Entry
Name
L-methionine (R)-S-oxide reductase;
fRMsr;
FRMsr;
free met-R-(o) reductase;
free-methionine (R)-S-oxide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming]
Reaction(IUBMB)
L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin [RN:
R07608 ]
Reaction(KEGG)
Substrate
Product
L-methionine (R)-S-oxide [CPD:
C15998 ];
thioredoxin [CPD:
C00342 ]
Comment
Requires NADPH. Unlike EC
1.8.4.12 , peptide-methionine (R)-S-oxide reductase, this enzyme cannot use peptide-bound methionine (R)-S-oxide as a substrate [1]. Differs from EC
1.8.4.13 , L-methionine (S)-S-oxide in that L-methionine (S)-S-oxide is not a substrate.
History
EC 1.8.4.14 created 1984 as EC 1.8.4.5, part transferred 2006 to EC 1.8.4.14
Pathway
ec00270 Cysteine and methionine metabolism
Orthology
K08968 L-methionine (R)-S-oxide reductase
Genes
CGR : 2887676(GVI51_F05731)
NCS : NCAS_0H03260(NCAS0H03260)
NDI : NDAI_0C00400(NDAI0C00400)
TPF : TPHA_0C02490(TPHA0C02490)
TBL : TBLA_0A10200(TBLA0A10200)
TDL : TDEL_0B07070(TDEL0B07070)
KAF : KAFR_0C04110(KAFR0C04110)
KNG : KNAG_0H00440(KNAG0H00440)
LBG : 92209386(LODBEIA_P41900)
CAL : CAALFM_C602800WA(CaO19.5553)
CTEN : 18247196(PSN45_003999)
YLI : 2908396(YALI2_E00728g)
NTE : NEUTE1DRAFT107492(NEUTE1DRAFT_107492)
SMP : 10807135(SMAC4_03230)
TATV : 25781496(TrAtP1_003260)
TASP : 36616883(TrAFT101_006954)
MAW : 19248208(J3458_005564)
PLJ : 28890783(PLICBS_004886)
CDET : 87950077(CDEST_13577)
CPW : 9692220(D8B26_005051)
PTRR : 6348221(PtrM4_085040)
ADAC : 96082744(ACET3X_002422)
CDEP : 91085788(L203_101575)
KMG : 30167139(I203_101759)
KNE : 92180320(IAR55_003062)
CCAC : CcaHIS019_0311380(YKL069W)
ABP : AGABI1DRAFT36823(AGABI1DRAFT_36823)
SCM : SCHCO_02670198(SCHCODRAFT_02670198)
EDJ : ECDH1ME8569_1778(yebR)
ECOI : ECOPMV1_01923(msrC)
KPO : KPN2242_14715 KPN2242_25221
KPNK : BN49_3453 BN49_pII0056
REE : electrica_01895(msrC)
RTG : NCTC13098_02761(msrC)
CLAP : NCTC11466_01798(msrC)
KIE : NCTC12125_00969(msrC)
AHN : NCTC12129_02013(msrC)
PSHI : SAMEA2665130_1954(msrC)
SMW : SMWW4_v1c21290(msrC)
SFJ : SAMEA4384070_2170(msrC)
SOF : NCTC11214_04726(msrC)
TPTY : NCTC11468_02096(msrC)
PHEI : NCTC12003_01861(msrC)
PRJ : NCTC6933_02061(msrC)
LRI : NCTC12151_01678(msrC)
PDAG : 4362423_00026(msrC)
XPH : XppCFBP6546_16240(XppCFBP6546P_16240)
XHD : LMG31886_37060(msrC)
LLZ : LYB30171_00442(msrC)
LSF : I8J32_006075 I8J32_009055
VPL : SA104470976_01233(msrC)
PVD : CFBP1590__1660(msrC)
PPRC : PFLCHA0_c43050(yebR)
PMUD : NCTC8068_01847(yebR)
PFW : PF1751_v1c17050(yebR)
PTAE : NCTC10697_01309(yebR)
SCAA : TUM17387_17960(yebR)
PTN : PTRA_a1098 PTRA_a2081
PIA : PI2015_1001 PI2015_1598
PBW : D172_005630 D172_008185
PRR : AT705_01870 AT705_06180
PLZ : S4054249_11670 S4054249_15790
PALN : B0W48_15925 B0W48_19825
PPIS : B1L02_05095 B1L02_07500
PEA : PESP_a1232 PESP_a2101
PSPO : PSPO_a1020 PSPO_a1741
PART : PARC_a1830 PARC_a2818
PNG : PNIG_a1155 PNIG_a2194
PTD : PTET_a1162 PTET_a1906
PSEN : PNC201_07840(msrC) PNC201_11685
PDJ : D0907_05005 D0907_07520
PAGA : PAGA_a1813 PAGA_a2672
PCAR : PC2016_1752 PC2016_2278
PMAA : CPA52_08865 CPA52_11320
PXI : J5O05_00415 J5O05_03360
PVB : J5X90_14040 J5X90_17775
PDV : FFU37_07410 FFU37_10460
PSHO : KQ246_02295 KQ246_06170
PSMM : PspMM1_10240 PspMM1_17340
PXSI : EJ103_05045 EJ103_08900
PSJS : GZH31_04805 GZH31_07415
LAL : AT746_00720 AT746_09470
SALH : HMF8227_01409 HMF8227_02909
MYA : MORIYA_2290 MORIYA_2293
LCJ : NCTC11976_02194(mnmC_3)
RHH : E0Z06_07250 E0Z06_10640
HAAH : HALA3H3_830122(msrC)
HSR : HSBAA_36650 HSBAA_36660
HAXI : HAALTHF_24570n HAALTHF_29000n HAALTHF_34900n HAALTHF_34910n
AEL : NCTC12917_02149(msrC)
CHJ : NCTC10426_02347(msrC)
CDIZ : CEDIAZO_01888(msrC)
NWE : SAMEA3174300_1496(msrC)
NZO : SAMEA4504057_1045(msrC)
NCI : NCTC10296_01154(msrC)
NANI : NCTC12227_00163(msrC)
CVC : BKX93_00250 BKX93_02375
CHRO : CXB49_09925 CXB49_10190
CHRI : DK842_17100 DK842_19130
CHRB : DK843_00225 DK843_02060
CRZ : D1345_08120 D1345_12150
CHRM : FYK34_05890 FYK34_07365
CHAE : CH06BL_17520 CH06BL_24920
AQS : DKK66_01350 DKK66_18170
PLG : NCTC10937_03919(yebR)
BTRM : SAMEA390648701348(msrC)
AXX : ERS451415_06072(msrC)
AKA : TKWG_04295 TKWG_04300
RDP : RD2015_1564 RD2015_2772
MIU : ABE85_10770 ABE85_11260
MANC : IV454_19560 IV454_23730
URU : DSM104443_00780(msrC) DSM104443_01453
UPL : DSM104440_00742(msrC) DSM104440_01362
EMX : FKV68_21520 FKV68_31640
BVY : NCTC9239_00698(msrC)
TSV : DSM104635_03116(msrC)
SINL : DSM14862_00419(msrC)
SPSE : SULPSESMR1_02945(msrC)
RMM : ROSMUCSMR3_03094(msrC)
AHT : ANTHELSMS3_02044(msrC)
LVS : LOKVESSMR4R_00301(msrC)
SPAG : sphantq_00792(msrC)
SFLA : SPHFLASMR4Y_00650(msrC)
MFU : LILAB_23450 LILAB_24465
MMAS : MYMAC_003089 MYMAC_003293
LUO : HHL09_02745 HHL09_17925
LAMB : KBB96_00895 KBB96_07300
TRC : DYE49_01560 DYE49_09950
TPSC : RBB77_06750 RBB77_07850
BTHO : Btheta7330_01201(msrC)
BCEL : BcellWH2_04164(msrC)
PCOP : I6J50_07740 I6J50_15960
PCAG : NCTC12856_01881(msrC)
POC : NCTC13071_00244(msrC)
SMIZ : 4412673_00476(msrC)
SDJ : NCTC13534_00485(msrC)
STHA : NCTC11429_00880(msrC)
CMR : Cycma_1478 Cycma_4880
CAMU : CA2015_1380 CA2015_4696
RHOZ : GXP67_25180 GXP67_36565
FIB : A6C57_06325 A6C57_12200
PKO : PKOR_06950 PKOR_20760
PACT : CA264_04095 CA264_17885
RTI : DC20_07480 DC20_20885
PRHO : PZB74_04350 PZB74_21020
TPEL : P0M28_04910 P0M28_29360
ZGA : ZOBELLIA_1170 ZOBELLIA_4233
PHG : KCTC32516_00325(msrC)
AALG : AREALGSMS7_00722(msrC) AREALGSMS7_03844
KOS : KORDIASMS9_00457(msrC)
KAN : IMCC3317_23590(msrC)
EMAR : D1013_17950 D1013_19700
CGLE : NCTC11432_05035(msrC)
CTAI : NCTC12078_03395(msrC)
CTAK : 4412677_02494(msrC)
CJG : NCTC13459_00844(msrC)
CANT : NCTC13489_00893(msrC)
PTAN : CRYO30217_00198(msrC)
BAZ : BAMTA208_14520(ytsP)
BFD : NCTC4823_03048(msrC)
BLEN : NCTC4824_01357(msrC)
SDP : NCTC12225_01292(msrC)
SPIC : SAMEA4384060_1240(msrC)
SSH : NCTC13712_01710(msrC)
SSIM : SAMEA4384339_1600(msrC)
SSTE : SAMEA4384403_1025(msrC)
LGZ : NCTC10812_01590(msrC)
GMO : NCTC11323_00958(msrC)
GHA : NCTC10459_00953(msrC)
LFB : C1X05_11515 C1X05_13025
KPUL : GXN76_10255 GXN76_12520
STU : STH8232_1373(fabG-1)
SVB : NCTC12167_01094(msrC)
SMEN : SAMEA4412692_1041(msrC)
SFER : NCTC12278_00615(msrC)
SCAI : NCTC12191_01324(msrC)
SPSU : NCTC13786_00637(msrC)
SPOC : NCTC10925_00612(msrC)
SAUP : NCTC3168_01929(msrC)
SURN : NCTC13766_00641(gaf)
SVF : NCTC3166_00818(msrC)
SMIE : NCTC11169_00995(msrC)
LOR : AYI71_01735 AYI71_14340
LHW : BSQ49_04625 BSQ49_09645
LNN : F0161_08375 F0161_10655
LPD : AYR62_03975 AYR62_09645
WPA : CO680_02235 CO680_07445
ECEC : NCTC12421_01655(msrC)
STHR : BXT84_06335 BXT84_14480
CBAR : PATL70BA_0600(msrC)
TKI : TKV_c16110 TKV_c16120
PHAR : NCTC13077_00045(msrC)
AHK : NCTC10172_01243(msrC)
AAXA : NCTC10138_00217(msrC)
MGLY : NCTC10194_00436(msrC)
MCOU : NCTC10179_00451(msrC)
MCOM : NCTC10178_00333(msrC)
MCIT : NCTC10181_00525(msrC)
MMEL : NCTC10153_00369(msrC)
TBM : BK010_08040 BK010_08550
NFR : ERS450000_04429(msrC)
LEPV : J4558_02190 J4558_14895
NCW : NIES2107_64570(msrC)
CALN : NIES2098_13910(msrC)
TVO : TVG0853481(TVG0853481)
» show all
Taxonomy
Reference
Authors
Etienne F, Spector D, Brot N, Weissbach H.
Title
A methionine sulfoxide reductase in Escherichia coli that reduces the R enantiomer of methionine sulfoxide.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.8.4.14
ExPASy - ENZYME nomenclature database: 1.8.4.14