KEGG   ENZYME: 1.8.5.8Help
Entry
EC 1.8.5.8                  Enzyme                                 

Name
eukaryotic sulfide quinone oxidoreductase;
SQR;
SQOR;
SQRDL (gene name)
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
sulfide:glutathione,quinone oxidoreductase
Reaction(IUBMB)
hydrogen sulfide + glutathione + a quinone = S-sulfanylglutathione + a quinol [RN:R11929]
Reaction(KEGG)
Substrate
hydrogen sulfide [CPD:C00283];
glutathione [CPD:C00051];
quinone [CPD:C15602]
Product
S-sulfanylglutathione [CPD:C17267];
quinol [CPD:C15603]
Comment
Contains FAD. This eukaryotic enzyme, located at the inner mitochondrial membrane, catalyses the first step in the metabolism of sulfide. While both sulfite and glutathione have been shown to act as sulfane sulfur acceptors in vitro, it is thought that the latter acts as the main acceptor in vivo. The electrons are transferred via FAD and quinones to the electron transfer chain. Unlike the bacterial homolog (EC 1.8.5.4, bacterial sulfide:quinone reductase), which repeats the catalytic cycle without releasing the product, producing a polysulfide, the eukaryotic enzyme transfers the persulfide to an acceptor at the end of each catalytic cycle.
History
EC 1.8.5.8 created 2017
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K22470  eukaryotic sulfide quinone oxidoreductase
Genes
HSA: 58472(SQOR)
PTR: 453405(SQOR)
PPS: 100984085(SQRDL)
GGO: 101146608(SQOR)
PON: 100452776(SQOR)
NLE: 100589960(SQOR)
MCC: 713699(SQOR)
MCF: 101926271(SQRDL)
CSAB: 103245691(SQRDL)
RRO: 104674037(SQOR)
RBB: 108530119(SQRDL)
CJC: 100410241(SQRDL)
SBQ: 101039585(SQRDL)
MMU: 59010(Sqor)
MCAL: 110312539(Sqor)
MPAH: 110319011(Sqor)
RNO: 691966(Sqrdl)
MUN: 110553250(Sqor)
CGE: 100770919(Sqor)
NGI: 103747009(Sqrdl)
HGL: 101725445(Sqrdl)
CCAN: 109676782(Sqrdl)
OCU: 100357085(SQRDL)
TUP: 102491065(SQRDL)
CFA: 478289(SQOR)
VVP: 112920034(SQOR)
AML: 100466768(SQRDL)
UMR: 103656586(SQRDL)
UAH: 113269573(SQOR)
ORO: 101363149(SQRDL)
ELK: 111161095
FCA: 101085805(SQOR)
PTG: 102956665(SQRDL)
PPAD: 109263034(SQRDL)
AJU: 106986292(SQOR)
BTA: 507858(SQOR)
BOM: 102272805(SQRDL)
BIU: 109565157(SQRDL)
BBUB: 102390525(SQOR)
CHX: 102183520(SQRDL)
OAS: 101113498(SQOR)
SSC: 100154990(SQOR)
CFR: 102506338(SQRDL)
CDK: 105104934(SQOR)
BACU: 103020738(SQRDL)
LVE: 103075323(SQRDL)
OOR: 101282852(SQRDL)
DLE: 111181631(SQOR)
PCAD: 102986038(SQOR)
ECB: 100070480(SQOR)
EPZ: 103554021(SQRDL)
EAI: 106834984(SQRDL)
MYB: 102250577(SQRDL)
MYD: 102773979(SQRDL)
MNA: 107536227(SQRDL)
HAI: 109396647(SQRDL)
DRO: 112311815(SQOR)
PALE: 102892873(SQOR)
RAY: 107514961(SQRDL)
MJV: 108400241(SQRDL)
LAV: 100659861(SQOR)
TMU: 101352821
MDO: 100013567(SQRDL)
SHR: 100935171(SQOR)
PCW: 110223654(SQOR)
OAA: 100088843(SQOR)
MGP: 100551322(SQOR)
CJO: 107318739(SQRDL)
NMEL: 110404052(SQOR)
APLA: 101794247(SQOR)
ACYG: 106033801(SQRDL)
TGU: 100220597(SQOR)
LSR: 110474252(SQOR)
SCAN: 103816028(SQOR)
GFR: 102036352(SQRDL)
FAB: 101814680(SQRDL)
PHI: 102105060(SQRDL)
PMAJ: 107209455(SQRDL)
CCAE: 111934099(SQOR)
CCW: 104683982(SQOR)
ETL: 114059945(SQOR)
FPG: 101922842(SQRDL)
FCH: 102052821(SQOR)
CLV: 102097058(SQOR)
EGZ: 104130927(SQRDL)
NNI: 104017121(SQRDL)
ACUN: 113484015(SQOR)
PADL: 103922742(SQRDL)
AAM: 106496523(SQRDL)
ASN: 102370416(SQOR)
AMJ: 102565876(SQRDL)
PSS: 102450989(SQOR)
CMY: 102937523(SQRDL)
CPIC: 101942158(SQRDL)
ACS: 100559421(sqrdl)
PVT: 110077232(SQOR)
PBI: 103062542(SQOR)
PMUR: 107282915(SQOR)
TSR: 106543411(SQRDL)
PMUA: 114584461(SQOR)
GJA: 107124460(SQRDL)
XLA: 379770(sqrdl.L) 380565(sqrdl-b)
XTR: 549710(sqor)
NPR: 108796990(SQRDL)
DRE: 550580(sqor)
CCAR: 109109435
IPU: 100304964(sqrdl)
PHYP: 113530085(sqor)
AMEX: 103025164(sqor)
EEE: 113581769(sqor)
LCO: 104940596(sqor)
NCC: 104960093(sqrdl)
MZE: 101475715(sqor)
ONL: 100694767(sqor)
OLA: 101171573(sqor)
XMA: 102221794(sqor)
XCO: 114136958(sqor)
PRET: 103466434(sqrdl)
CVG: 107096715(sqrdl)
NFU: 107395505(sqrdl)
KMR: 108230035(sqor)
ALIM: 106526844(sqrdl)
AOCE: 111577707 111577712(sqor)
CSEM: 103380463(sqrdl)
POV: 109624534(sqrdl)
LCF: 108876667(sqrdl)
SDU: 111229570(sqor)
SLAL: 111658550(sqor)
HCQ: 109507584(sqrdl)
BPEC: 110169311(sqor)
ELS: 105018365(sqor)
SFM: 108942041(sqor)
PKI: 111846664(sqor)
LCM: 102357687(SQRDL)
CMK: 103186591(sqrdl)
RTP: 109915700(sqor)
CIN: 100175914
SPU: 105446119
APLC: 110989700
SKO: 100378456
DME: Dmel_CG14997(CG14997)
DER: 6543723
DSI: Dsimw501_GD13825(Dsim_GD13825)
DSR: 110183569
DPE: 6601902
DMN: 108153404
DWI: 6645221
DAZ: 108612500
DNV: 115563131
DHE: 111597424
MDE: 101897148
LCQ: 111678673
AAG: 5573581
AME: 100577145
BIM: 100743158
BTER: 100642939
CCAL: 108627651
OBB: 114874199
SOC: 105196811
MPHA: 105839154
AEC: 105150250
ACEP: 105624256
PBAR: 105430605
VEM: 105569030
HST: 105189411
DQU: 106742065
CFO: 105258448
LHU: 105669764
PGC: 109855915
OBO: 105284522
PCF: 106794019
NVI: 100119840
CSOL: 105366595
MDL: 103578628
TCA: 659301
DPA: 109536361
ATD: 109595800
NVL: 108557478
BMOR: 101740027
BMAN: 114245409
HAW: 110372031
TNL: 113494746
PXY: 105395554
API: 103309578
DNX: 107173529
AGS: 114122914
RMD: 113559336
BTAB: 109034965
CLEC: 106669712
ZNE: 110833128
FCD: 110862606
TUT: 107365002
DPTE: 113790845
CSCU: 111635210
PTEP: 107444346
CEL: CELE_F02H6.5(sqrd-1) CELE_Y9C9A.16(Y9C9A.16)
CBR: CBG18748
BMY: Bm1_16225
TSP: Tsp_10064
PCAN: 112556938
CRG: 105342276
MYI: 110448710
OBI: 106871235
SHX: MS3_06126
EGL: EGR_07080
EPA: 110240088
ADF: 107340797
AMIL: 114966384
PDAM: 113670775
SPIS: 111324356
DGT: 114522863
HMG: 100214548
AQU: 100642085
MNG: MNEG_8172
NCR: NCU07112
NTE: NEUTE1DRAFT68211(NEUTE1DRAFT_68211)
MGR: MGG_10087
MAW: MAC_08700
ANG: ANI_1_1300034(An03g03640)
PNO: SNOG_12870(SNOG_12869)
SPO: SPBC2G5.06c(hmt2)
CNE: CNK03140
CNB: CNBK0340
HIR: HETIRDRAFT_32066(sqor)
ABP: AGABI1DRAFT111296(AGABI1DRAFT_111296)
ABV: AGABI2DRAFT190518(AGABI2DRAFT_190518)
MGL: MGL_1275
MRT: MRET_2870
DDI: DDB_G0292250(sqrdl)
DFA: DFA_07169(sqrdl)
SMIN: v1.2.018790.t1(symbB.v1.2.018790.t1)
 » show all
Taxonomy
Reference
1  [PMID:10224084]
  Authors
Vande Weghe JG, Ow DW
  Title
A fission yeast gene for mitochondrial sulfide oxidation.
  Journal
J Biol Chem 274:13250-7 (1999)
DOI:10.1074/jbc.274.19.13250
  Sequence
Reference
2  [PMID:18494801]
  Authors
Hildebrandt TM, Grieshaber MK
  Title
Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria.
  Journal
FEBS J 275:3352-61 (2008)
DOI:10.1111/j.1742-4658.2008.06482.x
Reference
3  [PMID:22852582]
  Authors
Jackson MR, Melideo SL, Jorns MS
  Title
Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite.
  Journal
Biochemistry 51:6804-15 (2012)
DOI:10.1021/bi300778t
  Sequence
[hsa:58472]
Reference
4  [PMID:25225291]
  Authors
Libiad M, Yadav PK, Vitvitsky V, Martinov M, Banerjee R
  Title
Organization of the human mitochondrial hydrogen sulfide oxidation pathway.
  Journal
J Biol Chem 289:30901-10 (2014)
DOI:10.1074/jbc.M114.602664
  Sequence
[hsa:58472]
Other DBs
ExplorEnz - The Enzyme Database: 1.8.5.8
IUBMB Enzyme Nomenclature: 1.8.5.8
ExPASy - ENZYME nomenclature database: 1.8.5.8
BRENDA, the Enzyme Database: 1.8.5.8

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