KEGG   ENZYME: 2.1.1.137
Entry
EC 2.1.1.137                Enzyme                                 

Name
arsenite methyltransferase;
S-adenosyl-L-methionine:arsenic(III) methyltransferase;
S-adenosyl-L-methionine:methylarsonite As-methyltransferase;
methylarsonite methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:arsenite As-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate [RN:R05755];
(2) S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate [RN:R05756]
Reaction(KEGG)
R05755 R05756
Substrate
S-adenosyl-L-methionine [CPD:C00019];
arsenite [CPD:C06697];
methylarsonite [CPD:C07295]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methylarsonate [CPD:C07294];
dimethylarsinate [CPD:C07308]
Comment
An enzyme of the biotransformation pathway that forms dimethylarsinate from inorganic arsenite and arsenate. It methylates arsenite to form methylarsonate, Me-AsO3H2, which is reduced by EC 1.20.4.2, methylarsonate reductase, to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate for this enzyme (EC 2.1.1.137), which converts it into the much less toxic compound dimethylarsinate (cacodylate), Me2As(O)-OH.
History
EC 2.1.1.137 created 2000, (EC 2.1.1.138 incorporated 2003), modified 2003
Orthology
K07755  arsenite methyltransferase
Genes
HSA: 57412(AS3MT)
PTR: 450703(AS3MT)
PPS: 100990214(AS3MT)
GGO: 101153169(AS3MT)
PON: 100450997(AS3MT)
NLE: 100599978(AS3MT)
MCC: 714122(AS3MT)
MCF: 102134286(AS3MT)
CSAB: 103216446(AS3MT)
RRO: 104656532(AS3MT)
RBB: 108515080(AS3MT) 108523719
CJC: 100396953(AS3MT)
SBQ: 101044998(AS3MT)
MMU: 57344(As3mt)
MCAL: 110285298(As3mt)
MPAH: 110330191(As3mt)
RNO: 140925(As3mt)
MUN: 110556617(As3mt)
CGE: 100758973(As3mt)
NGI: 103744032(As3mt)
CCAN: 109691338(As3mt)
OCU: 100341970(AS3MT)
TUP: 102472983(AS3MT)
CFA: 486865(AS3MT)
VVP: 112915552(AS3MT)
AML: 100477280(AS3MT)
UMR: 103681866(AS3MT)
UAH: 113251882(AS3MT)
ORO: 101385200(AS3MT)
ELK: 111145061
FCA: 101085409(AS3MT)
PTG: 102967021(AS3MT)
PPAD: 109272834(AS3MT)
AJU: 106966953(AS3MT)
BTA: 505482(AS3MT)
BOM: 102269963(AS3MT)
BIU: 109579076(AS3MT)
BBUB: 102398096(AS3MT)
CHX: 100861071(AS3MT)
OAS: 101115498(AS3MT)
SSC: 100622012(AS3MT)
CFR: 102508617(AS3MT)
CDK: 105095021(AS3MT)
BACU: 103007103(AS3MT)
LVE: 103071271(AS3MT)
OOR: 101274407(AS3MT)
DLE: 111172349(AS3MT)
PCAD: 102991375(AS3MT)
ECB: 100069819(AS3MT)
EPZ: 103557886(AS3MT)
EAI: 106838170(AS3MT)
HAI: 109379613(AS3MT)
DRO: 112300462(AS3MT)
PALE: 102884356(AS3MT)
MJV: 108394313(AS3MT)
LAV: 100655067(AS3MT)
TMU: 101356087
PCW: 110192390(AS3MT)
OAA: 100080992(AS3MT)
GGA: 423870(AS3MT)
MGP: 100540487(AS3MT)
CJO: 107316092(AS3MT)
NMEL: 110399429(AS3MT)
APLA: 106019053(AS3MT)
ACYG: 106031925(AS3MT)
TGU: 100231410(AS3MT)
LSR: 110473581(AS3MT)
SCAN: 103814140(AS3MT)
GFR: 102037472(AS3MT)
FAB: 101821864(AS3MT)
PHI: 102102307(AS3MT)
PMAJ: 107206791(AS3MT)
CCAE: 111942873(AS3MT)
CCW: 104695520(AS3MT)
ETL: 114070172(AS3MT)
FPG: 101921972(AS3MT)
FCH: 102054327(AS3MT)
CLV: 102088931(AS3MT)
EGZ: 104125601(AS3MT)
NNI: 104022306(AS3MT)
ACUN: 113481736(AS3MT)
PADL: 103916300(AS3MT)
AAM: 106494658(AS3MT)
ASN: 102372717(AS3MT)
AMJ: 102570140(AS3MT)
PSS: 102462506(AS3MT)
CMY: 102946003(AS3MT)
CPIC: 101933904(AS3MT)
ACS: 100559124(as3mt)
PVT: 110077626(AS3MT)
PMUA: 114597526(AS3MT)
GJA: 107117927(AS3MT)
XLA: 100037130(as3mt.2.L) 108704944
XTR: 100145277 100492233(as3mt.2)
DRE: 664699(as3mt) 767695(zgc:153372)
IPU: 100528174(as3mt) 108278319
PHYP: 113537719(as3mt) 113539034
AMEX: 103041662 103046689(as3mt)
EEE: 113577053(as3mt)
TRU: 101065150(as3mt) 105419121
LCO: 104921616(as3mt) 104922846
NCC: 104963176(as3mt)
MZE: 101473274(as3mt) 101478001
ONL: 100697033 100709629(as3mt)
OLA: 101161375(as3mt) 101172512
XMA: 102228324(as3mt) 102231770
XCO: 114133400 114145621(as3mt)
PRET: 103465085(as3mt) 103474544
CVG: 107090750(as3mt) 107095021
NFU: 107380384 107395361(as3mt)
KMR: 108236292(as3mt) 108246026
ALIM: 106518791(as3mt) 106518792
AOCE: 111566307(as3mt) 111585643
CSEM: 103383999(as3mt)
POV: 109627287(as3mt) 109630382
LCF: 108875601(as3mt) 108890357
SDU: 111229289(as3mt) 111238018
SLAL: 111653411 111666604(as3mt)
MALB: 109957917(as3mt)
ELS: 105012235(as3mt)
SFM: 108932414 108933575(as3mt)
PKI: 111837124(as3mt) 111856402
LCM: 102345342(AS3MT) 102352197
CMK: 103171735 103171996(as3mt)
RTP: 109924595 109926850(as3mt)
SPU: 579047
APLC: 110985821
CRG: 105330173
ADF: 107348394
AMIL: 114964712
AQU: 100636899
CRE: CHLREDRAFT_205859(COQ5E-3)
MGR: MGG_07594
MAW: MAC_07545
MAJ: MAA_10485
ANG: ANI_1_448044(An05g01160)
CIM: CIMG_12018(CIMG07773)
ABE: ARB_07197
TVE: TRV_06946
CNE: CNJ00700
CNB: CNBJ2790
SMIN: v1.2.010525.t1(symbB.v1.2.010525.t1)
AAF: AURANDRAFT_78115(Met1)
XNE: XNC1_1511
XNM: XNC2_1471
PSOS: POS17_3787(azo3174)
PAR: Psyc_1156
SSE: Ssed_4050
GPS: C427_1516
SDE: Sde_3620
SAGA: M5M_04670
MICT: FIU95_09420(ubiE2)
CBU: CBU_0834
CBD: CBUD_0899
CBG: CbuG_1167
CBC: CbuK_0702
MAH: MEALZ_1383(As3mt)
TCX: Tcr_1696
HMAR: HVMH_0560
TIG: THII_0119
BLEP: AL038_14525(arsM)
NOC: Noc_0586
NHL: Nhal_1114
NWA: Nwat_0786
NTT: TAO_0485
HAZ: A9404_04350(arsM)
GAI: IMCC3135_17180(menG)
HCH: HCH_02988
HCO: LOKO_01812(rebM_1) LOKO_01815(ubiE_1)
ABO: ABO_2182
ADI: B5T_00803
APAC: S7S_06185
AXE: P40_03785
SDF: ACG33_01220(arsM)
SLIM: SCL_2701
ENM: EBS_1045
PSE: NH8B_1267
BTD: BTI_2027
BOC: BG90_1027
BUL: BW21_2091
BPH: Bphy_7237
BFN: OI25_7742
RFR: Rfer_1612
POL: Bpro_2645
DAC: Daci_2653
MELA: C6568_16665(arsM)
CBAB: SMCB_1654
OFO: BRW83_1231(ubiE_3)
LCH: Lcho_1718
RGE: RGE_20810
RBN: RBXJA2T_04893(arsM)
NET: Neut_0320
TBD: Tbd_1428
GCA: Galf_1904
NIM: W01_05900
SDR: SCD_n02152(arsM) SCD_n02256 SCD_n03102(arsM)
SLAC: SKTS_17290
SUA: Saut_1902
SDL: Sdel_1472
SMUL: SMUL_2098
SHAL: SHALO_1852
SULJ: SJPD1_1852
SUN: SUN_0793
GLO: Glov_0896
GEM: GM21_1612
PCA: Pcar_0223
DVL: Dvul_1577
DVM: DvMF_2179
DDE: Dde_3542
DBA: Dbac_1559
DRT: Dret_0953
DPS: DP1652
DSF: UWK_01460
DOL: Dole_0762
DBR: Deba_1697
BSED: DN745_03555(arsM)
PCAY: FRD00_09275(arsM)
PLA: Plav_2318
BBT: BBta_4839
RPA: RPA3562
RPB: RPB_1968
RPD: RPD_3422
RPT: Rpal_4080
NHA: Nham_4641
MDI: METDI0637
MEX: Mext_0656
MET: M446_4310
MOR: MOC_2961
META: Y590_02335
BVR: BVIR_2069
MCG: GL4_2446
SIL: SPO2690
RUT: FIU92_08745(ubiG1)
JAN: Jann_2022
PSF: PSE_2097
LAQU: R2C4_06375
SPSE: SULPSESMR1_03651(ycgJ)
RID: RIdsm_01629 RIdsm_03380(ubiE_3)
ROT: FIV09_17105(ubiE2)
BLAS: BSY18_1846
ELI: ELI_00355
MGRY: MSR1_24400(ubiE_2)
MAGQ: MGMAQ_1552
MGM: Mmc1_1418
BAMA: RBAU_3104
BAMN: BASU_2892
BAMT: AJ82_16830
BAMY: V529_32320
BAO: BAMF_3064(RBAM_029720)
BQL: LL3_03341
BAMC: U471_30800
BAMF: U722_15990
BACI: B1NLA3E_08755(arsM)
BACP: SB24_13875
BBEV: BBEV_3082(ubiE-3)
GKA: GK0592
PTL: AOT13_12895(arsM)
LYB: C3943_15315(arsM) C3943_16600(arsM)
LPAK: GDS87_12485(arsM)
APAK: AP3564_14385(arsM)
PASA: BAOM_2343
SPAS: STP1_1347
GMO: NCTC11323_00339(ycgJ)
GHA: NCTC10459_00395(ycgJ)
PPO: PPM_3099(arsM)
PPOY: RE92_17420(arsM)
PSAB: PSAB_12345(arsM)
PDU: PDUR_08150(arsM) PDUR_10230 PDUR_14075(arsM)
PBD: PBOR_32135(arsM)
PGM: PGRAT_28750(arsM)
PAEN: P40081_33570(arsM)
PAEQ: R50912_24560(arsM)
PSTE: PSTEL_14450(arsM)
PAEH: H70357_18645(arsM)
PIB: BBD41_28675(arsM)
PCX: LPB68_10620(arsM)
PAIH: ASL14_15885(arsM)
AAC: Aaci_2989
CBA: CLB_0799
CBY: CLM_0912
CBB: CLD_3800
CBF: CLI_0840
CPAS: Clopa_0618
CPAT: CLPA_c05000(arsM)
CPAE: CPAST_c05000(arsM)
CSQ: CSCA_3240
CTYK: CTK_C17170
AMT: Amet_3267
AOE: Clos_1094
HHW: NCTC503_00128(bioC_1)
CALE: FDN13_12680(arsM)
CSD: Clst_1879
CAPR: EQM14_08865(arsM)
CSCI: HDCHBGLK_01878(dnrC)
STH: STH2369
SLP: Slip_2179
SALQ: SYNTR_2310
DAU: Daud_1985
OVA: OBV_43620
CTHM: CFE_1002
CHY: CHY_0555
TPZ: Tph_c04450(arsM)
TTM: Tthe_0352
TSH: Tsac_0926
TOC: Toce_0607
PMIC: NW74_02025
PIV: NCTC13079_01127(ubiG)
PUF: UFO1_3913
PFT: JBW_03094
MANA: MAMMFC1_00165(ubiE_2) MAMMFC1_00342(ubiE_4) MAMMFC1_00700(ubiE_5)
STED: SPTER_05360(ubiE_2) SPTER_06040(ubiE_3)
LPIL: LIP_0544
MPA: MAP_4097
MAO: MAP4_4222
MAVI: RC58_20955
MAVU: RE97_21005
MLP: MLM_3699
MSHG: MSG_00210
MVA: Mvan_0109
MGI: Mflv_0738
MPHL: MPHLCCUG_02107(bioC_1)
MVQ: MYVA_0106
MAUU: NCTC10437_00107(ubiE_1)
MSTE: MSTE_02929
MSAL: DSM43276_02744(ubiE_1)
MTER: 4434518_01372(ubiE_3)
MHIB: MHIB_09300
NFA: NFA_7870
NFR: ERS450000_03332(ubiE_2)
SCO: SCO3452(SCE46.09c)
SHY: SHJG_8484
SGE: DWG14_00330(ubiE_1)
MPRT: ET475_13875(arsM)
XCE: Xcel_3346
XYL: ET495_00315(arsM)
XYA: ET471_13770(arsM)
CFL: Cfla_3376
CFI: Celf_3648
CEJ: GC089_00245(arsM)
CELH: GXP71_12645(arsM)
SERW: FY030_04325(arsM)
JLI: EXU32_00620(arsM)
ORZ: FNH13_07055(arsD)
MIK: FOE78_05290(arsM)
RAIN: Rai3103_07050(arsM)
NOI: FCL41_03645(arsM)
NDP: E2C04_04410(arsM)
PSIM: KR76_16865
MGG: MPLG2_0468(arsM)
MUZ: H4N58_10055(arsM)
NML: Namu_0104
SACE: GIY23_10885(arsM)
AMD: AMED_0756
AMN: RAM_03855
AMM: AMES_0754
AMZ: B737_0755
AOI: AORI_0834(ubiE) AORI_2024
AMYY: YIM_26195(rebM5) YIM_26975 YIM_38435(ubiE7)
AORI: SD37_31050
PDX: Psed_1269
PAUT: Pdca_05670
ALO: CRK56442
SAQ: Sare_2794
AFS: AFR_27295
AHW: NCTC11636_02114(bioC)
ASLA: NCTC11923_00220(ycgJ)
EKE: EK0264_08515(arsM)
RXY: Rxyl_2880
RUB: GBA63_16115(arsM) GBA63_22155(arsM)
CWO: Cwoe_0591
ELE: Elen_2474
AEQ: AEQU_0851
SYW: SYNW0684
SYG: sync_0906
SYNR: KR49_05135
SYND: KR52_06350
PMM: PMM0416
PMT: PMT_1171
PRC: EW14_0453
MAR: MAE_36890
CYT: cce_4295
TER: Tery_1991
CALH: IJ00_23595
CTHE: Chro_2853
DET: DET1420
DEH: cbdbA1384
DMC: btf_1298
DMD: dcmb_1279
DMG: GY50_1258(arsM)
HAU: Haur_0110
TBH: Tbon_01320(arsM)
MIN: Minf_0141(smtA) Minf_1786(ubiE)
RBA: RB6746
PSL: Psta_3798
RUL: UC8_10280(arsD) UC8_16060
PEH: Spb1_22230(ubiE_4)
PLH: VT85_07060(ubiE_4) VT85_21590(ubiE_8)
GES: VT84_02080(ycgJ_1)
IPA: Isop_2577
SACI: Sinac_4607
PBOR: BSF38_05796(eryG)
AGV: OJF2_76100(ubiE_9)
TPED: TPE_0353
GRW: FTO74_16005(arsM)
EDA: GWR55_13155(arsM)
ABAC: LuPra_03085(ubiE_6) LuPra_04046(as3mt)
TAI: Taci_0499
SBR: SY1_16210
GBA: J421_2256
PMUC: ING2E5A_1787(arsM)
DORI: FH5T_14860
SRU: SRU_2461(arsM)
SRM: SRM_02682
RMR: Rmar_2577
CPI: Cpin_6112
FGG: FSB75_15185(arsM)
FLN: FLA_2992
PGO: FSB84_10465(arsM)
MGOT: MgSA37_01199(ubiE_2)
SLI: Slin_3937
SPIK: EXU85_34465(arsM)
FAE: FAES_5192
HSW: Hsw_0589
FOP: FNB79_11675(arsM)
ANP: FK178_02525(arsM)
FBE: FF125_19880(arsM)
CTAK: 4412677_00482(ubiE_1) 4412677_00644(ubiE_2)
IAL: IALB_2688
MRO: MROS_1044
NJA: NSJP_2692
LFC: LFE_1365
CTHI: THC_0727
MFC: BRM9_2029
MCUB: MCBB_2274(arsM)
MEAR: Mpt1_c14370(arsM2)
MARC: AR505_0981
METM: MSMTP_0716
MTHE: MSTHC_0377
MHOR: MSHOH_0765
MMET: MCMEM_0390
MPY: Mpsy_2039
MZI: HWN40_11995(arsM)
MTP: Mthe_1429
MHI: Mhar_1545
MPI: Mpet_2814
MPD: MCP_0689
MEZ: Mtc_2327
RCI: RCIX1264
HSL: OE_5444F(arsM)
HHI: HAH_2873(scm)
NMO: Nmlp_2711(arsM)
HTI: HTIA_2463
HPEL: HZS54_10200(arsM)
HWC: Hqrw_2170
HDF: AArcSl_1901(arsM)
HALY: HYG82_07260(arsM) HYG82_20625(arsM)
NMG: Nmag_1196
NPL: FGF80_18275(arsM)
MSE: Msed_1003
MCN: Mcup_0883
NEV: NTE_00056
TAA: NMY3_02003(ycgJ_2)
NFN: NFRAN_0049(arsM)
NDV: NDEV_0358
MARH: Mia14_0885
 » show all
Reference
1  [PMID:10604879]
  Authors
Zakharyan RA, Aposhian HV.
  Title
Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase.
  Journal
Chem Res Toxicol 12:1278-83 (1999)
DOI:10.1021/tx9901231
Reference
2  [PMID:10387927]
  Authors
Zakharyan RA, Ayala-Fierro F, Cullen WR, Carter DM, Aposhian HV.
  Title
Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes.
  Journal
Toxicol Appl Pharmacol 158:9-15 (1999)
DOI:10.1006/taap.1999.8687
Reference
3  [PMID:8806872]
  Authors
Zakharyan RA, Wildfang E, Aposhian HV.
  Title
Enzymatic methylation of arsenic compounds. III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic.
  Journal
Toxicol Appl Pharmacol 140:77-84 (1996)
DOI:10.1006/taap.1996.0199
Reference
4  [PMID:8605285]
  Authors
Zakharyan R, Wu Y, Bogdan GM, Aposhian HV.
  Title
Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver.
  Journal
Chem Res Toxicol 8:1029-38 (1995)
DOI:10.1021/tx00050a006
Reference
5  [PMID:11790780]
  Authors
Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ.
  Title
A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol.
  Journal
J Biol Chem 277:10795-803 (2002)
DOI:10.1074/jbc.M110246200
  Sequence
[rno:140925]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.137
IUBMB Enzyme Nomenclature: 2.1.1.137
ExPASy - ENZYME nomenclature database: 2.1.1.137
UM-BBD (Biocatalysis/Biodegradation Database): 2.1.1.137
BRENDA, the Enzyme Database: 2.1.1.137
CAS: 167140-41-2

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