Entry |
|
Name |
protein-disulfide reductase (glutathione);
glutathione-insulin transhydrogenase;
insulin reductase;
reductase, protein disulfide (glutathione);
protein disulfide transhydrogenase;
glutathione-protein disulfide oxidoreductase;
protein disulfide reductase (glutathione);
GSH-insulin transhydrogenase;
protein-disulfide interchange enzyme;
protein-disulfide isomerase/oxidoreductase;
thiol:protein-disulfide oxidoreductase;
thiol-protein disulphide oxidoreductase
|
Class |
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
|
Sysname |
glutathione:protein-disulfide oxidoreductase
|
Reaction(IUBMB) |
2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol [RN: R03915]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
glutathione disulfide [CPD: C00127];
protein dithiol [CPD: C02315]
|
Comment |
Reduces insulin and some other proteins.
|
History |
EC 1.8.4.2 created 1965
|
Pathway |
|
Orthology |
K05360 | protein-disulfide reductase (glutathione) |
|
Genes |
MTHB: | 126939120 126962538 |
MMMA: | 107136229 107141770(Txndc12) |
PPAM: | 129070190(TXNDC12) 129082303 |
PBRV: | 138164986 138165349 |
CTIG: | 120297429(TXNDC12) 120300026 |
XLA: | 380448(txndc12.S) 495430(txndc12.L) |
SANH: | 107681819 107690994 |
CAUA: | 113045995 113114536 |
CGIB: | 127950788 128026161 |
MASI: | 127440351 127442036 |
PSPA: | 121327251 121330575 |
ARUT: | 117411960 117416607 |
PMRN: | 116943204 116948886 116951997 |
LRJ: | 133349899 133350656 133352024 133359114 133359115 |
SPU: | 105446740 115928587 115928699 115928720 115928810 115928830 115928836 115928859 581130 586825 |
BCOO: | 119067650 119077152 119079323 119079325 |
CLEC: | 106666588 106668723 |
PHU: | Phum_PHUM095260 Phum_PHUM562480 Phum_PHUM562490 Phum_PHUM562500 |
CEL: | CELE_Y57A10A.23(txdc-12.1) |
NAI: | NECAME_13028 NECAME_16850 |
BMY: | BM_BM6891(Bma-txdc-12.1) |
BGT: | 106064349 106064350 106069446 106069454 |
ADF: | 107334366 107334421 107338931 |
EIV: | EIN_185160 EIN_226240 |
ACAN: | ACA1_253490 ACA1_359700 |
» show all
|
Reference |
|
Authors |
KATZEN HM, TIETZE F, STETTEN D Jr. |
Title |
Further studies on the properties of hepatic glutathione-insulin transhydro-genase. |
Journal |
J Biol Chem 238:1006-11 (1963) |
Reference |
2 |
Authors |
Kohnert K-D, Hahn H-J, Zuhlke H, Schmidt S, Fiedler H. |
Title |
Breakdown of exogenous insulin by Langerhans islets of the pancreas in vitro. |
Journal |
Biochim Biophys Acta 338:68-77 (1974) |
Other DBs |
ExplorEnz - The Enzyme Database: | 1.8.4.2 |
ExPASy - ENZYME nomenclature database: | 1.8.4.2 |
BRENDA, the Enzyme Database: | 1.8.4.2 |
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