KEGG   ENZYME: 2.1.1.122Help
Entry
EC 2.1.1.122                Enzyme                                 

Name
(S)-tetrahydroprotoberberine N-methyltransferase;
tetrahydroprotoberberine cis-N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine [RN:R04716]
Reaction(KEGG)
R04716;
(other) R04691 R08789
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Substrate
S-adenosyl-L-methionine [CPD:C00019];
(S)-7,8,13,14-tetrahydroprotoberberine [CPD:C05204]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine [CPD:C05318]
Comment
Involved in the biosynthesis of isoquinoline alkaloids in plants.
History
EC 2.1.1.122 created 1999
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13396  (S)-tetrahydroprotoberberine N-methyltransferase
Reference
1
  Authors
Rueffer, M., Zumstein, G., Zenk, M.H.
  Title
Partial purification and characterization of S-adenosyl-L-methionine:(S)-tetrahydroprotoberberine cis-N-methyltransferase from suspension-cultured cells of Eschscholtzia and Corydalis.
  Journal
Phytochemistry 29:3727-3733 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.122
IUBMB Enzyme Nomenclature: 2.1.1.122
ExPASy - ENZYME nomenclature database: 2.1.1.122
BRENDA, the Enzyme Database: 2.1.1.122
CAS: 106878-42-6

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