KEGG   ENZYME: 1.8.4.2
Entry
EC 1.8.4.2                  Enzyme                                 
Name
protein-disulfide reductase (glutathione);
glutathione-insulin transhydrogenase;
insulin reductase;
reductase, protein disulfide (glutathione);
protein disulfide transhydrogenase;
glutathione-protein disulfide oxidoreductase;
protein disulfide reductase (glutathione);
GSH-insulin transhydrogenase;
protein-disulfide interchange enzyme;
protein-disulfide isomerase/oxidoreductase;
thiol:protein-disulfide oxidoreductase;
thiol-protein disulphide oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
Sysname
glutathione:protein-disulfide oxidoreductase
Reaction(IUBMB)
2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol [RN:R03915]
Reaction(KEGG)
R03915;
(other) R02824
Substrate
glutathione [CPD:C00051];
protein disulfide [CPD:C02582]
Product
glutathione disulfide [CPD:C00127];
protein dithiol [CPD:C02315]
Comment
Reduces insulin and some other proteins.
History
EC 1.8.4.2 created 1965
Pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K05360  protein-disulfide reductase (glutathione)
Genes
HSA51060(TXNDC12)
PTR100610643(TXNDC12)
PPS100996005(TXNDC12)
GGO101134035(TXNDC12)
PON100451283(TXNDC12)
NLE105737527(TXNDC12)
MCC712891(TXNDC12)
MCF102121070(TXNDC12)
CSAB103224818(TXNDC12)
CATY105596046(TXNDC12)
PANU101006352(TXNDC12)
TGE112619107(TXNDC12)
RRO104667843(TXNDC12)
RBB108531798(TXNDC12)
TFN117092592(TXNDC12)
PTEH111523824(TXNDC12)
CJC100400300(TXNDC12)
SBQ101039421(TXNDC12)
CSYR103266583(TXNDC12)
MMUR105877554(TXNDC12)
OGA100946144(TXNDC12)
MMU66073(Txndc12)
MCAL110293228(Txndc12)
MPAH110323125(Txndc12)
RNO298370(Txndc12)
MCOC116096385(Txndc12)
MUN110563753(Txndc12)
CGE100753389(Txndc12)
PLEU114706379(Txndc12)
NGI103730255(Txndc12)
HGL101714855(Txndc12)
CPOC100728766(Txndc12)
CCAN109698160(Txndc12)
DORD105989989(Txndc12)
DSP122104420(Txndc12)
OCU103350186(TXNDC12)
OPI101519531(TXNDC12)
TUP102497800(TXNDC12)
CFA609843(TXNDC12)
VVP112914720(TXNDC12)
VLG121480971(TXNDC12)
AML100481735(TXNDC12)
UMR103670719(TXNDC12)
UAH113254678(TXNDC12)
UAR123793700(TXNDC12)
ELK111143212
LLV125097616
MPUF101692513(TXNDC12)
ORO101386371(TXNDC12)
EJU114212052(TXNDC12)
ZCA113924577(TXNDC12)
FCA101089631(TXNDC12)
PYU121027122(TXNDC12)
PBG122480495(TXNDC12)
PTG102956818(TXNDC12)
PPAD109266881(TXNDC12)
AJU106988188(TXNDC12)
HHV120236122(TXNDC12)
BTA506991(TXNDC12)
BOM102276264(TXNDC12)
BIU109556305(TXNDC12)
BBUB102406947(TXNDC12)
CHX102189539(TXNDC12)
OAS101113445(TXNDC12)
ODA120856142(TXNDC12)
CCAD122436978(TXNDC12)
SSC100517534(TXNDC12)
CFR102511212(TXNDC12)
CBAI105066453(TXNDC12)
CDK105092962(TXNDC12)
VPC102527180(TXNDC12)
BACU103015400(TXNDC12)
LVE103070023(TXNDC12)
OOR101283919(TXNDC12)
DLE111175807(TXNDC12)
PCAD102989379(TXNDC12)
PSIU116764524(TXNDC12)
ECB100062254(TXNDC12)
EPZ103556054(TXNDC12)
EAI106826060(TXNDC12)
MYB102252702(TXNDC12)
MYD102760942(TXNDC12)
MMYO118675278(TXNDC12)
MLF102428871(TXNDC12)
MNA107535416(TXNDC12)
PKL118724216(TXNDC12)
HAI109372589(TXNDC12)
DRO112314558(TXNDC12)
SHON118984997(TXNDC12)
AJM119058853(TXNDC12)
PDIC114496716(TXNDC12)
PHAS123831047(TXNDC12)
MMF118626552(TXNDC12)
PALE102881310
PVP105298991(TXNDC12)
RAY107497925(TXNDC12)
MJV108393111(TXNDC12)
TOD119235539(TXNDC12)
SARA101542310(TXNDC12)
LAV100655830(TXNDC12)
TMU101359872
DNM101423729(TXNDC12)
MDO103095270(TXNDC12)
GAS123244830(TXNDC12)
SHR105750619(TXNDC12)
PCW110209344(TXNDC12)
OAA100078583(TXNDC12)
GGA772208(TXNDC12)
PCOC116234682(TXNDC12)
MGP100541059(TXNDC12)
CJO107317647(TXNDC12)
NMEL110402314(TXNDC12)
APLA101799624(TXNDC12)
ACYG106033048(TXNDC12)
AFUL116491957(TXNDC12)
TGU100225061(KTI12) 115490553(TXNDC12)
LSR110470067(TXNDC12)
SCAN103815017(TXNDC12)
PMOA120503166(TXNDC12)
OTC121344915(TXNDC12)
PRUF121361924(TXNDC12)
GFR102041968(TXNDC12)
FAB101807031(TXNDC12)
PHI102103484(TXNDC12)
PMAJ107208050(TXNDC12)
CCAE111933053(TXNDC12)
CCW104695524(TXNDC12)
ETL114062664(TXNDC12)
ZAB102074027(TXNDC12)
FPG101917720(TXNDC12)
FCH102059863(TXNDC12)
CLV102085011(TXNDC12)
EGZ104131497(TXNDC12)
NNI104009361(TXNDC12)
ACUN113482716(TXNDC12)
TALA104359215(TXNDC12)
PADL103913670(TXNDC12)
ACHC115348723(TXNDC12)
AAM106491077(TXNDC12)
AROW112976067(TXNDC12)
NPD112943089(TXNDC12)
DNE112986447(TXNDC12)
ASN102381430(TXNDC12)
AMJ102573479(TXNDC12)
CPOO109307471(TXNDC12)
GGN109286661(TXNDC12)
PSS102446057(TXNDC12)
CMY102942750(TXNDC12)
CPIC101932560(TXNDC12)
TST117881680(TXNDC12)
CABI116817924(TXNDC12)
MRV120370626(TXNDC12)
ACS100562080(txndc12)
PVT110076174(TXNDC12)
SUND121928228(TXNDC12)
PBI103066536(TXNDC12)
PMUR107283055(TXNDC12)
TSR106552050(TXNDC12)
PGUT117658181 117664342(TXNDC12)
PMUA114599004(TXNDC12)
ZVI118088612(TXNDC12)
GJA107111061(TXNDC12)
XLA380448(txndc12.S) 495430(txndc12.L)
XTR100379783(txndc12)
NPR108783807(TXNDC12)
RTEM120945918(TXNDC12)
BBUF120979013(TXNDC12)
BGAR122943426(TXNDC12)
DRE324900(txndc12)
SRX107708672 107739415
SANH107681819 107690994
SGH107566463 107599851
CCAR109094186(txndc12)
CAUA113045995 113114536
IPU108267860(txndc12)
PHYP113540200(txndc12)
SMEO124387957(txndc12)
AMEX103026714(txndc12)
EEE113570148(txndc12)
TRU101067813(txndc12)
LCO104927482(txndc12)
NCC104957515(txndc12)
CGOB115022561(txndc12)
ELY117271844(txndc12)
PLEP121950999(txndc12)
SLUC116045821(txndc12)
ECRA117954363(txndc12)
PFLV114564960(txndc12)
GAT120816599(txndc12)
PPUG119209314(txndc12)
MSAM119902858(txndc12)
CUD121520011(txndc12)
MZE101479452(txndc12)
ONL100695664(txndc12)
OAU116313358(txndc12)
OLA101170372(txndc12)
OML112152472(txndc12)
XMA102228365(txndc12)
XCO114146965(txndc12)
XHE116721329(txndc12)
PRET103479915(txndc12)
PFOR103148573(txndc12)
PLAI106939519(txndc12)
PMEI106909811(txndc12)
GAF122840498(txndc12)
CVG107095432(txndc12)
CTUL119787858(txndc12)
GMU124869465(txndc12)
NFU107383523(txndc12)
KMR108232931(txndc12)
ALIM106520742(txndc12)
NWH119414763(txndc12)
AOCE111585887(txndc12)
CSEM103396690(txndc12)
POV109642682(txndc12)
SSEN122777727(txndc12)
HHIP117777660(txndc12)
LCF108884259(txndc12)
SDU111231084(txndc12)
SLAL111658385(txndc12)
XGL120798922(txndc12)
HCQ109507400(txndc12)
BPEC110174922(txndc12)
MALB109955296(txndc12)
SASA100286440(txndc12)
OTW112227276(txndc12)
OMY110509158(txndc12)
OGO124042196(txndc12)
ONE115103396(txndc12)
SALP112070295(txndc12)
SNH120020674(txndc12)
ELS105031232(txndc12)
SFM108923831(txndc12)
PKI111846014(txndc12)
AANG118228783(txndc12)
LOC102698837(txndc12)
PSPA121327251 121330575
ARUT117411960 117416607
LCM102357648(TXNDC12)
CMK103172677(txndc12)
RTP109918333(txndc12)
BFO118431775
BBEL109486244
CIN100185750
SCLV120340940
SPU105446740 115928587 115928699 115928720 115928810 115928830 115928836 115928859 581130 586825
APLC110977703
SKO100377044
AME113219403
ACER114578051
ALAB122716850
BIM112213299
BBIF117209049
BVK117233839
BVAN117160661
BTER110119393
BPYO122568867
CCAL108632819
OBB114871124
MGEN117228726
NMEA116424367
CGIG122395297
SOC105198763
MPHA105836541
AEC105148753
ACEP105618674
PBAR105422055
VEM105569082
HST105184875
DQU106743082
CFO112638907
FEX115244886
LHU105675269
PGC109856411
OBO105281249
FAS105273175
DAM107048947
AGIF122850198
CCIN107267063
BMOR101738456
BMAN114239392
MSEX115452091
DPLKGM_207330
BANY112054316
PMAC106721148
PPOT106110329
PXU106116668
PRAP110997338
ZCE119828882
HAW110376796
TNL113499370
OFU114365411
PXY105382641
BTAB109041552
DCI103518972 103519185
CLEC106666588 106668723
HHAL106685087
NLU111062936
PHUPhum_PHUM095260 Phum_PHUM562480 Phum_PHUM562490 Phum_PHUM562500
ZNE110839067
CSEC111875775
FCD110852856
PVM113820074
PJA122248535
HAME121879560
PCLA123750508
PTRU123516746
CELCELE_Y57A10A.23(txdc-12.1)
CBRCBG_20924
BMYBM_BM6891(Bma-txdc-12.1)
LOALOAG_03724
NAINECAME_13028 NECAME_16850
TSPTsp_10270
LGILOTGIDRAFT_234262
PCAN112574039
BGT106064349 106064350 106069446 106069454
GAE121374316
HRF124115583
CRG105343685
MYI110463281
PMAX117325974
MMER123524049
OBI106868638
OSN115215105
LAK106151803
NVE5515850
EPA110231598
ATEN116293063
ADF107330219 107334366 107334421 107338931
AMIL114963500
PDAM113686981
SPIS111320955 111343278
XEN124443519 124443520 124444982
TADTRIADDRAFT_59397
CRECHLRE_06g272150v5
VCNVOLCADRAFT_115761
CSLCOCSUDRAFT_54141
MBRMONBRDRAFT_37391
SREPTSG_07890
EIVEIN_185160 EIN_226240
ACANACA1_253490 ACA1_359700
GTTGUITHDRAFT_108537
HDNHden_2835
HDTHYPDE_37723
HMCHYPMC_4105
 » show all
Reference
1  [PMID:14031343]
  Authors
KATZEN HM, TIETZE F, STETTEN D Jr.
  Title
Further studies on the properties of hepatic glutathione-insulin transhydro-genase.
  Journal
J Biol Chem 238:1006-11 (1963)
Reference
2
  Authors
Kohnert, K.-D., Hahn, H.-J., Zuhlke, H., Schmidt, S. and Fiedler, H.
  Title
Breakdown of exogenous insulin by Langerhans islets of the pancreas in vitro.
  Journal
Biochim Biophys Acta 338:68-77 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 1.8.4.2
IUBMB Enzyme Nomenclature: 1.8.4.2
ExPASy - ENZYME nomenclature database: 1.8.4.2
BRENDA, the Enzyme Database: 1.8.4.2
CAS: 9082-53-5

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