KEGG ENZYME: 1.8.99.2

ENZYME: 1.8.99.2

Entry

EC 1.8.99.2                 Enzyme

Name

adenylyl-sulfate reductase;
adenosine phosphosulfate reductase;
adenosine 5'-phosphosulfate reductase;
APS-reductase;
APS reductase;
AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)

Class

Oxidoreductases;
Acting on a sulfur group of donors;
With unknown physiological acceptors

Sysname

AMP,sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)

Reaction(IUBMB)

AMP + sulfite + acceptor = adenylyl sulfate + reduced acceptor [RN:R00860]

Reaction(KEGG)

R00860 > R08553;
(other) R04927

Substrate

AMP [CPD:C00020];
sulfite [CPD:C00094];
acceptor [CPD:C00028]

Product

adenylyl sulfate [CPD:C00224];
reduced acceptor [CPD:C00030]

Comment

An iron flavoprotein (FAD). Methyl viologen can act as acceptor.

History

EC 1.8.99.2 created 1972

Pathway

ec00920

Sulfur metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K00394

adenylylsulfate reductase, subunit A

K00395

adenylylsulfate reductase, subunit B

Genes

TIG:	THII_3105 THII_3106

THIS:

HZT40_21240(aprB) HZT40_21245

TUN:	J9260_16720(aprB) J9260_16725

TLO:	J9253_18120(aprB) J9253_18125

TSB:	HMY34_11175(aprB) HMY34_11180

TANI:

J8380_05600 J8380_12965(aprB) J8380_12970

TWN:	L2Y54_05785(aprB) L2Y54_05790(aprA)

TLC:	RCF98_10685(aprB) RCF98_10690(aprA)

TSJ:	L3K52_04575(aprB) L3K52_04580(aprA)

TPUT:

QJT81_03285(aprB) QJT81_03290(aprA)

ALV:	Alvin_1120 Alvin_1121

ATEP:

Atep_15380 Atep_15390

TVI:	Thivi_3299 Thivi_3300

TMB:	Thimo_1219 Thimo_1220

TSY:	THSYN_16395 THSYN_16400

TTP:	E6P07_06890 E6P07_06895(aprB)

THIP:

N838_08140 N838_08145(aprB) N838_10735(aprB) N838_10740

CJAP:

GWK36_04765(aprB) GWK36_04770

THIM:

KFB96_04245(aprB) KFB96_04250

TBOG:

LT988_00210(aprA) LT988_00215(aprB)

TLR:	Thiosp_01613(aprB) Thiosp_01614(aprA)

TFRI:

Thiofri_03807(aprA) Thiofri_03808(aprB)

TWG:	Thiowin_00433(aprB) Thiowin_00434(aprA)

TGR:	Tgr7_0350 Tgr7_0351

TKM:	TK90_0064 TK90_0065

TNI:	TVNIR_3611 TVNIR_3612

TTI:	THITH_01410 THITH_01415

TBN:	TBH_C0421 TBH_C0422

EPS:	L0Y14_00895(aprB) L0Y14_00900(aprA)

SEDS:

AAY24_12255 AAY24_12260

TTC:	FOKN1_1662 FOKN1_1663

THIC:

TspCOW1_09810 TspCOW1_09820

SLIM:

SCL_0600 SCL_0601 SCL_2473 SCL_2474

SVA:	SVA_2607 SVA_2608 SVA_3564 SVA_3565

ACII:

C4901_07620(aprA) C4901_07625(aprB) C4901_14675(aprB) C4901_14680(aprA)

ATY:	A9R16_009310(aprA) A9R16_009315(aprB) A9R16_013560(aprB) A9R16_013565(aprA)

TSN:	W908_01270 W908_01275

THIN:

CRN91_00270(aprB) CRN91_00275(aprA)

THO:	SP60_04585 SP60_04590

REV:	HUE57_00495 HUE57_00500(aprB)

RMA:	Rmag_0087 Rmag_0088

REO:	HUE58_06190(aprB) HUE58_06195

VOK:	COSY_0091(aprB) COSY_0092(aprA)

EBH:	BSEPE_0126(aprB) BSEPE_0127(aprA)

BTHG:

MS2017_2046 MS2017_2047

ENM:	EBS_2148(aprA) EBS_2149(aprB)

IFO:	CVFO_0391(aprB) CVFO_0392(aprA)

APHF:

CVPH_1379(aprA) CVPH_1380(aprB)

SHD:	SUTH_02771(aprA) SUTH_02772(aprB)

NPV:	OHM77_12500(aprB) OHM77_12505(aprA)

TBD:	Tbd_0872 Tbd_0873 Tbd_2282 Tbd_2283

TSW:	VA613_04525(aprA) VA613_04530(aprB)

SLT:	Slit_1714 Slit_1715

SEME:

MIZ01_1494 MIZ01_1495

SDR:	SCD_n01726(aprB) SCD_n01727(aprA)

SPLB:

SFPGR_21700 SFPGR_21710(aprB) SFPGR_28000(aspB) SFPGR_28010(apsA)

SLAC:

SKTS_25230(aspB) SKTS_25240(apsA) SKTS_27380 SKTS_27390

DDZ:	DSYM_23230 DSYM_23240

FIL:	BN1229_v1_3249 BN1229_v1_3251

FIY:	BN1229_v1_2672 BN1229_v1_2673

MAGQ:

MGMAQ_3494 MGMAQ_3495

VSU:	P3M64_01125(aprB) P3M64_01130(aprA)

PUB:	SAR11_0836(aprB) SAR11_0837(aprA)

PEG:	E5R92_01800 E5R92_01805(aprB)

APM:	HIMB5_00004970 HIMB5_00004980

DDS:	Ddes_2129 Ddes_2130

DFI:	AXF13_12610 AXF13_12615

DPG:	DESPIGER_1662 DESPIGER_1663 DESPIGER_2209 DESPIGER_2210

DEF:	CNY67_01435(aprB) CNY67_01440(aprA)

DTR:	RSDT_0365(aprA) RSDT_0366(aprB)

DFL:	DFE_2055 DFE_2056

PSYF:

N1030_16805(aprB) N1030_16810(aprA)

DSB:	LN040_15555(aprB) LN040_15560(aprA)

DMA:	DMR_05390(aprB) DMR_05400(aprA) DMR_29670 DMR_29680

DCB:	C3Y92_17705(aprA) C3Y92_17710(aprB)

DGG:	DGI_0457(aprA) DGI_0458(aprB)

DDE:	Dde_1109 Dde_1110

DMS:	E8L03_09650 E8L03_09655(aprB)

DSA:	Desal_0229 Desal_0230

DHY:	DESAM_20543(aprA) DESAM_20544

DAF:	Desaf_0100 Desaf_0101 Desaf_0338 Desaf_0339

DAS:	Daes_3033 Daes_3034

DPI:	BN4_11809(aprA) BN4_11810(aprB)

DEJ:	AWY79_04195 AWY79_04200

PPRF:

DPRO_2420(aprB) DPRO_2421(aprA)

PSEL:

GM415_07085(aprB) GM415_07090

DDN:	DND132_2643 DND132_2644

PSEF:

PSDVSF_18940(aprA) PSDVSF_18950(aprB)

PPOR:

JCM14722_15710(aprA) JCM14722_15720(aprB)

PNW:	SYK_21010(aprA) SYK_21020(aprB)

PTHE:

LF599_17890(aprB) LF599_17895(aprA)

PMEN:

V8V93_01105(aprA) V8V93_01110(aprB)

DSX:	GD604_03185(aprB) GD604_03190

DSD:	GD606_15920(aprB) GD606_15925

PBIZ:

LWC08_14795(aprA) LWC08_14800(aprB)

DVU:	DVU_0846(aprB) DVU_0847(aprA)

DVL:	Dvul_2136 Dvul_2137

DVM:	DvMF_1709 DvMF_1710 DvMF_2892 DvMF_2893

DVG:	Deval_0776 Deval_0777

CLIH:

KPS_001952 KPS_001953 KPS_003337(aprB) KPS_003338(aprA)

TMUR:

JBF11_01690 JBF11_01695

DBA:	Dbac_3197 Dbac_3198

DOA:	AXF15_05945 AXF15_05950

DESU:

NLA06_15975(aprB) NLA06_15980(aprA)

THEW:

TDMWS_04730(aprB) TDMWS_04740(aprA)

DRT:	Dret_1966(aprA) Dret_1967(aprB)

DPS:	DP1104 DP1105

DSF:	UWK_02023 UWK_02024

DLM:	DPPLL_04770(aprB) DPPLL_04780(aprA)

DAK:	DaAHT2_1471 DaAHT2_1472

DPR:	Despr_0771 Despr_0772

DEO:	CAY53_05535 CAY53_05540 CAY53_10880 CAY53_10885

DOG:	HP555_07435(aprB) HP555_07440

DBK:	DGMP_04490(aprB) DGMP_04500(aprA)

DDU:	GF1_23660(aprA) GF1_23670(aprB)

ECOM:

QTN59_11325(aprA) QTN59_11330(aprB)

EAJ:	Q3M24_01205(aprA) Q3M24_01210(aprB)

ELAX:

KKHLCK_17275(aprB) KKHLCK_17280(aprA)

EAQ:	LDFHOB_02325(aprB) LDFHOB_02330(aprA)

DOL:	Dole_0997 Dole_0998

DAL:	Dalk_1569 Dalk_1570

DAT:	HRM2_04510(aprA) HRM2_04520(aprB)

DTO:	TOL2_C04460(aprA) TOL2_C04470(aprB)

DOV:	DSCO28_47930(aprA) DSCO28_47940(aprB)

DWD:	DSCW_40190(aprB) DSCW_40200(aprA) DSCW_42360 DSCW_42370(aspB)

DALK:

DSCA_38700(aprA) DSCA_38710(aprB_1) DSCA_40820 DSCA_40830 DSCA_58900(aprB_2)

DESB:

BuS5_02433 BuS5_02434

DML:	Dmul_31450(aprA) Dmul_31460(aprB)

DLI:	dnl_16910(aprB) dnl_16920(aprA)

DMM:	dnm_076460(aprB) dnm_076470(aprA)

DEK:	DSLASN_36220(aspB_2) DSLASN_36230(aprA)

DAO:	Desac_0736 Desac_0737

DTI:	Desti_1442 Desti_1443

SFU:	Sfum_1047 Sfum_1048

DAX:	FDQ92_09410(aprB) FDQ92_09415(aprA)

DBR:	Deba_0981 Deba_0982

DMP:	FAK_04710(aspB) FAK_04720

TID:	Thein_0285 Thein_0286

TOP:	TOPB45_0176 TOPB45_0177

TCM:	HL41_08915 HL41_08920

THET:

F1847_07175 F1847_07180(aprB)

CTHI:

THC_1311 THC_1312

TAV:	G4V39_03260 G4V39_03265(aprB)

TMAI:

FVE67_03060 FVE67_03065(aprB)

DAW:	HS1_000253(aprA) HS1_000254(aprB)

TNR:	Thena_1598 Thena_1599

TACI:

TDSAC_1570 TDSAC_1571

KST:	KSMBR1_3875(aprB) KSMBR1_3876(apsA)

BROC:

IPI25_12130 IPI25_12135

BPIT:

BPIT_06990 BPIT_07000

JET:	L3J17_12740 L3J17_12745

FSU:	Fisuc_0144 Fisuc_0145

FSC:	FSU_0547 FSU_0548

CTE:	CT0864(aspB) CT0865(apsA)

CLZ:	BIU88_06785 BIU88_06790

CCH:	Cag_1585 Cag_1586

CPB:	Cphamn1_1837 Cphamn1_1838

PPH:	Ppha_0039 Ppha_0040

PROW:

OO006_03305(aprB) OO006_03310(aprA)

PROI:

OO005_03210(aprB) OO005_03215(aprA)

TYE:	THEYE_A1832(aprA) THEYE_A1833(aprB)

TOB:	V4D31_02155(aprB) V4D31_02160(aprA)

TAUT:

V4D30_05895(aprA) V4D30_05900(aprB)

DTP:	JZK55_21800(aprA) JZK55_21810(aprB)

LFC:	LFE_1826 LFE_1827

LFI:	LFML04_0489 LFML04_0490

LFP:	Y981_02510 Y981_02515

LEG:	ABH19_02945 ABH19_02950

DHR:	LGS26_04230(aprB) LGS26_04235(aprA)

CAC:	CA_C0104 CA_C0105

CAE:	SMB_G0105(frdA) SMB_G0106

CAY:	CEA_G0105 CEA_G0106

CBE:	Cbei_4188 Cbei_4189

CBZ:	Cbs_4188 Cbs_4189

CBEI:

LF65_04697 LF65_04698

CKL:	CKL_1797 CKL_1798(aprA)

CKR:	CKR_1669 CKR_1670

CCB:	Clocel_0525 Clocel_0526

CLS:	CXIVA_15130 CXIVA_15140

CSR:	Cspa_c29740 Cspa_c29750

CPAS:

Clopa_4346 Clopa_4347

CPAT:

CLPA_c35250 CLPA_c35260

CPAE:

CPAST_c35250 CPAST_c35260

CSB:	CLSA_c38940 CLSA_c38950

CLT:	CM240_2791 CM240_2792

CACE:

CACET_c13370 CACET_c13380

CCK:	Ccar_10430 Ccar_10435

CBUT:

ATN24_08820 ATN24_08825

CTYK:

CTK_C12860 CTK_C12870

CEU:	A7L45_10245 A7L45_10250

CFM:	BJL90_12010 BJL90_12015

CDY:	F3K33_21430 F3K33_21435

CMAH:

C1I91_02180 C1I91_02185

CRW:	CROST_003020(aprA) CROST_003030

CFB:	CLFE_000110(cutD) CLFE_000120(aprA)

CAUN:

CLAUR_027070(cutD) CLAUR_027080(aprA)

CNN:	CNEO_3245 CNEO_3246

CGEL:

psyc5s11_27950 psyc5s11_27960

CINT:

HZF06_00540 HZF06_00545

CLOL:

ONV75_07610 ONV75_07615

HSC:	HVS_02765(nadB1) HVS_02770

RUM:	CK1_29010 CK1_29020

RUJ:	E5Z56_09520 E5Z56_09525

RUC:	LCN94_02905 LCN94_02910

CARL:

PXC00_10960 PXC00_10965

DOR:	Desor_1735 Desor_1736

DAI:	Desaci_2312 Desaci_2319 Desaci_2320

DMI:	Desmer_0631 Desmer_0632 Desmer_1686 Desmer_1687

DCA:	Desca_2377 Desca_2378

PTH:	PTH_0239(SdhA) PTH_0240

DRM:	Dred_0636 Dred_0637

DRU:	Desru_0816 Desru_0817 Desru_3376 Desru_3377

DFG:	B0537_03650 B0537_03655

DAE:	Dtox_3577 Dtox_3578

DKU:	Desku_1073 Desku_1074 Desku_1950 Desku_1951

DAU:	Daud_0788 Daud_0789 Daud_1885 Daud_1886 Daud_1888 Daud_1889

AACX:

DEACI_0464 DEACI_0465 DEACI_4177 DEACI_4178

TJR:	TherJR_2248 TherJR_2249

DGI:	Desgi_1510 Desgi_1511 Desgi_3701 Desgi_3702

CTHM:

CFE_1042 CFE_1043

RRK:	H8S51_003600 H8S51_003605

COO:	CCU_23240 CCU_23250

CEV:	LK421_04960 LK421_04965

ROB:

CK5_24520

BLAB:

EYS05_06475 EYS05_06480

BLIQ:

INP51_13750 INP51_13755

BWX:	NQ550_19060 NQ550_19065

BMAS:

LK422_16945 LK422_16950

BLUI:

Blut17040_30580 Blut17040_30590

CPY:	Cphy_1830 Cphy_1831

LXA:	OW255_14580 OW255_14585

BPRL:

CL2_12010 CL2_12020

EHL:	EHLA_0507 EHLA_0508

ANR:	Ana3638_18045

ACEL:

acsn021_29500 acsn021_29510

EEL:	EUBELI_01895 EUBELI_01896

WCP:	H9Q76_03810 H9Q76_03815

ERE:	EUBREC_2471 EUBREC_2472

ERT:	EUR_26600 EUR_26610

ERA:	ERE_07490 ERE_07500

CLE:	Clole_0049 Clole_0050

CEW:	EKH84_03165 EKH84_03170

ABUT:

Ami103574_14725 Ami103574_14730

EMJ:	V1225_13395

AMT:	Amet_3494 Amet_3495

GFE:	Gferi_06095 Gferi_06100

TEB:	T8CH_2747 T8CH_2748(aprA)

ADG:	Adeg_0924 Adeg_0925 Adeg_1080 Adeg_1081

DBC:	MFMK1_002773 MFMK1_002774

HOR:	Hore_02120 Hore_02130

HALS:

D7D81_17745 D7D81_17750

IFN:	GM661_14395 GM661_14400

AAR:	Acear_1952 Acear_1970 Acear_1971

HHL:	Halha_2337 Halha_2338

CAD:	Curi_c25240 Curi_c25250(aprA)

VRM:	44547418_00331(frdA) 44547418_00332

MED:	MELS_1712 MELS_1713

MMAX:

LCQ47_01130 LCQ47_01135

SRI:	SELR_27430(fdx) SELR_27440

PUF:	UFO1_1134 UFO1_1135

PFT:	JBW_03276 JBW_03277

MANA:

MAMMFC1_02591(nadB_1) MAMMFC1_02592

SSPH:

SPSPH_008440(aprA) SPSPH_008450

SSID:

SPSIL_035690(aprB) SPSIL_035700(aprA)

EBM:	SG0102_26840 SG0102_26850

CSC:	Csac_1640 Csac_1641

ATE:	Athe_1191 Athe_1192

CHD:	Calhy_1541 Calhy_1542

CKI:	Calkr_1174 Calkr_1175

CKN:	Calkro_1506 Calkro_1507

CCHA:

ELD05_08150 ELD05_08155

CDIA:

CaldiYA01_13150 CaldiYA01_13160

CDAN:

SOJ16_001141 SOJ16_001142

ATB:	J4859_12670 J4859_12675

IPO:	Ilyop_2845 Ilyop_2846

LBA:	Lebu_0374 Lebu_0375

LOT:	AXF11_03240 AXF11_03245

LEQ:	BCB68_05990 BCB68_05995

LHF:	JCM16775_2043 JCM16775_2044

LSZ:	JCM16776_1593 JCM16776_1594

LWD:	JCM16777_1749 JCM16777_1750

AFU:	AF_1669 AF_1670

AFG:	AFULGI_00019180 AFULGI_00019190

APO:	Arcpr_1261 Arcpr_1262

AVE:	Arcve_0422 Arcve_0423

AST:	Asulf_02111 Asulf_02112

FPL:	Ferp_2217 Ferp_2218

GAC:	GACE_1095 GACE_1096

GAH:	GAH_02065 GAH_02066

PAI:	PAE2561 PAE2562 PAE2563 PAE2564

PCL:	Pcal_1428 Pcal_1429

PAS:	Pars_1234 Pars_1235

PYR:	P186_1798 P186_1799

POG:	Pogu_1003 Pogu_1004

CMA:	Cmaq_0272 Cmaq_0273

TTN:	TTX_0438(apsA) TTX_0439

TUZ:	TUZN_0714 TUZN_0715

VDI:	Vdis_2089 Vdis_2090

VMO:	VMUT_0493 VMUT_0494

VSO:	Vsou_25680 Vsou_25690

» show all

Reference

1 [PMID:5421934]

Authors

Michaels GB, Davidson JT, Peck HD Jr.

Title

A flavin-sulfite adduct as an intermediate in the reaction catalyzed by adenylyl sulfate reductase from Desulfovibrio vulgaris.

Journal

Biochem Biophys Res Commun 39:321-8 (1970)
DOI:10.1016/0006-291X(70)90579-6

Other DBs

ExplorEnz - The Enzyme Database:

1.8.99.2

IUBMB Enzyme Nomenclature:

1.8.99.2

ExPASy - ENZYME nomenclature database:

1.8.99.2

BRENDA, the Enzyme Database:

1.8.99.2

CAS:

9027-75-2

DBGET integrated database retrieval system