KEGG   ENZYME: 1.8.98.1
Entry
EC 1.8.98.1                 Enzyme                                 
Name
dihydromethanophenazine:CoB-CoM heterodisulfide reductase;
hdrDE (gene names);
CoB---CoM heterodisulfide reductase (ambiguous);
heterodisulfide reductase (ambiguous);
coenzyme B:coenzyme M:methanophenazine oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With other, known, physiological acceptors
Sysname
CoB:CoM:methanophenazine oxidoreductase
Reaction(IUBMB)
CoB + CoM + methanophenazine = CoM-S-S-CoB + dihydromethanophenazine [RN:R04540]
Reaction(KEGG)
R04540
Substrate
CoB [CPD:C04628];
CoM [CPD:C03576];
methanophenazine [CPD:C11903]
Product
CoM-S-S-CoB [CPD:C04832];
dihydromethanophenazine [CPD:C11904]
Comment
This enzyme, found in methanogenic archaea that belong to the Methanosarcinales order, regenerates CoM and CoB after the action of EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It is a membrane-bound enzyme that contains (per heterodimeric unit) two distinct b-type hemes and two [4Fe-4S] clusters. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase and EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase.
History
EC 1.8.98.1 created 2003, modified 2017
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08264  heterodisulfide reductase subunit D
K08265  heterodisulfide reductase subunit E
Genes
DALDalk_1625 Dalk_4954
DTOTOL2_C11570 TOL2_C26590
DMMdnm_031590
DTIDesti_0745 Desti_5348 Desti_5359
SFUSfum_1176 Sfum_1801
DBRDeba_2985
BJUBJ6T_87480
BJPRN69_42255
RHZRHPLAN_09760
BFDNCTC4823_02385(fadF_3)
DDHDesde_0778
DORDesor_4327
FWADCMF_14825
TPZTph_c19580
STEDSPTER_30050(fadF)
NOYEXE57_05600
SACGFDZ84_28325
AABA4R43_03725
PFLAPflav_045230
SBAEDSM104329_00833(fadF_2)
AFOAfer_2003
IPOIlyop_2594
TTZFHG85_09305
BLQL21SP5_02604
MBASALGA_3860
CPICpin_5887
CBAECOR50_13570
CHITFW415_20490
CHIHGWR21_09610
COYHF329_01105
CFILMYF79_25515
CHFKTO58_14505
NKONiako_1556
NSONIASO_03040
NIAA8C56_10605
FLASY85_01580
FGGFSB75_03010
ARBA9P82_03355
ARKD6B99_09835
AGIFSB73_01485
ARACE0W69_001825
ATEEK9M52_02030
FLNFLA_3557
PSEGD3H65_13080
PGINFRZ67_22330
PGOFSB84_26060
FLSGLV81_13430
LACSH4075_16130
FLPLK994_01005
SEDTTEGAF0_07040
HHYHalhy_5427
SGNSGRA_1094
PHEPhep_0746
PEPAQ505_23080
PCMAY601_3496
PSTYBFS30_13330
PGSCPT03_21790
PEJFYC62_09550
PEKFFJ24_002060
PROEH9L23_03405
PEXIZT61_19030
PMUOLOK61_01830
PRKH9N25_02790
PSNPedsa_2286
SHGSph21_2360
SHTKO02_05680
SPHNBV902_09755
SMIZ4412673_03018
SPSCE2P86_13770
SPHZE3D81_07405
SPHEGFH32_04735
SPDRG6053_20940
SDJNCTC13534_04277(glpC)
STHANCTC11429_03180(glpC)
SSPII6J01_13095
SMUII6J00_25295
SSIYJVX97_23120
SFAEMUK51_13280
SCNSolca_0344
MUPA0256_23605
MUCMuYL_1450
MGOTMgSA37_03727
MUHHYN43_029580
MGINFRZ54_22435
MGKFSB76_19545
MRUBDEO27_031095
MGOSDIU38_031635
MMABHQ865_04225
MGIKGO620_015985
AGDFRZ59_17375
OLIFKG96_08805
SBXCA265_02450
CMRCycma_2119
CAMUCA2015_2060
BBDBelba_1407
EVIEchvi_0731
ESTDN752_09990
ECHIFKX85_03275
EMAIKZP23_03890
ALMAO498_01100
MDAIPZ59_05590
CHUCHU_0123(ykgE)
SLISlin_5544
SRDSD10_26905
SMONAWR27_20185
SPIRCWM47_10335
SPIKEXU85_34595
SPIBG8759_01960
STAEHNV11_22985
SRHOHH216_05395
CHRWKA713_12780
RHOZGXP67_16275
DFEDfer_4016
DSNHWI92_17800
DYCNFI80_17455
LBYLbys_2731
RSIRunsl_0024
RUNDR864_25325
RUPDTQ70_03490
EOLEmtol_1497
FAEFAES_0224
FIBA6C57_06130
ALSDJ013_18050
MAQALAG90_13175
FLIFleli_1856
HSWHsw_4302
HYMN008_07815
HYDPK28_02150
HYEAM218_13890
HYGAUC43_04080
HYPA0257_12155
HYZAXW84_19790
HNVDDQ68_14340
HYHD3Y59_13865
HYJFHG12_07860
HRSHER32_10015
HBNGUY19_14455
HTSHMJ29_07845
HMTMTP16_06740
HTBMTX78_22095
PKOPKOR_06740
PACTCA264_17680
RUFTH63_17295
RTIDC20_07905
RUDTH61_06835
NIBGU926_12680
ADDHUW48_06335
ASWUHUW51_07595
MTTFtrac_2753
FPFDCC35_03270
FLMMY04_1429
FLLEI427_09070
FYAKMW28_09060
FKAKM029_01455
FBTD770_15485
CHKD4L85_08130
FUVJR347_04130
GFOGFO_1636
GRLLPB144_03495
GFLGRFL_3307
GRSC7S20_14605
FPSZAMR72_03525
FINKQS_07140
FATDVK85_11295
FKIFK004_14905
FSEDI487_14440
FCCLOS86_06465
FCBLOS89_06780
COCCoch_0507
CCMCcan_16730
COLAM608_06160
CHGAXF12_00090
CAPNCBG49_00915
CGHCGC50_13120
CLKCGC53_04455
CSPUCGC55_07790
CCYNCGC48_02435
CAPHCGC49_10695
CSTOCGC58_10455
CAPQCGC52_10695
CAPFFOC45_10365
RBIRB2501_13274
ZPRZPR_2739
CATCA2559_11058
FBCFB2170_09906
MARMYQ22_14830
MARTBTR34_14710
MARBCJ263_00655
MAREEJ994_06665
CAOCelal_3113
CLYCelly_2605
CLHIX49_13095
CBALM667_12255
CBATM666_12175
KDIKrodi_0073
DOKMED134_03739
DDOI597_2441(glpC_2)
DODDCS32_12010
LANLacal_2576
LVNBWR22_07870
LACICW733_05110
ZGAZOBELLIA_3743
MRSMurru_2302
MLTVC82_2479
MUTGVT53_05650
MAQILDL77_16980
SPONHME9304_02805(glcD)
ASLAeqsu_2744
AEVEI546_02505
AICJK629_12925
PTQP700755_003641
NDODDD_3081
NOMAAT17_00635
NSDBST91_05265
NOBCW736_12440
NOJEJ995_09825
POMMED152_03265
POBLPB03_03590
PRNBW723_15000
POLABXQ17_00410
POACW731_15110
PHALH9I45_15635
PLITK8354_05725
PPECH9W90_07070
PBATJL193_15005
PCEAJ3359_17885
PUNNQP51_05480
MYRMYRA21_2578
MPWMPR_1407
MODAS202_12695
MYZBK054_12245
WINWPG_3012
WIJBWZ20_02500
SZEAW14_11430
AHZAPS56_03640
SYISB49_02315
TDIAUW17_04005
TENLPB136_05965
TJETJEJU_1348
TMARMARIT_1250
TMPF9Y86_13675
LUTLupro_12705
LULLPB138_05940
WFUAXE80_10510
FORFORMB_22460
FOHFORMA_16320
FOPFNB79_12880
SALTAO058_12400
SMISLDL76_14450
SEONBWZ22_15780
AALGAREALGSMS7_03214
OLLCW732_12060
OAQDZC78_01000
FEKC1H87_22755
TAJC1A40_14590
AUEC5O00_12405
KOSKORDIASMS9_03723
KANIMCC3317_06930(lutA)
MARFCJ739_3272
AQBD1818_25055
AQAD1815_07260
AQDD1816_06650
EMARD1013_14235
MUREQY75_04500
PSYNE9099_17240
AFLAFHG64_01125
ANPFK178_04225
OCIFEZ18_01120
MGELG5B37_01925
MESQC7H62_2405
GAAHX109_01440
CAGGHYG79_15380
ALTIALE3EI_2262
MARXINR76_11050
LPALLDL79_12595
SINHLS482_03300
ASAGFGM00_05870
FLBLV704_00080
SABUMBM09_10845
ZSPMQE36_15145
BIAGMA17_04055
FBEFF125_13975
FBMMQE35_02645
SAHNJRG66_14835
FBAFIC_00133
FBUUJ101_02687(glcD)
RANRiean_0988
RAIRA0C_1249
RARRIA_1247
RAGB739_0901
RAEG148_0626
RATM949_1368
WVIWeevi_1441
ORHOrnrh_0443
ORIQ785_07515
EAOBD94_3883
EMNM876_16265
EENBBD30_07550
ELBVO54_02815(lutA_1)
EMGBBD33_04340
EGOBBD34_08460
EGMAYC65_18490
ELZFCS00_11565
ELTFGE20_05480
CHZCHSO_4739
CGNOK18_06595
CIHATE47_18135
CHHA0O34_10450
CIOCEQ15_17035
CHRYCEY12_13240
CPIPCJF12_15465
CHRSEAG08_12580
CHRZCO230_00615
CARHEGY05_20490
CSHAEG350_01140
CNKEG343_12810
CJTEG359_13505
CILEG358_00515
CCAUEG346_07810
CBENEG339_04440
CGLENCTC11432_03055
CTAINCTC12078_02590
CLACEG342_03980
CTAK4412677_01428
CSALNBC122_00751(lutA)
CBPEB354_21035
CNPM0D58_10145
CCAOH5J24_24045
CFAELL667_07705
CRHIKB553_14100
CORZMTP08_13450
CSUPMTP09_13560
CJGNCTC13459_02299(glpC)
CCASEIB73_11365
CANTNCTC13489_02356
KDAEIB71_05390
KHIEG338_04620
KBEJ4771_08155
KFAQ73A0000_13390
KAQL0B70_06465
EVAEIB75_02100
EZEKI430_14495
CNREB819_10230
EBVF0358_08550
EFALFH779_12885
ESTEHNV03_08130
BCADDBX24_03145
APIBG8C43_08415
CIVIMZ16_05810
FBOJ9309_01640
FTEFluta_3389
FLUCHH17_09030
CRMK6119_02815
OHOOweho_0206
CHYDH4K34_16030
BBAUAEM51_14180
MMGMTBMA_c05890
METCMTCT_0104
METEtca_00123(glpC)
METKFVF72_01610
MOLYLM1_0621
METVK4897_09005
MEWMSWAN_1269
METHMBMB1_0927
MSUBBK009_03990
METNBK008_11685
MEMEHYG87_10385
AFGAFULGI_00005160
ASTAsulf_01639
FPLFerp_0942
GACGACE_1903
GAHGAH_00753
MBAMbar_A1598 Mbar_A1599
MBYMSBRM_2859 MSBRM_2860
MBWMSBRW_3132 MSBRW_3133
MBARMSBR2_2817 MSBR2_2818
MBAKMSBR3_1887 MSBR3_1888
MACMA_0687(hdrE) MA_0688(hdrD)
MMAMM_1843(hdrE) MM_1844(hdrD)
MMAZMmTuc01_1919 MmTuc01_1920
MMJMSMAS_2838 MSMAS_2839
MMACMSMAC_1591 MSMAC_1592
MVCMSVAZ_2770 MSVAZ_2771
MEKMSKOL_2763 MSKOL_2764
MLSMSLAZ_0424 MSLAZ_0425
METMMSMTP_2735 MSMTP_2736
MEFMSWH1_0437 MSWH1_0438
MEQMSWHS_0448 MSWHS_0449
MSJMSSAC_0623 MSSAC_0624
MSZMSSIH_0574 MSSIH_0575
MSWMSSIT_0606 MSSIT_0607
MTHRMSTHT_2243 MSTHT_2244
MTHEMSTHC_1036 MSTHC_1037
MHORMSHOH_3536 MSHOH_3537
MFZAOB57_004610 AOB57_004615
MBUMbur_0470 Mbur_2436 Mbur_2437
MMETMCMEM_0578 MCMEM_0579 MCMEM_0900
MELOJ7W08_00925 J7W08_00930 J7W08_03275
MMHMmah_0146 Mmah_0632 Mmah_0633 Mmah_0921
MHAZBHR79_00205 BHR79_00210 BHR79_02695 BHR79_08975
MEVMetev_0541 Metev_0542 Metev_1534
MZHMzhil_0597 Mzhil_0598
MPYMpsy_0935 Mpsy_0936
MZIHWN40_03860 HWN40_03865 HWN40_05290
MHZMetho_1043 Metho_1505 Metho_1506
MTPMthe_0980 Mthe_0981
MCJMCON_3441(hdrE) MCON_3442(hdrD)
MHIMhar_0792 Mhar_0793
MPLMpal_0770 Mpal_0771
MELUMTLP_11950
MEAMMU439_00500
TARTALC_01537
MAXMMALV_16610
MERMMINT_01020
MEARMpt1_c14100(hdrD2)
MARCAR505_0040
ABIAboo_0983
ACFAciM339_1141
BARCAOA65_0539(hdrD_2) AOA65_0555(hdrD_3) AOA65_1721(hdrD_4) AOA65_2237(hdrD_5)
BARBAOA66_1745(hdrD_3) AOA66_1757(hdrD_4)
LOKILokiarch_00520(hdrD_1) Lokiarch_07600(hdrD_4) Lokiarch_10620(hdrD_5) Lokiarch_19710(hdrD_6) Lokiarch_23220 Lokiarch_23520(hdrD_7) Lokiarch_26320(hdrD_9) Lokiarch_40880(hdrD_11)
PSYTDSAG12_01123(hdrD_1) DSAG12_02413(hdrD_2) DSAG12_02953(hdrD_3)
 » show all
Reference
1  [PMID:2121478]
  Authors
Hedderich R, Berkessel A, Thauer RK
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 193:255-61 (1990)
DOI:10.1111/j.1432-1033.1990.tb19331.x
Reference
2  [PMID:9555882]
  Authors
Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U.
  Title
Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1.
  Journal
J Bacteriol 180:2027-32 (1998)
DOI:10.1128/JB.180.8.2027-2032.1998
Reference
3  [PMID:9665708]
  Authors
Simianu M, Murakami E, Brewer JM, Ragsdale SW.
  Title
Purification and properties of the heme- and iron-sulfur-containing heterodisulfide reductase from Methanosarcina thermophila.
  Journal
Biochemistry 37:10027-39 (1998)
DOI:10.1021/bi9726483
Reference
4  [PMID:11034998]
  Authors
Murakami E, Deppenmeier U, Ragsdale SW.
  Title
Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophila.
  Journal
J Biol Chem 276:2432-9 (2001)
DOI:10.1074/jbc.M004809200
Other DBs
ExplorEnz - The Enzyme Database: 1.8.98.1
IUBMB Enzyme Nomenclature: 1.8.98.1
ExPASy - ENZYME nomenclature database: 1.8.98.1
BRENDA, the Enzyme Database: 1.8.98.1

DBGET integrated database retrieval system