EC                 Enzyme                                 

peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase
Acting on a sulfur group of donors;
With other, known, physiological acceptors
peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
ATP [CPD:C00002];
RSH [CPD:C01336]
ADP [CPD:C00008];
phosphate [CPD:C00009];
In the course of the reaction of EC, peroxiredoxin, its cysteine residue is alternately oxidized to the sulfenic acid, S-hydroxycysteine, and reduced back to cysteine. Occasionally the S-hydroxycysteine residue is further oxidized to the sulfinic acid S-hydroxy-S-oxocysteine, thereby inactivating the enzyme. The reductase provides a mechanism for regenerating the active form of peroxiredoxin, i.e. the peroxiredoxin-(S-hydroxycysteine) form. Apparently the reductase first catalyses the phosphorylation of the -S(O)-OH group by ATP to give -S(O)-O-P, which is attached to the peroxiredoxin by a cysteine residue, forming an -S(O)-S- link between the two enzymes. Attack by a thiol splits this bond, leaving the peroxiredoxin as the sulfenic acid and the reductase as the thiol.
EC created 2005
K12260  sulfiredoxin
HSA: 140809(SRXN1)
PTR: 469853(SRXN1)
PPS: 100983325(SRXN1)
GGO: 101149749(SRXN1)
PON: 100437984(SRXN1)
NLE: 100601542(SRXN1)
MCC: 714997(SRXN1)
MCF: 102125068(SRXN1)
CSAB: 103215990(SRXN1)
RRO: 104660811(SRXN1)
RBB: 108544558(SRXN1)
CJC: 100386992(SRXN1)
SBQ: 101043399(SRXN1)
MMU: 76650(Srxn1)
MCAL: 110284183(Srxn1)
MPAH: 110319377(Srxn1)
RNO: 296271(Srxn1)
MUN: 110555824(Srxn1)
CGE: 100759653(Srxn1)
NGI: 103751626(Srxn1)
HGL: 101726463(Srxn1)
CCAN: 109687014(Srxn1)
OCU: 100359116(SRXN1)
TUP: 102471871(SRXN1)
CFA: 100686728(SRXN1)
VVP: 112909942(SRXN1)
AML: 100473816(SRXN1)
UMR: 103674490(SRXN1)
UAH: 113258439(SRXN1)
ORO: 101372818(SRXN1)
ELK: 111141840
FCA: 101090507(SRXN1)
PTG: 102956412(SRXN1)
PPAD: 109272628(SRXN1)
AJU: 106985978(SRXN1)
BTA: 531606(SRXN1)
BOM: 102264913(SRXN1)
BIU: 109567331(SRXN1)
BBUB: 102390007(SRXN1)
CHX: 102180685(SRXN1)
OAS: 101121699(SRXN1)
SSC: 100517736(SRXN1)
CFR: 102517673(SRXN1)
CDK: 105100802(SRXN1)
BACU: 103001633(SRXN1)
LVE: 103086303(SRXN1)
OOR: 101283749(SRXN1)
DLE: 111184345(SRXN1)
PCAD: 102975619(SRXN1)
ECB: 100067865(SRXN1)
EPZ: 103556919(SRXN1)
MYB: 102259833(SRXN1)
MYD: 102763568(SRXN1)
MNA: 107527726(SRXN1)
HAI: 109384433(SRXN1)
DRO: 112304136(SRXN1)
PALE: 102883256(SRXN1)
RAY: 107512909(SRXN1)
MJV: 108401945(SRXN1)
LAV: 100655164(SRXN1)
MDO: 100012125(SRXN1)
SHR: 100916952(SRXN1)
PCW: 110211401(SRXN1)
OAA: 100089356(SRXN1)
GGA: 100858692(SRXN1)
MGP: 104914015(SRXN1)
CJO: 107323173(SRXN1)
NMEL: 110408366(SRXN1)
APLA: 113845774(SRXN1)
TGU: 100222859(SRXN1)
LSR: 110468987(SRXN1)
SCAN: 103818679(SRXN1)
GFR: 102035740(SRXN1)
FAB: 101815811(SRXN1)
PHI: 102103918(SRXN1)
PMAJ: 107213136(SRXN1)
CCAE: 111938130(SRXN1)
CCW: 120411063(SRXN1)
ETL: 114062977(SRXN1)
FPG: 101921005(SRXN1)
FCH: 102057426(SRXN1)
CLV: 102098754(SRXN1)
NNI: 104011939(SRXN1)
ASN: 102382329(SRXN1)
AMJ: 102564303(SRXN1)
CMY: 102934189(SRXN1)
CPIC: 101932001(SRXN1)
ACS: 103280288(srxn1)
PVT: 110086046(SRXN1)
PBI: 103068041(SRXN1)
TSR: 106546624(SRXN1)
PMUA: 114598386(SRXN1)
GJA: 107109820(SRXN1)
XTR: 116408042(srxn1)
NPR: 108786987(SRXN1)
DRE: 100331561(srxn1)
SRX: 107711830(srxn1)
SANH: 107680324(srxn1)
SGH: 107594516(srxn1)
CCAR: 109083350(srxn1)
IPU: 108264881(srxn1)
PHYP: 113537236(srxn1)
AMEX: 103029943(srxn1)
EEE: 113591011(srxn1)
TRU: 101063345(srxn1)
LCO: 104919946(srxn1)
NCC: 104943988(srxn1)
MZE: 101487142(srxn1)
ONL: 100711804(srxn1)
XMA: 102218601(srxn1)
XCO: 114141060(srxn1)
PRET: 103467763(srxn1)
CVG: 107090713(srxn1)
KMR: 108249563(srxn1)
ALIM: 106522947(srxn1)
AOCE: 111572118(srxn1)
LCF: 108890476(srxn1)
BPEC: 110164815(srxn1)
SASA: 106567196(srxn1)
OTW: 112221419(srxn1)
SALP: 111976825(srxn1)
ELS: 105022325(srxn1)
SFM: 108939220(srxn1)
LCM: 102367152(SRXN1)
CMK: 103188622(srxn1)
RTP: 109938980(srxn1)
BFO: 118419255
CIN: 100185108
SPU: 764239
APLC: 110975776
SKO: 100377903
DME: Dmel_CG6762(CG6762)
DER: 6550168
DSE: 6614794
DSI: Dsimw501_GD17370(Dsim_GD17370)
DSR: 110181505
DPE: 6597572
DMN: 108164569
DWI: 6649225
DAZ: 108618930
DNV: 108656228
DHE: 111596728
DVI: 6634585
MDE: 101889303
LCQ: 111688833
AAG: 5578621
CCAL: 113464399
SOC: 105195926
MPHA: 105835928
AEC: 105150043
ACEP: 105620649
PBAR: 105426939
VEM: 105558812
HST: 105182533
DQU: 106745483
CFO: 105253157
LHU: 105670259
OBO: 113561391
PCF: 106785213
CSOL: 105364370
MDL: 103576855
TCA: 663169
DPA: 109535847
NVL: 108566869
BMOR: 101735518
BMAN: 114242615
PMAC: 106711988
PRAP: 110991803
HAW: 110374621
TNL: 113494613
PXY: 105398636
API: 100161553
DNX: 107170591
AGS: 114124508
RMD: 113551530
BTAB: 109032454
ZNE: 110832200
TUT: 107362143
DPTE: 113790247
CSCU: 111637813
PTEP: 107448169
CRG: 105322669
OBI: 106871679
LAK: 106176400
NVE: 5520071
ADF: 107352059
AMIL: 114975764
PDAM: 113682404
SPIS: 111332304
ATH: AT1G31170(SRX)
ALY: 9327189
CRB: 17898306
BRP: 103833827
BOE: 106325136
RSZ: 108820781
THJ: 104798553
CPAP: 110817809
CIT: 102612116
TCC: 18607054
GRA: 105763059
GAB: 108477170
DZI: 111298228
EGR: 104445793
GMX: 100527425
GSJ: 114403855
VRA: 106766966
VAR: 108334637
VUN: 114176771
CCAJ: 109806087
CAM: 101497213
LJA: Lj4g3v0654390.1(Lj4g3v0654390.1) Lj5g3v0309110.1(Lj5g3v0309110.1)
ADU: 107484129
AIP: 107639269
LANG: 109341411
FVE: 101291900
PPER: 18779336
PMUM: 103325453
PAVI: 110770623
MDM: 103435288
ZJU: 107425505
CSV: 101217757
CMO: 103498252
MCHA: 111012631
RCU: 8289489
JCU: 105629049
HBR: 110632536
MESC: 110603166
POP: 7453987
PEU: 105129523
JRE: 109003588
QSU: 111986909
VVI: 100245605
SLY: 101260008
SPEN: 107011242
SOT: 102592429
CANN: 107857945
NSY: 104216162
NTO: 104089833
NAU: 109209612
INI: 109147294
SIND: 105175880
OEU: 111370425
HAN: 110895872
LSV: 111882054
CCAV: 112512707
DCR: 108204245
BVG: 104892382
SOE: 110784360
NNU: 104599677
PSOM: 113290058
OSA: 9268874
DOSA: Os06t0174300-01(Os06g0174300)
OBR: 102719394
BDI: 100838881
ATS: 109752607
SBI: 8076174
SITA: 101770539
EGU: 105056125
MUS: 103978725
DCT: 110110974
PEQ: 110023413
AOF: 109833405
ATR: 18448098
PPP: 112284903
APRO: F751_3028
ERC: Ecym_3406
KMX: KLMA_60166(SRX1)
NCS: NCAS_0H03330(NCAS0H03330)
NDI: NDAI_0C00330(NDAI0C00330)
TPF: TPHA_0L02000(TPHA0L02000)
TBL: TBLA_0A00770(TBLA0A00770)
TDL: TDEL_0B07360(TDEL0B07360)
KAF: KAFR_0C03950(KAFR0C03950)
CAL: CAALFM_C205060CA(CaO19.3537)
SPO: SPBC106.02c(srx1)
CNE: CNA06340
DFA: DFA_09143
PAMO: BAR1_16660
SYG: sync_2409
CYA: CYA_0926
CYB: CYB_1043
AMR: AM1_5201
MAR: MAE_40190
MPK: VL20_2886
NSH: GXM_05120
AVA: Ava_0758
CALH: IJ00_23395
CTHE: Chro_2871
 » show all
1  [PMID:14586471]
Biteau B, Labarre J, Toledano MB
ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin.
Nature 425:980-4 (2003)
2  [PMID:15448164]
Chang TS, Jeong W, Woo HA, Lee SM, Park S, Rhee SG
Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine.
J Biol Chem 279:50994-1001 (2004)
[hsa:140809] [mmu:76650]
3  [PMID:15590625]
Woo HA, Jeong W, Chang TS, Park KJ, Park SJ, Yang JS, Rhee SG.
Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins.
J Biol Chem 280:3125-8 (2005)
Other DBs
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IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 710319-61-2

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