KEGG   ENZYME: 1.8.4.2
Entry
EC 1.8.4.2                  Enzyme                                 
Name
protein-disulfide reductase (glutathione);
glutathione-insulin transhydrogenase;
insulin reductase;
reductase, protein disulfide (glutathione);
protein disulfide transhydrogenase;
glutathione-protein disulfide oxidoreductase;
protein disulfide reductase (glutathione);
GSH-insulin transhydrogenase;
protein-disulfide interchange enzyme;
protein-disulfide isomerase/oxidoreductase;
thiol:protein-disulfide oxidoreductase;
thiol-protein disulphide oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
Sysname
glutathione:protein-disulfide oxidoreductase
Reaction(IUBMB)
2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol [RN:R03915]
Reaction(KEGG)
R03915;
(other) R02824
Substrate
glutathione [CPD:C00051];
protein disulfide [CPD:C02582]
Product
glutathione disulfide [CPD:C00127];
protein dithiol [CPD:C02315]
Comment
Reduces insulin and some other proteins.
History
EC 1.8.4.2 created 1965
Pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K05360  protein-disulfide reductase (glutathione)
Genes
HSA51060(TXNDC12)
PTR100610643(TXNDC12)
PPS100996005(TXNDC12)
GGO101134035(TXNDC12)
PON100451283(TXNDC12)
NLE105737527(TXNDC12)
HMH116473156(TXNDC12)
MCC712891(TXNDC12)
MCF102121070(TXNDC12)
MTHB126939120 126962538
MNI105481117(TXNDC12)
CSAB103224818(TXNDC12)
CATY105596046(TXNDC12)
PANU101006352(TXNDC12)
TGE112619107(TXNDC12)
RRO104667843(TXNDC12)
RBB108531798(TXNDC12)
TFN117092592(TXNDC12)
PTEH111523824(TXNDC12)
CJC100400300(TXNDC12)
SBQ101039421(TXNDC12)
CIMI108318047(TXNDC12)
CSYR103266583(TXNDC12)
MMUR105877554(TXNDC12)
LCAT123635655(TXNDC12)
PCOQ105806365(TXNDC12)
OGA100946144(TXNDC12)
MMU66073(Txndc12)
MCAL110293228(Txndc12)
MPAH110323125(Txndc12)
RNO298370(Txndc12)
MCOC116096385(Txndc12)
ANU117708278(Txndc12)
MUN110563753(Txndc12)
CGE100753389(Txndc12)
MAUA101832189(Txndc12)
PROB127225149(Txndc12)
PLEU114706379(Txndc12)
MORG121448020(Txndc12)
MFOT126497966
AAMP119816127(Txndc12)
NGI103730255(Txndc12)
HGL101714855(Txndc12)
CPOC100728766(Txndc12)
CCAN109698160(Txndc12)
DORD105989989(Txndc12)
DSP122104420(Txndc12)
PLOP125355156(Txndc12)
NCAR124960640
MMMA107136229 107141770(Txndc12)
OCU103350186
OPI101519531(TXNDC12)
TUP102497800(TXNDC12)
GVR103593902(TXNDC12)
CFA609843(TXNDC12)
CLUD112642464(TXNDC12)
VVP112914720(TXNDC12)
VLG121480971(TXNDC12)
NPO129520583(TXNDC12)
AML100481735(TXNDC12)
UMR103670719(TXNDC12)
UAH113254678(TXNDC12)
UAR123793700(TXNDC12)
ELK111143212
LLV125097616
MPUF101692513(TXNDC12)
MNP132000867(TXNDC12)
MLK131808868(TXNDC12)
NVS122899968(TXNDC12)
ORO101386371(TXNDC12)
EJU114212052(TXNDC12)
ZCA113924577(TXNDC12)
NSU110575288(TXNDC12)
LWW102750023(TXNDC12)
FCA101089631(TXNDC12)
PYU121027122(TXNDC12)
PCOO112871739(TXNDC12)
PBG122480495(TXNDC12)
LRUF124515186
PTG102956818(TXNDC12)
PPAD109266881(TXNDC12)
AJU106988188
HHV120236122(TXNDC12)
BTA506991(TXNDC12)
BOM102276264(TXNDC12)
BIU109556305(TXNDC12)
BBUB102406947(TXNDC12)
BBIS104995797(TXNDC12)
CHX102189539(TXNDC12)
OAS101113445(TXNDC12)
BTAX128044844(TXNDC12)
ODA120856142(TXNDC12)
CCAD122436978(TXNDC12)
SSC100517534(TXNDC12)
CFR102511212(TXNDC12)
CBAI105066453(TXNDC12)
CDK105092962(TXNDC12)
VPC102527180(TXNDC12)
BACU103015400(TXNDC12)
LVE103070023(TXNDC12)
OOR101283919(TXNDC12)
DLE111175807(TXNDC12)
PCAD102989379(TXNDC12)
PSIU116764524(TXNDC12)
NASI112395883(TXNDC12)
ECB100062254(TXNDC12)
EPZ103556054(TXNDC12)
EAI106826060(TXNDC12)
MYB102252702(TXNDC12)
MYD102760942(TXNDC12)
MMYO118675278(TXNDC12)
MLF102428871(TXNDC12)
MNA107535416(TXNDC12)
PKL118724216(TXNDC12)
EFUS103284026(TXNDC12)
HAI109372589(TXNDC12)
DRO112314558(TXNDC12)
SHON118984997(TXNDC12)
AJM119058853(TXNDC12)
PDIC114496716(TXNDC12)
PHAS123831047(TXNDC12)
MMF118626552(TXNDC12)
PPAM129070190(TXNDC12) 129082303
PALE102881310
PVP105298991(TXNDC12)
RAY107497925(TXNDC12)
TOD119235539(TXNDC12)
SARA101542310(TXNDC12)
LAV100655830(TXNDC12)
TMU101359872
ETF101644102(TXNDC12)
DNM101423729(TXNDC12)
MDO103095270(TXNDC12)
GAS123244830(TXNDC12)
SHR105750619(TXNDC12)
AFZ127563324
PCW110209344(TXNDC12)
OAA100078583(TXNDC12)
GGA772208(TXNDC12)
PCOC116234682(TXNDC12)
MGP100541059(TXNDC12)
CJO107317647(TXNDC12)
TPAI128072352(TXNDC12)
LMUT125693130(TXNDC12)
NMEL110402314(TXNDC12)
APLA101799624(TXNDC12)
ACYG106033048(TXNDC12)
CATA118243271(TXNDC12)
AFUL116491957(TXNDC12)
TGU100225061(KTI12) 115490553(TXNDC12)
LSR110470067(TXNDC12)
SCAN103815017(TXNDC12)
PMOA120503166(TXNDC12)
OTC121344915(TXNDC12)
PRUF121361924(TXNDC12)
GFR102041968(TXNDC12)
FAB101807031(TXNDC12)
OMA130256157(TXNDC12)
PHI102103484(TXNDC12)
PMAJ107208050(TXNDC12)
CCAE111933053(TXNDC12)
CCW104695524(TXNDC12)
CBRC103621956(TXNDC12)
ETL114062664(TXNDC12)
ZAB102074027(TXNDC12)
ACHL103801602(TXNDC12)
SVG106849785(TXNDC12)
MMEA130574067(TXNDC12)
HRT120756266(TXNDC12)
FPG101917720(TXNDC12)
FCH102059863(TXNDC12)
CLV102085011(TXNDC12)
EGZ104131497(TXNDC12)
NNI104009361(TXNDC12)
PCRI104025887(TXNDC12)
PLET104614553(TXNDC12)
EHS104509497(TXNDC12)
PCAO104049481(TXNDC12)
ACUN113482716(TXNDC12)
TALA104359215(TXNDC12)
PADL103913670(TXNDC12)
AFOR103905734(TXNDC12)
ACHC115348723(TXNDC12)
HALD104312230(TXNDC12)
HLE104841023(TXNDC12)
AGEN126041573
GCL127019007
CCRI104156350(TXNDC12)
CSTI104551705(TXNDC12)
CMAC104483669
MUI104538624(TXNDC12)
BREG104633036(TXNDC12)
FGA104071357(TXNDC12)
GSTE104262612(TXNDC12)
LDI104352073(TXNDC12)
MNB103781548(TXNDC12)
OHA104334195(TXNDC12)
NNT104400745(TXNDC12)
SHAB115612113(TXNDC12)
DPUB104307027(TXNDC12)
PGUU104470915(TXNDC12)
ACAR104519640(TXNDC12)
CPEA104394443(TXNDC12)
AVIT104269083(TXNDC12)
CVF104286251(TXNDC12)
RTD128913733(TXNDC12)
CUCA104060189(TXNDC12)
TEO104375332(TXNDC12)
BRHI104488597
AAM106491077(TXNDC12)
AROW112976067(TXNDC12)
NPD112943089(TXNDC12)
TGT104577532(TXNDC12)
DNE112986447(TXNDC12)
SCAM104149617(TXNDC12)
ASN102381430(TXNDC12)
AMJ102573479(TXNDC12)
CPOO109307471(TXNDC12)
GGN109286661(TXNDC12)
PSS102446057(TXNDC12)
CMY102942750(TXNDC12)
CCAY125641239(TXNDC12)
CPIC101932560(TXNDC12)
TST117881680(TXNDC12)
CABI116817924(TXNDC12)
MRV120370626(TXNDC12)
ACS100562080(txndc12)
ASAO132773920(TXNDC12)
PVT110076174(TXNDC12)
SUND121928228(TXNDC12)
PBI103066536(TXNDC12)
PMUR107283055(TXNDC12)
CTIG120297429(TXNDC12) 120300026
TSR106552050(TXNDC12)
PGUT117658181 117664342(TXNDC12)
APRI131195866(TXNDC12)
PTEX113440651(TXNDC12)
NSS113411016(TXNDC12)
PMUA114599004(TXNDC12)
PRAF128415772(TXNDC12)
ZVI118088612(TXNDC12)
HCG128324871(TXNDC12)
GJA107111061(TXNDC12)
STOW125432340(TXNDC12)
EMC129331264(TXNDC12)
XLA380448(txndc12.S) 495430(txndc12.L)
XTR100379783(txndc12)
NPR108783807(TXNDC12)
RTEM120945918(TXNDC12)
BBUF120979013(TXNDC12)
BGAR122943426(TXNDC12)
MUO115471922(TXNDC12)
GSH117346852(TXNDC12)
DRE324900(txndc12)
SRX107708672 107739415
SANH107681819 107690994
SGH107566463 107599851
CCAR109094186(txndc12)
CAUA113045995 113114536
CGIB127950788 128026161
PTET122355819(txndc12)
LROH127154842(txndc12)
OMC131526909(txndc12)
PPRM120470357(txndc12)
RKG130097537(txndc12)
MAMB125251014(txndc12)
CIDE127523641
MASI127440351 127442036
TROS130554511(txndc12)
TDW130417753(txndc12)
MANU129442599(txndc12)
IPU108267860
IFU128609726(txndc12)
PHYP113540200(txndc12)
SMEO124387957(txndc12)
TFD113649142(txndc12)
TVC132848251(txndc12)
AMEX103026714(txndc12)
CMAO118826245(txndc12)
EEE113570148(txndc12)
CHAR105889519(txndc12)
TRU101067813(txndc12)
TFS130538769(txndc12)
LCO104927482(txndc12)
NCC104957515(txndc12)
TBEN117500227(txndc12)
CGOB115022561(txndc12)
PGEO117462835(txndc12)
GACU117540849(txndc12)
ELY117271844(txndc12)
EFO125901703(txndc12)
PLEP121950999(txndc12)
SLUC116045821(txndc12)
ECRA117954363(txndc12)
ESP116699007(txndc12)
PFLV114564960(txndc12)
GAT120816599(txndc12)
PPUG119209314(txndc12)
AFB129113092(txndc12)
CLUM117746131(txndc12)
MSAM119902858(txndc12)
SCHU122887103(txndc12)
CUD121520011(txndc12)
ALAT119011458(txndc12)
MZE101479452(txndc12)
ONL100695664(txndc12)
OAU116313358(txndc12)
OLA101170372(txndc12)
OML112152472(txndc12)
XMA102228365(txndc12)
XCO114146965(txndc12)
XHE116721329(txndc12)
PRET103479915(txndc12)
PFOR103148573(txndc12)
PLAI106939519(txndc12)
PMEI106909811(txndc12)
GAF122840498(txndc12)
CVG107095432(txndc12)
CTUL119787858(txndc12)
GMU124869465(txndc12)
NFU107383523(txndc12)
KMR108232931(txndc12)
ALIM106520742(txndc12)
NWH119414763(txndc12)
AOCE111585887(txndc12)
MCEP125010517(txndc12)
CSEM103396690(txndc12)
POV109642682(txndc12)
SSEN122777727(txndc12)
HHIP117777660(txndc12)
HSP118117352(txndc12)
LCF108884259
SDU111231084(txndc12)
SLAL111658385(txndc12)
XGL120798922(txndc12)
HCQ109507400(txndc12)
SSCV125984967
SBIA133510678(txndc12)
PEE133411260(txndc12)
PTAO133488845(txndc12)
BPEC110174922(txndc12)
MALB109955296(txndc12)
BSPL114844297(txndc12)
SJO128369190(txndc12)
SASA100286440(txndc12)
STRU115170224(txndc12)
OTW112227276(txndc12)
OMY110509158(txndc12)
OGO124042196(txndc12)
ONE115103396(txndc12)
OKI109879694(txndc12)
OKE118377540(txndc12)
SALP112070295(txndc12)
SNH120020674(txndc12)
CCLU121580547(txndc12)
ELS105031232(txndc12)
SFM108923831(txndc12)
PKI111846014(txndc12)
AANG118228783(txndc12)
LOC102698837(txndc12)
PSPA121327251 121330575
ARUT117411960 117416607
PSEX120514706(txndc12)
LCM102357648(TXNDC12)
CMK103172677(txndc12)
RTP109918333(txndc12)
CPLA122554336(txndc12)
HOC132819095(txndc12)
PMRN116943204 116948886 116951997
LRJ133349899 133350656 133352024 133359114 133359115
BFO118431775
BBEL109486244
CIN100185750
SCLV120340940
SPU105446740 115928587 115928699 115928720 115928810 115928830 115928836 115928859 581130 586825
LPIC129271190
APLC110977703
AJC117101235
SKO100377044
BCOO119067650 119077152 119079323 119079325
AME113219403
ACER114578051
ALAB122716850
ADR102681781
AFLR100864712
BIM112213299
BBIF117209049
BVK117233839
BVAN117160661
BTER110119393
BAFF126920993
BPYO122568867
BPAS132916366
FVI122536824
CCAL108632819
OBB114871124
MGEN117228726
NMEA116424367
CGIG122395297
SOC105198763
MPHA105836541
AEC105148753
ACEP105618674
PBAR105422055
VEM105569082
HST105184875
DQU106743082
CFO112638907
FEX115244886
LHU105675269
PGC109856411
OBO105281249
LBD127284698
FAS105273175
DAM107048947
AGIF122850198
CCIN107267063
DSM124410148
NPT124220000
NFB124183278
NLO124294692
NVG124304770
BMOR101738456
BMAN114239392
MSEX115452091
DPLKGM_207330
MJU123876912
NIQ126776531
VCD124538780
MCIX123663921
PMAC106721148
PPOT106110329
PXU106116668
PRAP110997338
ZCE119828882
CCRC123700749
HAW110376796
HZE124640617
TNL113499370
SLIU111348724
OFU114365411
PXY105382641
PGW126380390
BTAB109041552
DCI103518972 103519185
CLEC106666588 106668723
HHAL106685087
NLU111062936
HVI124355379
MQU128997006 129005719
PHUPhum_PHUM095260 Phum_PHUM562480 Phum_PHUM562490 Phum_PHUM562500
ZNE110839067
CSEC111875775
SGRE126272159
IEL124157771
FCD110852856
PVM113820074
PJA122248535
PCHN125029054
PMOO119574040
HAME121879560
PCLA123750508
CQD128686753
PTRU123516746
ESN126999967
LSM121131791 121131795
TCF131893187
CELCELE_Y57A10A.23(txdc-12.1)
CBRCBG_20924
CRQGCK72_006662
NAINECAME_13028 NECAME_16850
BMYBM_BM6891(Bma-txdc-12.1)
LOALOAG_03724
TSPTsp_10270
LGILOTGIDRAFT_234262
PCAN112574039
BGT106064349 106064350 106069446 106069454
GAE121374316
HRF124115583
CRG105343685
CVN111119277 111121482
CANU128165740
OED125671040
MYI110463281
PMAX117325974
MCAF127727052
RPHI132727301
DPOL127874484
OBI106868638
OSN115215105
LAK106151803
NVE5515850
EPA110231598
ATEN116293063
ADF107334366 107334421 107338931
AMIL114963500
PDAM113686981
SPIS111343278
XEN124443519 124444982
TADTRIADDRAFT_59397
CRECHLRE_06g272150v5
VCNVOLCADRAFT_115761
CSLCOCSUDRAFT_54141
MBRMONBRDRAFT_37391
SREPTSG_07890
EIVEIN_185160 EIN_226240
ACANACA1_253490 ACA1_359700
GTTGUITHDRAFT_108537
HDNHden_2835
HDTHYPDE_37723
HMCHYPMC_4105
 » show all
Reference
1  [PMID:14031343]
  Authors
KATZEN HM, TIETZE F, STETTEN D Jr.
  Title
Further studies on the properties of hepatic glutathione-insulin transhydro-genase.
  Journal
J Biol Chem 238:1006-11 (1963)
Reference
2
  Authors
Kohnert, K.-D., Hahn, H.-J., Zuhlke, H., Schmidt, S. and Fiedler, H.
  Title
Breakdown of exogenous insulin by Langerhans islets of the pancreas in vitro.
  Journal
Biochim Biophys Acta 338:68-77 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 1.8.4.2
IUBMB Enzyme Nomenclature: 1.8.4.2
ExPASy - ENZYME nomenclature database: 1.8.4.2
BRENDA, the Enzyme Database: 1.8.4.2
CAS: 9082-53-5

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