KEGG   ENZYME: 2.1.1.1Help
Entry
EC 2.1.1.1                  Enzyme                                 

Name
nicotinamide N-methyltransferase;
nicotinamide methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:nicotinamide N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide [RN:R01269]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
nicotinamide [CPD:C00153]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
1-methylnicotinamide [CPD:C02918]
History
EC 2.1.1.1 created 1961
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
Orthology
K00541  nicotinamide N-methyltransferase
Genes
HSA: 4837(NNMT)
PTR: 451558(NNMT)
PPS: 100986024(NNMT)
GGO: 101125265(NNMT)
PON: 100448230(NNMT)
NLE: 100592910(NNMT)
MCC: 695185(NNMT)
MCF: 102127301(NNMT)
CSAB: 103248504(NNMT)
RRO: 104669403(NNMT)
RBB: 108536424(NNMT)
CJC: 100406861(NNMT)
SBQ: 101045951(NNMT)
MMU: 18113(Nnmt)
RNO: 300691(Nnmt)
CGE: 100767696(Nnmt)
NGI: 103729026(Nnmt)
HGL: 101716424(Nnmt)
CCAN: 109696853(Nnmt)
TUP: 102502244(NNMT) 106735122
CFA: 489396 489397
AML: 100476505(NNMT)
UMR: 103662369(NNMT)
ORO: 101365581(NNMT) 101377589
FCA: 101083433 101094108
PTG: 102965347 102965649
AJU: 106980591(NNMT) 106980596
BTA: 511161 782610
BOM: 102279908 102280192
BIU: 109568796 109569910
PHD: 102324461
CHX: 102180514(NNMT)
OAS: 101111049
SSC: 100144485(NNMT)
CFR: 102513656(NNMT)
CDK: 105091729(NNMT)
BACU: 103010251 103011412
LVE: 103089764
OOR: 101288581
ECB: 100070808(NNMT)
EPZ: 103558245 103558248
EAI: 106840236(NNMT)
MYB: 102252520(NNMT)
MYD: 102769607(NNMT)
HAI: 109376323(NNMT)
RSS: 109459117(NNMT)
PALE: 102893498(NNMT)
LAV: 100673708(NNMT)
TMU: 101359298
MDO: 100032114(NNMT)
SHR: 100913500 100913763
OAA: 100080750(NNMT) 100080807
CCW: 104692167(NNMT)
FPG: 101913616(NNMT)
FCH: 102055024(NNMT)
CLV: 102085200(NNMT)
EGZ: 104133392
ASN: 102377471 102377716 102377959 102378197 112548934
AMJ: 102560500 102572902(NNMT)
PSS: 102444782 102445023 102448323 102451583(NNMT)
CMY: 102931305 102931529 102931755
CPIC: 101936796 101938004 101938274 101942273 101943202 101943292 101952940 103307224 103307225
ACS: 100551703 100552889 100553089 100553278 100553476 100553997 100566590
PBI: 103049922 103060931
GJA: 107119745 107119751 107119752 107119754 107125468
XLA: 108696503 108697007 108697125 108697615 108698159 108698849 108698850 108699502 108699503 108699504 108704938 379555 447151(LOC100496844.L)
XTR: 100127789 100145174 100496871 496676(nnmt) 548368(nnmt) 594886(inmt)
NPR: 108799095 108799723 108799724 108799725 108799727 108799732 108799733 108799951 108800501 108800654 108802770 108802771 108802772 108802901 108802902 108802903 108802904 108802907 108802908 108802909 108803161 108803162 108803164 108803259 108803761 108803762 108804096
DRE: 393330(zgc:64002)
SRX: 107739813
SANH: 107700100
SGH: 107588841
CCAR: 109093888
IPU: 108258972
AMEX: 103032094
SASA: 100286563(nnmt)
OTW: 112237820 112256954
ELS: 105011159
SFM: 108941486
BFO: BRAFLDRAFT_158711 BRAFLDRAFT_158928 BRAFLDRAFT_169639 BRAFLDRAFT_202946 BRAFLDRAFT_213474 BRAFLDRAFT_213757 BRAFLDRAFT_221094 BRAFLDRAFT_222663 BRAFLDRAFT_227084 BRAFLDRAFT_234975 BRAFLDRAFT_236022
SKO: 100368597 100368621 100368775 100369070 100369215 100369659 100372362 100375774 102808377
DPX: DAPPUDRAFT_236398 DAPPUDRAFT_313127
ISC: IscW_ISCW002344 IscW_ISCW014740 IscW_ISCW019697 IscW_ISCW024239
CEL: CELE_B0303.2(anmt-1)
CBR: CBG00588
NAI: NECAME_10003 NECAME_10971
BMY: Bm1_41455
LOA: LOAG_01142 LOAG_12069
TSP: Tsp_04293
MYI: 110443852 110448291 110453188 110454664 110456662
LAK: 106150474 106152759 106152768 106161909 106170526
NVE: NEMVE_v1g164399
EPA: 110232770 110232796 110235157 110236313 110237610 110237611 110248464 110248751
AQU: 105313139 105313443 105313708 105314477 105314910
 » show all
Taxonomy
Reference
1  [PMID:14832232]
  Authors
CANTONI GL.
  Title
Methylation of nicotinamide with soluble enzyme system from rat liver.
  Journal
J Biol Chem 189:203-16 (1951)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.1
IUBMB Enzyme Nomenclature: 2.1.1.1
ExPASy - ENZYME nomenclature database: 2.1.1.1
BRENDA, the Enzyme Database: 2.1.1.1
CAS: 9029-74-7

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (373)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (224)   
   KEGG MGENES (3)   
   RefGene (145)   
Protein sequence (71)   
   UniProt (20)   
   SWISS-PROT (4)   
   RefSeq(pep) (19)   
   PDBSTR (28)   
DNA sequence (78)   
   RefSeq(nuc) (29)   
   GenBank (27)   
   EMBL (22)   
3D Structure (8)   
   PDB (8)   
Protein domain (2)   
   PROSITE(DOC) (2)   
All databases (544)   

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