KEGG   ENZYME: 2.1.1.137
Entry
EC 2.1.1.137                Enzyme                                 
Name
arsenite methyltransferase;
AS3MT (gene name);
arsM (gene name);
S-adenosyl-L-methionine:arsenic(III) methyltransferase;
S-adenosyl-L-methionine:methylarsonite As-methyltransferase;
methylarsonite methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:arsenous acid As-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + arsenic triglutathione + thioredoxin + 2 H2O = S-adenosyl-L-homocysteine + methylarsonous acid + 3 glutathione + thioredoxin disulfide [RN:R12917];
(2) 2 S-adenosyl-L-methionine + arsenic triglutathione + 2 thioredoxin + H2O = S-adenosyl-L-homocysteine + dimethylarsinous acid + 3 glutathione + 2 thioredoxin disulfide [RN:R12918];
(3) 3 S-adenosyl-L-methionine + arsenic triglutathione + 3 thioredoxin = S-adenosyl-L-homocysteine + trimethylarsane + 3 glutathione + 3 thioredoxin disulfide [RN:R12919]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
arsenic triglutathione [CPD:C22431];
thioredoxin [CPD:C00342];
H2O [CPD:C00001]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methylarsonous acid [CPD:C07295];
glutathione [CPD:C00051];
thioredoxin disulfide [CPD:C00343];
dimethylarsinous acid [CPD:C20300];
trimethylarsane [CPD:C22417]
Comment
An enzyme responsible for synthesis of trivalent methylarsenical antibiotics in microbes [11] or detoxification of inorganic arsenous acid in animals. The in vivo substrate is arsenic triglutathione or similar thiol (depending on the organism) [6], from which the arsenic is transferred to the enzyme forming bonds with the thiol groups of three cysteine residues [10] via a disulfide bond cascade pathway [7, 8]. Most of the substrates undergo two methylations and are converted to dimethylarsinous acid [9]. However, a small fraction are released earlier as methylarsonous acid, and a smaller amount proceeds via a third methylation, resulting in the volatile product trimethylarsane. Methylation involves temporary oxidation to arsenic(V) valency, followed by reduction back to arsenic(III) valency using electrons provided by thioredoxin or a similar reduction system. The arsenic(III) products are quickly oxidized in the presence of oxygen to the corresponding arsenic(V) species.
History
EC 2.1.1.137 created 2000, (EC 2.1.1.138 incorporated 2003), modified 2003, modified 2021
Orthology
K07755  arsenite methyltransferase
Genes
HSA57412(AS3MT)
PTR450703(AS3MT)
PPS100990214(AS3MT)
GGO101153169(AS3MT)
PON100450997(AS3MT)
NLE100599978(AS3MT)
HMH116484116(AS3MT)
MCC714122(AS3MT)
MCF102134286(AS3MT)
MTHB126962756
MNI105478339(AS3MT)
CSAB103216446(AS3MT)
CATY105581935(AS3MT)
PANU100997593(AS3MT)
TGE112631494(AS3MT)
MLEU105537799(AS3MT)
RRO104656532(AS3MT)
RBB108515080(AS3MT) 108523719
TFN117067486(AS3MT)
PTEH111538858(AS3MT)
CANG105522770(AS3MT)
CJC100396953(AS3MT)
SBQ101044998(AS3MT)
CIMI108306264(AS3MT)
MMUR105874484(AS3MT)
LCAT123650070(AS3MT)
PCOQ105824266(AS3MT)
OGA100957933(AS3MT)
MMU57344(As3mt)
MCAL110285298(As3mt)
MPAH110330191(As3mt)
RNO140925(As3mt)
MCOC116101362(As3mt)
ANU117721854(As3mt)
MUN110556617(As3mt)
CGE100758973(As3mt)
MAUA121139532(As3mt) 121139535
PROB127233395(As3mt)
PLEU114696744(As3mt)
MORG121454263(As3mt)
MFOT126504270
AAMP119811078(As3mt)
NGI103744032(As3mt)
CCAN109691338(As3mt)
DORD105986637(As3mt)
DSP122116013(As3mt)
PLOP125346100(As3mt)
NCAR124984665
MMMA107149953(As3mt)
OCU100341970
OPI101532673(AS3MT)
TUP102472983(AS3MT)
CFA486865(AS3MT)
CLUD112672261(AS3MT)
VVP112915552(AS3MT)
VLG121484622(AS3MT)
NPO129493528(AS3MT)
AML100477280(AS3MT)
UMR103681866(AS3MT)
UAH113251882(AS3MT)
UAR123795917(AS3MT)
ELK111145061
LLV125084796
MPUF101693640(AS3MT)
MNP132016743(AS3MT)
MLK131828490(AS3MT)
NVS122901073(AS3MT)
ORO101385200(AS3MT)
EJU114205417(AS3MT)
ZCA113923634(AS3MT)
MLX118025668(AS3MT)
NSU110589574(AS3MT)
LWW102729054(AS3MT)
FCA101085409(AS3MT)
PYU121037174(AS3MT)
PCOO112854301(AS3MT)
PBG122493196(AS3MT)
PVIV125147972(AS3MT)
LRUF124507109
PTG102967021(AS3MT)
PPAD109272834(AS3MT)
PUC125932925
AJU106966953
HHV120239562(AS3MT)
BTA505482(AS3MT)
BOM102269963(AS3MT)
BIU109579076(AS3MT)
BBUB102398096(AS3MT)
BBIS105002663(AS3MT)
CHX100861071(AS3MT)
OAS101115498(AS3MT)
BTAX128067900(AS3MT)
ODA120873592(AS3MT)
CCAD122445956(AS3MT)
MBEZ129535888 129555393(AS3MT)
SSC100622012(AS3MT)
CFR102508617(AS3MT)
CBAI105081880(AS3MT)
CDK105095021(AS3MT)
VPC102528121(AS3MT)
BACU103007103(AS3MT)
BMUS118883000(AS3MT)
LVE103071271(AS3MT)
OOR101274407(AS3MT)
DLE111172349(AS3MT)
PCAD102991375(AS3MT)
PSIU116741166(AS3MT)
NASI112393006(AS3MT)
ECB100069819(AS3MT)
EPZ103557886(AS3MT)
EAI106838170(AS3MT)
MMYO118670307(AS3MT)
MLF111827425(AS3MT)
DRO112300462(AS3MT)
PDIC114497046(AS3MT)
PALE102884356(AS3MT)
PGIG120608936(AS3MT)
PVP105309669(AS3MT)
MJV108394313(AS3MT)
TOD119233473 119233474(AS3MT)
SARA101555413(AS3MT)
SETR126033433(AS3MT)
LAV100655067(AS3MT)
TMU101356087
ETF101640774(AS3MT)
DNM101439728(AS3MT)
GAS123234243(AS3MT)
PCW110192390(AS3MT)
OAA100080992(AS3MT)
GGA423870(AS3MT)
PCOC116231660(AS3MT)
MGP100540487(AS3MT)
CJO107316092(AS3MT)
TPAI128077762(AS3MT)
LMUT125693905(AS3MT)
NMEL110399429(AS3MT)
APLA106019053(AS3MT)
ACYG106031925(AS3MT)
CATA118248617(AS3MT)
AFUL116491617(AS3MT)
TGU100231410(AS3MT)
LSR110473581(AS3MT)
SCAN103814140(AS3MT)
PMOA120502030(AS3MT)
OTC121341829(AS3MT)
PRUF121350188(AS3MT)
GFR102037472(AS3MT)
FAB101821864(AS3MT)
OMA130254685(AS3MT)
PHI102102307(AS3MT)
PMAJ107206791(AS3MT)
CCAE111942873(AS3MT)
CCW104695520(AS3MT)
CBRC103624667(AS3MT)
ETL114070172(AS3MT)
ZAB102062278(AS3MT)
ZLE135449518(AS3MT)
ACHL103811951(AS3MT)
SVG106857619(AS3MT)
MMEA130581532(AS3MT)
HRT120755875(AS3MT)
FPG101921972(AS3MT)
FCH102054327(AS3MT)
CLV102088931(AS3MT)
EGZ104125601(AS3MT)
NNI104022306(AS3MT)
PCRI104031923(AS3MT)
PLET104622145(AS3MT)
EHS104511478(AS3MT)
PCAO104048574(AS3MT)
ACUN113481736(AS3MT)
TALA104368520(AS3MT)
PADL103916300(AS3MT)
AFOR103897708(AS3MT)
ACHC115348427(AS3MT)
HALD104323417(AS3MT)
HLE104830217(AS3MT)
AGEN126042905
GCL127017833
CCRI104159254(AS3MT)
CSTI104558175(AS3MT)
CMAC104477014(AS3MT)
MUI104534323(AS3MT)
BREG104641961(AS3MT)
FGA104070445(AS3MT)
GSTE104250828(AS3MT)
LDI104352757(AS3MT)
MNB103772510(AS3MT)
OHA104336424(AS3MT)
NNT104400222(AS3MT)
SHAB115608955(AS3MT)
DPUB104307172(AS3MT)
PGUU104458893(AS3MT)
ACAR104518679(AS3MT)
CPEA104390960(AS3MT)
AVIT104268322(AS3MT)
CVF104283442(AS3MT)
RTD128911625(AS3MT)
CUCA104059766(AS3MT)
TEO104370830(AS3MT)
BRHI104489118(AS3MT)
AAM106494658(AS3MT)
AROW112967922(AS3MT)
NPD112957110(AS3MT)
TGT104565298(AS3MT)
DNE112989271(AS3MT)
SCAM104138174(AS3MT)
ASN102372717(AS3MT)
AMJ102570140(AS3MT)
CPOO109323820(AS3MT)
GGN109287572(AS3MT)
PSS102462506(AS3MT)
CMY102946003(AS3MT)
CCAY125640074(AS3MT)
DCC119858291(AS3MT)
CPIC101933904(AS3MT)
TST117880262(AS3MT)
CABI116817101(AS3MT)
MRV120369217(AS3MT)
ACS100559124(as3mt)
ASAO132770905(AS3MT)
PVT110077626(AS3MT)
SUND121926699(AS3MT)
VKO123027235(AS3MT)
PMUA114597526(AS3MT)
PRAF128414284(AS3MT)
ZVI118093472(AS3MT)
HCG128349369(AS3MT)
GJA107117927(AS3MT)
STOW125438325(AS3MT)
EMC129332816(AS3MT)
XLA100037130(as3mt.2.L) 108704944(as3mt.1.L)
XTR100145277 100492233(as3mt.2)
NPR108784548 108784550
RTEM120946982 120946983
BBUF121005179 121005523
BGAR122941181 122942192(AS3MT)
DRE664699(as3mt) 767695(zgc:153372)
SRX107708678 107738479 107757291
SANH107682590 107704323
SGH107568781 107587555 107602732
CCAR109103954 109104339
CAUA113044417(as3mt) 113058566 113114856
CGIB127949368 127972756(zgc:153372) 128028910
PTET122341543(as3mt) 122358452 122358497(zgc:153372)
LROH127175480(as3mt) 127177129(zgc:153372)
OMC131549001(as3mt) 131554186(zgc:153372)
PPRM120468865(as3mt) 120473146(zgc:153372)
RKG130087869(as3mt) 130104583(zgc:153372)
MAMB125249540(zgc:153372) 125272369(as3mt)
CIDE127495426(zgc:153372) 127522757
MASI127421758(zgc:153372) 127444184 127444752
TROS130560720(as3mt) 130564530(zgc:153372)
TDW130428692(zgc:153372) 130437008(as3mt)
MANU129438166(zgc:153372) 129444655(as3mt)
IPU100528174(as3mt) 108278319(zgc:153372)
IFU128601679(as3mt) 128621568(zgc:153372)
PHYP113537719(as3mt) 113539034
SMEO124378043(as3mt) 124395045(zgc:153372)
TFD113645319(zgc:153372) 113663816(as3mt)
TVC132839588(as3mt) 132858450(zgc:153372)
TRN134328663(as3mt) 134334646(zgc:153372)
AMEX103041662 103046689(as3mt)
CMAO118801954(as3mt) 118804131(zgc:153372)
EEE113577053(as3mt)
CHAR105891028(as3mt) 105901386(zgc:153372)
TRU101065150(as3mt) 105419121
TFS130526949(as3mt) 130526950
TNGGSTEN00022701G001 GSTEN00022702G001
LCO104921616(as3mt) 104922846
NCC104963176(as3mt)
TBEN117470237(zgc:153372) 117474714(as3mt) 117486410
CGOB115009992(as3mt) 115018070
PGEO117453474(as3mt) 117457874(zgc:153372)
GACU117552223(zgc:153372) 117561584(as3mt)
EMAC134864377(as3mt) 134879887(zgc:153372)
ELY117254629(as3mt) 117260245(zgc:153372)
EFO125885422(as3mt) 125888578(zgc:153372)
PLEP121942215(as3mt) 121943554(zgc:153372)
SLUC116043058(as3mt) 116048310(zgc:153372)
ECRA117937628(as3mt) 117942043(zgc:153372)
ESP116673552 116696833(as3mt)
PFLV114553247 114566383(as3mt)
GAT120825130(as3mt) 120826967(zgc:153372)
PPUG119217544(as3mt) 119218153(zgc:153372)
AFB129092432(zgc:153372) 129095775(as3mt)
CLUM117734343(as3mt) 117741306(zgc:153372)
PSWI130190005(as3mt) 130210353(zgc:153372)
MSAM119883279(zgc:153372) 119899578(as3mt)
SCHU122873659(as3mt) 122878804(zgc:153372)
CUD121509141(as3mt) 121525449(zgc:153372)
ALAT119028717(as3mt) 119033329(zgc:153372)
MZE101473274(as3mt) 101478001
ONL100697033 100709629(as3mt)
OAU116315852(zgc:153372) 116331094(as3mt)
OLA101161375(as3mt) 101172512
OML112137297(as3mt) 112149541(zgc:153372)
CSAI133442340(zgc:153372) 133444960(as3mt)
XMA102228324(as3mt) 102231770
XCO114133400 114145621(as3mt)
XHE116708155 116719385(as3mt)
PRET103465085(as3mt) 103474544
PFOR103131453(as3mt) 103145596
PLAI106945657(as3mt) 106948068
PMEI106903504(as3mt) 106924307
GAF122829564(as3mt) 122833164(zgc:153372)
PPRL129359104(zgc:153372) 129366877(as3mt)
CVG107090750(as3mt) 107095021
CTUL119782833(zgc:153372) 119783255(as3mt)
GMU124868588(as3mt) 124884227(zgc:153372)
NFU107380384 107395361(as3mt)
KMR108236292(as3mt) 108246026(zgc:153372)
ALIM106518791(as3mt) 106518792
NWH119422847(as3mt)
AOCE111566307(as3mt) 111585643
MCEP125004723(as3mt) 125013350(zgc:153372)
CSEM103383999(as3mt)
POV109627287(as3mt) 109630382
SSEN122771552(as3mt) 122773401(zgc:153372)
HHIP117770748(as3mt) 117773437(zgc:153372)
HSP118106498(zgc:153372) 118122885(as3mt)
PPLT128437223(as3mt) 128440641(zgc:153372)
SMAU118299334(zgc:153372) 118312836(as3mt)
LCF108875601 108890357(zgc:153372)
SDU111229289(as3mt) 111238018
SLAL111653411 111666604(as3mt)
XGL120791602(zgc:153372) 120800897(as3mt)
HCQ109527316 109527318
SSCV125968669 125968670
SBIA133506116 133506597
PEE133403941 133404532
PTAO133476426 133476427
BPEC110154127 110162626 110175702(as3mt)
MALB109957917(as3mt)
BSPL114853048(as3mt) 114867656(zgc:153372)
SJO128360256(zgc:153372) 128371847(as3mt)
SASA100286452(as3mt) 106568062 106581028 106588782
STRU115147246 115148907 115163330 115177793
OTW112230255(as3mt) 112234734(zgc:153372) 112259120
OMY110485757(as3mt) 110503846 110507677(zgc:153372) 110537446
OGO123993943(zgc:153372) 124000516 124015456(as3mt)
ONE115103674(as3mt) 115104674 115136822
OKI109883915(as3mt) 109892714 109905649
OKE118377189(as3mt) 118391788 118397391(zgc:153372)
SALP111949892 111981505 112071259 112073881(as3mt)
SNH120017408 120018769(zgc:153372) 120032495 120044315
CCLU121533104(as3mt) 121568371 121574326
ELS105012235(as3mt)
SFM108932414 108933575(as3mt)
PKI111837124(as3mt) 111856402
AANG118209811(zgc:153372) 118218134(as3mt)
LOC102683367 102683513(as3mt)
PSPA121320393(zgc:153372) 121325109(as3mt)
ARUT117406385 117417968(as3mt) 117972745
PSEX120514408 120515933
LCM102345342(AS3MT) 102352197
CMK103171735(zgc:153372) 103171996(as3mt)
RTP109924595(zgc:153372) 109926850(as3mt)
CPLA122555424(zgc:153372) 122561332(as3mt)
HOC132820874(zgc:153372) 132826538(as3mt)
LERI129703062(zgc:153372) 129704120(as3mt)
PMRN116941418(AS3MT) 116950756
LRJ133354234(AS3MT)
BFO118413357 118428036
BBEL109462967 109485678
CIN100179278 100181209
SCLV120333176 120345855
SPU579047
LPIC129271044 129271590
APLC110985821
AJC117111003 117111014
SKO100371538 100374082
FCD110846140 110848375
LGILOTGIDRAFT_108332 LOTGIDRAFT_126867 LOTGIDRAFT_129599 LOTGIDRAFT_129680 LOTGIDRAFT_167413 LOTGIDRAFT_221596 LOTGIDRAFT_65150
PVUL126812319 126815585 126820319
PCAN112556469 112556470 112556471 112556475 112561980 112561981
BGT106062897 106071078
GAE121378338 121379220 121379287 121380036 121382828 121384352
HRF124111739 124130589 124135859 124135894 124135895 124135896
HRJ124262704 124262715 124262717 124262718 124266639 124284801
CRG105330173 117680465
CVN111132629 111132630 111132631 111132632 111135029
CANU128180811
OED125657483 125658752
MYI110449238 110449241
PMAX117338842 117338843
MCAF127734156
OBI106879433 106879434
OSN115229965 115232676
LJP135467780
LAK106173797 106173798
LLON135489308 135489901
NVE5515086 5515132
EPA110231523 110237650
ATEN116293296 116304912
ADF107348394
AMIL114964712
PDAM113682841 113682842
SPIS111329977 111329978
DGT114516007 114516008
XEN124444054 124444614
HMG100203411 105843548
AQU100636899
CRECHLRE_11g467612v5
VCNVOLCADRAFT_86558 VOLCADRAFT_95757
MNGMNEG_13544
CSLCOCSUDRAFT_64157
CVRCHLNCDRAFT_23051 CHLNCDRAFT_32055 CHLNCDRAFT_9950
OLUOSTLU_25654 OSTLU_28006
OTAOT_ostta17g00510
BPGBathy06g01450
MISMICPUN_112687 MICPUN_81388
MPPMICPUCDRAFT_30169(JGI:MicpuC2_30169) MICPUCDRAFT_70215(JGI:MicpuC2_70215)
CMECYME_CME010C CYME_CMT024C
GSLGasu_26140 Gasu_31630
DHADEHA2D14190g
PANPODANSg3268
TTTTHITE_116487 THITE_122302 THITE_2132530
MTMMYCTH_2306234
FGRFGSG_04845
FPUFPSE_04020
FVRFVEG_12196
FOXFOXG_13346
NHENECHADRAFT_57802
FKRNCS57_00201300
FMUJ7337_007525
TRETRIREDRAFT_53428
TRRM419DRAFT_38545
MAWMAC_07545
MAJMAA_10485
PLJVFPFJ_04781
PTKZJDV02_002794
SAPOSAPIO_CDS1478 SAPIO_CDS2166
PSCOLY89DRAFT_692379
GLZGLAREA_09939
AFMAFUA_1G16110 AFUA_5G15020
ACTACLA_061900
NFINFIA_003560 NFIA_099320
ANGAn05g01160
ACHEACHE_50083S
PCSN7525_003319
POUPOX_f08110
TMFEYB26_009912
TRGTRUGW13939_03856
CIMCIMG_12018(CIMG07773)
CPWCPC735_042020
UREUREG_02124
PBLPAAG_01704
PBNPADG_00073
ABEARB_07197
TVETRV_06946
AJEHCAG_00249
BGHBDBG_00075
AALTCC77DRAFT_941674
CNECNJ00700
CNBCNBJ2790
HIRHETIRDRAFT_322938
FMEFOMMEDRAFT_149614
GTRGLOTRDRAFT_116889
LBCLACBIDRAFT_153702
CCICC1G_01021
SCMSCHCO_02609414(SCHCODRAFT_02609414)
CPUTCONPUDRAFT_137653
SLASERLADRAFT_433897
SREPTSG_01809
ACANACA1_184130
SMINv1.2.010525.t1(symbB.v1.2.010525.t1)
PTIPHATRDRAFT_39627
FCYFRACYDRAFT_178178
TPSTHAPSDRAFT_7607
NGDNGA_0334100
AAFAURANDRAFT_78115(Met1)
PIFPITG_00572
PSOJPHYSODRAFT_561420 PHYSODRAFT_561424
EHXEMIHUDRAFT_426057
GTTGUITHDRAFT_62819
NGRNAEGRDRAFT_51817 NAEGRDRAFT_74947
TVATVAG_2v0335390 TVAG_2v1018730
PTTVY86_09450
XNEXNC1_1511
XNMXNC2_1471
LSOLGOY17_13065
LAREHIV01_007815
LAUXLA521A_25190
RHDR2APBS1_3816
RTHLRK53_10075
PKRAYO71_00130 AYO71_02410
PNBNK667_27445(arsM)
ACXAchr_20740
PNNKEM63_06445
MLQASQ50_17220
MANPEHN06_00865 EHN06_06185
KAKKalk_01360 Kalk_06090
PARPsyc_1156
PSOPSYCG_06595
PSPGAK823_09370
PSYGAK825_09590
APOTMZO21_13505
SSESsed_4050
COLWA3Q33_20000
PLZS4054249_22315
GPSC427_1516
ALKMNKI27_12125
ASEMNNL22_08540
SDESde_3620
SAGAM5M_04670
ZALAZF00_16300
OSGBST96_05760
MTHDA3224_15335
MIIBTJ40_10210
MICTFIU95_09420(ubiE2)
MICZGL2_37500
MVBMJO52_11300
CBUCBU_0834
CBSCOXBURSA331_A1116
CBDCBUD_0899
CBGCbuG_1167
CBCCbuK_0702
MMTMetme_1127
MDNJT25_007720
METLU737_07350 U737_12940
MELLIVG45_05845 IVG45_22325
MRPNM686_008735
MMOTQZJ86_20040
MAHMEALZ_1383(As3mt)
MBUREQU24_06230
MPSYCEK71_12635
MMAIsS8_0921 sS8_5126
MEINmethR_P1427 methR_P1755
MOZMoryE10_06180
MESLKKZ03_17765
MCAUMIT9_P1514
TCXTcr_1696
HTREPV75_09025
HMARHVMH_0560
THIOAYJ59_04890
TZOTHMIRHAT_05090
TIGTHII_0119
BLEPAL038_14525(arsM)
NOCNoc_0586
NHLNhal_1114
NWANwat_0786
NWRE3U44_17615
TEETel_01315 Tel_13290(arsM) Tel_15785
NTTTAO_0485
THIPN838_23890
THIMKFB96_09080
AEHMlg_1633 Mlg_1636
TGRTgr7_0251 Tgr7_1710 Tgr7_1715
TNITVNIR_0140 TVNIR_0146
TTITHITH_00755 THITH_00790
SHAILMH63_10360
NAXHC341_16185 HC341_16200
HAZA9404_04350(arsM)
GAIIMCC3135_17180(menG)
EPSL0Y14_09135
TTCFOKN1_1646
THICTspCOW1_10030
HCHHCH_02988
HAHEENC22_17025
HAHHO5O45_11950
HCOLOKO_01812(rebM_1) LOKO_01815(ubiE_1)
HSVHNO53_16465 HNO53_16480
HCAMI4484_15970 I4484_16000
HSXHNO51_15895 HNO51_15925
HTXEKK97_18000 EKK97_18030
ABOABO_2182
ALNAS19_22360
ALCAASALC70_02972(ycgJ_2)
ADIB5T_00803
AXEP40_03785
APACS7S_06185
OAIOLEAN_C10370
BMARHF888_08860
OMEOLMES_0430
ENWMJO57_23565
ENGO2T12_08540
EMPEZMO1_3239(menG) EZMO1_4535
SDFACG33_01220(arsM)
SLIMSCL_2701
SVASVA_0845 SVA_2553 SVA_2555 SVA_2846 SVA_3649
REVHUE57_03125
ENMEBS_1045
BTDBTI_2027
BOCBG90_1027
BUDAQ610_09820
BULBW21_2091
BPHBphy_7237
BFNOI25_7742
BCAIK788_0001918
PHSC2L64_44040
PTERC2L65_41405
PCAFDSC91_000820
PACSFAZ98_28475
PSAAQEN71_29780
PRBX636_16395
LIMNHKT17_03715
RFRRfer_1612
RHFEUB48_03320
POLBpro_2645
VPDVAPA_2c05900
HYLLPB072_17805
HYCE5678_11585
HTNKI616_07135
MELAC6568_16665(arsM)
CBABSMCB_1654
RGERGE_20810
RBNRBXJA2T_04893(arsM)
LCHLcho_1718
MENYLSQ66_16760
OFOBRW83_1231(ubiE_3)
OVBNB640_11025(arsM) NB640_12790(arsM)
BBAGE1O_05550 E1O_18660
NETNeut_0320
NITNAL212_2034
NIINit79A3_2348
NURATY38_14765
NLCEBAPG3_003100
NIZNNRS527_02986
TBDTbd_1428
GCAGalf_1904
SDRSCD_n02152(arsM) SCD_n02256 SCD_n03102(arsM)
SLACSKTS_17290
ARESIWH25_00265
ABREpbN1_01970
AZIAzCIB_2323
AZDCDA09_10770
TMZTmz1t_3557
NTUNTH_01029(ubiE_1)
CHEAPVE73_21715
PLAPlav_2318
PMOBHG718_01655(arsM)
RBSRHODOSMS8_00612 RHODOSMS8_02001(ubiE)
RTRRTCIAT899_PC05935
BJUBJ6T_55300
BJPRN69_26805
BBTBBta_4839
BARHWN72_14480 WN72_23570
RPATX73_018460
RPBRPB_1968
RPDRPD_3422
RPTRpal_4080
RPXRpdx1_1792
NHANham_4641
APRAG3A50_16710
MRDMrad2831_2550
METM446_4310
MORMOC_2961
CHELAL346_23205
HDTHYPDE_27373
RVARvan_1928 Rvan_3533
RLACQMO75_16790
MCGGL4_2446
METGHT051_06950
DEQXM25_00475
YTIFNA67_00425 FNA67_04565
BVRBVIR_2069
MIWASS37A_00670
MECQMSC49_16620
PSFPSE_2097
LABRCHH27_21965
CHQAQ619_12515
SILSPO2690
RUAD1823_04200
RUTFIU92_08745(ubiG1)
RCONK3740_09710
JANJann_2022
RPONG3256_09215
LMDMETH_05560
LEJETW24_12615
LAQUR2C4_06375
LEVETW23_06985
LCAEK3721_10985
CEHCEW89_07390
SULIC1J05_08870
RIDRIdsm_01629 RIdsm_03380(ubiE_3)
ROMEI983_08880
ROTFIV09_17105(ubiE2)
HATRC74_19170
LALGLentiSH36_01597
PTPRCA23_c13780
SEDIEBB79_06725
PAEDG5B38_05775
PAMOBAR1_05270
SGLCM1K48_08000
CIJWG74_06700
BLASBSY18_1846
BFWB5J99_00075
BMAAT8S45_09170
PALGHFP57_14875
PARPHFP51_14045
SPHSETR14_08650
ERYCP97_04410
EGNBMF35_b0064
QSPL1F33_05255
QGEK3136_06215
ELIELI_00355
EMVHQR01_03230
LCKHN018_12950 HN018_16150
RAPRHOA_3204(arsM) RHOA_5581
MGYMGMSRv2__3976
MGRYMSR1_24400(ubiE_2)
MAGQMGMAQ_1552
PBRPB2503_09119
MGMMmc1_1418
KOZKFF44_03190
AFJAFERRID_02410
MAESGa0123461_1151
MFNGa0123462_1205
SUASaut_1902
SPALFM071_09395
SDLSdel_1472
SMULSMUL_2098
SHALSHALO_1852
SULSSdiek1_1936
SULJSJPD1_1852
SULTFA592_01790
SUNSUN_0793
SLHYH65_07720
GMEGmet_1806 Gmet_2791
GEMGM21_1612
GEFFO488_04400
GURGura_2444 Gura_3885
GEOGeob_2472
GLOGlov_0896
PCAPcar_0223
PACEA6070_14440
PEFA7E78_09415
DVEDESUT3_09420
DDSDdes_1820 Ddes_1926
DFIAXF13_03455
DPGDESPIGER_0128
DEFCNY67_02540 CNY67_03315
DMADMR_36000 DMR_37290
DCBC3Y92_03980 C3Y92_19050
DGGDGI_0906 DGI_1308
DDEDde_3542
DMSE8L03_11895
DAFDesaf_0410 Desaf_2164
DSXGD604_04740 GD604_17750
DSDGD606_04475
DVMDvMF_2179
DBADbac_1559
DOAAXF15_08740
THEWTDMWS_15220
DRTDret_0953
DPSDP1652
DSFUWK_01460
DLMDPPLL_27760 DPPLL_36510
DPRDespr_1245
DEOCAY53_03285
DOGHP555_04815
DOLDole_0762
DATHRM2_07050
DOVDSCO28_54450 DSCO28_63000
DWDDSCW_27600 DSCW_31240 DSCW_47990
DLIdnl_19440 dnl_22280
DTIDesti_0262 Desti_1514
SFUSfum_0266 Sfum_1190 Sfum_1312
DAXFDQ92_12120
CTHITHC_0727
AFWAnae109_2358 Anae109_3171
AORYAMOR_12390(arsM)
SCLsce1968 sce3044(tam1) sce5622 sce6755
SCUSCE1572_04620 SCE1572_11870 SCE1572_18430 SCE1572_19975
MRMA7982_07894 A7982_07897
SAMYDB32_001574 DB32_006739
LLUAKJ09_02913
BSEDDN745_03555(arsM)
PCAYFRD00_09275(arsM)
BBAEFRD01_16845
BAYRBAM_029720
BAQBACAU_2998
BAMLBAM5036_2886
BAMARBAU_3104
BAMNBASU_2892
BAMTAJ82_16830
BAMYV529_32320
BAOBAMF_3064(RBAM_029720)
BAZBAMTA208_16510
BQLLL3_03341
BXHBAXH7_03368
BAMCU471_30800
BAMFU722_15990
BACIB1NLA3E_08755(arsM)
BACPSB24_13875
CSOALIS82_13655
BDAFSZ17_20795(arsM)
GKAGK0592
GTEGTCCBUS3UF5_6540
BCALCWI35_07275(arsM)
GMCGY4MC1_1903
GZAIC807_16515
GTHGeoth_1972
PTLAOT13_12895(arsM)
PCALBV455_03938(ycgJ_2)
PARGPspKH34_31710
ACAIISX45_07615
LYBC3943_15315(arsM) C3943_16600(arsM)
LPAKGDS87_12485(arsM)
LAGRFJQ98_13440
LYPMTP04_37080
VIGBKP57_06300
VPNA21D_03025
APAKAP3564_14385(arsM)
BBEVBBEV_3082(ubiE-3)
GAJMY490_10085
TEIQS257_13015
SLGSLGD_00314
SLNSLUG_03110 SLUG_19560
SXYBE24_10975
SXLSXYLSMQ121_0222
SXOSXYL_00222
GOTAXE85_05355
GMONCTC11323_00339(ycgJ)
GEQCG018_07285
GSAFOC50_06020
GHANCTC10459_00395(ycgJ)
BRWGOP56_04570
BRUMNDK47_11410
PPOPPM_3099(arsM)
PPOYRE92_17420(arsM)
PSABPSAB_12345(arsM)
PDUPDUR_08150(arsM) PDUR_10230 PDUR_14075(arsM)
PBDPBOR_32135(arsM)
PGMPGRAT_28750(arsM)
PAENP40081_33570(arsM)
PAEQR50912_24560(arsM)
PSTEPSTEL_14450(arsM)
PAEHH70357_18645(arsM)
PBJVN24_25945
PSONJI735_20030
POWIJ21_35390
PBVAR543_p0183 AR543_p0201
PDHB9T62_03060(arsM) B9T62_03095 B9T62_36430
PIBBBD41_28675(arsM)
PCXLPB68_10620(arsM)
PAIHASL14_15885(arsM)
PPSCEHS13_17920
PSOPKP014_10805 KP014_17240
PTRIKDC22_17180
PALRHGI30_09120
PDYQJQ58_08650
PMAELMZ02_09300
PHKSK066_12520
CHEBHH215_35395
AACAaci_2989
KURASO14_1480
VIJJNUCC6_06160
FHMR0V13_07855
CBACLB_0799
CBYCLM_0912
CBBCLD_3800
CBFCLI_0840
CBJH04402_00818
CLJCLJU_c24100
CLBClo1100_3407 Clo1100_3499
CSRCspa_c06920
CPASClopa_0618
CPATCLPA_c05000(arsM)
CPAECPAST_c05000(arsM)
CAHCAETHG_3659(arsM)
CLTCM240_2722
CSQCSCA_3240
CLDCLSPO_c24140
CACECACET_c35610
CCKCcar_11270 Ccar_24795
CTYKCTK_C17170
CEUA7L45_05850
CFMBJL90_11375
CARGRSJ17_04405
CDRKB9W14_03725
CLOSDMR38_07905(arsM) DMR38_12370
CMAHC1I91_14595
HHWNCTC503_00128(bioC_1)
CALEFDN13_12680(arsM)
RBPB6259_04440
CSSCst_c19610
CSDClst_1879
OVAOBV_43620
CAMLH6X83_11765(arsM)
CLFGJQ69_06075(arsM)
CAPREQM14_08865(arsM)
STHSTH2369
SLPSlip_2179
SALQSYNTR_2310
DSYDSY1286 DSY1950 DSY1984 DSY4148
DHDDhaf_1201 Dhaf_2386 Dhaf_3113 Dhaf_3142
DDHDesde_0017 Desde_1900 Desde_2599
DDLDesdi_0957 Desdi_1577
DMTDESME_03710 DESME_05130 DESME_05535
DORDesor_1277 Desor_2823
DAIDesaci_2621 Desaci_2703
DMIDesmer_1175 Desmer_2281
DCADesca_1012 Desca_1567
PTHPTH_0440 PTH_0682
DRUDesru_0526
DFGB0537_02755 B0537_09135 B0537_11330
DAEDtox_2552 Dtox_3437
DAUDaud_1985
FWADCMF_01285
AACXDEACI_2176 DEACI_2886
TJRTherJR_0449
DGIDesgi_0273 Desgi_4147
AWOAwo_c27160
CTHMCFE_1002
FMSM1R53_01255
BLABEYS05_07755
CSCIHDCHBGLK_01878(dnrC)
ACHTbsdcttw_15100
AMTAmet_3267
AOEClos_1094
GFEGferi_19180 Gferi_20370
PBIFKXZ80_16545(arsM)
PSORRSJ16_09100
TEMJW646_19310(arsM)
TGCL0P85_09100(arsM)
PBQC3V37_03795
CMIUB1H56_07005
CHYCHY_0555
TPZTph_c04450(arsM)
GEKkuro4_22920
TTMTthe_0352
TTOThethe_00297
TXYThexy_0248
TSHTsac_0926
TOCToce_0607
NCDACONDI_00455(bioC)
HASHalsa_0649
AARAcear_2035
HHLHalha_1468
FMAFMG_0149 FMG_1631
PMICNW74_02025
PIVNCTC13079_01127(ubiG)
SPOAEQM13_15655
TISP3962_11650
TIZRBU61_03010(arsM)
SEDZJYG23_03700
ECOUM1R54_08615
MHWACT01_06030
PUFUFO1_3913
PFTJBW_03094
MANAMAMMFC1_00165(ubiE_2) MAMMFC1_00342(ubiE_4) MAMMFC1_00700(ubiE_5)
STEDSPTER_05360(ubiE_2) SPTER_06040(ubiE_3)
LPILLIP_0544
CALKHUE98_04495(arsM)
FCZIMF26_10120(arsM)
SHIShel_13340
ELEElen_2474
EYYEGYY_23350
GPAGPA_19610 GPA_34790 GPA_34810
AEQAEQU_0851
AHATADCFC_14780
DDTAAY81_09655
BWAHLV38_04610
RTSCE91St31_21980
ERZER308_06345 ER308_06350
MPAMAP_4097
MAOMAP4_4222
MAVIRC58_20955
MAVURE97_21005
MAVMAV_4539 MAV_5229
MITOCO_11410 OCO_44310 OCO_50580
MIAOCU_11390 OCU_44070 OCU_50510
MIDMIP_01832 MIP_06725 MIP_07653
MYOOEM_44520 OEM_50780
MCHIAN480_12965 AN480_23080 AN480_26250
MIROCQ_11420 OCQ_45460 OCQ_51570
MMALCKJ54_05555 CKJ54_21105 CKJ54_24145
MLPMLM_3699
MMANMMAN_38790 MMAN_54670
MSAMycsm_02304
MMCMmcs_0094 Mmcs_1964
MKMMkms_0103 Mkms_2010
MJLMjls_0084 Mjls_1944
MMMW7S_22320 W7S_25330
MYEAB431_06495
MHADB586_01915 B586_12150
MSHGMSG_00210
MFJMFLOJ_26430 MFLOJ_33060
MSTOMSTO_37330 MSTO_38050
MSIMMSIM_22600
MSAKMSAS_35890
MLWMJO58_01215
MXEMYXE_04560 MYXE_20690 MYXE_40540
MNVMNVI_11760 MNVI_17660 MNVI_24620 MNVI_45220
MPAGC0J29_05960
MNMMNVM_08320 MNVM_11840
MGORH0P51_10415
MCOOMCOO_33410 MCOO_40910 MCOO_43160
MBAIMB901379_02765(ycgJ_2)
MSEOMSEO_26940 MSEO_41110 MSEO_47700
MHEKJMUB5695_00414 JMUB5695_03961(COQ5_3)
MGAUMGALJ_46150 MGALJ_60300 MGALJ_62020
MBRDMBRA_15090 MBRA_47790
MMAMK3U93_01030 K3U93_03965
MSPGF6B93_12615
MMEHM5I08_19595(arsM) M5I08_24205(arsM)
MVAMvan_0109
MGIMflv_0738
MSPMspyr1_00940
MCBMycch_4042
MPHLMPHLCCUG_02107(bioC_1)
MVQMYVA_0106
MRHMycrhN_1613 MycrhN_2746
MDUMDUV_41710
MDRMDOR_13510
MAUUNCTC10437_00107(ubiE_1)
MMORMMOR_03040
MIJMINS_38320
MGADMGAD_30920 MGAD_44480
MHEVMHEL_30350
MPOFMPOR_06810
MMONEWR22_00570 EWR22_09975
MKRMKOR_07240 MKOR_23230 MKOR_35080
MPAKMIU77_01850 MIU77_07890(arsM) MIU77_15350
MIZBAB75_15950
MSTEMSTE_02929
MSAOMYCSP_13365
MSALDSM43276_02744(ubiE_1)
MJDJDM601_0647 JDM601_1006
MTER4434518_01372(ubiE_3)
MHIBMHIB_09300
MHERK3U94_03635 K3U94_08090 K3U94_18220
MVMMJO54_03615 MJO54_04675(arsM)
NFANFA_7870
NFRERS450000_03332(ubiE_2)
NCYNOCYR_0033
NBRO3I_000195 O3I_024020 O3I_039310
NNONONO_c13090 NONO_c20310 NONO_c74930
NSLBOX37_00190
NSRNS506_06193 NS506_06865
NTPCRH09_09490
NOZDMB37_19280(mraW) DMB37_21230 DMB37_36850
NODFOH10_08265
NAHF5544_09545 F5544_19020(arsM)
NADNCTC11293_00796
NWLNWFMUON74_58920
NIEKV110_00185 KV110_08245 KV110_18480(arsM)
NHUH0264_31995(arsM)
NYALTV02_15870(arsM)
RHWBFN03_14470
RANTRHODO2019_02975(arsD)
GOCCXX93_04740
GSIP5P27_17525
SCOSCO3452(SCE46.09c)
SGRFSGFS_004200
SCYER2B67_35675(arsM)
SSXSACTE_5977
SHYSHJG_8484
SHOSHJGH_8244
SDVBN159_4299 BN159_4302
SVTSVTN_17945
SLDT261_3851
SCXAS200_38770
SPAVSpa2297_04055
SGSAVL59_45900
SGMGCM10017557_79710
SCADDN051_36445
SPLULK06_014920
SPUNBFF78_24210
SALFSMD44_02419
SNZDC008_01715
SGEDWG14_00330(ubiE_1)
SCYAEJ357_21685
STIRDDW44_23985
SRKFGW37_00485
SSPODDQ41_25720
SFYGFH48_26740(arsM)
SBYH7H31_12455
SRIMCP984_06275
SPHVF9278_45830(arsM)
SCHACP983_20355
SGXH4W23_02310
SBATG4Z16_06100
STUIGCM10017668_00990
SHUNDWB77_00672(ubiE_1)
SCYGS1361_19625(ubiE5)
SLIAHA039_29775(arsM)
SROIIAG44_04155(arsM)
SGJIAG43_29615
SGOBtest1122_05500
SINEKI385_14925(arsM)
SAOVG3H79_35145(arsM)
SDURM4V62_19310(arsM)
SSPNLXH13_01780(arsM)
SCIRSTRCI_008047(arsM)
SXTKPP03845_106400(arsM_2)
SJNRI060_14325(arsM)
SHAUK9S39_21720(arsM) K9S39_38985
SCOAQU709_22245(arsM)
SLAIP8A22_12925(arsM)
SFPQUY26_29100(arsM)
SINNABB07_21020
STRZOYE22_12230
YIALO772_26970 LO772_27070
PSICJ4E96_14240(arsM)
MIOAOA12_10085
MPRTET475_13875(arsM)
CARTPA27867_2661
CRYB7495_12935
ARQBWQ92_19450
AODQ8Z05_02700
APNAsphe3_30350
RKRI6G21_03615(arsM)
AULDCC27_005680
AIGQDX25_05320
ALXLVQ62_01735(arsM)
XCEXcel_3346
XYLET495_00315(arsM)
XYAET471_13770(arsM)
CFLCfla_3376
CFICelf_3648
CGACelgi_2701
CEZCBP52_10640
CEJGC089_00245(arsM)
CELHGXP71_12645(arsM)
CIRALFM56_01750(arsM)
CPALF1D97_00120(arsM)
CELCK5O09_01415(arsM)
CDONKKR89_01315(arsM)
CWANKG103_00965(arsM)
CFENKG102_16780(arsM)
CWNNP075_00970(arsM)
CCHENP064_15570(arsM)
CXIENP048_18640(arsM)
ICAIntca_0407
JTEASJ30_14225
JLIEXU32_00620(arsM)
JAYH7A72_14520(arsM)
JCRO9K63_10380(arsM)
TEHGKE56_09275
SERWFY030_04325(arsM)
ORNDV701_06310
ORZFNH13_07055(arsD)
BCAUI6G59_10660(arsM)
GYUFE374_17730(arsM)
PBOPACID_23480
AACIASQ49_10260
MPHMLP_26910 MLP_35580 MLP_37580
MIKFOE78_05290(arsM)
RAINRai3103_07050(arsM)
BROObrsh051_07360
NCANoca_3308 Noca_3743
NOIFCL41_03645(arsM)
NDPE2C04_04410(arsM)
NSNEXE58_15250
NAROCFH99_08640
NMARHPC71_09420(arsM)
NFCKG111_11610(arsM)
PSIMKR76_16865
ASEZH9L21_10585(arsM)
ADBNP095_10795(arsM)
MGGMPLG2_0468(arsM)
MUZH4N58_10055(arsM)
KFLKfla_0345 Kfla_1574
KQIF1D05_22435 F1D05_27325
NGVCDO52_16925
AMAZLUW76_26890
NOABKM31_18415
NGNLCN96_29670
NFSOIE67_16555 OIE67_44215
MHAIOHB01_26225
NMLNamu_0104
NAKAH7F38_13485(arsM)
BSDBLASA_3316
SVISvir_12710
AMDAMED_0756
AMNRAM_03855
AMMAMES_0754
AMZB737_0755
AOIAORI_0834(ubiE) AORI_2024
AJAAJAP_29410 AJAP_35405
AMQAMETH_3141 AMETH_4450
AMYCCU254_26720 CU254_28050
AMYBBKN51_02275
AABA4R43_10060 A4R43_39425
AMYYYIM_26195(rebM5) YIM_26975 YIM_38435(ubiE7)
AORISD37_31050
APRTMUY14_08010
ARHDVSH64_41345(arsM)
AMOGQRX60_33240
ACYNORV05_00700(arsM)
PDXPsed_1269
PAUTPdca_05670
SSYIEKG83_07075
KPHYAOZ06_29400 AOZ06_48915
ACTAC1701_18755
ALOCRK56442
PMADBAY61_08955
SACEGIY23_10885(arsM)
ACTYOG774_04100 OG774_20485
UMERM788_06025(arsM)
STPStrop_2596
SAQSare_2794
AMSAMIS_45070
ACTNL083_4383 L083_5247
AFSAFR_27295
PLKCIK06_05805
ATLAthai_16980
ASERAsera_57550
PRYPrubr_50970
SNASnas_1723 Snas_3423 Snas_5386
AHWNCTC11636_02114(bioC)
ASLANCTC11923_00220(ycgJ)
AWEJG540_02835
FSLEJO69_10840
FLHEJ997_12555
EKEEK0264_08515(arsM)
JCYM6B22_06545(arsM)
ABAIIMCC26256_111492
RXYRxyl_2880
RRDRradSPS_3003
RUBGBA63_16115(arsM) GBA63_22155(arsM)
RMARGBA65_19495(arsM)
BSOLFSW04_09735(arsM) FSW04_11940 FSW04_13930
BALADSM104299_00947(arsM_1) DSM104299_02524
CWOCwoe_0591
PARNNBH00_23825
SBAEDSM104329_01914(arsM_2)
PBAJLRS13_13110(arsM) LRS13_22065(arsM)
SYDSyncc9605_1984
SYESyncc9902_0677
SYGsync_0906
SYRSynRCC307_1420
SYXSynWH7803_1638
SYNKKR100_12330
SYNRKR49_05135
SYNDKR52_06350
SYHSyncc8109_2086
SYNWSynWH8103_00784
SYNCCB0101_00505
SYNYBM449_05915
SYWSYNW0684
CGCCyagr_2507
CYICBM981_1137
PMMPMM0416
PMTPMT_1171
PMIPMT9312_0411
PMBA9601_04661
PMCP9515_04771
PMFP9303_08531
PMGP9301_04351
PMHP9215_04921
PMJP9211_04141
PRCEW14_0453
CYNCyan7425_3607
LENLEP3755_08870
LBOLBWT_36040
KOVK9N68_28660
PSEUPse7367_2847
CHONNIES4102_08030
GENGM3709_1219
GEEGM3708_2355
CANCyan10605_1450
SYPSYNPCC7002_A1464
SYVAWQ23_07505
SYLAWQ21_07445
LEPLepto7376_0149
SYNNNIES970_16940
MARMAE_36890
MIQB5D77_01755
MVZmyaer102_11830
CYTcce_4295
CWACwatDRAFT_3898
CYPPCC8801_4075
CYHCyan8802_4114
CYCPCC7424_2227
CYJCyan7822_1983
TERTery_1991
ARPNIES39_J01260
OXYHCG48_25055
LFSHFV01_16605
PHORJWS08_16585
PYHNEA10_16475
GEIGEI7407_0068
ANBANA_C12692
RSINB6N60_01712
NSPBMF81_03332
DOUBMF77_03061
DFSHGD76_08875
NCNBZZ01_07375
CTHEChro_2853
PLPPle7327_0736
SCSSta7437_3631
STANSTA3757_31300
DETDET1420
DEHcbdbA1384
DEBDehaBAV1_1228
DEVDhcVS_1202
DEGDehalGT_1138
DMCbtf_1298
DMDdcmb_1279
DMGGY50_1258(arsM)
DMXX792_06665
DMYX793_06515
DMZX794_06095
DUCUCH007_11810
DLYDehly_1422
DEWDGWBC_1683
DFODform_02109
DETHHX448_00825
RRSRoseRS_1224
RCARcas_2312 Rcas_3189
HAUHaur_0110
CALLOZ401_004416(arsM)
ATMANT_20850
PSUBPelsub_P0583
CAPCLDAP_37010
PBFCFX0092_A1857
KBSEPA93_08215(arsM) EPA93_09300 EPA93_45165(arsM)
KBBccbrp13_22350
TBHTbon_01320(arsM)
TFLAO0235_12280(arsM)
THUGKNN16_07445
PMETG4Y79_11820(arsM)
STISthe_2038
TANTKNN15_05070
FGIOP10G_2922
NPYNPRO_08060
CCOTCCAX7_003040
OTEOter_0301 Oter_1590
PUORZN69_13470
FPESNXS98_10055(arsM)
MINMinf_0141(smtA) Minf_1786(ubiE)
MEAPMTHMO_0668 MTHMO_0777 MTHMO_0782 MTHMO_1306(arsM) MTHMO_1581
VBSEGM51_15430
RBARB6746
PSLPsta_3798
RULUC8_10280(arsD) UC8_16060
RMLFF011L_32960 FF011L_47100(arsD)
MFFMFFC18_01920
ROLCA51_51020
RUVEC9_02910
RCFPoly24_01760
AHELQ31a_16800(arsD) Q31a_17020
LCREPla8534_56550
AAGGETAA8_17520(ubiE_4)
BVOPan97_45650
BREMPSR63_15645
RLCK227x_10730 K227x_33710
SMAMMal15_66500
SNEPEnr13x_68640
LPAVPLANPX_1685
LLHI41_54940(ubiE_6)
PNDPla175_03960(ubiE_2)
AMOBHG15A2_34590 HG15A2_40910
BMEISpa11_16810(rebM)
BGOKPr1d_48350(ubiE_3)
PBSPlabr_2993
PLHVT85_21590(ubiE_8)
FMRFuma_02264
GMRGmarT_17350
GIMF1728_06105
GPNPan110_17180 Pan110_46500(ubiE_4)
GFMEnr17x_20050
GAZPan241w_19100
GAWV144x_39780
MRIMal4_23470(ubiE_3)
SDYNMal52_18450
PLONPla110_40490
ACAFCA12_08470(ubiE_1)
SVPPan189_30920
CHYAV22_40920
CCOSPan44_19340(arsD)
PVARSH412_002993(arsD) SH412_004615(arsM)
GOGC1280_20525
GMSSOIL9_25110
LRSPX52LOC_03157
ULIETAA1_29610(rebM_2) ETAA1_37350(rebM_4)
TSPHKIH39_22675
IPAIsop_2577
SACISinac_4607
PBORBSF38_05796(eryG)
AGVOJF2_76100(ubiE_9)
TPLAElP_68840(ubiE_6)
JETL3J17_10055
PCORKS4_14300(rebM_1)
MCADPan265_19810 Pan265_28930(ubiE_4)
HBSIPV69_20935(arsM)
UAMUABAM_04756 UABAM_05591
PBAPPla133_15120(ycgJ_2)
LPROPQO03_21855
TPEDTPE_0353
TRMJO41_00815
TRZGWP43_08005
TMEDDWB79_10270
TRPABH09_07545
SLRL21SP2_2452
OCKEXM22_05110
LAJA0128_13875
LKBLPTSP3_g28000
ABAAcid345_2959
ACMAciX9_1799
GMAAciX8_0247
GRWFTO74_16005(arsM)
TSAAciPR4_3730
TRSTerro_0051 Terro_0398 Terro_1689
TALBFTW19_07115(arsM)
EDAGWR55_13155(arsM)
ADINH7849_17305(arsM)
ORPMOP44_21405
SUSAcid_4410
PFERIRI77_08905 IRI77_10685 IRI77_22920
CTMCabther_B0627
CVLJ8C06_12375 J8C06_13765
CHLOJ8C02_11745
ABACLuPra_03085(ubiE_6) LuPra_04046(as3mt)
LUBTBR22_A21540
GEXGETHOR_26300
MSILMETEAL_13560 METEAL_23570
MSEAMETESE_13960
IPOIlyop_2570
LEOAMK43_01775
LGOJCM16774_1362
TAITaci_0499
ACOAmico_1773
AMIZRBH88_00575(arsM)
AMOAnamo_1237
ARAMKAR29_00545(arsM)
GAUGAU_0703 GAU_1268
GPHGEMMAAP_15100
GGRHKW67_16525
GBAJ421_2256
PMUCING2E5A_1787(arsM)
PETPEIBARAKI_5768
DYSG7050_06840 G7050_10875
DYHG7051_11165
PGOLK6V26_24350(arsM)
AITAI2BBH_14750(arsM)
BACCBRDCF_p1842
DORIFH5T_14860
MCOSGM418_01490(arsM)
ANFAQPE_1246
CPICpin_6112
CBAECOR50_18735
CHITFW415_17060
CHIHGWR21_10455
COYHF329_09255
CFILMYF79_14330 MYF79_21315
CHORMKQ68_11800 MKQ68_18985
CSACSIO70_20060
NKONiako_4079
FLASY85_10560
FGGFSB75_15185(arsM)
ARKD6B99_10310
AGIFSB73_15655 FSB73_18010(arsM)
ATEEK9M52_18470
FLNFLA_2992
PSEGD3H65_00575
PGINFRZ67_10440(arsM) FRZ67_18720 FRZ67_18800(arsM)
PGOFSB84_10465(arsM)
LACSH4075_18270
FLPLK994_06195
FLCKJS93_17125
FLVKJS94_13650
THEOIMW88_04005
HHYHalhy_5320
SCNSolca_3634
SLASL2B55_00395
MGOTMgSA37_01199(ubiE_2)
MUHHYN43_004775
MRUBDEO27_004990
MGOSDIU38_004755
MMABHQ865_22415
ALMAO498_03465
SLISlin_3937
SRDSD10_02035
SMONAWR27_13980
SPIRCWM47_22315 CWM47_34800
SPIKEXU85_34465(arsM)
SPIBG8759_14230 G8759_17135
STAEHNV11_06350
SOQLQ777_10680 LQ777_28295 LQ777_28965
SFOLH3H32_07370 H3H32_08705
SENFGJR95_06110(arsM)
RHOZGXP67_17265
PSEZHME7025_02560
EMZMB380_12590
RSIRunsl_4128
FAEFAES_5192
FIBA6C57_09505
HSWHsw_0589
HYMN008_05050
HYGAUC43_12810
HRSHER32_14065
HBNGUY19_12005
HTSHMJ29_10535
HTBMTX78_22630
HYKO9Z63_00550
HSKH4317_16175
HCWO3303_18360
HAEIMUN82_02255
HCUMUN79_14310
HVLMUN86_22130
HCFMUN80_13335
ADDHUW48_00145 HUW48_02360
ASWUHUW51_00445 HUW51_09305
FPFDCC35_11045
CLITOQ292_03820
IRORT717_23125
CHRWKA713_13645
FMMLVD15_24385
FLWLVD16_12335
TPELP0M28_12550
FAXFUAX_51800(arsM)
CHGAXF12_01540
FBCFB2170_11321
ASLAeqsu_0604
AEVEI546_00850 EI546_04705
PUNNQP51_02250(arsM)
AHZAPS56_01835
FOPFNB79_11675(arsM)
ANPFK178_02525(arsM)
SINHLS482_15175
FBEFF125_19880(arsM)
CTAK4412677_00482(ubiE_1) 4412677_00644(ubiE_2)
CSUPMTP09_08895
CJGNCTC13459_00597(rebM_1)
CCASEIB73_04640
CANTNCTC13489_00186(ycgJ)
KDAEIB71_08710
KBEJ4771_04060
KFAQ73A0000_07520(arsM)
KAQL0B70_13105
CNREB819_04325
CHYDH4K34_03400
PTANCRYO30217_01886(COQ5_3)
CPBCphamn1_0759
RMRRmar_2577
RMGRhom172_2593
RLOGQ464_005895(arsM)
SRUSRU_2461
SRMSRM_02682
IALIALB_2688
MROMROS_1044
GTLEP073_04190
FSIFlexsi_2045 Flexsi_2050
NDENIDE3699 NIDE3709
NMVNITMOv2_3847 NITMOv2_4157 NITMOv2_4197
NIONITINOP_1518
NJANSJP_2692
NKFNkreftii_000321 Nkreftii_000667 Nkreftii_004012
NTIDNFV4_01190 DNFV4_02178 DNFV4_03858
NALLPP769_05490
NNEOPQG83_16695
LFCLFE_1365
NLIG3M70_10495
NVAG3M78_07515
BANABARAN1_0887
BIHBIP78_0027 BIP78_1019
MELMetbo_1857
MEWMSWAN_2348
MFCBRM9_2029
MFIDSM1535_0222
MCUBMCBB_2274(arsM)
MSUBBK009_08545 BK009_11170
METNBK008_04190
METTCIT01_04500 CIT01_05135
METOCIT02_05655
MEMEHYG87_06005(arsM)
MBAMbar_A1714
MBYMSBRM_0053 MSBRM_2964
MBWMSBRW_3021
MBARMSBR2_0052 MSBR2_2927
MBAKMSBR3_0031 MSBR3_0131
MACMA_3783 MA_4620
MMAMM_0661 MM_2243
MMAZMmTuc01_0667 MmTuc01_2293
MMJMSMAS_0652 MSMAS_2453
MMACMSMAC_0654 MSMAC_1994
MVCMSVAZ_0403
MEKMSKOL_0389
MLSMSLAZ_2458
METMMSMTP_0716
MEFMSWH1_0816
MEQMSWHS_0870
MSJMSSAC_0038 MSSAC_3574
MSZMSSIH_3116
MSWMSSIT_3184
MTHRMSTHT_0346 MSTHT_0908
MTHEMSTHC_0377
MHORMSHOH_0765
MFZAOB57_000530
MMETMCMEM_0390
MELOJ7W08_03985 J7W08_09125(arsM)
MMHMmah_1297
MHAZBHR79_07095
MPOTBKM01_04585
MEVMetev_0754
MPYMpsy_2039
MZIHWN40_11995(arsM)
MEHFMmiHf6_08650(arsM)
MEESMmiEs2_05470(arsM)
MTPMthe_1429
MCJMCON_3017 MCON_3109
MHIMhar_1545
MPIMpet_2814
MPDMCP_0689
MEZMtc_2327
RCIRCIX1264
HALAAC82905.1
HSLOE_5444F(arsM)
HANRLJ422_11770
HDLHALDL1_07210(arsM) HALDL1_07745
HAGSJT689_01360
HABOJRZ79_12975
HJEHacjB3_06810
HALXM0R89_11015(arsM) M0R89_21645
HAXZM0R88_11475(arsM)
HAYCNGM10_10710
HAXYNGM07_17030
SALIL593_03670 L593_09130
HHIHAH_2873(scm)
HHNHISP_14605
HABSG26_06745
HALJG9465_02375 G9465_20515
HSINKDQ40_17715
NMONmlp_2711(arsM)
NHOHWV23_11660
NSALHWV07_03175(arsM)
HTIHTIA_2463
HALAHrd1104_02025
HSNDV733_05590
HPELHZS54_10200(arsM)
HLTI7X12_01400(arsM)
HARCHARCEL1_07410
SSAIN0B31_18070(arsM)
HAADMW046_14270
HWCHqrw_2170
HALEG3A49_08170
HLNSVXHx_3151(arsm)
HAQDU484_05325 DU484_11390
HAJDU500_05770 DU500_11665
HAERDU502_01445
HLAHlac_1246 Hlac_1585
HALPDOS48_14965
HALQHrr1229_009260
SRUBC2R22_21295
HALGHUG10_06380 HUG10_17265
HALUHUG12_07985(arsM) HUG12_08885 HUG12_17310
HMPK6T50_04925 K6T50_08385(arsM)
HREK6T36_04735 K6T36_08175(arsM)
HDFAArcSl_1901(arsM)
HTUHtur_1027 Htur_3046
HSALJMJ58_13185(arsM)
NMGNmag_1196
NPLFGF80_18275(arsM)
HALYHYG82_07260(arsM) HYG82_20625(arsM)
SAWLNGM29_03645 NGM29_06235
NOUNatoc_3656
HLCCHINAEXTREME18085
NAJB1756_09905
NARAQQ977_11095 QQ977_15785
NBGDV706_04045
NASGCU68_09245 GCU68_18555(arsM)
MEAEQEN48_00155 QEN48_03665(arsM)
MEARMpt1_c14370(arsM2)
MEUZKRP56_05475(arsM)
MARCAR505_0981
NIDNPIRD3C_0359
NICDSQ20_02645
NGANgar_c35810
NVNNVIE_020760
NEVNTE_00056
TAANMY3_02003(ycgJ_2)
NFNNFRAN_0049(arsM)
NIUDSQ19_09210
NCKQVH35_01850(arsM)
NDVNDEV_0358
FLTSv326_0620
LOBNEF87_004410
 » show all
Reference
1  [PMID:8605285]
  Authors
Zakharyan R, Wu Y, Bogdan GM, Aposhian HV.
  Title
Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver.
  Journal
Chem Res Toxicol 8:1029-38 (1995)
DOI:10.1021/tx00050a006
Reference
2  [PMID:8806872]
  Authors
Zakharyan RA, Wildfang E, Aposhian HV.
  Title
Enzymatic methylation of arsenic compounds. III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic.
  Journal
Toxicol Appl Pharmacol 140:77-84 (1996)
DOI:10.1006/taap.1996.0199
Reference
3  [PMID:10604879]
  Authors
Zakharyan RA, Aposhian HV.
  Title
Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase.
  Journal
Chem Res Toxicol 12:1278-83 (1999)
DOI:10.1021/tx9901231
Reference
4  [PMID:10387927]
  Authors
Zakharyan RA, Ayala-Fierro F, Cullen WR, Carter DM, Aposhian HV.
  Title
Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes.
  Journal
Toxicol Appl Pharmacol 158:9-15 (1999)
DOI:10.1006/taap.1999.8687
Reference
5  [PMID:11790780]
  Authors
Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ
  Title
A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol.
  Journal
J Biol Chem 277:10795-803 (2002)
DOI:10.1074/jbc.M110246200
  Sequence
[rno:140925]
Reference
6  [PMID:15526190]
  Authors
Hayakawa T, Kobayashi Y, Cui X, Hirano S.
  Title
A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19.
  Journal
Arch Toxicol 79:183-91 (2005)
DOI:10.1007/s00204-004-0620-x
Reference
7  [PMID:25325836]
  Authors
Dheeman DS, Packianathan C, Pillai JK, Rosen BP.
  Title
Pathway of human AS3MT arsenic methylation.
  Journal
Chem Res Toxicol 27:1979-89 (2014)
DOI:10.1021/tx500313k
Reference
8  [PMID:25760600]
  Authors
Marapakala K, Packianathan C, Ajees AA, Dheeman DS, Sankaran B, Kandavelu P, Rosen BP.
  Title
A disulfide-bond cascade mechanism for arsenic(III) S-adenosylmethionine methyltransferase.
  Journal
Acta Crystallogr D Biol Crystallogr 71:505-15 (2015)
DOI:10.1107/S1399004714027552
Reference
9  [PMID:27105594]
  Authors
Yang HC, Rosen BP.
  Title
New mechanisms of bacterial arsenic resistance.
  Journal
Biomed J 39:5-13 (2016)
DOI:10.1016/j.bj.2015.08.003
Reference
10 [PMID:29894638]
  Authors
Packianathan C, Kandavelu P, Rosen BP.
  Title
The Structure of an As(III) S-Adenosylmethionine Methyltransferase with 3-Coordinately Bound As(III) Depicts the First Step in Catalysis.
  Journal
Biochemistry 57:4083-4092 (2018)
DOI:10.1021/acs.biochem.8b00457
Reference
11 [PMID:30520200]
  Authors
Chen J, Yoshinaga M, Rosen BP.
  Title
The antibiotic action of methylarsenite is an emergent property of microbial communities.
  Journal
Mol Microbiol 111:487-494 (2019)
DOI:10.1111/mmi.14169
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.137
IUBMB Enzyme Nomenclature: 2.1.1.137
ExPASy - ENZYME nomenclature database: 2.1.1.137
UM-BBD (Biocatalysis/Biodegradation Database): 2.1.1.137
BRENDA, the Enzyme Database: 2.1.1.137
CAS: 167140-41-2

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