcyox1)

TNG:	GSTEN00003251G001 GSTEN00017330G001 GSTEN00029963G001

LCO:	104923352(pcyox1)

NCC:	104961020(pcyox1)

MZE:

101485660

ONL:	100704244(pcyox1)

OLA:	101172915(pcyox1)

XMA:	102229017(pcyox1)

XCO:	114149713(pcyox1)

PRET:

103473683(pcyox1) 103475662

CVG:	107092669(pcyox1)

NFU:	107372848(pcyox1)

KMR:	108232575(pcyox1)

ALIM:

106514514(pcyox1)

AOCE:

111568369(pcyox1)

CSEM:

103390492(pcyox1)

POV:	109626079(pcyox1)

LCF:	108879214(pcyox1)

SDU:	111234251(pcyox1)

SLAL:

111668094(pcyox1)

HCQ:	109513148(pcyox1)

BPEC:

110160541(pcyox1)

MALB:

109963438(pcyox1)

SASA:

106564891

OTW:	112219406(pcyox1)

SALP:

111961511(pcyox1)

ELS:

105014988

SFM:	108935642(pcyox1)

PKI:	111849890(pcyox1)

LCM:	102366651(PCYOX1)

CMK:	103190257(pcyox1)

BFO:	BRAFLDRAFT_91394

CIN:

100186242

SPU:

582165

APLC:

110989094 110991177

SKO:	100370797 102805603

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:	105193102 105198266 105206662 113002713

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM389870

ZNE:

110832717

FCD:

110846125

DPX:	DAPPUDRAFT_269767 DAPPUDRAFT_304769 DAPPUDRAFT_95738

PVM:

DPTE:

CSCU:

PTEP:

LOA:	LOAG_06248

TSP:

Tsp_01052

LGI:	LOTGIDRAFT_236715

PCAN:

CRG:

MYI:

OBI:

LAK:

SMM:	Smp_125500

SHX:

MS3_00151

OVI:	T265_00458

EGL:

EGR_06057

NVE:	NEMVE_v1g22904

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

AQU:

ATH:	AT5G63910(FCLY)

ALY:	ARALYDRAFT_496583

CRB:

17875809

CSAT:

104727020 104741908 104762535

EUS:	EUTSA_v10004131mg

BRP:

103873809

BNA:	106347946 106348069

BOE:

106336305

RSZ:

108856168

THJ:	104818420 104819345

CPAP:

110816574

CIT:

102619140

CIC:	CICLE_v10000962mg

TCC:

18611918

GRA:

105763575

GHI:	107925476 107945423

GAB:

108483661

DZI:	111292606 111300977

EGR:	104418080 104418081

GMX:

100819877

GSJ:

114415804

PVU:	PHAVU_009G154600g

VRA:

VAR:

VUN:

CCAJ:

MTR:	MTR_3g096675

CAM:

101495143

LJA:	Lj1g3v1355770.1(Lj1g3v1355770.1)

ADU:

AIP:

LANG:

FVE:

RCN:	112171896 112188298

PPER:

PMUM:

PAVI:

MDM:

PXB:

ZJU:

CSV:

CMO:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:	18100924 7466760

JRE:

108996352

QSU:	112013734 112028612 112029314 112029316

VVI:

SLY:

SPEN:

SOT:

CANN:

NTA:	107773308 107795977 107826766

NSY:

104243491

NTO:	104115921 104118441

NAU:

109237424

INI:

109172521

SIND:

105178024

OEU:	111401093 111408094

HAN:

110873277

LSV:

111899421

CCAV:

112519116

DCR:	108192525 108226355

BVG:

104890578

SOE:	110779740 110798959

CQI:	110701286 110736618

NNU:	104605839 104606672

PSOM:

113356270

DOSA:

Os04t0692800-00(Os04g0692800)

OBR:

102720704

BDI:

100821994

ATS:	109768343(LOC109768343)

SBI:

ZMA:

SITA:

PDA:

EGU:

MUS:

DCT:

PEQ:	110021299 110034777

AOF:

109826352

ATR:

18432903

SMO:	SELMODRAFT_170018 SELMODRAFT_443023

PPP:

112279627

CSL:	COCSUDRAFT_47763

CVR:	CHLNCDRAFT_142455

APRO:

F751_1899

CCP:	CHC_T00001248001

SLB:	AWJ20_3123

NCR:

NCU09710

NTE:	NEUTE1DRAFT131085(NEUTE1DRAFT_131085)

SMP:	SMAC_06050

PAN:	PODANSg1272

TTT:	THITE_2145487

MTM:	MYCTH_2308190

MGR:

MGG_03858

TMN:	UCRPA7_7168

SSCK:

SPSK_04174

FGR:	FGSG_06053

FPU:	FPSE_04205

FVR:	FVEG_04685

FOX:	FOXG_07758

NHE:	NECHADRAFT_78887

TRE:	TRIREDRAFT_47814

TRR:	M419DRAFT_55662

MAW:

MAC_01917

MAJ:

MAA_04674

PLJ:	VFPFJ_02124

VAL:	VDBG_03079

VDA:	VDAG_03987

CFJ:	CFIO01_06455

ELA:	UCREL1_4173

PFY:	PFICI_03485

SSL:	SS1G_07921

BFU:	BCIN_15g00860

MBE:

MBM_07457

PSCO:

LY89DRAFT_686416 LY89DRAFT_786734

GLZ:	GLAREA_07174 GLAREA_12356

ANI:

AN3057.2

AFM:	AFUA_3G09330

ANG:	ANI_1_1612144(An16g02960)

AFV:	AFLA_085430

ACT:	ACLA_037250

NFI:	NFIA_067810

PCS:	Pc12g16150

PDP:	PDIP_75960

CIM:	CIMG_01871

CPW:	CPC735_046370

PBL:	PAAG_07424

PBN:	PADG_05122

URE:	UREG_06824

ABE:

ARB_01153

TVE:

TRV_03271

AJE:	HCAG_05398

PNO:	SNOG_11973

PTE:

PTT_12890

BZE:	COCCADRAFT_80711

BSC:	COCSADRAFT_157070

BOR:	COCMIDRAFT_83964

AALT:

CC77DRAFT_1028353

ZTR:	MYCGRDRAFT_23211

PFJ:	MYCFIDRAFT_87304

BCOM:

BAUCODRAFT_371035

TML:	GSTUM_00006317001

CNE:

CNK01940

CNB:

CNBK1600

CGI:	CGB_K2060C

TMS:	TREMEDRAFT_73026

TVS:	TRAVEDRAFT_172083

DSQ:	DICSQDRAFT_155080

PCO:	PHACADRAFT_259228

SHS:	STEHIDRAFT_89550

HIR:	HETIRDRAFT_308119

PSQ:	PUNSTDRAFT_94528 PUNSTDRAFT_94532

ADL:	AURDEDRAFT_109626

FME:	FOMMEDRAFT_146234

GTR:	GLOTRDRAFT_69176

LBC:	LACBIDRAFT_300931

MRR:

Moror_288

CCI:	CC1G_01677

SCM:	SCHCODRAFT_46910

ABP:	AGABI1DRAFT117116(AGABI1DRAFT_117116)

ABV:	AGABI2DRAFT214837(AGABI2DRAFT_214837)

CPUT:

CONPUDRAFT_68904

SLA:	SERLADRAFT_445942

WSE:	WALSEDRAFT_33355

WIC:	J056_001304

UMA:	UMAG_04318

PFP:	PFL1_04520

MGL:

MGL_3751

MRT:

MRET_1718

PGR:	PGTG_03244

MLR:	MELLADRAFT_79816

MBR:	MONBRDRAFT_26319

SRE:	PTSG_07160 PTSG_10804

DDI:	DDB_G0287201

DPP:	DICPUDRAFT_94966

DFA:

DFA_01059

ACAN:

ACA1_031620 ACA1_108260

TGO:	TGME49_236010

TET:	TTHERM_00158490

PTM:	GSPATT00000286001 PTMB.231c

SMIN:

v1.2.010012.t1(symbB.v1.2.010012.t1) v1.2.010012.t2(symbB.v1.2.010012.t2) v1.2.035027.t1(symbB.v1.2.035027.t1)

PTI:	PHATRDRAFT_47005

TPS:	THAPSDRAFT_5586

SPAR:

SPRG_14908

EHX:	EMIHUDRAFT_109080

GTT:	GUITHDRAFT_162871

NGR:	NAEGRDRAFT_62621

HSU:	HLASF_1152

HSF:	HLASA_1140

» show all

Reference

1 [PMID:19969520]

Authors

Huizinga DH, Denton R, Koehler KG, Tomasello A, Wood L, Sen SE, Crowell DN

Title

Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis.

Journal

Mol Plant 3:143-55 (2010)
DOI:10.1093/mp/ssp091

Sequence

[ath:AT5G63910]

Reference

2 [PMID:17425716]

Authors

Crowell DN, Huizinga DH, Deem AK, Trobaugh C, Denton R, Sen SE

Title

Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine.

Journal

Plant J 50:839-47 (2007)
DOI:10.1111/j.1365-313X.2007.03091.x

Sequence

[ath:AT5G63910]

Other DBs

ExplorEnz - The Enzyme Database:

1.8.3.6

IUBMB Enzyme Nomenclature:

1.8.3.6

ExPASy - ENZYME nomenclature database:

1.8.3.6

BRENDA, the Enzyme Database:

1.8.3.6

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (1595)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (455)   
   KEGG MGENES (72)   
   RefGene (1067)   
Protein sequence (6)   
   UniProt (5)   
   SWISS-PROT (1)   
DNA sequence (2)   
   GenBank (2)   
All databases (1616)   

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