Entry |
|
Name |
homocysteine S-methyltransferase;
S-adenosylmethionine homocysteine transmethylase;
S-methylmethionine homocysteine transmethylase;
adenosylmethionine transmethylase;
methylmethionine:homocysteine methyltransferase;
adenosylmethionine:homocysteine methyltransferase;
homocysteine methylase;
homocysteine methyltransferase;
homocysteine transmethylase;
L-homocysteine S-methyltransferase;
S-adenosyl-L-methionine:L-homocysteine methyltransferase;
S-adenosylmethionine-homocysteine transmethylase;
S-adenosylmethionine:homocysteine methyltransferase
|
Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
Sysname |
S-methyl-L-methionine:L-homocysteine S-methyltransferase
|
Reaction(IUBMB) |
S-methyl-L-methionine + L-homocysteine = 2 L-methionine [RN: R11063]
|
Reaction(KEGG) |
|
Substrate |
S-methyl-L-methionine [CPD: C03172];
L-homocysteine [CPD: C00155]
|
Product |
|
Comment |
The enzyme uses S-adenosyl-L-methionine as methyl donor less actively than S-methyl-L-methionine.
|
History |
EC 2.1.1.10 created 1965, modified 2010
|
Pathway |
ec00270 | Cysteine and methionine metabolism |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K00547 | homocysteine S-methyltransferase |
|
Genes |
AJM: | 119035983(BHMT2) 119041118 |
PCW: | 110204254 110216594(BHMT2) |
BBUF: | 120995817 120995818 |
BGAR: | 122930895 122930896 |
SANH: | 107659029 107692348 |
CGIB: | 128015588(zgc:172121) |
PTET: | 122346712(zgc:172121) |
LROH: | 127166692(zgc:172121) |
OMC: | 131542378(zgc:172121) |
PPRM: | 120493131(zgc:172121) |
RKG: | 130081330(zgc:172121) |
MAMB: | 125273933(zgc:172121) |
CIDE: | 127514784(zgc:172121) |
CERY: | 137010532(zgc:172121) |
MASI: | 127446364 127448768 |
TROS: | 130556498(zgc:172121) |
TDW: | 130425228(zgc:172121) |
MANU: | 129450620(zgc:172121) |
IPU: | 108271828(zgc:172121) |
IFU: | 128614433(zgc:172121) |
SMEO: | 124382658(zgc:172121) |
TFD: | 113643000(zgc:172121) |
TVC: | 132844346(zgc:172121) |
TRN: | 134316794(zgc:172121) |
AMEX: | 103040478(zgc:172121) |
CMAO: | 118808011(zgc:172121) |
CHAR: | 122131892(zgc:172121) |
TFS: | 130528356(zgc:172121) |
TBEN: | 117497728(zgc:172121) |
CGOB: | 115006978 115007003 |
PGEO: | 117441846 117441869 |
ELY: | 117254067(zgc:172121) |
EFO: | 125895698(zgc:172121) |
PLEP: | 121940970(zgc:172121) |
SLUC: | 116058905(zgc:172121) |
ECRA: | 117950588(zgc:172121) |
GAT: | 120824048(zgc:172121) |
PPUG: | 119216757(zgc:172121) |
AFB: | 129095040(zgc:172121) |
CLUM: | 117729571(zgc:172121) |
PSWI: | 130194377(zgc:172121) |
CVE: | 137883722(zgc:172121) |
MSAM: | 119901151(zgc:172121) |
SCHU: | 122877605(zgc:172121) |
CUD: | 121512274(zgc:172121) |
ALAT: | 119028074(zgc:172121) |
ASTR: | 137599509(zgc:172121) |
OAU: | 116313009(zgc:172121) |
OML: | 112150470(zgc:172121) |
GAF: | 122838295(zgc:172121) |
PPRL: | 129351370(zgc:172121) |
CTUL: | 119795741(zgc:172121) |
GMU: | 124873610(zgc:172121) |
KMR: | 108240198(zgc:172121) |
NWH: | 119408158(zgc:172121) |
MCEP: | 125009416(zgc:172121) |
SSEN: | 122781214(zgc:172121) |
HHIP: | 117760499(zgc:172121) |
HSP: | 118120723(zgc:172121) |
PPLT: | 128447977(zgc:172121) |
SMAU: | 118317923(zgc:172121) |
XGL: | 120790575(zgc:172121) |
SSCV: | 125970792(zgc:172121) |
PEE: | 133406851(zgc:172121) |
PTAO: | 133481159(zgc:172121) |
SJO: | 128362189(zgc:172121) |
STRU: | 115151432 115151436 |
OTW: | 112237519(zgc:172121) |
OMY: | 110527472(zgc:172121) |
OGO: | 123996060(zgc:172121) |
OKE: | 118378297(zgc:172121) |
SNH: | 120053593(zgc:172121) |
CCLU: | 121576420(zgc:172121) |
AANG: | 118214172(zgc:172121) |
PSPA: | 121321024 121327618(zgc:172121) |
ARUT: | 117406702(zgc:172121) |
PSEX: | 120523399(zgc:172121) |
CMK: | 103177420(zgc:172121) |
CPLA: | 122550427(zgc:172121) |
HOC: | 132816346(zgc:172121) |
LERI: | 129698305(zgc:172121) |
APLC: | 110987963 110987976 |
DME: | Dmel_CG10621(CG10621) Dmel_CG10623(Bhmt) |
DSI: | Dsimw501_GD21796(Dsim_GD21796) Dsimw501_GD21797(Dsim_GD21797) |
DYA: | Dyak_GE12691 Dyak_GE12692 |
DMO: | Dmoj_GI17170 Dmoj_GI17171 |
MDE: | 101892870 101898018 101898193 131804063 |
SCAC: | 106090333 106090350 |
HIS: | 119646369 119659822 119661263 119661539 119661540 |
ACER: | 107994994 107994995 |
ALAB: | 122713592 122713607 |
AFLR: | 100863089 100863439 |
BBIF: | 117215681 117215685 |
BVAN: | 117164753 117164755 |
BHUN: | 126867255 126867257 |
BTER: | 100646654 105665652 |
BAFF: | 126914723 126914724 |
BPYO: | 122567054 122567055 |
BPAS: | 132909710 132909711 |
CCAL: | 108622448 108622450 |
MGEN: | 117218879 117218880 |
NMEA: | 116425293 116425294 |
CGIG: | 122403639 122403655 |
MPHA: | 105828563 105835840 |
AEC: | 105145473 105149413 105149415 |
ACEP: | 105627254 105627258 105627260 |
PBAR: | 105431302 105431306 |
HST: | 105190725 105190726 105190727 105190729 105190730 105190733 105190734 |
DQU: | 106742437 106742438 106742439 106742440 106742441 106742442 106742443 106742446 106742447 106742448 106742449 106742450 106742478 106742482 106742494 106742495 |
TPRE: | 106660384 106660385 106660507 |
CGLO: | 123271209 123271569 |
AGIF: | 122851321 122852498 |
CINS: | 118065754 118065756 |
VCAN: | 122405974 122409987 |
CCIN: | 107268841 107272769 |
APLN: | 108743880 112906227 |
PPYR: | 116171246 116171353 |
MSEX: | 115446014 119192454 |
PMAC: | 106710685 106715835 |
PRAP: | 110994926 110997287 |
PNAP: | 125056960 125063457 |
LSIN: | 126972835 126977992 |
SLIU: | 111349113 111361772 |
ATRA: | 106136057 132902850 |
CFEL: | 113366063 113367448 113367449 113367462 113367464 113367465 |
CCRN: | 123290404 123301402 |
AGS: | 114121405 114121418 114126734 |
BTAB: | 109035244 109040238 |
DCI: | 103512502 103512506 103512891 103514429 |
HHAL: | 106691648 106691929 106692008 |
HVI: | 124364353 124364355 124364356 124364898 124365007 124370828 124371833 124372509 |
MQU: | 129000119 129000179 129000979 129000993 129001692 |
CSEC: | 111865931 111873585 |
SGRE: | 126322497 126322561 |
DSV: | 119435826 119441481 119445072 |
RSAN: | 119386635 119386639 119388760 |
CEL: | CELE_T13G4.4(T13G4.4) |
CANU: | 128160196 128180376 |
CVN: | 111104122 111108277 111108390 111109970 111135702 |
OED: | 125654815 125658435 125676131 130048255 130048308 |
AIRR: | 138305124 138305194 138307758 |
RPHI: | 132731578 132738771 132747134 |
MAEA: | 128220040 128220353 |
AMIL: | 114953583 114966848 |
PDAM: | 113668767 113686958 |
SPIS: | 111331666 111336506 |
ATH: | AT3G22740(HMT3) AT3G25900(HMT-1) AT3G63250(HMT2) |
ALY: | 9313006 9314575 9321588 |
CRB: | 17886001 17887238 17892352 |
CSAT: | 104699552 104710370 104746736 104746739 104748990 104766170 104779789 104787697 104788663 104790212 |
EUS: | EUTSA_v10004584mg EUTSA_v10006074mg EUTSA_v10021051mg |
BRP: | 103842126 103862723 103869013 103875335 |
BNA: | 106349415 106382000 106396739 106399494 106415841 106444935 106455056 125578518 125596865 125596870 |
BOE: | 106292759 106301865 106307277 106342238 |
RSZ: | 108830539 108833428 108857084 |
THJ: | 104808566 104823038 104824031 104825700 |
CPAP: | 110814027 110816931 110819286 |
CIT: | 102614076 102618286 102628438 |
CIC: | CICLE_v10005328mg CICLE_v10020605mg CICLE_v10032092mg |
PVY: | 116111025 116122411 116136644 116143572 |
MINC: | 123213318 123220252 123222704 |
TCC: | 18603031 18609262 18613297 |
GRA: | 105790700 105794739 105796669 |
GHI: | 107887709 107909578 107914791 107927633 107951360 |
GAB: | 108470042 108474797 108474827 |
HSYR: | 120136915 120171777 120178164 120189067 120204836 120218268 |
DZI: | 111283426 111291509 111317803 |
GMX: | 100790567 100811127 100812265 |
GSJ: | 114400571 114403900 114422855 |
PVU: | 137806320 137814234 137828363 |
CCAJ: | 109791432 109815852 109816129 |
APRC: | 113861833 113869761 113872926 |
MTR: | 11422561 25485172 25499146 |
TPRA: | 123892702 123902309 123907717 |
CAM: | 101508323 101508973 101513890 |
PSAT: | 127091952 127118922 127130321 |
VVO: | 131610379 131612478 131621708 131628585 131643484 131646001 |
LJA: | 130718383 130730603 130739546 |
AIP: | 107610739 107618670 107645201 |
AHF: | 112696236 112711770 112721544 112742725 112756338 112772454 112775854 112776347 112805600 |
LANG: | 109337573 109346831 109348481 109359517 109359520 |
PCIN: | 129308653 129317485 129319652 129322895 |
QSA: | O6P43_007000 O6P43_021541 O6P43_032753 |
FVE: | 101292308 101293186 101303869 |
AANS: | 126782735 126790491 126791971 |
RCN: | 112169970 112197481 112197760 112197766 112198595 112200358 |
PPER: | 18767574 18789427 18791688 |
PMUM: | 103324014 103334212 103341478 |
PAVI: | 110763468 110764110 110768664 |
PDUL: | 117616480 117635631 117636709 |
MDM: | 103402706(HMT) 103424053 103432414 103448967 |
MSYL: | 126588352 126596560 126607260 126615974 |
PXB: | 103928017 103947531 103957203 103960106 |
ZJU: | 107423145 107426397 107429447 |
MNT: | 21385627 21392443 21397785 |
CSAV: | 115703995 115712805 115723464 |
CSV: | 101218830 101221323 101222725 |
CMO: | 103489284 103491241 103492639 |
BHJ: | 120082078 120086029 120092549 |
MCHA: | 111009694 111018483 111018744 |
CMAX: | 111467714 111487630 111488001 111494830 111499379 |
CMOS: | 111436743 111449762 111456035 111460426 |
CPEP: | 111778868 111801349 111806412 111807663 111808673 |
RCU: | 8275420 8280877 8285786 |
MEAN: | 126670090 126671056 126688035 |
JCU: | 105632023 105642025 105649955 |
HBR: | 110632770 110633554 110635061 110645170 110664934 |
MESC: | 110602523 110611553 110615622 110617715 110631215 |
POP: | 7464849 7466898 7467500 7474182 7480020 |
PEU: | 105113438 105126823 105127323 105130037 105131403 |
PALZ: | 118048057 118049346 118056288 118061605 118061667 |
PNZ: | 133691612 133694472 133696235 133696392 133706028 |
JRE: | 108989475 108994524 109005065 |
CILL: | 122278353 122295665 122300779 |
CAVE: | 132171950 132179819 132183784 |
AGLU: | 133852450 133866547 133875363 |
QSU: | 112018549 112019472 112039323 |
QLO: | 115969840 115990524 115993590 |
TWL: | 119991353 120001644 120011028 |
VVI: | 100247323 100264835 100852835 |
VRI: | 117904462 117913941 117919210 |
SPEN: | 107029752 107031665 |
SSTN: | 125851856 125870520 |
SDUL: | 129881828 129882807 |
CANN: | 107842464 107864144 |
NTA: | 107759758 107796068 107798163 107799272 107823528 107831596 |
NSY: | 104245742 104246515 104249776 |
NAU: | 109218873 109221165 109227184 |
INI: | 109151911 109175310 109182779 |
ITR: | 116000885 116016769 116026307 |
SIND: | 105156388 105160993 105162110 105163294 105171316 |
OEU: | 111371651 111408104 111412371 |
EGT: | 105952130 105953041 105953303 105961191 105966174 |
SSPL: | 121755682 121767139 121778187 121781056 121793506 121801448 |
SMIL: | 130986351 130991433 131016325 |
SHIS: | 125197508 125214855 125222041 |
APAN: | 127242950 127249248 127261777 |
HAN: | 110872038 110884097 110915104 |
ECAD: | 122581696 122596164 122607043 |
LSV: | 111894472 111899138 111921674 |
CCAV: | 112503163 112513194 112518118 112522663 |
DCR: | 108196489 108196490 108201858 108205005 |
CSIN: | 114273364 114282185 114288908 114307024 |
RVL: | 131310794 131315884 131333777 |
AEW: | 130757326 130758560 130761275 130771736 130792057 |
CQI: | 110691213 110715024 110719231 110728993 110734467 |
ATRI: | 130798523 130807478 |
MOF: | 131152437 131154581 131155198 |
NNU: | 104596590 104596905 104598641 104601878 104602967 |
MING: | 122061685 122069465 122078951 |
TSS: | 122639546 122643757 122664019 |
PSOM: | 113347152 113348290 113350053 113351919 113357741 |
OSA: | 4324713 4332095 4348656 4352747 |
DOSA: | Os01g0772900 Os03g0221200 Os10g0422200 Os12g0607000 |
OBR: | 102705053 102715708 102718131 102720634 |
OGL: | 127752787 127753348 127757685 127767202 |
BDI: | 100836808 100838685 100841399 |
ATS: | 109738631 109740917 109769593 |
TDC: | 119272125 119281576 119284963 119291173 119299229 119307492 |
TAES: | 123062208 123070948 123074822 123085147 123092940 123098214 123102264 123110477 123119451 |
TUA: | 125507861 125529161 125552493 |
LPER: | 127296456 127298744 127333792 127338705 |
LRD: | 124652416 124653096 124668437 124676831 124677145 124696825 124696958 |
SBI: | 8056874 8070125 8072141 |
ZMA: | 541873 541874 541875 541876 |
MFLO: | 136505352 136508575 136540383 |
SITA: | 101761102 101774971 |
PVIR: | 120646827 120666881 120692058 120700075 |
PHAI: | 112875927 112884429 |
PAUA: | 133905313 133906576 133906951 133911926 133916623 |
PDA: | 103711353 103716281 103718093 |
EGU: | 105042323 105048506 105057316 |
MUS: | 103995107 135584993 135615606 135618696 |
ZOF: | 121972336 121972808 121994982 121999355 121999399 122000965 122004974 122008314 122009900 122010416 122016751 122016989 122026587 122040083 122042245 122046776 122054802 |
AOF: | 109821465 109832995 109833766 |
ACAK: | 137934434 137948312 137956126 |
NCOL: | 116248142 116258476 |
SMO: | SELMODRAFT_108383 SELMODRAFT_168384 SELMODRAFT_179106 SELMODRAFT_88753 |
PPP: | 112275479 112276750 112285349 |
SCE: | YLL062C(MHT1) YPL273W(SAM4) |
SEUB: | DI49_1324 DI49_2250 DI49_5198 |
SPAO: | SPAR_L00030 SPAR_M04360 SPAR_P00060 |
AGO: | AGOS_ABL125W AGOS_AFR410W |
LTH: | KLTH0C03850g KLTH0H12716g |
NCS: | NCAS_0D04940(NCAS0D04940) |
NDI: | NDAI_0F00250(NDAI0F00250) |
TPF: | TPHA_0G03760(TPHA0G03760) TPHA_0I00260(TPHA0I00260) |
TBL: | TBLA_0B03260(TBLA0B03260) |
TDL: | TDEL_0E00240(TDEL0E00240) TDEL_0E05690(TDEL0E05690) |
KAF: | KAFR_0B00210(KAFR0B00210) KAFR_0F04420(KAFR0F04420) KAFR_0L00150(KAFR0L00150) |
KNG: | KNAG_0B06970(KNAG0B06970) |
LBG: | 92205653(LODBEIA_P04570) |
CAL: | CAALFM_C108410CA(SAM4) |
NTE: | NEUTE1DRAFT89911(NEUTE1DRAFT_89911) |
SMP: | 10810270(SMAC4_01479) |
TATV: | 25780194(TrAtP1_012963) |
TASP: | 36616409(TrAFT101_009785) |
PLJ: | 28888242(PLICBS_003445) |
CDET: | 87945835(CDEST_09332) |
CIM: | CIMG_11788(CIMG06640) |
CPW: | 9695400(D8B26_006135) |
PTRR: | 6341476(PtrM4_068720) |
CDEP: | 91086664(L203_102452) |
KMG: | 30161616(I203_107056) |
KNE: | 92182668(IAR55_005410) |
CCAC: | CcaHIS019_0607020(CcaverHIS019_0607020) |
ABP: | AGABI1DRAFT56118(AGABI1DRAFT_56118) |
ABV: | AGABI2DRAFT185360(AGABI2DRAFT_185360) |
SCM: | SCHCO_02362140(SCHCODRAFT_02362140) |
TCR: | 506479.120 508993.20 |
LMAT: | 92510820(LSCM1_00666) |
LOI: | 92356682(LSCM4_00672) |
LENR: | 94167964(CUR178_00673) |
LEIN: | 94184444(JIQ42_00683) |
PHET: | 94287043(JKF63_00917) |
NGR: | NAEGRDRAFT_60084 NAEGRDRAFT_80673 |
GTT: | GUITHDRAFT_115747 GUITHDRAFT_66436 |
EDJ: | ECDH1ME8569_0249(mmuM) |
REE: | electrica_04031(mmuM) |
RTG: | NCTC13098_05897(mmuM) |
KIE: | NCTC12125_02686(mmuM) |
SMW: | SMWW4_v1c35820(mmuM) |
SERS: | SERRSCBI_17410(mmuM) |
SFJ: | SAMEA4384070_3598(mmuM) |
SOF: | NCTC11214_03191(mmuM_1) NCTC11214_03192(mmuM_2) |
SSAR: | SSARUM_003458(mmuM) |
PAQU: | DMB82_0012630(mmuM) |
TPTY: | NCTC11468_03571(mmuM_2) |
XFU: | XFF4834R_chr31050(mmuM) |
XPH: | XppCFBP6546_04445(mmuM) |
XHD: | LMG31886_29240(mmuM) |
HAAH: | HALA3H3_720026(mmuM) |
HOL: | HORIV_46950 HORIV_46960 |
BAZ: | BAMTA208_01130(mmuM) |
BAE: | BATR1942_19850(mmuM) |
BFM: | BP422_09795 BP422_26955 |
PPQ: | PPSQR21_050120(mHT1) |
PNK: | AASFL403_19760(mmuM) |
SMC: | SmuNN2025_1077(mmuM) |
SGG: | SGGBAA2069_c12430(mmuM) |
STRS: | SSAL8618_03075(mmuM) |
SVB: | NCTC12167_00616(mmuM) |
SFER: | NCTC12278_01029(mmuM) |
LAY: | LAB52_05015(mmuM) LAB52_05130(mmuM) |
LUU: | H4B44_06165(mmuM) H4B44_10905(mmuM) |
LRU: | HMPREF0538_20070(mmuM) |
LFD: | QFX10_04630(mmuM) QFX10_06075 |
LPD: | AYR62_10585 AYR62_11740 |
ECEC: | NCTC12421_01066(mmuM) |
CGEL: | psyc5s11_15870(mmuM) |
VRM: | 44547418_00379(mmuM) |
VDN: | NCTC11831_00340(mmuM) |
DHO: | Dia5BBH33_00020(ybgG) |
MHEK: | JMUB5695_01905(mmuM) |
MTER: | 4434518_01348(mmuM) |
CMIN: | NCTC10288_01909(mmuM) |
NSPU: | IFM12276_51260(mmuM) |
SAMB: | SAM23877_5852(ybgG) |
SLE: | sle_15450(sle_15450) |
SGM: | GCM10017557_16840(mmuM) |
SGE: | DWG14_00408(mmuM_1) DWG14_01942(mmuM_2) |
STUI: | GCM10017668_56280(mmuM) |
SGOB: | test1122_21825(mmuM) |
SXT: | KPP03845_105632(mmuM_2) |
FSB: | GCM10025867_32280(mmuM) |
ARH: | AHiyo8_32540 AHiyo8_42230 |
PAUS: | NCTC13651_00351(mmuM) |
ANE: | ATCC27039_05560(metH) |
AHW: | NCTC11636_00030(mmuM) |
ASLA: | NCTC11923_01479(mmuM) |
AVC: | NCTC10951_00328(mmuM) |
ACAP: | MANAM107_19880(metH) |
» show all
|
Reference |
|
Authors |
Balish E, Shapiro SK. |
Title |
Methionine biosynthesis in Escherichia coli: induction and repression of methylmethionine(or adenosylmethionine):homocysteine methyltransferase. |
Journal |
|
Reference |
|
Authors |
SHAPIRO SK. |
Title |
Adenosylmethioninehomocysteine transmethylase. |
Journal |
|
Reference |
|
Authors |
SHAPIRO SK, YPHANTIS DA. |
Title |
Assay of S-methylmethionine and S-adenosylmethionine homocysteine transmethylases. |
Journal |
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Reference |
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Authors |
Mudd SH, Datko AH |
Title |
The S-Methylmethionine Cycle in Lemna paucicostata. |
Journal |
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Reference |
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Authors |
Ranocha P, McNeil SD, Ziemak MJ, Li C, Tarczynski MC, Hanson AD |
Title |
The S-methylmethionine cycle in angiosperms: ubiquity, antiquity and activity. |
Journal |
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Sequence |
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Reference |
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Authors |
Ranocha P, Bourgis F, Ziemak MJ, Rhodes D, Gage DA, Hanson AD |
Title |
Characterization and functional expression of cDNAs encoding methionine-sensitive and -insensitive homocysteine S-methyltransferases from Arabidopsis. |
Journal |
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Sequence |
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Reference |
7 |
Authors |
Grue-Sorensen G, Kelstrup E, Kjaer A, Madsen JO. |
Title |
Diastereospecific, enzymically catalysed transmethylation from S-methyl-L-methionine to L-homocysteine, a naturally occurring process. |
Journal |
J Chem Soc Perkin Trans 1 1091-1097 (1984) |
Other DBs |
ExplorEnz - The Enzyme Database: | 2.1.1.10 |
ExPASy - ENZYME nomenclature database: | 2.1.1.10 |
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