KEGG   ENZYME: 2.1.1.1
Entry
EC 2.1.1.1                  Enzyme                                 
Name
nicotinamide N-methyltransferase;
nicotinamide methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:nicotinamide N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide [RN:R01269]
Reaction(KEGG)
R01269
Substrate
S-adenosyl-L-methionine [CPD:C00019];
nicotinamide [CPD:C00153]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
1-methylnicotinamide [CPD:C02918]
History
EC 2.1.1.1 created 1961
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
Orthology
K00541  nicotinamide N-methyltransferase
Genes
HSA4837(NNMT)
PTR451558(NNMT)
PPS100986024(NNMT)
GGO101125265(NNMT)
PON100448230(NNMT)
NLE100592910(NNMT)
MCC695185(NNMT)
MTHB126935927
CSAB103248504(NNMT)
CATY105588660(NNMT)
PANU101024384(NNMT)
TGE112606199(NNMT)
RRO104669403(NNMT)
RBB108536424(NNMT)
TFN117080113(NNMT)
PTEH111540156(NNMT)
CANG105501050(NNMT)
CJC100406861(NNMT)
SBQ101045951(NNMT)
CSYR103275892(NNMT)
MMUR105862036(NNMT)
LCAT123641650(NNMT)
PCOQ105822253(NNMT)
OGA100955459(NNMT)
MMU18113(Nnmt)
MCAL110302139(Nnmt)
MPAH110328508(Nnmt)
RNO300691(Nnmt)
MCOC116072596(Nnmt)
MUN110546484(Nnmt)
CGE100767696(Nnmt)
MAUA101844903(Nnmt)
PLEU114690360(Nnmt)
MORG121438382(Nnmt)
MFOT126510053
AAMP119810066(Nnmt)
NGI103729026(Nnmt)
HGL101716424(Nnmt)
CPOC100735757(Nnmt)
CCAN109696853(Nnmt)
DORD105980823(Nnmt)
DSP122110266(Nnmt)
NCAR124958170
TUP102502244(NNMT) 106735122
GVR103594593(NNMT)
CFA489396(NNMT) 489397
CLUD112671308 112671309
VVP112925892 112926001
VLG121499290 121500621
AML100476505(NNMT)
UMR103662369(NNMT)
UAH113260035(NNMT)
UAR123792585(NNMT)
ELK111153899
LLV125079420
MPUF101681892(NNMT)
ORO101377589
EJU114211419(NNMT)
ZCA113915356(NNMT)
MLX118013251(NNMT)
NSU110586218(NNMT)
LWW102738763(NNMT)
FCA101083433 101094108
PYU121035411 121035413
PBG122482983 122482985
LRUF124504621 124505243
PTG102965347 102965649
PPAD109278623(NNMT) 109278624
AJU106980591(NNMT) 106980596
HHV120229857 120229900
BTA511161 782610
BOM102279908 102280192
BIU109568796 109569910
BBUB102399479
BBIS104981327 104981491
CHX102180514
OAS101111049(NNMT)
ODA120876099 120876274(NNMT)
CCAD122449764
SSC100144485(NNMT)
CFR102513656(NNMT)
CBAI105067871(NNMT)
CDK105091729(NNMT)
VPC102536987(NNMT)
BACU103010251 103011412
LVE103089764
OOR101288581
DLE111166938(NNMT)
PCAD102992107(NNMT)
PSIU116758458(NNMT)
ECB100070808(NNMT)
EPZ103558245 103558248
EAI106840236
MYB102252520(NNMT)
MYD102769607(NNMT)
MMYO118664312(NNMT)
MLF102417100(NNMT)
MNA107534002(NNMT)
PKL118713157(NNMT)
HAI109376323(NNMT)
DRO112314324(NNMT)
SHON119000551(NNMT)
AJM119048096(NNMT)
PDIC114499838(NNMT)
PHAS123820019(NNMT)
MMF118628904(NNMT)
RFQ117029888(NNMT)
PALE102893498(NNMT)
PGIG120622009(NNMT)
PVP105295618(NNMT)
RAY107505073(NNMT)
MJV108402130(NNMT)
SARA101541943(NNMT)
LAV100673708(NNMT)
TMU101359298
ETF101646032
MDO100032109 100032114(NNMT)
GAS123239062(NNMT) 123241922
SHR100913500 100913763
PCW110210659
OAA100080750(NNMT) 100080807
CBRC103618623(NNMT)
ETL114056330(NNMT)
ACHL103808850
FPG101913616(NNMT)
FCH102055024(NNMT)
CLV102085200(NNMT)
ACUN113488591(NNMT)
TALA116964808(NNMT)
PADL103916557(NNMT)
AFOR103894365(NNMT)
ACHC115344226(NNMT)
HALD104323846
HLE104836476(NNMT)
AGEN126038414
GCL127025895
CCRI104157875
FGA104078927
GSTE104254963(NNMT)
MNB103770439
NNT104407258
PGUU104461888(NNMT)
AVIT104270024(NNMT)
CVF104296104(NNMT)
CUCA104068935(NNMT)
TEO104372165(NNMT)
ASN102377716 102377959 102378197 112548934
AMJ102560500 102572902(NNMT)
CPOO109316431 109324515(NNMT) 109324516
GGN109293765 109293797 109293811 109296424
PSS102445023 102448323 102451583(NNMT)
CMY102931305 102931529 102931755
CPIC101936796 101938004 101938274 101943202 101943292 101952940 103307225
TST117868482 117868483
CABI116834157 116834158 116834180
MRV120375563 120375564 120375565 120375566 120375803 120375804 120375870
ACS100551703 100552889 100553089 100553278 100553476 100553997 100566590
SUND121918005 121934604 121934787
PBI103049922 103060931
PMUR107284760 107284786 107284811 107284812
CTIG120311236 120311237 120311239 120311241 120311294
TSR106553046 106555489
PGUT117670156 117670228
PMUA114585538 114585612 114585649 114585651
ZVI118097057 118097205 118097289
GJA107119745 107119751 107119752 107119754 107125468
STOW125441420 125441495 125441496 125441828
XLA108696503 108697007 108697125 108697615 108698159 108698849 108698850 108699502 108699503 108699504 108704938(XB5789557.S) 379555(XB5789557.L) 447151(XB5814630.L)
XTR100127789 100127826 100145174 100485680 100485824 100485981 100491049 100491286 100491384 100491890 100492062 100492223 100492724 100492889 100493051 100493148 100494680 100496844 100496871 100497003 100497161 100497323 100497639 100497944 101731924 101733847 101734878 101735031 108645503 108645664 108645666 493451 548368 594886
NPR108799095 108799723 108799724 108799725 108799727 108799732 108799733 108799951 108800501 108800654 108802770 108802771 108802772 108802900 108802901 108802902 108802903 108802904 108802907 108802908 108802909 108803161 108803162 108803164 108803256 108803259 108803761 108804096
RTEM120910259 120915493 120915494 120915495 120915497 120915498 120915499 120915506 120915523 120915525 120915527 120915528 120915529 120915530 120915531 120915532 120915533 120915534 120915535 120915536 120915537 120915538 120915539 120915540 120915627 120915628 120915629 120915630 120915631 120915632 120915633 120915634 120915635 120915636 120915637 120915638 120915639 120915640 120915642 120915643 120915644 120915855 120915856 120915860 120915861 120916098 120916099 120916100 120916116 120924518 120928521
BBUF120986840 120986908 120990457 120990458 120995813 120995989 120996039 120996389 120996652 120996676 120996737 120996758 120996779 120996823 120996865 120999252 120999258 120999266 120999273 120999287 120999292 120999300 120999336 120999347 121003226 121003229 121004514
BGAR122926210 122926285 122926680 122926681 122926702 122926830 122926831 122926832 122926835 122926836 122926933 122926935 122926936 122926937 122926938 122928838 122928839 122928840 122928841 122928843 122928943 122928944 122928945 122928946 122935107 122935881 122941012 122941121
DRE393330(zgc:64002)
SRX107739813
SANH107700100
SGH107588841
CCAR109093888
CAUA113105512
PPRM120459996(zgc:64002)
MAMB125272303(zgc:64002)
IPU108258972(zgc:64002)
PHYP113537473
SMEO124378233(zgc:64002)
TFD113648769(zgc:64002)
AMEX103032094
EEE113590733
SASA100286563(nnmt)
STRU115153815
OTW112237820(zgc:64002)
OMY110533262(zgc:64002)
OGO123990966(zgc:64002)
ONE115125013
SALP112073894
SNH120056413(zgc:64002)
CCLU121555388(zgc:64002)
ELS105011159
SFM108941486
PKI111840573 111851351
AANG118210329 118210330
LOC102682678(nnmt)
PSEX120535870(zgc:64002)
RTP109914452
BFO118408156 118412151 118414819 118414821 118416129 118423608 118424887
BBEL109466635 109468190 109468491 109469295 109471698 109475280 109475509 109476350
SKO100368621 100368775 100369070 100369215 100369659 100372362 100375774 102808377
DPXDAPPUDRAFT_236398 DAPPUDRAFT_313127
PJA122244224
EAF111710293
ISCIscW_ISCW002344 IscW_ISCW014740 IscW_ISCW019460 IscW_ISCW019697 IscW_ISCW024239
DSV119435429 119455841
RSAN119371859 119385365
RMP119163187
VDE111252041
VJA111266180
CSCU111615694 111617186 111622752 111623848 111623849 111629367 111637649 111641732 111641736
PTEP107448533 107448535
SDM118182271 118189227 118191929 118195269
CELCELE_B0303.2(anmt-1) CELE_T07C12.9(anmt-3)
CBRCBG_00588 CBG_19415
BMYBM_BM11577(Bma-anmt-3) BM_BM1744(Bma-anmt-1)
LOALOAG_01142 LOAG_12069
NAINECAME_10003 NECAME_10971
TSPTsp_04293
GAE121366115 121366855 121371564 121376830 121377781 121379456
HRF124121134 124122497 124132440 124132460 124143407 124143408 124143438 124145948 124145957 124146365 124146699
HRJ124258497 124260859 124260862 124268448 124278686 124291002
MYI110443852 110448291 110453188 110454664 110456662
PMAX117317390 117317699 117317740 117317742 117317781 117317783 117317907 117317953 117343614
LAK106152759 106152768 106161909 106170526
NVE5515270
EPA110232770 110232796 110235157 110236313 110237610 110237611 110248464 110248751 110254497
ATEN116299147 116299156 116299157
SPIS111339789
DGT114519231 114524724 114524854 114524967 114532341 114532549
AQU105313139 105313443 105313708 105314477 105314910
DMMdnm_038790
 » show all
Reference
1  [PMID:14832232]
  Authors
CANTONI GL.
  Title
Methylation of nicotinamide with soluble enzyme system from rat liver.
  Journal
J Biol Chem 189:203-16 (1951)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.1
IUBMB Enzyme Nomenclature: 2.1.1.1
ExPASy - ENZYME nomenclature database: 2.1.1.1
BRENDA, the Enzyme Database: 2.1.1.1
CAS: 9029-74-7

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