KEGG ENZYME: 1.8.4.2

ENZYME: 1.8.4.2

Entry

EC 1.8.4.2                  Enzyme

Name

protein-disulfide reductase (glutathione);
glutathione-insulin transhydrogenase;
insulin reductase;
reductase, protein disulfide (glutathione);
protein disulfide transhydrogenase;
glutathione-protein disulfide oxidoreductase;
protein disulfide reductase (glutathione);
GSH-insulin transhydrogenase;
protein-disulfide interchange enzyme;
protein-disulfide isomerase/oxidoreductase;
thiol:protein-disulfide oxidoreductase;
thiol-protein disulphide oxidoreductase

Class

Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor

Sysname

glutathione:protein-disulfide oxidoreductase

Reaction(IUBMB)

2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol [RN:R03915]

Reaction(KEGG)

R03915;
(other) R02824

Substrate

glutathione [CPD:C00051];
protein disulfide [CPD:C02582]

Product

glutathione disulfide [CPD:C00127];
protein dithiol [CPD:C02315]

Comment

Reduces insulin and some other proteins.

History

EC 1.8.4.2 created 1965

Pathway

ec00480

Glutathione metabolism

ec01100

Metabolic pathways

Orthology

K05360

protein-disulfide reductase (glutathione)

Genes

HSA:	51060(TXNDC12)

PTR:	100610643(TXNDC12)

PPS:	100996005(TXNDC12)

GGO:	101134035(TXNDC12)

PON:	100451283(TXNDC12)

PPYG:

129036612(TXNDC12)

NLE:	105737527(TXNDC12)

HMH:	116473156(TXNDC12)

SSYN:

129468810(TXNDC12)

MCC:	712891(TXNDC12)

MCF:	102121070(TXNDC12)

MTHB:

126939120 126962538

MNI:	105481117(TXNDC12)

CSAB:

103224818(TXNDC12)

CATY:

105596046(TXNDC12)

PANU:

101006352(TXNDC12)

TGE:	112619107(TXNDC12)

RRO:	104667843(TXNDC12)

RBB:	108531798(TXNDC12)

TFN:	117092592(TXNDC12)

PTEH:

111523824(TXNDC12)

CJC:	100400300(TXNDC12)

SBQ:	101039421(TXNDC12)

CIMI:

108318047(TXNDC12)

ANAN:

105705076(TXNDC12)

CSYR:

103266583(TXNDC12)

MMUR:

105877554(TXNDC12)

LCAT:

123635655(TXNDC12)

PCOQ:

105806365(TXNDC12)

OGA:	100946144(TXNDC12)

MMU:	66073(Txndc12)

MCAL:

110293228(Txndc12)

MPAH:

110323125(Txndc12)

RNO:	298370(Txndc12)

MCOC:

116096385(Txndc12)

ANU:	117708278(Txndc12)

MUN:	110563753(Txndc12)

CGE:	100753389(Txndc12)

MAUA:

101832189(Txndc12)

PROB:

127225149(Txndc12)

PLEU:

114706379(Txndc12)

MORG:

121448020(Txndc12)

MFOT:

126497966

AAMP:

119816127(Txndc12)

NGI:	103730255(Txndc12)

HGL:	101714855(Txndc12)

CPOC:

100728766(Txndc12)

CCAN:

109698160(Txndc12)

DORD:

105989989(Txndc12)

DSP:	122104420(Txndc12)

PLOP:

125355156(Txndc12)

NCAR:

124960640

MMMA:

107136229 107141770(Txndc12)

OCU:

103350186

OPI:	101519531(TXNDC12)

TUP:	102497800(TXNDC12)

GVR:	103593902(TXNDC12)

CFA:	609843(TXNDC12)

CLUD:

112642464(TXNDC12)

VVP:	112914720(TXNDC12)

VLG:	121480971(TXNDC12)

NPO:	129520583(TXNDC12)

AML:	100481735(TXNDC12)

UMR:	103670719(TXNDC12)

UAH:	113254678(TXNDC12)

UAR:	123793700(TXNDC12)

ELK:

111143212

LLV:

125097616

MPUF:

101692513(TXNDC12)

MNP:	132000867(TXNDC12)

MLK:	131808868(TXNDC12)

NVS:	122899968(TXNDC12)

ORO:	101386371(TXNDC12)

EJU:	114212052(TXNDC12)

ZCA:	113924577(TXNDC12)

NSU:	110575288(TXNDC12)

LWW:	102750023(TXNDC12)

FCA:	101089631(TXNDC12)

PYU:	121027122(TXNDC12)

PCOO:

112871739(TXNDC12)

PBG:	122480495(TXNDC12)

PVIV:

125173421(TXNDC12)

LRUF:

124515186

PTG:	102956818(TXNDC12)

PPAD:

109266881(TXNDC12)

AJU:

106988188

HHV:	120236122(TXNDC12)

BTA:	506991(TXNDC12)

BOM:	102276264(TXNDC12)

BIU:	109556305(TXNDC12)

BBUB:

102406947(TXNDC12)

BBIS:

104995797(TXNDC12)

CHX:	102189539(TXNDC12)

OAS:	101113445(TXNDC12)

BTAX:

128044844(TXNDC12)

ODA:	120856142(TXNDC12)

CCAD:

122436978(TXNDC12)

SSC:	100517534(TXNDC12)

CFR:	102511212(TXNDC12)

CBAI:

105066453(TXNDC12)

CDK:	105092962(TXNDC12)

VPC:	102527180(TXNDC12)

BACU:

103015400(TXNDC12)

BMUS:

118900879(TXNDC12)

LVE:	103070023(TXNDC12)

OOR:	101283919(TXNDC12)

DLE:	111175807(TXNDC12)

PCAD:

102989379(TXNDC12)

PSIU:

116764524(TXNDC12)

NASI:

112395883(TXNDC12)

ECB:	100062254(TXNDC12)

EPZ:	103556054(TXNDC12)

EAI:	106826060(TXNDC12)

MYB:	102252702(TXNDC12)

MYD:	102760942(TXNDC12)

MMYO:

118675278(TXNDC12)

MLF:	102428871(TXNDC12)

MDT:	132231086(TXNDC12)

PKL:	118724216(TXNDC12)

EFUS:

103284026(TXNDC12)

MNA:	107535416(TXNDC12)

DRO:	112314558(TXNDC12)

SHON:

118984997(TXNDC12)

AJM:	119058853(TXNDC12)

PDIC:

114496716(TXNDC12)

PHAS:

123831047(TXNDC12)

MMF:	118626552(TXNDC12)

PPAM:

129070190(TXNDC12) 129082303

HAI:	109372589(TXNDC12)

PALE:

102881310

PVP:	105298991(TXNDC12)

RAY:	107497925(TXNDC12)

TOD:	119235539(TXNDC12)

SARA:

101542310(TXNDC12)

SETR:

126011318(TXNDC12)

LAV:	100655830(TXNDC12)

TMU:

101359872

ETF:	101644102(TXNDC12)

DNM:	101423729(TXNDC12)

MDO:	103095270(TXNDC12)

GAS:	123244830(TXNDC12)

SHR:	105750619(TXNDC12)

AFZ:

127563324

PCW:	110209344(TXNDC12)

TVP:	118848797(TXNDC12)

OAA:	100078583(TXNDC12)

GGA:	772208(TXNDC12)

PCOC:

116234682(TXNDC12)

MGP:	100541059(TXNDC12)

CJO:	107317647(TXNDC12)

TPAI:

128072352(TXNDC12)

LMUT:

125693130(TXNDC12)

NMEL:

110402314(TXNDC12)

APLA:

101799624(TXNDC12)

ACYG:

106033048(TXNDC12)

CATA:

118243271(TXNDC12)

AFUL:

116491957(TXNDC12)

TGU:	115490553(TXNDC12)

LSR:	110470067(TXNDC12)

SCAN:

103815017(TXNDC12)

PMOA:

120503166(TXNDC12)

OTC:	121344915(TXNDC12)

PRUF:

121361924(TXNDC12)

GFR:	102041968(TXNDC12)

FAB:	101807031(TXNDC12)

OMA:	130256157(TXNDC12)

PHI:	102103484(TXNDC12)

PMAJ:

107208050(TXNDC12)

CCAE:

111933053(TXNDC12)

CCW:	104695524(TXNDC12)

CBRC:

103621956(TXNDC12)

ETL:	114062664(TXNDC12)

ZAB:	102074027(TXNDC12)

ZLE:	135450817(TXNDC12)

ACHL:

103801602(TXNDC12)

SVG:	106849785(TXNDC12)

MMEA:

130574067(TXNDC12)

HRT:	120756266(TXNDC12)

SATI:

136365150(TXNDC12)

FPG:	101917720(TXNDC12)

FCH:	102059863(TXNDC12)

CCRI:

104156350(TXNDC12)

NNT:	104400745(TXNDC12)

SHAB:

115612113(TXNDC12)

ACUN:

113482716(TXNDC12)

TALA:

104359215(TXNDC12)

ACHC:

115348723(TXNDC12)

HALD:

104312230(TXNDC12)

HLE:	104841023(TXNDC12)

AGEN:

126041573

GCL:

127019007

CSTI:

104551705(TXNDC12)

LDI:	104352073(TXNDC12)

MNB:	103781548(TXNDC12)

DPUB:

104307027(TXNDC12)

AVIT:

104269083(TXNDC12)

BRHI:

104488597

EGZ:	104131497(TXNDC12)

NNI:	104009361(TXNDC12)

PCRI:

104025887(TXNDC12)

PCAO:

104049481(TXNDC12)

PADL:

103913670(TXNDC12)

AFOR:

103905734(TXNDC12)

FGA:	104071357(TXNDC12)

GSTE:

104262612(TXNDC12)

CLV:	102085011(TXNDC12)

MUI:	104538624(TXNDC12)

PGUU:

104470915(TXNDC12)

PLET:

104614553(TXNDC12)

EHS:	104509497(TXNDC12)

CMAC:

104483669

CUCA:

104060189(TXNDC12)

TEO:	104375332(TXNDC12)

BREG:

104633036(TXNDC12)

OHA:	104334195(TXNDC12)

ACAR:

104519640(TXNDC12)

CPEA:

104394443(TXNDC12)

CVF:	104286251(TXNDC12)

RTD:	128913733(TXNDC12)

AAM:	106491077(TXNDC12)

AROW:

112976067(TXNDC12)

NPD:	112943089(TXNDC12)

TGT:	104577532(TXNDC12)

DNE:	112986447(TXNDC12)

SCAM:

104149617(TXNDC12)

ASN:	102381430(TXNDC12)

AMJ:	102573479(TXNDC12)

CPOO:

109307471(TXNDC12)

GGN:	109286661(TXNDC12)

PSS:	102446057(TXNDC12)

CMY:	102942750(TXNDC12)

CCAY:

125641239(TXNDC12)

CPIC:

101932560(TXNDC12)

TST:	117881680(TXNDC12)

CABI:

116817924(TXNDC12)

MRV:	120370626(TXNDC12)

ACS:	100562080(txndc12)

ASAO:

132773920(TXNDC12)

PVT:	110076174(TXNDC12)

SUND:

121928228(TXNDC12)

PBI:	103066536(TXNDC12)

PMUR:

107283055(TXNDC12)

CTIG:

120297429(TXNDC12) 120300026

TSR:	106552050(TXNDC12)

PGUT:

117658181(TXNDC12)

APRI:

131195866(TXNDC12)

PTEX:

113440651(TXNDC12)

NSS:	113411016(TXNDC12)

PMUA:

114599004(TXNDC12)

PRAF:

128415772(TXNDC12)

ZVI:	118088612(TXNDC12)

HCG:	128324871(TXNDC12)

GJA:	107111061(TXNDC12)

STOW:

125432340(TXNDC12)

EMC:	129331264(TXNDC12)

XLA:	380448(txndc12.S) 495430(txndc12.L)

XTR:	100379783(txndc12)

NPR:	108783807(TXNDC12)

RTEM:

120945918(TXNDC12)

BBUF:

120979013(TXNDC12)

BGAR:

122943426(TXNDC12)

MUO:	115471922(TXNDC12)

GSH:	117346852(TXNDC12)

DRE:	324900(txndc12)

SRX:	107708672 107739415

SANH:

107681819 107690994

SGH:	107566463 107599851

CCAR:

109094186(txndc12)

CAUA:

113045995 113114536

CGIB:

127950788 128026161

PTET:

122355819(txndc12)

LROH:

127154842(txndc12)

OMC:	131526909(txndc12)

PPRM:

120470357(txndc12)

RKG:	130097537(txndc12)

MAMB:

125251014(txndc12)

CIDE:

127523641

CERY:

137003557(txndc12)

MASI:

127440351 127442036

TROS:

130554511(txndc12)

TDW:	130417753(txndc12)

MANU:

129442599(txndc12)

IPU:

108267860

IFU:	128609726(txndc12)

PHYP:

113540200(txndc12)

SMEO:

124387957(txndc12)

TFD:	113649142(txndc12)

TVC:	132848251(txndc12)

TRN:	134311329(txndc12)

AMEX:

103026714(txndc12)

CMAO:

118826245(txndc12)

EEE:	113570148(txndc12)

CHAR:

105889519(txndc12)

TRU:	101067813(txndc12)

TFS:	130538769(txndc12)

LCO:	104927482(txndc12)

NCC:	104957515(txndc12)

TBEN:

117500227(txndc12)

CGOB:

115022561(txndc12)

PGEO:

117462835(txndc12)

GACU:

117540849(txndc12)

EMAC:

134865612(txndc12)

ELY:	117271844(txndc12)

EFO:	125901703(txndc12)

PLEP:

121950999(txndc12)

SLUC:

116045821(txndc12)

ECRA:

117954363(txndc12)

ESP:	116699007(txndc12)

PFLV:

114564960(txndc12)

GAT:	120816599(txndc12)

PPUG:

119209314(txndc12)

AFB:	129113092(txndc12)

CLUM:

117746131(txndc12)

PSWI:

130197777(txndc12)

MSAM:

119902858(txndc12)

SCHU:

122887103(txndc12)

CUD:	121520011(txndc12)

ALAT:

119011458(txndc12)

MZE:	101479452(txndc12)

ONL:	100695664(txndc12)

OAU:	116313358(txndc12)

OLA:	101170372(txndc12)

OML:	112152472(txndc12)

CSAI:

133452467(txndc12)

XMA:	102228365(txndc12)

XCO:	114146965(txndc12)

XHE:	116721329(txndc12)

PRET:

103479915(txndc12)

PFOR:

103148573(txndc12)

PLAI:

106939519(txndc12)

PMEI:

106909811(txndc12)

GAF:	122840498(txndc12)

PPRL:

129378026(txndc12)

CVG:	107095432(txndc12)

CTUL:

119787858(txndc12)

GMU:	124869465(txndc12)

NFU:	107383523(txndc12)

KMR:	108232931(txndc12)

ALIM:

106520742(txndc12)

NWH:	119414763(txndc12)

AOCE:

111585887(txndc12)

MCEP:

125010517(txndc12)

CSEM:

103396690(txndc12)

POV:	109642682(txndc12)

SSEN:

122777727(txndc12)

HHIP:

117777660(txndc12)

HSP:	118117352(txndc12)

PPLT:

128454309(txndc12)

SMAU:

118310507(txndc12)

LCF:

108884259

SDU:	111231084(txndc12)

SLAL:

111658385(txndc12)

XGL:	120798922(txndc12)

HCQ:	109507400(txndc12)

SSCV:

125984967

SBIA:

133510678(txndc12)

PEE:	133411260(txndc12)

PTAO:

133488845(txndc12)

BPEC:

110174922(txndc12)

MALB:

109955296(txndc12)

BSPL:

114844297(txndc12)

SJO:	128369190(txndc12)

SASA:

100286440(txndc12)

STRU:

115170224(txndc12)

OTW:	112227276(txndc12)

OMY:	110509158(txndc12)

OGO:	124042196(txndc12)

ONE:	115103396(txndc12)

OKI:	109879694(txndc12)

OKE:	118377540(txndc12)

SALP:

112070295(txndc12)

SNH:	120020674(txndc12)

CCLU:

121580547(txndc12)

ELS:	105031232(txndc12)

SFM:	108923831(txndc12)

PKI:	111846014(txndc12)

AANG:

118228783(txndc12)

LOC:	102698837(txndc12)

PSPA:

121327251 121330575

ARUT:

117411960 117416607

PSEX:

120514706(txndc12)

LCM:	102357648(TXNDC12)

CMK:	103172677(txndc12)

RTP:	109918333(txndc12)

CPLA:

122554336(txndc12)

HOC:	132819095(txndc12)

PMRN:

116943204 116948886 116951997

LRJ:	133349899 133350656 133352024 133359114 133359115

BFO:

118431775

BBEL:

109486244

CIN:

100185750

SCLV:

120340940

SPU:	105446740 115928587 115928699 115928720 115928810 115928830 115928836 115928859 581130 586825

LPIC:

129271190

APLC:

110977703

ARUN:

117297856

AJC:

117101235

SKO:

100377044

BCOO:

119067650 119077152 119079323 119079325

AME:

113219403

ACER:

114578051

ALAB:

122716850

ADR:

102681781

AFLR:

100864712

BIM:

112213299

BBIF:

117209049

BVK:

117233839

BVAN:

117160661

BTER:

110119393

BAFF:

126920993

BPYO:

122568867

BPAS:

132916366

FVI:

122536824

CCAL:

108632819

OBB:

114871124

OLG:

117605415

MGEN:

117228726

NMEA:

116424367

CGIG:

122395297

SOC:

105198763

MPHA:

105836541

AEC:

105148753

ACEP:

105618674

PBAR:

105422055

VEM:

105569082

HST:

105184875

DQU:

106743082

CFO:

112638907

FEX:

115244886

LHU:

105675269

PGC:

109856411

OBO:

105281249

LBD:

127284698

FAS:

105273175

DAM:

107048947

AGIF:

122850198

CCIN:

107267063

DSM:

124410148

NPT:

124220000

NFB:

124183278

NLO:

124294692

NVG:

124304770

AROA:

105691644

BMOR:

101738456

BMAN:

114239392

MSEX:

115452091

DPL:	KGM_207330

MJU:

123876912

NIQ:

126776531

VCD:

124538780

MCIX:

123663921

PMAC:

106721148

PPOT:

106110329

PXU:

106116668

PRAP:

110997338

ZCE:

119828882

CCRC:

123700749

AAGE:

121736156

HAW:

110376796

HZE:

124640617

TNL:

113499370

SLIU:

111348724

OFU:

114365411

ATRA:

106131573

GMW:

113520399

PXY:

105382641

PGW:

126380390

LGLY:

125235250

BTAB:

109041552

DCI:	103518972 103519185

CLEC:

106666588 106668723

HHAL:

106685087

NLU:

111062936

HVI:

124355379

MQU:	128997006 129005719

PHU:	Phum_PHUM095260 Phum_PHUM562480 Phum_PHUM562490 Phum_PHUM562500

ZNE:

110839067

CSEC:

111875775

SGRE:

126272159

BROR:

134532844

IEL:

124157771

FCD:

110852856

PVM:

113820074

PJA:

122248535

PCHN:

125029054

PMOO:

119574040

HAME:

121879560

PCLA:

123750508

CQD:

128686753

PTRU:

123516746

ESN:

126999967

LSM:	121131791 121131795

TCF:

131893187

CEL:	CELE_Y57A10A.23(txdc-12.1)

CBR:

CBG_20924

CRQ:	GCK72_006662

NAI:	NECAME_13028 NECAME_16850

BMY:	BM_BM6891(Bma-txdc-12.1)

LOA:	LOAG_03724

TSP:

Tsp_10270

LGI:	LOTGIDRAFT_234262

PCAN:

112574039

BGT:	106064349 106064350 106069446 106069454

GAE:

121374316

HRF:

124115583

CRG:

105343685

CANU:

128165740

CVN:	111119277 111121482

OED:

125671040

MYI:

110463281

PMAX:

117325974

MCAF:

127727052

RPHI:

132727301

DPOL:

127874484

MAEA:

128213522

OBI:

106868638

OSN:

115215105

LJP:

135469827

LAK:

106151803

LLON:

135486526

NVE:

5515850

EPA:

110231598

ATEN:

116293063

ADF:	107334366 107334421 107338931

AMIL:

114963500

PDAM:

113686981

SPIS:

111343278

XEN:

124443519

TAD:	TRIADDRAFT_59397

CRE:	CHLRE_06g272150v5

VCN:	VOLCADRAFT_115761

CSL:	COCSUDRAFT_54141

MBR:	MONBRDRAFT_37391

SRE:	PTSG_07890

EIV:	EIN_185160 EIN_226240

ACAN:

ACA1_253490 ACA1_359700

GTT:	GUITHDRAFT_108537

HDN:

Hden_2835

HDT:	HYPDE_37723

HMC:	HYPMC_4105

» show all

Reference

1 [PMID:14031343]

Authors

KATZEN HM, TIETZE F, STETTEN D Jr.

Title

Further studies on the properties of hepatic glutathione-insulin transhydro-genase.

Journal

J Biol Chem 238:1006-11 (1963)

Reference

Authors

Kohnert K-D, Hahn H-J, Zuhlke H, Schmidt S, Fiedler H.

Title

Breakdown of exogenous insulin by Langerhans islets of the pancreas in vitro.

Journal

Biochim Biophys Acta 338:68-77 (1974)

Other DBs

ExplorEnz - The Enzyme Database:

1.8.4.2

IUBMB Enzyme Nomenclature:

1.8.4.2

ExPASy - ENZYME nomenclature database:

1.8.4.2

BRENDA, the Enzyme Database:

1.8.4.2

CAS:

9082-53-5

DBGET integrated database retrieval system