KEGG   ENZYME: 2.1.1.109
Entry
EC 2.1.1.109                Enzyme                                 

Name
demethylsterigmatocystin 6-O-methyltransferase;
demethylsterigmatocystin methyltransferase;
O-methyltransferase I
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 6-demethylsterigmatocystin = S-adenosyl-L-homocysteine + sterigmatocystin [RN:R03112]
Reaction(KEGG)
R03112;
(other) R10403
Substrate
S-adenosyl-L-methionine [CPD:C00019];
6-demethylsterigmatocystin [CPD:C03683]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
sterigmatocystin [CPD:C00961]
Comment
Dihydrodemethylsterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi.
History
EC 2.1.1.109 created 1992
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17649  demethylsterigmatocystin 6-O-methyltransferase
Genes
PAN: PODANSg8572
PFY: PFICI_09442
PSCO: LY89DRAFT_659800
AOR: AO090026000025
ANG: ANI_1_2158014(An01g00880)
AFV: AFLA_006292
URE: UREG_07660
PNO: SNOG_08160
AALT: CC77DRAFT_1098501
Reference
1  [PMID:2802602]
  Authors
Yabe K, Ando Y, Hashimoto J, Hamasaki T.
  Title
Two distinct O-methyltransferases in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 55:2172-7 (1989)
DOI:10.1128/AEM.55.9.2172-2177.1989
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.109
IUBMB Enzyme Nomenclature: 2.1.1.109
ExPASy - ENZYME nomenclature database: 2.1.1.109
BRENDA, the Enzyme Database: 2.1.1.109
CAS: 123516-47-2

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