KEGG ENZYME: 2.1.1.114

ENZYME: 2.1.1.114

Entry

EC 2.1.1.114                Enzyme

Name

polyprenyldihydroxybenzoate methyltransferase;
3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase;
dihydroxyhexaprenylbenzoate methyltransferase;
COQ3 (gene name);
Coq3 O-methyltransferase;
DHHB O-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:3,4-dihydroxy-5-all-trans-polyprenylbenzoate 3-O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate [RN:R08771]

Reaction(KEGG)

R08771 > R04711

Substrate

S-adenosyl-L-methionine [CPD:C00019];
3,4-dihydroxy-5-all-trans-polyprenylbenzoate [CPD:C17554]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate [CPD:C17559]

Comment

This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast [3]. The enzymes from yeast and rat also catalyse the methylation of 3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively [2] (this activity is classified as EC 2.1.1.64, 3-demethylubiquinol 3-O-methyltransferase).

History

EC 2.1.1.114 created 1999

Pathway

ec00130

Ubiquinone and other terpenoid-quinone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K00591

polyprenyldihydroxybenzoate methyltransferase / 3-demethylubiquinol 3-O-methyltransferase

Genes

HSA:	51805(COQ3)

PTR:	472079(COQ3)

PPS:	100989523(COQ3)

GGO:	101130141(COQ3)

PON:	100460505(COQ3)

PPYG:

129038962(COQ3)

NLE:	100605053(COQ3)

HMH:	116469987(COQ3)

SSYN:

129471174(COQ3)

MCC:	694215(COQ3)

MCF:	102115755(COQ3)

MTHB:

126952182

MNI:	105499051(COQ3)

CSAB:

103240691(COQ3)

CATY:

105588941(COQ3)

PANU:

101027017(COQ3)

TGE:	112622631(COQ3)

MLEU:

105534804(COQ3)

RRO:	104665775(COQ3)

RBB:	108540682(COQ3)

TFN:	117097118(COQ3)

PTEH:

111538514(COQ3)

CANG:

105522065(COQ3)

CJC:	100393993(COQ3)

SBQ:	101043606(COQ3)

CIMI:

108288693(COQ3)

ANAN:

105711448(COQ3)

CSYR:

103268352(COQ3)

MMUR:

105856863 105874007(COQ3)

LCAT:

123633098(COQ3)

PCOQ:

105824417(COQ3)

OGA:	100961359(COQ3)

MMU:	230027(Coq3)

MCAL:

110292882(Coq3)

MPAH:

110338896(Coq3)

RNO:	29309(Coq3)

MCOC:

116088019(Coq3)

ANU:	117698752(Coq3)

ASYL:

127680593(Coq3)

CGE:	100763494(Coq3)

MAUA:

101828608(Coq3)

PROB:

127232409(Coq3)

PLEU:

114699089(Coq3)

MORG:

121458407(Coq3)

MFOT:

126503426

AAMP:

119825961(Coq3)

NGI:	103739284(Coq3)

HGL:	101715057(Coq3)

CPOC:

100724558(Coq3)

CCAN:

109695058(Coq3)

DORD:

105990077(Coq3)

DSP:	122107739(Coq3)

PLOP:

125357110(Coq3)

NCAR:

124989051

MMMA:

107153945(Coq3)

ITI:	101958804(Coq3)

OCU:

100358169

OPI:	101528382(COQ3)

TUP:	102497158(COQ3)

GVR:	103591945(COQ3)

CFA:	475004(COQ3)

CLUD:

112658653(COQ3)

VVP:	112923176(COQ3)

VLG:	121501565(COQ3)

NPO:	129512487(COQ3)

AML:	100467925(COQ3)

UMR:	103675878(COQ3)

UAH:	113264805(COQ3)

UAR:	123798537(COQ3)

ELK:

111158309

LLV:

125103306

MPUF:

101690789(COQ3)

MNP:	132018314(COQ3)

MLK:	131833578(COQ3)

NVS:	122904390(COQ3)

ORO:	101362353(COQ3)

EJU:	114210011(COQ3)

ZCA:	113927407(COQ3)

MLX:	118001336(COQ3)

NSU:	110583330(COQ3)

LWW:	102747835(COQ3)

FCA:	101084711(COQ3)

PYU:	121029819(COQ3)

PCOO:

112862521(COQ3)

PBG:	122489795(COQ3)

PVIV:

125165442(COQ3)

LRUF:

124529031

LGF:	123608769(COQ3)

AJU:

106979821

PTG:	102957897(COQ3)

PPAD:

109263453(COQ3)

PUC:

125938728

PLEZ:

122220208(COQ3)

HHV:	120245198(COQ3)

BTA:	540298(COQ3)

BOM:	102280603(COQ3)

BIU:	109563521(COQ3)

BBUB:

102394970(COQ3)

BBIS:

104984808(COQ3)

CHX:	102187404(COQ3)

OAS:	101103985(COQ3)

BTAX:

128053323(COQ3)

CSUM:

138089819(COQ3)

ODA:	120862959(COQ3)

CCAD:

122422910(COQ3)

MREE:

136150635(COQ3)

OVR:	110136557(COQ3)

MBEZ:

129561235(COQ3)

SSC:	100152047(COQ3)

CFR:	102506087(COQ3)

CBAI:

105063766(COQ3)

CDK:	105092245(COQ3)

VPC:	102530065(COQ3)

BACU:

102998851(COQ3)

BMUS:

118904914(COQ3)

LVE:	103071140(COQ3)

OOR:	101278528(COQ3)

LALB:

132530793(COQ3)

DLE:	111163938(COQ3)

PCAD:

102980697(COQ3)

PSIU:

116763631(COQ3)

PPHC:

136132143(COQ3)

NASI:

112409317(COQ3)

ECB:	100071606(COQ3)

EPZ:	103550511(COQ3)

EAI:	106829737(COQ3)

MYB:	102240639(COQ3)

MYD:	102773416(COQ3)

MMYO:

118659789(COQ3)

MLF:	102423108(COQ3)

MDT:	132237053(COQ3)

MYUM:

139013108(COQ3)

PKL:	118705158(COQ3)

EFUS:

103284585(COQ3)

MNA:	107542777(COQ3)

DRO:	112296972(COQ3)

SHON:

118996363(COQ3)

AJM:	119049487(COQ3)

PDIC:

114495600(COQ3)

PHAS:

123821686(COQ3)

MMF:	118621132(COQ3)

PPAM:

129067654(COQ3)

HAI:	109383324(COQ3)

RFQ:	117020858(COQ3)

PALE:

102878048(COQ3)

PGIG:

120594859(COQ3)

PVP:	105292500(COQ3)

RAY:	107514366(COQ3)

MJV:	108393579(COQ3)

TOD:	119252724(COQ3)

SARA:

101549542(COQ3)

SFUM:

130033470(COQ3)

SETR:

126006006(COQ3)

LAV:	100672677(COQ3)

TMU:

101346207

ETF:	101652108(COQ3)

DNM:	101425683(COQ3)

MDO:	100027296(COQ3)

GAS:	123245364(COQ3)

SHR:	100930795(COQ3)

AFZ:

127562027

PCW:	110216496(COQ3)

TVP:	118858568(COQ3)

PBRV:

138153044(COQ3)

OAA:	100075467(COQ3)

TACU:

119940841(COQ3)

GGA:	421797(COQ3)

PCOC:

116240666(COQ3)

MGP:	100550124(COQ3)

CJO:	107311936(COQ3)

TPAI:

128083307(COQ3)

LMUT:

125689684(COQ3)

NMEL:

110395375(COQ3)

APLA:

101802629(COQ3)

ACYG:

106032545(COQ3)

CATA:

118255528(COQ3)

AFUL:

116488243(COQ3)

TGU:	100226304(COQ3)

LSR:	110478399(COQ3)

SCAN:

103822333(COQ3)

PMOA:

120512020(COQ3)

OTC:	121341436(COQ3)

PRUF:

121359303(COQ3)

ATRC:

139599254(COQ3)

GFR:	102035378(COQ3)

FAB:	101812692(COQ3)

OMA:	130251426(COQ3)

PHI:	102111433(COQ3)

PMAJ:

107201279(COQ3)

CCAE:

111925696(COQ3)

CCW:	104691951(COQ3)

CBRC:

103619375(COQ3)

ACOE:

138108435(COQ3)

ETL:	114066897(COQ3)

ZAB:	102070464(COQ3)

ZLE:	135445193(COQ3)

ACHL:

103801165(COQ3)

SVG:	106857520(COQ3)

MMEA:

130572408(COQ3)

HRT:	120750934(COQ3)

SATI:

136358964(COQ3)

CCIC:

134041738(COQ3)

FPG:	101922657(COQ3)

FCH:	102051117(COQ3)

CCRI:

104155864(COQ3)

NNT:	104399923(COQ3)

SHAB:

115609874(COQ3)

ACUN:

113478599(COQ3)

TALA:

104356353(COQ3)

ACHC:

115333800(COQ3)

HALD:

104311622(COQ3)

HLE:	104835398(COQ3)

AGEN:

126045956

HHAR:

128139284(COQ3)

GCL:

127014057

LDI:	104341019(COQ3)

MNB:	103768417(COQ3)

DPUB:

104298084(COQ3)

PPUS:

135189596(COQ3)

AVIT:

104271130(COQ3)

BRHI:

104488323(COQ3)

EGZ:	104135397(COQ3)

NNI:	104021932(COQ3)

PCRI:

104030505(COQ3)

PCAO:

104053885(COQ3)

PADL:

103913631(COQ3)

AFOR:

103895726(COQ3)

FGA:	104071209(COQ3)

GSTE:

104252176(COQ3)

CBOY:

140648985(COQ3)

CLV:	102086869(COQ3)

CNIC:

135987655(COQ3)

MUI:	104534568(COQ3)

PGUU:

104459641(COQ3)

PLET:

104615307(COQ3)

EHS:	104504430(COQ3)

CMAC:

104474682(COQ3)

CUCA:

104062428(COQ3)

TEO:	104383291(COQ3)

BREG:

104630801(COQ3)

OHA:	104337457(COQ3)

ACAR:

104519351(COQ3)

CPEA:

104396476(COQ3)

CVF:	104289973(COQ3)

RTD:	128907574(COQ3)

CRID:

134513357(COQ3)

AAM:	106489741(COQ3)

AROW:

112962817(COQ3)

NPD:	112946491(COQ3)

TGT:	104566904(COQ3)

DNE:	112996549(COQ3)

SCAM:

104149287(COQ3)

ASN:	102382553(COQ3)

AMJ:	102561582(COQ3)

CPOO:

109312133(COQ3)

GGN:	109299716(COQ3)

PSS:	102448168(COQ3)

CMY:	102939536(COQ3)

CCAY:

125634345(COQ3)

DCC:	119853854(COQ3)

CPIC:

101933988(COQ3)

TST:	117875082(COQ3)

CABI:

116824666(COQ3)

MRV:	120401866(COQ3)

ACS:	100552641(coq3)

ASAO:

132760818(COQ3)

PVT:	110073091(COQ3)

SUND:

121925266(COQ3)

PBI:	103065538(COQ3)

PMUR:

107291197

CTIG:

120313799(COQ3)

TSR:	106537640(COQ3)

PGUT:

117660793(COQ3)

APRI:

131194177(COQ3)

PTEX:

113455371(COQ3)

NSS:	113411504(COQ3)

VKO:	123022053(COQ3)

PMUA:

114593982(COQ3)

PRAF:

128410371(COQ3)

ZVI:	118082236(COQ3)

HCG:	128341313(COQ3)

GJA:	107121898(COQ3)

STOW:

125431235(COQ3)

EMC:	129331949(COQ3)

XLA:	443690(coq3.L)

XTR:	100486084(coq3)

NPR:

108793957

RTEM:

120937141(COQ3)

ACAT:

141140133(COQ3)

BBUF:

120998214(COQ3)

BGAR:

122934694(COQ3)

DTC:	141100833(COQ3)

PWL:	138296429(COQ3)

MUO:	115464826 115465250

GSH:	117358102(COQ3)

DRE:	436893(coq3)

SRX:	107711746 107716851

SANH:

107700757

SGH:

107552820

CCAR:

109106117 109106591

CAUA:

113100084 113116766

CGIB:

127974754 128030553

PTET:

122359872(coq3)

LROH:

127178370(coq3)

GRF:	141342089(coq3)

OMC:	131521410(coq3)

PPRM:

120484812(coq3)

RKG:	130090885(coq3)

MAMB:

125243839(coq3)

CIDE:

127497537

CERY:

137026827(coq3)

MASI:

127453329 127454357

TROS:

130558682(coq3)

TDW:	130432872(coq3)

MANU:

129448238(coq3)

PDAB:

135788897(coq3)

IPU:

108280168

IFU:	128624526(coq3)

PHYP:

113543171(coq3)

SMEO:

124403400(coq3)

TFD:	113640282(coq3)

TVC:	132840183(coq3)

CGAR:

128513131(coq3)

NGRA:

132871175(coq3)

TRN:	134305882(coq3)

AMEX:

103032671(coq3)

CMAO:

118797403(coq3)

EEE:	113591150(coq3)

CHAR:

105897612(coq3)

SPIL:

134082500(coq3)

TRU:	101068003(coq3)

TFS:	130531977(coq3)

TNG:	GSTEN00013481G001

LCO:	104937659(coq3)

NCC:	104953824(coq3)

TBEN:

117480552(coq3)

CGOB:

115020743(coq3)

PGEO:

117461572(coq3)

GACU:

117554768(coq3)

EMAC:

134861431(coq3)

ELY:	117265536(coq3)

EFO:	125893781(coq3)

PLEP:

121945999(coq3)

SLUC:

116066548(coq3)

ECRA:

117946157(coq3)

ESP:	116691632(coq3)

PFLV:

114557146(coq3)

GAT:	120810113(coq3)

PPUG:

119197747(coq3)

AFB:	129109895(coq3)

CLUM:

117728092(coq3)

PSWI:

130187907(coq3)

CANA:

137781540(coq3)

CVE:	137887235(coq3)

MSAM:

119898031(coq3)

SCHU:

122881223(coq3)

CUD:	121513140(coq3)

SPUL:

138584640(coq3)

LMIX:

132983200(coq3)

ALAT:

119005535(coq3)

ASTR:

137609939(coq3)

MZE:	101477606(coq3)

ONL:	100694801(coq3)

OAU:	116320611(coq3)

OLA:	101159463(coq3)

OML:	112144102(coq3)

CSAI:

133440878(coq3)

XMA:	102218300(coq3)

XCO:	114144867(coq3)

XHE:	116716784(coq3)

PRET:

103478229(coq3)

PFOR:

103148584(coq3)

PLAI:

106936579(coq3)

PMEI:

106914342(coq3)

GAF:	122831737(coq3)

PPRL:

129367481(coq3)

CVG:

107104003

CTUL:

119773299(coq3)

GMU:	124865921(coq3)

NFU:	107378827(coq3)

KMR:	108234166(coq3)

ALIM:

106528267(coq3)

NWH:	119410241(coq3)

AOCE:

111575801(coq3)

EJA:	138194565(coq3)

BFRE:

138622937(coq3)

MCEP:

125016197(coq3)

CSEM:

103388578(coq3)

POV:	109632073(coq3)

SSEN:

122774200(coq3)

SSOE:

131471637(coq3)

HHIP:

117777031(coq3)

HSP:	118113431(coq3)

PPLT:

128450037(coq3)

SMAU:

118300392(coq3)

LCF:

108887396

SDU:	111227779(coq3)

SLAL:

111658045(coq3)

XGL:	120784193(coq3)

HCQ:	109507095(coq3)

SSCV:

125974761(coq3)

SBIA:

133501171(coq3)

PEE:	133401172(coq3)

PTAO:

133479165(coq3)

BPEC:

110171757(coq3)

ENY:	140373958(coq3)

BSPL:

114842583(coq3)

SJO:	128366330(coq3)

SSCO:

133983582(coq3)

GMH:	115554497(coq3)

SASA:

106584027(COQ3) 106605038

STRU:

115175724 115177398

OTW:	112223160 112232701

OMY:	110490015 110519152(coq3)

OGO:	123997503 124005594

ONE:	115106538 115141398

OKI:	109864723 109902218

OKE:	118364192 118367269(coq3)

OMM:	135519996(coq3)

OCLA:

139367166 139394807

SALP:

111959183 111965300

SNH:	120031501(coq3) 120048261

CCLU:

121555950 121585892

ELS:	105028972(coq3)

OEP:	134023200(coq3)

SFM:	108937244(coq3)

PKI:	111844517(coq3)

AANG:

118231080(coq3)

AROT:

135258751(coq3)

CCOG:

133137528(coq3)

LOC:	102692257(coq3)

PSPA:

121316246 121317373(coq3)

ARUT:

117411598(coq3)

PSEX:

120525363(coq3)

LCM:	102345501(COQ3)

CMK:	103178294(coq3)

RTP:	109927827(coq3)

CPLA:

122539954(coq3)

HOC:	132805609(coq3)

LERI:

129697381(coq3)

HAKA:

140732997(coq3)

PMRN:

116952949(COQ3)

LRJ:	133354178(COQ3)

BFO:

118423612

BBEL:

109487400

CIN:

113475354

SCLV:

120331881

SPU:

585619

LPIC:

129259633

AJJ:

139962654

APLC:

110974917

ARUN:

117296197 117296374

AAMU:

139947553

AFIL:

140144046 140156354

AJC:

117100400

SKO:

100366871

PFLL:

139142632

DME:	Dmel_CG9249(Coq3)

DER:

6548784

DSE:

6618248

DSI:	Dsimw501_GD21650(Dsim_GD21650)

DYA:	Dyak_GE13000

DAN:

6502448

DSR:

110187422

DPO:

4818186

DPE:

6593399

DMN:

108162669

DWI:

6646617

DGR:

6566680

DMO:	Dmoj_GI14517

DAZ:

108612023

DNV:

108658473

DHE:

111595821

DVI:	6635634(Coq3)

CCAT:

101449981 101455379

BOD:

106615267

BDR:	105231162 105231163

RZE:	108357712 108357732

AOQ:

129249316

ALUD:

128862976

TDA:

119689974

SCAC:

106081742 106081743 106081744

LCQ:

111686435

LSQ:

119611129

CVJ:	135951827(Coq3)

GFS:	119632957 119633375

ECOE:

129939392

CLON:

129608271 129612915

HIS:

119654558

AGA:	1275264 1275266

ACOZ:

120957077 120958582

AARA:

120901876 120901877

AMER:

121599364 121599656

ASTE:

118506042 118506043 118516405 118516409

AMAP:

126556244 126556254

AFUN:

125769665 125769666

AMOU:

128296795 128298315

AMRS:

128707016 128709070

AALI:

118463113 118463621

ACOS:

131259204 131271924

AAG:

5565506

AALB:

109418670

ASUA:

134219943 134219951

CQU:	CpipJ_CPIJ011660

CPII:

120414085 120416201

CBRI:

134832068

CNS:

116345376

BCOO:

119078812

LLL:	129789216 129794278 129796320

PPAP:

129803110

AME:

412082

ACER:

107992625

ALAB:

122717233

ADR:

102673006

AFLR:

100864667

BIM:

100743019

BBIF:

117214288

BVK:

117242421

BVAN:

117161099

BHUN:

126874532

BTER:

100646934

BAFF:

126925783

BPYO:

122576218

BPAS:

132914827

FVI:

122532595

CCAL:

108625765

OBB:

114872203

OLG:

117606599

MGEN:

117227011

NMEA:

116433039

CGIG:

122401072

SOC:

105195087

MPHA:

105828156 105835080

AEC:

105147357

ACEP:

105619456 105620929 105624786

PBAR:

105430215 105434350

VEM:	105560942 105567141

COBS:

139103358 139107902(Coq3)

TLN:	139816139 139818129(Coq3)

HST:	105181953 105184787

DQU:	106741330 106741331

CFO:

105257596

FEX:

115237717

PMEC:

138932490(Coq3)

LHU:	105668996(Coq3)

PGC:

109852748

OBO:	105285419 105285422

PCF:

106785710

PFUC:

122519683

VPS:

122630471

VCRB:

124424360 124427022

VVE:	124950731 124952201

NVI:

100119297

CSOL:

105361322

TPRE:

106649810

LHT:	122502722 122502767 122502768

LBD:

127279306

MDL:

103570243

CGLO:

123262473

FAS:

105267509

DAM:

107037176

AGIF:

122855046

CINS:

118072803

VCAN:

122405990

CCIN:

107268888

DSM:

124408799

NPT:	124217588(Coq3)

NFB:

124180253

NLO:

107217665

NVG:

124302611

AROA:

105690562

TCA:

100141867

TMOL:

138123061 138123444 138124413

DPA:

109544127

ESIM:

136414944(Coq3)

EFOR:

136341812(Coq3)

SOY:

115889469

AGRG:

126735531

ATD:

109594349

CSET:

123308703

HAXR:

123682183

AGB:

108917296

LDC:

111510247

DVV:

114347531

APLN:

108743297

PPYR:

116158620 116158621 116158623 116158669 116159764 116160629 116161196 116163297 116163298 116166495 116166496 116166497 116170871 116173439 116173731 116173732 116174772 116175380 116176992 116177090 116177091 116179134 116179541 116179799 116180872 116180895 116182668

OTU:	111414825 111422786

BMOR:

101747145

BMAN:

114245597

MSEX:

115442662

DPL:	KGM_209147

BANY:

112048978 112048979 112048980 112048999 112053655 112053656 112054749 112057925

MJU:	123869453 123869751 123869758 123869759 123870401

NIQ:

126772511

VCD:	124543800 124543900

MCIX:

123658171

PMAC:

106713833

PPOT:

106111618

PXU:

106121903

BPHI:

137918532 137933778

PRAP:

110993192 110999904 110999906 111004477 111004478

PBX:	123708366 123713357 123718905 123718912

PNAP:

125051221 125052356 125059944

ZCE:	119833841 119833849 119833883 119834005 119834020

CCRC:

123696574 123696575 123696576 123696577 123696578

LSIN:

126975353 126975354

AAGE:

121733787 121733788

HAW:

110381146

HZE:

124634070

TNL:

113497927

SLIU:

111357738

OFU:	114359903 114359904

ONU:	135075861 135076103

ATRA:

106135637

GMW:

113509624

PXY:

105387053

PGW:

126371100

LGLY:

125229409 125229913

CSTB:

134744986

CFUM:

141435997(Coq3)

CFEL:

113377902

CCRN:

123300180

API:	100165711(Coq3)

DNX:

107170362

AGS:

114124467

RMD:

113560636

ACOO:

126834190

DVT:

126904325

BTAB:

109033909

HHAL:

106688162(Coq3)

NLU:

111046101

HVI:

124360906

MQU:	128991738 128992281

PHU:	Phum_PHUM106910

FOC:

113213344

TPAL:

117652148

ZNE:

110831402

CSEC:

111875259

PAME:

138705917 138714984 138714985 138714986

SGRE:

126323248 126336759

BROR:

134546262

IEL:

124166008

HAMR:

139686508(Coq3)

FCD:

110853913

DPX:	DAPPUDRAFT_204530 DAPPUDRAFT_304225

DMK:	116917670 116917672

DPZ:	124329374 124329375

AFRA:

136037161

PVM:

113804873

PJA:	122264095 122264096

PCHN:

125028942

PMOO:

119574623

HAME:

121862891

PCLA:

123763535

PTRU:

123517123

ESN:

126999723

MNZ:

135210302

MRJ:	136853470(Coq3)

PORN:

139756782

HAZT:

108664845

EAF:

111706791

LSM:	121131782(Coq3)

TCF:

131889021

PPOI:

119100787

DSV:

119460964

RSAN:

119396868

RMP:

119174958

VDE:

111247877

VJA:

111265194

GOE:

100905107

TUT:

107367378

DPTE:

113789926

DFR:

124495996

CSCU:

111614989

CVS:

136968916

ABRU:

129956738

UDV:

129223862

SDM:

118198361

LPOL:

106476637

PMEO:

129582614 129593712 129599930

CEL:	CELE_Y57G11C.11(coq-3)

CBR:	CBG_21513(Cbr-coq-3)

CRQ:	GCK72_012871

LOA:	LOAG_08944

TSP:

Tsp_07034

HRO:	HELRODRAFT_186006

LGI:	LOTGIDRAFT_210097

PVUL:

126811638 126819444

PCAN:

112566186

LSAX:

138962301 138962331

BGT:

106052132

GAE:

121372019

HRF:

124138290

HRJ:

124281716

HASI:

137288098

HCRA:

139474604

CRG:

105345298

CANU:

128183458

CVN:	111104439 111104443

OED:	125674890 125675867

MYI:

110451595

PMAX:

117327834

AIRR:

138323601

MCAF:

127724301

MMER:

123552186

RPHI:

132759352

DPOL:

127853781

MAEA:

128237377

OBI:

106868239

OSN:

115227775

LJP:

135482237

LAK:

106169042

SMM:	Smp_029060

OVI:	T265_10717

EGL:

EGR_00756

LLON:

135487817

NVE:	116604343 5513769

EPA:

110251814

ATEN:

116302338

ADF:

107335639

AMIL:

114970399

MCAZ:

138053379

MFOO:

137996402

PDAM:

113666715

SPIS:

111328439

DGT:

114536662

XEN:

124450633

HMG:

100204468

HSY:	130644632 130645944

RES:

135685174

TAD:	TRIADDRAFT_61065

ATH:	AT2G30920(COQ3)

ALY:

9315354

CRB:

17889573

CSAT:

104700381 104749784

EUS:	EUTSA_v10016964mg

BRP:

103865085

BNA:	106402442 125608428

BOE:

106337471

RSZ:

108851513

THJ:

104800821

CIT:

102628803

CIC:	CICLE_v10017823mg

PVY:

116116092

MINC:

123210116

TCC:

18612125

GRA:

105785987

GHI:	107922391 107925417

GAB:

108467173

HSYR:

120166762

DZI:

111292470

EGR:

104440595

RARG:

115755390 115755432

GMX:	100783802 100807770

GSJ:	114385101 114402025

PVU:

137825589

VRA:

106763865

VAR:

108336341

VUN:

114195553

VUM:

124826842

CCAJ:

109819007

APRC:

113848185

MTR:

11426775

TPRA:

123882240

CAM:

101514643

PSAT:

127117729

VVO:

131615834

LJA:	130740238 130741336

ADU:

107496455

AIP:

107608552

AHF:	112702018 112765076

LANG:

109359219

PCIN:

129317036

QSA:	O6P43_013766 O6P43_021109

FVE:

101308783

AANS:

126799305

RCN:	112177865 112188555 112196988

PPER:

18784017

PMUM:

103328744

PAVI:

110744478

PDUL:

117620687

MDM:	103405199 103443219

MSYL:

126612054 126634126

PXB:	103931749 103941527

PCOX:

137708634 137740845

ZJU:

107416376

MNT:	112091045 21403799

CSAV:

115698611

CSV:

101220123

CMO:

103496335

BHJ:

120088766

MCHA:

111018122

CMAX:

111469658

CMOS:

111450999

CPEP:

111794669

RCU:

8275179

MEAN:

126675346

JCU:

105638344

HBR:

110649540

MESC:

110605603 110627749

POP:

7494128

PEU:

105134599

PALZ:

118041566

PNZ:

133681885

JRE:

108984831

CILL:

122304180

CAVE:

132180940

AGLU:

133879948

QSU:

112025445

QLO:

115953264

TWL:

120016006

VVI:

109121384

VRI:

117918484

SLY:

101257784

SPEN:

107024527

SOT:

102594881

SSTN:

125876596

SDUL:

129893049

CANN:

107878470

LBB:

132618275

NTA:	107822696 107826256

NSY:

104217617

NTO:

104098748

NAU:

109228760

INI:

109175332

ITR:

116001547

SIND:

105165591

EGT:

105964336

SSPL:

121743144 121759663 121811274

SMIL:

131009089

SHIS:

125188019 125196171

APAN:

127247056

HAN:	110885947 110894738

ECAD:

122584743

LSV:

111902467

CCAV:

112525219

DCR:

108217606

CSIN:

114275345

RVL:

131329952

AEW:	130751121 130789431

DLT:

127792476

BVG:

104903580

SOE:

110783724

CQI:	110696844 110699670

ATRI:

130820410

MOF:

131149619

NNU:

104609002

MING:

122069676

TSS:	122650342 122650995

PSOM:

113287462 113309652

OSA:

4340157

DOSA:

Os06g0152300

OBR:

102706202

OGL:	127777263 127777264

BDI:

100838272

ATS:

109762703

TDC:	119331612 119340604

TAES:

123151503 123160250 123165173

TUA:

125522525

LPER:

127311244 127311806

LRD:	124699434 124705517

SBI:

8071329

ZMA:	100272292 103635598 109941453 109941456

MFLO:

136519892 136522058 136528212

SITA:

101762675 101778786

SVS:	117838066 117853252

PVIR:

120649130 120670471 120687479 120702650

PHAI:

112873851 112891203

PAUA:

133926258 133930847

PDA:

103711036

EGU:

105040573

MUS:

103997549

ZOF:	122019877 122024779

DCT:

110099596

PEQ:

110017992

AOF:

109844842

MSIN:

131245489

ACAK:

137938982 137960258

NCOL:

116247904

ATR:

18437492

CJF:	131034260 131075944

PPP:

112293916

SCE:	YOL096C(COQ3)

SEUB:

DI49_2309

SPAO:

SPAR_O00570

AGO:	AGOS_ADR115W

ERC:

Ecym_2788

KLA:	KLLA0_C03630g

KMX:	KLMA_10163(COQ3)

LTH:	KLTH0C09812g

VPO:	Kpol_1053p29

ZRO:	ZYRO0B06336g

CGR:	2888978(GVI51_I07425)

NCS:	NCAS_0B04170(NCAS0B04170)

NDI:	NDAI_0G04260(NDAI0G04260)

TPF:	TPHA_0A00670(TPHA0A00670)

TBL:	TBLA_0B02330(TBLA0B02330)

TGB:	HG536_0G02000

TDL:	TDEL_0D05250(TDEL0D05250)

KAF:	KAFR_0C01400(KAFR0C01400)

KNG:	KNAG_0K00720(KNAG0K00720)

ZMK:	HG535_0H03280

SLUD:

SCDLUD_002572

DHA:	DEHA2F12100g

PIC:	PICST_31991(COQ3)

PGU:	PGUG_00884

SPAA:

SPAPADRAFT_57194

LEL:	PVL30_005500(COQ3)

LBG:	92209433(LODBEIA_P42370)

CAL:	CAALFM_C601840CA(COQ3)

CTP:	CTRG_02881

COT:	CORT_0F03280

CDU:	CD36_61970

CTEN:

18249542(COQ3)

CLU:	CLUG_03921

CLUS:

A9F13_01g02057

CAUR:

CJI96_0004154

ASAU:

88175525(PUMCH_004465)

PPA:	PAS_chr3_0169

PKZ:	C5L36_0C07580

BNN:	FOA43_003734

BBRX:

BRETT_000434

OPA:	HPODL_02089

YLI:	2907025(YALI2_C00448g)

SLB:	AWJ20_5240(COQ3)

NCR:

NCU05982

NTE:	NEUTE1DRAFT69561(NEUTE1DRAFT_69561)

SMP:	10808182(SMAC4_07908)

PAN:	PODANSg3177

PBEL:

QC761_406900(COQ3)

PPSD:

QC762_406900(COQ3)

PPSP:

QC763_406900(COQ3)

PPSA:

QC764_406900(COQ3)

TTT:	THITE_2012986

MTM:	MYCTH_2306542

CTHR:

CTHT_0043890

RTHE:

98128730(VTJ83DRAFT_7281)

MGR:

MGG_01048

PPEI:

PpBr36_08092

PGRI:

PgNI_08196

SSCK:

SPSK_05377

FGR:	FGSG_08453

FPU:	FPSE_05669

FPOA:

FPOAC1_004557

FVN:	FVRRES_05054

FVR:	FVEG_02122

FOX:	FOXG_03251

NHE:	NECHADRAFT_35351

FFC:	NCS54_00382800

FKR:	NCS57_00388100

FMU:	J7337_008466

TRE:	TRIREDRAFT_123758

TRR:	M419DRAFT_115130

TATV:

25780307(TrAtP1_008659)

TASP:

36607815(TrAFT101_002770)

MAW:	19247765(COQ3)

MAJ:

MAA_02253

MBRN:

26239833(coq3)

PCHM:

VFPPC_01412

CMT:

CCM_04502

AMUS:

LMH87_011360

PLJ:	28884828(PLICBS_006036)

PTKZ:

JDV02_008531(COQ3)

VAL:	VDBG_08067

VDA:	VDAG_01563

CFJ:	CFIO01_11896

CLUP:

CLUP02_00459

CHIG:

CH63R_08031

CDET:

87945257(CDEST_08754)

ELA:	UCREL1_1530

PFY:	PFICI_10102

SSL:	SS1G_11371

BFU:	BCIN_08g04760(Bccoq3)

MBE:

MBM_01094

PSCO:

LY89DRAFT_388649

GLZ:	GLAREA_04560

ANI:	ANIA_01999

AFM:	AFUA_4G10370

ACT:	ACLA_049570

NFI:	NFIA_105700

AOR:	AO090003001180

ANG:	An04g06490

AFV:	AFLA_000487

ALUC:

AKAW2_30342A(COQ3)

ACHE:

ACHE_10760A(COQ3)

APUU:

APUU_21053A(COQ3)

PCS:	N7525_005103

PDP:	PDIP_25210

POU:	POX_f08096

TMF:	EYB26_005231

TRG:	TRUGW13939_02728

CIM:	CIMG_10579

CPW:	9691915(COQ3)

URE:	UREG_00594

ABE:

ARB_03737

TVE:

TRV_06586

PBL:	PAAG_07075

PBN:	PADG_01600

BGH:	BDBG_02291

PNO:	SNOG_14452

PTE:

PTT_06944

PTRR:

6338331(PtrM4_020950)

BZE:	COCCADRAFT_35964

BSC:	COCSADRAFT_250155

BOR:	COCMIDRAFT_108264

AALT:

CC77DRAFT_1020257

ARAB:

EKO05_0006092

ZTR:	MYCGRDRAFT_69451

PFJ:	MYCFIDRAFT_210943

FFU:	CLAFUR5_05639

CBET:

CB0940_08342

BCOM:

BAUCODRAFT_67139

NPA:	UCRNP2_3081

TML:	GSTUM_00010637001

SPO:	2538771(coq3)

SOM:	SOMG_04791(coq3)

CNE:

CNK00940

CNB:

CNBK2560

CNG:	CNAG_02609

CGI:	CGB_K3310W

CDEU:

CNBG_3178

CDEC:

89991595(IAS62_004824)

CTEG:

91991952(I308_105096)

CBAS:

91985494(I312_105449)

CDEP:

91090449(L203_106241)

KMG:	30162005(I203_107439)

KNE:	92181973(IAR55_004715)

KDJ:	28965744(I303_101819)

KBI:	30208388(I302_100615)

KPIN:

30174728(I206_101672)

KSH:	87954030(IL334_001899)

KER:	91104772(V865_005971)

TMS:	TREMEDRAFT_45810

TASA:

A1Q1_00080

CCAC:

CcaHIS019_0608260(COQ3)

TVS:	TRAVEDRAFT_72260

DSQ:	DICSQDRAFT_100783

PCO:	PHACADRAFT_104382

SHS:	STEHIDRAFT_168822

HIR:	HETIRDRAFT_246380

PSQ:	PUNSTDRAFT_90723

ADL:	AURDEDRAFT_183713

FME:	FOMMEDRAFT_171172

GTR:	GLOTRDRAFT_74959

LBC:	LACBIDRAFT_229597

CCI:	CC1G_00829

ABP:	AGABI1DRAFT118851(AGABI1DRAFT_118851)

ABV:	AGABI2DRAFT205921(AGABI2DRAFT_205921)

PCUB:

JR316_0007942

MRR:	Moror_7005

E1B28_007352

SCM:	SCHCO_02495421(SCHCODRAFT_02495421)

CPUT:

CONPUDRAFT_167122

SLA:	SERLADRAFT_451244

WSE:	WALSEDRAFT_60037

UMA:	UMAG_10369

PFP:	PFL1_01266

SGRA:

EX895_000228 EX895_005689

MGL:

MGL_3622

MRT:

MRET_0387

MSYM:

MSY001_1363

PGR:	PGTG_12261

PTRC:

PtA15_2A813

PSTR:

Pst134EA_005178

MLR:	MELLADRAFT_71815

RIE:	OCT59_025586

DDI:	DDB_G0279037(coq3)

DPP:	DICPUDRAFT_10678

DFA:	DFA_01836(coq3)

ACAN:

ACA1_117250

BBES:

BESB_049710

TET:	TTHERM_00803610

PTM:	GSPATT00008980001

» show all

Reference

1 [PMID:1885593]

Authors

Clarke CF, Williams W, Teruya JH.

Title

Ubiquinone biosynthesis in Saccharomyces cerevisiae. Isolation and sequence of COQ3, the 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase gene.

Journal

J Biol Chem 266:16636-44 (1991)

Sequence

[sce:YOL096C]

Reference

2 [PMID:10419476]

Authors

Poon WW, Barkovich RJ, Hsu AY, Frankel A, Lee PT, Shepherd JN, Myles DC, Clarke CF

Title

Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis.

Journal

J Biol Chem 274:21665-72 (1999)
DOI:10.1074/jbc.274.31.21665

Sequence

[sce:YOL096C]

Reference

3 [PMID:10777520]

Authors

Jonassen T, Clarke CF

Title

Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis.

Journal

J Biol Chem 275:12381-7 (2000)
DOI:10.1074/jbc.275.17.12381

Sequence

[hsa:51805]

Reference

4 [PMID:21636923]

Authors

Xing L, Zhu Y, Fang P, Wang J, Zeng F, Li X, Teng M, Li X

Title

Crystallization and preliminary crystallographic studies of UbiG, an O-methyltransferase from Escherichia coli.

Journal

Acta Crystallogr Sect F Struct Biol Cryst Commun 67:727-9 (2011)
DOI:10.1107/S1744309111014278

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.114

IUBMB Enzyme Nomenclature:

2.1.1.114

ExPASy - ENZYME nomenclature database:

2.1.1.114

BRENDA, the Enzyme Database:

2.1.1.114

CAS:	139569-31-6

All links

Gene (1987)   
   MGENES (771)   
   RefGene (1216)   
Protein sequence (3117)   
   UniProt (3082)   
   SWISS-PROT (9)   
   RefSeq(pep) (26)   
DNA sequence (81)   
   RefSeq(nuc) (39)   
   GenBank (26)   
   EMBL (16)   
Protein domain (3)   
   InterPro (3)   
All databases (5188)   

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