KEGG   ENZYME: 1.8.4.7
Entry
EC 1.8.4.7                  Enzyme                                 
Name
enzyme-thiol transhydrogenase (glutathione-disulfide);
[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase;
enzyme-thiol transhydrogenase (oxidized-glutathione);
glutathione-dependent thiol:disulfide oxidoreductase;
thiol:disulphide oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
Sysname
[xanthine-dehydrogenase]:glutathione-disulfide S-oxidoreductase
Reaction(IUBMB)
[xanthine dehydrogenase] + glutathione disulfide = [xanthine oxidase] + 2 glutathione [RN:R04039]
Reaction(KEGG)
R04039
Substrate
[xanthine dehydrogenase] [CPD:C03544];
glutathione disulfide [CPD:C00127]
Product
[xanthine oxidase] [CPD:C02756];
glutathione [CPD:C00051]
Comment
Converts EC 1.17.1.4 xanthine dehydrogenase into EC 1.17.3.2 xanthine oxidase in the presence of glutathione disulfide; also reduces the disulfide bond of ricin. Not inhibited by Cu2+ or thiol reagents.
History
EC 1.8.4.7 created 1989, modified 2002
Pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:6960894]
  Authors
Battelli MG, Lorenzoni E.
  Title
Purification and properties of a new glutathione-dependent thiol:disulphide oxidoreductase from rat liver.
  Journal
Biochem J 207:133-8 (1982)
DOI:10.1042/bj2070133
Other DBs
ExplorEnz - The Enzyme Database: 1.8.4.7
IUBMB Enzyme Nomenclature: 1.8.4.7
ExPASy - ENZYME nomenclature database: 1.8.4.7
BRENDA, the Enzyme Database: 1.8.4.7
CAS: 85030-79-1

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (5)   
   UniProt (1)   
   PDBSTR (4)   
DNA sequence (13)   
   GenBank (7)   
   EMBL (6)   
3D Structure (1)   
   PDB (1)   
All databases (29)   

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