KEGG   ENZYME: 2.1.1.100Help
Entry
EC 2.1.1.100                Enzyme                                 

Name
protein-S-isoprenylcysteine O-methyltransferase;
farnesyl cysteine C-terminal methyltransferase;
farnesyl-protein carboxymethyltransferase;
protein C-terminal farnesylcysteine O-methyltransferase;
farnesylated protein C-terminal O-methyltransferase;
isoprenylated protein methyltransferase;
prenylated protein methyltransferase;
protein S-farnesylcysteine C-terminal methyltransferase;
S-farnesylcysteine methyltransferase;
prenylcysteine carboxylmethyltransferase [misleading];
prenylcysteine carboxymethyltransferase [misleading];
prenylcysteine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester [RN:R04496]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
protein C-terminal S-farnesyl-L-cysteine [CPD:C04506]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
protein C-terminal S-farnesyl-L-cysteine methyl ester [CPD:C04748]
Comment
C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, but more slowly.
History
EC 2.1.1.100 created 1992 (EC 2.1.1.24 created 1972, modified 1983, modified 1989, part incorporated 1992)
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K00587  protein-S-isoprenylcysteine O-methyltransferase
Genes
HSA: 23463(ICMT)
PTR: 469782(ICMT)
PPS: 100978940(ICMT)
GGO: 101151352(ICMT)
PON: 100456656(ICMT)
NLE: 100583818(ICMT)
MCC: 702925(ICMT)
MCF: 102143064(ICMT)
CSAB: 103225698(ICMT)
RRO: 104657578(ICMT)
RBB: 108517923(ICMT)
CJC: 100407809(ICMT)
SBQ: 101033335(ICMT)
MMU: 57295(Icmt)
MCAL: 110292612(Icmt)
MPAH: 110323024(Icmt)
RNO: 170818(Icmt)
MUN: 110552727(Icmt)
CGE: 100765763(Icmt)
NGI: 103725122(Icmt)
HGL: 101708049(Icmt)
CCAN: 109688359(Icmt)
OCU: 100354959(ICMT)
TUP: 102481076(ICMT)
CFA: 489628(ICMT)
VVP: 112924563(ICMT)
AML: 100473805(ICMT)
UMR: 103666895(ICMT)
UAH: 113270577(ICMT)
ORO: 101378501(ICMT)
FCA: 101093374(ICMT)
PTG: 102972150(ICMT)
PPAD: 109274017(ICMT)
AJU: 106982168(ICMT)
BTA: 785548(ICMT)
BOM: 102284128(ICMT)
BIU: 109570158(ICMT)
BBUB: 102389281(ICMT)
CHX: 102181140(ICMT)
OAS: 101117687(ICMT)
SSC: 100514410(ICMT)
CFR: 102506005 102517592(ICMT)
CDK: 105104720(ICMT)
BACU: 102998274(ICMT)
LVE: 103075548(ICMT)
OOR: 101269224(ICMT)
DLE: 111187160(ICMT)
PCAD: 102984361(ICMT) 112067426
ECB: 100059680(ICMT)
EPZ: 103558992(ICMT)
EAI: 106844258(ICMT)
MYB: 102243859(ICMT)
MYD: 102752083(ICMT)
MNA: 107538334(ICMT)
HAI: 109392161(ICMT)
DRO: 112299056(ICMT)
PALE: 102888174(ICMT)
RAY: 107521009(ICMT)
MJV: 108393173(ICMT)
LAV: 100667691(ICMT)
TMU: 101352144
MDO: 100026574(ICMT)
SHR: 100922116(ICMT)
PCW: 110200025(ICMT)
OAA: 100082737(ICMT)
GGA: 419373(ICMT)
CJO: 107323474(ICMT)
NMEL: 110408696(ICMT)
APLA: 101796351(ICMT)
ACYG: 106047254(ICMT)
TGU: 100226385(ICMT)
LSR: 110472535(ICMT)
SCAN: 103820933(ICMT)
GFR: 102035025(ICMT)
FAB: 101807717(ICMT)
PHI: 102099231(ICMT)
PMAJ: 107213586(ICMT)
CCAE: 111938471(ICMT)
CCW: 104693277(ICMT)
ETL: 114060109(ICMT)
FPG: 101917928(ICMT)
FCH: 102051478(ICMT)
CLV: 102091468(ICMT)
EGZ: 104132051(ICMT)
NNI: 104009029(ICMT)
ACUN: 113487801(ICMT)
PADL: 103916263(ICMT)
AAM: 106492669(ICMT)
ASN: 102370476(ICMT)
AMJ: 102558543(ICMT)
PSS: 102445166(ICMT)
CMY: 102930965(ICMT)
CPIC: 101940078(ICMT)
PVT: 110082455(ICMT)
PBI: 103060255(ICMT)
PMUR: 107284654(ICMT)
PMUA: 114602348(ICMT)
GJA: 107126275(ICMT)
XLA: 108696603(icmt.L) 397717(icmt.S)
XTR: 100127802(icmt)
NPR: 108783712(ICMT)
DRE: 550281(icmt)
IPU: 100528610(icmt)
PHYP: 113530714(icmt)
AMEX: 103047473(icmt)
EEE: 113570032(icmt)
TRU: 101073203(icmt)
LCO: 104939109(icmt)
NCC: 104943661(icmt)
MZE: 101470789(icmt)
ONL: 100700130(icmt)
OLA: 101174897(icmt)
XMA: 102236165(icmt)
XCO: 114142415(icmt)
PRET: 103466978(icmt)
CVG: 107100394(icmt)
NFU: 107391379(icmt)
KMR: 108250891(icmt)
ALIM: 106529330(icmt)
AOCE: 111574444(icmt)
CSEM: 103384860(icmt)
POV: 109630969(icmt)
LCF: 108900467(icmt)
SDU: 111233790(icmt)
SLAL: 111658859(icmt)
HCQ: 109528364(icmt)
BPEC: 110165621(icmt)
MALB: 109951050(icmt)
ELS: 105013890
SFM: 108918346 108933493(icmt)
CMK: 103181416(icmt)
RTP: 109931576(rpl22)
CIN: 100180736
SPU: 590850
APLC: 110990580
SKO: 100367732
DME: Dmel_CG11268(ste14)
DER: 6544938
DSI: Dsimw501_GD14422(Dsim_GD14422)
DSR: 110177511
DPE: 6595775
DMN: 108152572
DWI: 6639514
DAZ: 108614435
DNV: 108651467
DHE: 111597308
MDE: 101892329
LCQ: 111677116
AAG: 5575637
AME: 726380
BIM: 100742012
BTER: 100643105
CCAL: 108622574
OBB: 114879958
SOC: 105197150
MPHA: 105837712
AEC: 105145975
ACEP: 105622214
PBAR: 105429358
VEM: 105560211
HST: 105185274
DQU: 106746204
CFO: 105256735
LHU: 105671850
PGC: 109855265
OBO: 105279718
PCF: 106788840
NVI: 100120654(Icmt)
CSOL: 105360746
MDL: 103575965
TCA: 663323
DPA: 109539963
ATD: 109601490
NVL: 108569044
BMOR: 101739673
PMAC: 106710357
PRAP: 110997181
HAW: 110383716
TNL: 113501825
PXY: 105384312
API: 100164090
DNX: 107163542
AGS: 114119728
RMD: 113554961
BTAB: 109038542
CLEC: 106671913
ZNE: 110832892
FCD: 110846976
PVM: 113806295
TUT: 107363991
DPTE: 113791187
CSCU: 111625561
PTEP: 107442040
CEL: CELE_F21F3.3(icmt-1) CELE_M01E11.1(M01E11.1)
CBR: CBG14895
BMY: Bm1_06675
TSP: Tsp_01153
PCAN: 112557095
CRG: 105346111
MYI: 110462725
OBI: 106868383
LAK: 106174929
SHX: MS3_01050
EPA: 110237603
ADF: 107355711
AMIL: 114967500
PDAM: 113680524
SPIS: 111345496
DGT: 114518340
HMG: 100212062
AQU: 100636862
ATH: AT5G08335(ATSTE14B) AT5G23320(STE14A)
ALY: ARALYDRAFT_487666(ATSTE14B) ARALYDRAFT_910344(ATSTE14)
BOE: 106336082
THJ: 104800704
CPAP: 110814012
CIT: 102617349
GMX: 100784645
GSJ: 114390988
VRA: 106764479
VAR: 108344723
VUN: 114181981
CCAJ: 109812098
CAM: 101506180
LJA: Lj0g3v0167899.1(Lj0g3v0167899.1) Lj2g3v1717600.1(Lj2g3v1717600.1) Lj5g3v2246100.1(Lj5g3v2246100.1)
ADU: 107490573
AIP: 107644074
FVE: 101310986
RCN: 112197795
PPER: 18790090
PMUM: 103321092
PAVI: 110754619
PXB: 103943223
ZJU: 107412754
CSV: 101223195
CMO: 103499053
JCU: 105648964
MESC: 110620247
SLY: 101267014
SPEN: 107015732
SOT: 102586096
CANN: 107870370
NSY: 104239723
NTO: 104120910
NAU: 109210243
INI: 109160050
SIND: 105168244
NNU: 104612300
OSA: 4336894
DOSA: Os04t0602900-01(Os04g0602900)
OBR: 102707769
BDI: 100846368
ATS: 109739451(LOC109739451)
SBI: 8085675
ZMA: 100284671(pco145633)
SITA: 101778469
MUS: 103991185
DCT: 110111382
PEQ: 110024627
ATR: 18435584
PPP: 112280103
MIS: MICPUN_58408(ICMT)
MPP: MICPUCDRAFT_15590(ICMT)
APRO: F751_1413
SCE: YDR410C(STE14)
ERC: Ecym_5461
KMX: KLMA_30652(STE14)
NCS: NCAS_0A12100(NCAS0A12100)
NDI: NDAI_0A04160(NDAI0A04160)
TPF: TPHA_0E02030(TPHA0E02030)
TBL: TBLA_0A06820(TBLA0A06820)
TDL: TDEL_0A03740(TDEL0A03740)
KAF: KAFR_0E03400(KAFR0E03400)
CAL: CAALFM_C601120CA(CaO19.119) CAALFM_C601130WA(CaO19.120)
NCR: NCU00034
MGR: MGG_05331
SSCK: SPSK_02638
MAW: MAC_07177
MAJ: MAA_07087
CMT: CCM_05030
MBE: MBM_04463
ANI: AN6162.2
ANG: ANI_1_1694104(An12g03660)
ABE: ARB_04882
TVE: TRV_06581
PTE: PTT_19748
SPO: SPAC10F6.12c(mam4)
CNE: CNC01050
CNB: CNBC6220
MGL: MGL_0263
MRT: MRET_1048
DDI: DDB_G0272799(icmA-1) DDB_G0273995(icmA-2)
EHI: EHI_006100(83.t00023)
SMIN: v1.2.027086.t1(symbB.v1.2.027086.t1) v1.2.037642.t1(symbB.v1.2.037642.t1)
SPAR: SPRG_05716
XCC: XCC0107
XCB: XC_0112
XCP: XCR_0125
XCV: XCV0113
XAX: XACM_0112
XOO: XOO0023(STE14)
XOM: XOO0023(XOO0023)
XPH: XppCFBP6546_11255(XppCFBP6546P_11255)
 » show all
Taxonomy
Reference
1  [PMID:3290900]
  Authors
Clarke S, Vogel JP, Deschenes RJ, Stock J.
  Title
Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.
  Journal
Proc Natl Acad Sci U S A 85:4643-7 (1988)
DOI:10.1073/pnas.85.13.4643
Reference
2  [PMID:2753892]
  Authors
Ota IM, Clarke S.
  Title
Enzymatic methylation of 23-29-kDa bovine retinal rod outer segment membrane proteins. Evidence for methyl ester formation at carboxyl-terminal cysteinyl residues.
  Journal
J Biol Chem 264:12879-84 (1989)
Reference
3  [PMID:2398053]
  Authors
Stephenson RC, Clarke S.
  Title
Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate.
  Journal
J Biol Chem 265:16248-54 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.100
IUBMB Enzyme Nomenclature: 2.1.1.100
ExPASy - ENZYME nomenclature database: 2.1.1.100
BRENDA, the Enzyme Database: 2.1.1.100
CAS: 130731-20-3

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