KEGG   ENZYME: 1.8.98.2
Entry
EC 1.8.98.2                 Enzyme                                 
Name
sulfiredoxin;
Srx1;
sulphiredoxin;
peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With other, known, physiological acceptors
Sysname
peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]
Reaction(IUBMB)
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
Substrate
peroxiredoxin-(S-hydroxy-S-oxocysteine);
ATP [CPD:C00002];
RSH [CPD:C01336]
Product
peroxiredoxin-(S-hydroxycysteine);
ADP [CPD:C00008];
phosphate [CPD:C00009];
R-S-S-R
Comment
In the course of the reaction of EC 1.11.1.15, peroxiredoxin, its cysteine residue is alternately oxidized to the sulfenic acid, S-hydroxycysteine, and reduced back to cysteine. Occasionally the S-hydroxycysteine residue is further oxidized to the sulfinic acid S-hydroxy-S-oxocysteine, thereby inactivating the enzyme. The reductase provides a mechanism for regenerating the active form of peroxiredoxin, i.e. the peroxiredoxin-(S-hydroxycysteine) form. Apparently the reductase first catalyses the phosphorylation of the -S(O)-OH group by ATP to give -S(O)-O-P, which is attached to the peroxiredoxin by a cysteine residue, forming an -S(O)-S- link between the two enzymes. Attack by a thiol splits this bond, leaving the peroxiredoxin as the sulfenic acid and the reductase as the thiol.
History
EC 1.8.98.2 created 2005
Orthology
K12260  sulfiredoxin
Genes
HSA140809(SRXN1)
PTR469853(SRXN1)
PPS100983325(SRXN1)
GGO101149749(SRXN1)
PON100437984(SRXN1)
NLE100601542(SRXN1)
MCC714997(SRXN1)
MCF102125068(SRXN1)
MTHB126964317
CSAB103215990(SRXN1)
CATY105582200(SRXN1)
PANU101003655(SRXN1)
TGE112607937 112633670(SRXN1)
RRO104660811(SRXN1)
RBB108544558(SRXN1)
TFN117068591(SRXN1)
PTEH111548111(SRXN1)
CANG105525177(SRXN1)
CJC100386992(SRXN1)
SBQ101043399(SRXN1)
MMUR105866069(SRXN1)
LCAT123622880(SRXN1)
PCOQ105804973(SRXN1)
OGA100949744(SRXN1)
MMU76650(Srxn1)
MCAL110284183(Srxn1)
MPAH110319377(Srxn1)
RNO296271(Srxn1)
MCOC116091158(Srxn1)
MUN110555824(Srxn1)
CGE100759653(Srxn1)
MAUA101826522(Srxn1)
PLEU114705553(Srxn1)
MORG121460472(Srxn1)
MFOT126506914
AAMP119815808(Srxn1)
NGI103751626(Srxn1)
HGL101726463(Srxn1)
CPOC100715729(Srxn1)
CCAN109687014(Srxn1)
DSP122120293(Srxn1)
NCAR124977657
OCU100359116
OPI101522193(SRXN1)
TUP102471871(SRXN1)
GVR103583599 103593136(SRXN1)
CFA100686728(SRXN1)
CLUD112673736(SRXN1)
VVP112909942(SRXN1)
VLG121478190(SRXN1)
AML100473816(SRXN1)
UMR103674490(SRXN1)
UAH113258439(SRXN1)
UAR123798821(SRXN1)
ELK111141840
LLV125109279
MPUF101689474(SRXN1)
ORO101372818(SRXN1)
EJU114220702(SRXN1)
ZCA113937092(SRXN1)
MLX118011367(SRXN1)
NSU110579454(SRXN1)
LWW102733819(SRXN1)
FCA101090507(SRXN1)
PBG122496442(SRXN1)
LRUF124503333
PTG102956412(SRXN1)
PPAD109272628(SRXN1)
AJU106985978(SRXN1)
HHV120235469(SRXN1)
BTA531606(SRXN1)
BOM102264913(SRXN1)
BIU109567331(SRXN1)
BBUB102390007(SRXN1)
BBIS104990013(SRXN1)
CHX102180685(SRXN1)
OAS101121699(SRXN1)
ODA120868785(SRXN1)
CCAD122448415(SRXN1)
SSC100517736(SRXN1)
CFR102517673(SRXN1)
CDK105100802(SRXN1)
VPC102533423(SRXN1)
BACU103001633(SRXN1)
LVE103086303(SRXN1)
OOR101283749(SRXN1)
DLE111184345(SRXN1)
PCAD102975619(SRXN1)
PSIU116740946(SRXN1)
ECB100067865(SRXN1)
EPZ103556919(SRXN1)
EAI106833752(SRXN1)
MYB102259833(SRXN1)
MYD102763568(SRXN1)
MMYO118663214(SRXN1)
MLF102436660(SRXN1)
MNA107527726(SRXN1)
PKL118707826(SRXN1)
HAI109384433(SRXN1)
DRO112304136(SRXN1)
SHON118985587(SRXN1)
AJM119047704(SRXN1)
PDIC114506574(SRXN1)
PHAS123814813(SRXN1)
MMF118618549(SRXN1)
RFQ117016206(SRXN1)
PALE102883256(SRXN1)
PGIG120603497(SRXN1)
PVP105305485(SRXN1)
RAY107512909(SRXN1)
MJV108401945(SRXN1)
TOD119254090(SRXN1)
SARA101540746(SRXN1)
LAV100655164(SRXN1)
ETF101641474(SRXN1)
MDO100012125(SRXN1)
GAS123235410(SRXN1)
SHR100916952(SRXN1)
PCW110211401(SRXN1)
OAA100089356(SRXN1)
GGA100858692(SRXN1)
PCOC116227797(SRXN1)
MGP104914015(SRXN1)
CJO107323173(SRXN1)
NMEL110408366(SRXN1)
APLA113845774(SRXN1)
AFUL116495638(SRXN1)
TGU100222859(SRXN1)
LSR110468987(SRXN1)
SCAN103818679(SRXN1)
PMOA120507173(SRXN1)
OTC121331559(SRXN1)
GFR102035740(SRXN1)
FAB101815811(SRXN1)
PHI102103918(SRXN1)
PMAJ107213136(SRXN1)
CCAE111938130(SRXN1)
CCW120411063(SRXN1)
CBRC103616119(SRXN1)
ETL114062977(SRXN1)
FPG101921005(SRXN1)
FCH102057426(SRXN1)
CLV102098754(SRXN1)
NNI104011939(SRXN1)
TALA122154172(SRXN1)
ACHC115339195(SRXN1)
HLE104832980(SRXN1)
DPUB104301404(SRXN1)
CPEA104392871(SRXN1)
CVF104293868(SRXN1)
CUCA104060808(SRXN1)
NPD112949488(SRXN1)
ASN102382329(SRXN1)
AMJ102564303(SRXN1)
CPOO109313062(SRXN1)
GGN109292537(SRXN1)
CMY102934189(SRXN1)
CPIC101932001(SRXN1)
TST117885867(SRXN1)
CABI116816827(SRXN1)
MRV120380932(SRXN1)
ACS103280288(srxn1)
PVT110086046(SRXN1)
SUND121929258(SRXN1)
PBI103068041(SRXN1)
CTIG120313645(SRXN1)
TSR106546624(SRXN1)
PGUT117656987(SRXN1)
VKO123036494(SRXN1)
PMUA114598386(SRXN1)
ZVI118078053 118088996(SRXN1)
GJA107109820(SRXN1)
STOW125432984(SRXN1)
XLA108700963 108702679
XTR116408042(srxn1)
NPR108786987(SRXN1)
RTEM120918626(SRXN1)
BBUF121003714(SRXN1)
BGAR122940737(SRXN1)
DRE100331561(srxn1)
SRX107711830(srxn1)
SANH107680324(srxn1)
SGH107594516(srxn1)
CCAR109083350(srxn1)
CAUA113107523(srxn1)
PPRM120484256(srxn1)
MAMB125280324(srxn1)
IPU108264881(srxn1)
PHYP113537236(srxn1)
SMEO124400035(srxn1)
TFD113655732(srxn1)
AMEX103029943(srxn1)
EEE113591011(srxn1)
TRU101063345(srxn1)
TNGGSTEN00023462G001
LCO104919946(srxn1)
NCC104943988(srxn1)
CGOB115005600(srxn1)
ELY117258745(srxn1)
EFO125892125(srxn1)
PLEP121947163(srxn1)
SLUC116043557(srxn1)
ECRA117948275(srxn1)
ESP116692099(srxn1)
PFLV114559216(srxn1)
GAT120829452(srxn1)
PPUG119205318(srxn1)
MSAM119906133(srxn1)
CUD121517017(srxn1)
ALAT119022222(srxn1)
MZE101487142(srxn1)
ONL100711804(srxn1)
OAU116317183(srxn1)
OML112158999(srxn1)
XMA102218601(srxn1)
XCO114141060(srxn1)
XHE116713502(srxn1)
PRET103467763(srxn1)
PFOR103139107(srxn1)
PLAI106952851(srxn1)
PMEI106916823(srxn1)
GAF122838785(srxn1)
CVG107090713(srxn1)
CTUL119799461(srxn1)
GMU124869067(srxn1)
KMR108249563(srxn1)
ALIM106522947(srxn1)
NWH119416729(srxn1)
AOCE111572118(srxn1)
MCEP125013771(srxn1)
LCF108890476
XGL120803883(srxn1)
BPEC110164815(srxn1)
BSPL114858660(srxn1)
SASA106567196(srxn1)
STRU115168025(srxn1)
OTW112221419(srxn1)
OMY110492129(srxn1)
OGO124045124(srxn1)
ONE115101672(srxn1)
SALP111976825(srxn1)
SNH120058886(srxn1)
CCLU121546712(srxn1)
ELS105022325(srxn1)
SFM108939220(srxn1)
AANG118207420(srxn1)
LOC102692306(srxn1)
PSPA121297921(srxn1)
ARUT117397656(srxn1)
LCM102367152(SRXN1)
RTP109938980(srxn1)
BFO118419255
BBEL109474874
CIN100185108
SCLV120345031
SPU764239
APLC110975776
SKO100377903
DMEDmel_CG6762(CG6762)
DER6550168
DSE6614794
DSIDsimw501_GD17370(Dsim_GD17370)
DYADyak_GE17693
DSR110181505
DPO4815226
DPE6597572
DMN108164569
DWI6649225
DGR6564592
DMODmoj_GI16197
DAZ108618930
DNV108656228
DHE111596728
DVI6634585
CCAT101460192
BOD106614294
RZE108368272 108382211
MDE101889303
SCAC106084421
LCQ111688833
LSQ119603626
HIS119657125
AAG5578621
AALB109422140 115260348
CQUCpipJ_CPIJ009003
CPII120413366
BBIF117208092
BVK117235395
BVAN117153788
BPYO122565793
CCAL113464399
CGIG122398454
SOC105195926
MPHA105835928
AEC105150043
ACEP105620649
PBAR105426939
VEM105558812
HST105182533
DQU106745483
CFO105253157
FEX115241774
LHU105670259
OBO113561391
PCF106785213
PFUC122525772
VPS122633638
CSOL105364370
MDL103576855
CGLO123272537
FAS105273421
LHT122506920
TCA663169
DPA109535847
SOY115874998
ATD109600740 109607006
AGB108910007
NVL108566869
APLN108741208
OTU111427986
BMOR101735518
BMAN114242615
MSEX115453820
DPLKGM_208841
BANY112056065
NIQ126777808
PMAC106711988
PPOT106108060
PXU106117215
PRAP110991803
PBX123718378
PNAP125063399
ZCE119830477
CCRC123702993
HAW110374621
HZE124638731
TNL113494613
SLIU111352935
OFU114351916
PXY105398636
CFEL113387883
API100161553
DNX107170591
AGS114124508
RMD113551530
BTAB109032454
NLU111058796
PHUPhum_PHUM488840
FOC113207346
TPAL117641684
ZNE110832200
CSEC111865301
SGRE126298515
DPXDAPPUDRAFT_329227 DAPPUDRAFT_62353 DAPPUDRAFT_63423 DAPPUDRAFT_70136
DMK116924610
DPZ124342467
ISCIscW_ISCW011176 IscW_ISCW024306 IscW_ISCW024409
DSV119436546 119436661 119437120 119459716
RSAN119395227 119395254
RMP119161226 119161227 119161228
TUT107362143
DPTE113790247
DFR124495439
CSCU111637813
PTEP107448169
SDM118203487
LGILOTGIDRAFT_205973
GAE121383169
CRG105322669
MMER123551732
OBI106871679
OSN118765500
LAK106176400
NVE5520071
EPA110231940 110236394
ATEN116294958 116302800
ADF107352059
AMIL114975764
PDAM113682404
SPIS111332304
ATHAT1G31170(SRX)
ALY9327189
CRB17898306
CSAT104741702 104757511 104777154
EUSEUTSA_v10009117mg
BRP103833827
BNA106390216 106390584
BOE106325136
RSZ108820781
THJ104798553
CPAP110817809
CIT102612116
CICCICLE_v10017175mg
PVY116126520
MINC123227178 123227181
TCC18607054
GRA105763059
GHI107928688 107945222
GAB108477170
DZI111298228
EGR104445793
GMX100527425
GSJ114403855
PVUPHAVU_002G097300g
VRA106766966
VAR108334637
VUN114176771
CCAJ109806087
APRC113858423
MTR11444056
CAM101497213
PSAT127100356
LJALj4g3v0654390.1(Lj4g3v0654390.1) Lj5g3v0309110.1(Lj5g3v0309110.1)
ADU107484129
AIP107639269
AHF112741980 112796699
LANG109341411
FVE101291900
RCN112174098 112184280 112201957 121049478
PPER18779336
PMUM103325453
PAVI110770623
PDUL117623980
MDM103435288
ZJU107425505
MNT21401464
CSV101217757
CMO103498252
BHJ120083365
MCHA111012631
CMAX111490496 111495694
CMOS111434089 111456749
CPEP111782623 111801588
RCU8289489
JCU105629049
HBR110632536
MESC110603166
POP7453987
PEU105129523
PALZ118060627
JRE109003588
CILL122275264
QSU111986909
QLO115967297
TWL120005808
VVI100245605
VRI117915930
SLY101260008
SPEN107011242
SOT102592429
SSTN125848616
CANN107857945
NTA107764730 107776142
NSY104216162
NTO104089833
NAU109209612
INI109147294
ITR116026842
SIND105175880
OEU111370425
EGT105950900
SSPL121768821
APAN127247266
HAN110895872
ECAD122595351
LSV111882054
CCAV112512707
DCR108204245
CSIN114271539
BVG104892382
SOE110784360
CQI110702539 110719418
NNU104599677
MING122076698
TSS122638547
PSOM113290058
OSA9268874
DOSAOs06t0174300-01(Os06g0174300)
OBR102719394
BDI100838881
ATS109752607
TDC119332020 119338577 119341213 119341227
TAES123152686 123153088 123155712 123158909 123164497 123166110 123166710 123170405
TUA125523824 125533825
LPER127318025 127318026
SBI8076174
ZMA100194080 103649094
SITA101770539
SVS117852784
PVIR120670044 120702774
PHAI112890891
EGU105056125
MUS103978725
ZOF121982494 121986399
DCT110110974
PEQ110023413
AOF109833405
NCOL116267612
ATR18448098
SMOSELMODRAFT_103767 SELMODRAFT_18837
PPP112284903
CRECHLRE_05g232800v5 CHLRE_17g729950v5
VCNVOLCADRAFT_105833 VOLCADRAFT_59680
CSLCOCSUDRAFT_19571
CVRCHLNCDRAFT_59633
APROF751_3028
MPPMICPUCDRAFT_9111
SCEYKL086W(SRX1)
SEUBDI49_3289
SPAOSPAR_K01260
AGOAGOS_ADR152CA
ERCEcym_3406
KLAKLLA0_F25938g
KMXKLMA_60166(SRX1)
LTHKLTH0C01144g
VPOKpol_1073p6
ZROZYRO0E00858g
CGRCAGL0L05258g
NCSNCAS_0H03330(NCAS0H03330)
NDINDAI_0C00330(NDAI0C00330)
TPFTPHA_0L02000(TPHA0L02000)
TBLTBLA_0A00770(TBLA0A00770)
TGBHG536_0G00430
TDLTDEL_0B07360(TDEL0B07360)
KAFKAFR_0C03950(KAFR0C03950)
ZMKHG535_0E04540
PPAPAS_chr2-1_0236
DHADEHA2C06270g
PICPICST_34284
PGUPGUG_05341
SPAASPAPADRAFT_55210
LELLELG_00954
CALCAALFM_C205060CA(CaO19.3537)
CTPCTRG_01656
COTCORT_0A09415
CDUCD36_19570
CTENCANTEDRAFT_92582
YLIYALI0D16709g
CLUCLUG_02779
CLUSA9F13_07g00517
CAURCJI97_000171
PKZC5L36_0B03650
BNNFOA43_002218
BBRXBRETT_004988
OPAHPODL_00698
SLUDSCDLUD_003098
NPAUCRNP2_673
SPOSPBC106.02c(srx1)
CNECNA06340
CNBCNBA6150
CNGCNAG_00654
CGICGB_A7130W
TMSTREMEDRAFT_19218
WSEWALSEDRAFT_29138
WICJ056_003254
DPPDICPUDRAFT_12802
DFADFA_09143
ACANACA1_111970
NGRNAEGRDRAFT_67173
MESWA9K65_020825
THWBMG03_13230
SALOEF888_05700
PAMOBAR1_16660
HDHG5B40_12620
SYUM744_02535
SYGsync_2409
SYXSynWH7803_2510
CYACYA_0926
CYBCYB_1043
SYNESyn6312_0045
DSLDacsa_2887
CYICBM981_2446
AMRAM1_5201
TVNNIES2134_104450
SLWBRW62_07375
THNNK55_01220
THECFFX45_10485
LENLEP3755_60040
LETO77CONTIG1_04452
LBOLBWT_42560
KOVK9N68_27510
LSCKIK02_15350
LSKJ5X98_16985
HHGXM38_017170
THEUHPC62_19295
GLPGlo7428_0286
MARMAE_40190
MPKVL20_2886
MIQB5D77_04865
MVZmyaer102_14950
HAOPCC7418_2682
ENNFRE64_11415
CYPPCC8801_3317
CYHCyan8802_2800
CYCPCC7424_0989
CYJCyan7822_4546
CYNCyan7425_4330
OXYHCG48_20895
GEIGEI7407_2690
OACOscil6304_4403
ONIOsc7112_6102
MPROBJP34_01705
CEPCri9333_0113
NOSNos7107_2539
NOPNos7524_0958
NONNOS3756_15180
NOECLI64_06710
NSHGXM_05120
AVAAva_0758
ACYAnacy_0621
ANNEH233_04530
CSGCylst_4444
RSINB6N60_00450
CALOCal7507_5873
CALTCal6303_0123
CALHIJ00_23395
RIVRiv7116_4311
FISFIS3754_15990
NSPBMF81_03423
TOQHCG51_33220
NCNBZZ01_06615
CTHEChro_2871
PLPPle7327_4606
SCSSta7437_4431
STANSTA3757_16610
 » show all
Reference
1  [PMID:14586471]
  Authors
Biteau B, Labarre J, Toledano MB
  Title
ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin.
  Journal
Nature 425:980-4 (2003)
DOI:10.1038/nature02075
  Sequence
[sce:YKL086W]
Reference
2  [PMID:15448164]
  Authors
Chang TS, Jeong W, Woo HA, Lee SM, Park S, Rhee SG
  Title
Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine.
  Journal
J Biol Chem 279:50994-1001 (2004)
DOI:10.1074/jbc.M409482200
  Sequence
[hsa:140809] [mmu:76650]
Reference
3  [PMID:15590625]
  Authors
Woo HA, Jeong W, Chang TS, Park KJ, Park SJ, Yang JS, Rhee SG.
  Title
Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins.
  Journal
J Biol Chem 280:3125-8 (2005)
DOI:10.1074/jbc.C400496200
  Sequence
[hsa:140809]
Other DBs
ExplorEnz - The Enzyme Database: 1.8.98.2
IUBMB Enzyme Nomenclature: 1.8.98.2
ExPASy - ENZYME nomenclature database: 1.8.98.2
BRENDA, the Enzyme Database: 1.8.98.2
CAS: 710319-61-2

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