KEGG   ENZYME: 2.1.1.117
Entry
EC 2.1.1.117                Enzyme                                 

Name
(S)-scoulerine 9-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (S)-scoulerine = S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine [RN:R03835]
Reaction(KEGG)
R03835
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(S)-scoulerine [CPD:C02106]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-tetrahydrocolumbamine [CPD:C04118]
Comment
The product of this reaction is a precursor for protoberberine alkaloids in plants
History
EC 2.1.1.117 created 1999
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13397  (S)-scoulerine 9-O-methyltransferase
Genes
FVE: 101292538 101314449
RCN: 112164599 112175727 112178128
PPER: 18780355
PMUM: 103325170
PAVI: 110774000
PDUL: 117626380
MDM: 103435029
PXB: 103951323 103951351 103951352 103966079 103966114
JRE: 108979314 108981078 108981935 108986025 109004694 109018241 109018878 118348298
QSU: 111993653 111993655 112036190
QLO: 115961636
TWL: 120012623
VVI: 100265214
VRI: 117924373
 » show all
Reference
1  [PMID:24253642]
  Authors
Muemmler S, Rueffer M, Nagakura N, Zenk MH
  Title
S-adenosyl-L-methionine: (S)-scoulerine 9-O-methyltransferase, a highly stereo- and regio-specific enzyme in tetrahydroprotoberberine biosynthesis.
  Journal
Plant Cell Rep 4:36-9 (1985)
DOI:10.1007/BF00285501
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.117
IUBMB Enzyme Nomenclature: 2.1.1.117
ExPASy - ENZYME nomenclature database: 2.1.1.117
BRENDA, the Enzyme Database: 2.1.1.117
CAS: 96380-65-3

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