KEGG ENZYME: 2.1.1.145

ENZYME: 2.1.1.145

Entry

EC 2.1.1.145                Enzyme

Name

trans-aconitate 3-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate [RN:R05764]

Reaction(KEGG)

R05764

Substrate

S-adenosyl-L-methionine [CPD:C00019];
trans-aconitate [CPD:C02341]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
(E)-2-(methoxycarbonylmethyl)butenedioate [CPD:C11515]

Comment

Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate as the product, that from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.144, trans-aconitate 2-methyltransferase)

History

EC 2.1.1.145 created 2002

Orthology

K22438

trans-aconitate 3-methyltransferase

Genes

ASN:

102381625

AMJ:

102569370

PSS:

102451271

CMY:

102933461

CPIC:

101943168

DRE:	555292(zgc:162396)

SRX:

107733630

SANH:

107663909

SGH:	107551942 107568094

CCAR:

109107004(zgc:162396)

CAUA:

113053218 113108780

CGIB:

127965376 128019852(zgc:162396)

PTET:

122352016(zgc:162396)

LROH:

127171143(zgc:162396)

GRF:

141341120

OMC:	131547449(zgc:162396)

PPRM:

120486788(zgc:162396)

RKG:	130076837(zgc:162396)

MAMB:

125270279(zgc:162396)

CIDE:

127518392 127519089

CERY:

137035995(zgc:162396)

MASI:

127447136(zgc:162396) 127448444

TDW:	130427498(zgc:162396)

MANU:

129452461 129452464

PDAB:

135733257 135733258

IPU:	108266249 108266250 108266251

IFU:	128608645 128608647 128608650

PHYP:

113535005 113535006

SMEO:

124383001 124383099

TFD:

113646289

TVC:

132849841

CGAR:

128523863 128523864 128523865

NGRA:

132891600

TRN:

134324371

AMEX:

103038316 103038625

CMAO:

118808797(zgc:162396) 118808805

EEE:

113592256

TRU:	101073661 101073886 101079061 105419080 115252434

TFS:	130522726(si:ch211-93g23.2) 130531280 130531286 130531292 130537080

LCO:	104928317 104936015

NCC:

104955817

TBEN:

117485985(zgc:162396)

CGOB:

115026389

PGEO:

117466988

GACU:

117541559(zgc:162396)

EMAC:

134867219(zgc:162396)

ELY:	117249875 117250211 117251436(zgc:162396)

EFO:	125885012 125885268 125899955

PLEP:

121949088(zgc:162396) 121962625 121962958

SLUC:

116044448(zgc:162396) 116044711

ECRA:

117939401 117953053(zgc:162396)

ESP:	116673918 116687495

PFLV:

114551225 114563992 114563993

GAT:	120820226 120833789(zgc:162396)

PPUG:

119223154 119229299(zgc:162396)

AFB:	129104600(zgc:162396) 129112019(si:ch211-93g23.2)

CLUM:

117745975(si:ch211-93g23.2) 117750605

PSWI:

130204080 130204723(si:ch211-93g23.2)

CANA:

137783104(zgc:162396) 137794213 137794233

CVE:	137879221 137891885(zgc:162396)

MSAM:

119884027 119887689 119903860(zgc:162396) 119904595(si:ch211-93g23.2)

SCHU:

122885253(zgc:162396)

CUD:	121506312 121522769(zgc:162396)

SPUL:

138592834 138603755

LMIX:

132987030(zgc:162396)

ALAT:

119014933 119014934 119015529 119026322(zgc:162396)

ASTR:

137591640 137591651 137604693(zgc:162396)

MZE:	101466574 101467129

ONL:	100699555 100701305

OAU:	116325710(zgc:162396) 116332103

OLA:	101157984 101159172

OML:	112155144(zgc:162396) 112156639

CSAI:

133446125(zgc:162396)

XMA:	102229857 102232349

XCO:	114141210 114148361

XHE:	116716257 116723317

PRET:

103460220 103473420

PFOR:

103148686 103153518

PLAI:

106956832 106958200

PMEI:

106916065 106925664

GAF:	122826850 122840085(zgc:162396)

PPRL:

129374527(zgc:162396)

CVG:	107084235 107094147

CTUL:

119780812 119796555(zgc:162396)

GMU:	124861695 124871276(zgc:162396)

NFU:

107389394

KMR:	108238497(zgc:162396)

ALIM:

106529443

NWH:	119419027(zgc:162396)

AOCE:

111563024

EJA:	138200755 138206976

BFRE:

138620761 138621006

MCEP:

125000598 125017698(zgc:162396)

POV:	109631040 109631041

SSEN:

122785799(zgc:162396)

SSOE:

131455591(zgc:162396)

HHIP:

117754786(zgc:162396)

HSP:	118120267(zgc:162396)

PPLT:

128455507 128455509 128455510 128455511 128455512 128455883 128456328 128456450

SMAU:

118282749(zgc:162396)

LCF:	108873045(si:ch211-93g23.2) 108887095(zgc:162396)

SDU:	111218885 111233950

SLAL:

111665341 111667426

XGL:

120798272

HCQ:

109528745

SSCV:

125988729 125988730

SBIA:

133506529

PEE:

133404979

PTAO:

133465403

BPEC:

110170910

ENY:	140361479 140361488

BSPL:

114847555 114847556

SJO:	128354367 128368236(zgc:162396)

SSCO:

133976452 133992972(zgc:162396)

GMH:

115533101

SASA:

106575799 106586297(Y3374) 106586299 106586300(Y3374)

STRU:

115160878 115160879 115160880 115179683 115196467

OTW:	112237921 112246667 121846070

OMY:	110520214 110520215 110520216 110527273 118941089

OGO:	124018237 124042916 124043957 124043959

ONE:

115110267

OKI:	109867618 109867629 109885188 109885190 109904341 109904352

OKE:	118366661 118366966 127915097

OMM:	135519364 135519365 135531253 135537521 135537523

OCLA:

139372978 139400125 139400136 139400155 139414042

SALP:

111976662

SNH:	120058313 120058314

CCLU:

121536237 121536688

ELS:	105023182 105026255

OEP:	134016441(zgc:162396)

SFM:	108922275 108922288

PKI:

111851601

LOC:	102685425 107078729

PSPA:

121322465

ARUT:

117426119

PSEX:

120530755

RTP:	109910913 109928000(si:ch211-93g23.2) 109929170

CPLA:

122551410 122551416

PMRN:

116950130

LRJ:

133348979

BFO:	118418082 118421340

CIN:	100175142 100176950 100181852 100182452 100182735 100183251 100186622 101243446

SCLV:

120326477 120329823 120329826 120330086 120331042 120331058 120331215 120334108 120334551 120334553 120335394 120337508 120339298 120339302 120339305 120339306 120339307 120339622 120339627 120341097 120341180 120346028 120346482 120347349

SPU:	100888493 100892755 100893113 100893205

LPIC:

129269129 129269860 129272496

AJJ:	139966252 139966257 139966266 139966300 139966317 139973738 139974211 139974959 139981603

APLC:

110982107 110982152 110982157 110984568 110984569

ARUN:

117292111 117292134

AFIL:

140138782 140151302 140160387 140161135 140163710 140163711

SKO:	100368336 100369162

PFLL:

139137162 139137165 139137169 139137174 139137193 139140712 139140767 139140783 139145653

BTAB:

109040316

DCI:

103504902

NLU:

111057126

HVI:

124364437

MQU:

129001113

CSEC:

111866386

BROR:

134537413

IEL:

124166729

HAMR:

139695128

FCD:	110841945 110846634 110859337 110862381

DPX:	DAPPUDRAFT_221341

AFRA:

136025372

PJA:	122252772 122267778

PCHN:

125038208

HAME:

121869100 121871327

PCLA:

123746667 123767344

CQD:	128698938 138852143

PTRU:

123520302

ESN:

127007095

MNZ:	135208158 135208811

MRJ:

136825813

PORN:

139762709 139762907

HAZT:

108666396 108678825

EAF:	111696101 111699948

PPOI:

119093534 119093723 119093800 119094023

DSV:	119446603 119446604

RSAN:

119383276 119388732 119389774

TUT:	107359408 107368944

ABRU:

129983920

SDM:

118197135

HRO:	HELRODRAFT_154743

LAK:	106154626 106158400 106158401 106158442 106168153 106173575 106174760 106180744

LLON:

135497390

TAD:	TRIADDRAFT_60934 TRIADDRAFT_61353

SCE:	YER175C(TMT1)

SEUB:

DI49_1584

SPAO:

SPAR_E02490

AGO:	AGOS_AGR110W

KLA:	KLLA0_C17864g

KMX:	KLMA_30285(TMT1)

LTH:	KLTH0B01936g KLTH0G14212g KLTH0H09460g

VPO:	Kpol_1032p55

ZRO:	ZYRO0B11924g ZYRO0B11946g ZYRO0E10032g

CGR:	2888519(GVI51_H00231) 2890954(GVI51_L11957)

NCS:	NCAS_0A03100(NCAS0A03100) NCAS_0B04900(NCAS0B04900)

NDI:	NDAI_0B02310(NDAI0B02310) NDAI_0I02680(NDAI0I02680)

TPF:	TPHA_0A01900(TPHA0A01900)

TBL:	TBLA_0C01350(TBLA0C01350) TBLA_0C01360(TBLA0C01360) TBLA_0F03870(TBLA0F03870)

TGB:	HG536_0H02960

TDL:	TDEL_0G00510(TDEL0G00510) TDEL_0G00520(TDEL0G00520)

KAF:	KAFR_0B02610(KAFR0B02610) KAFR_0B06440(KAFR0B06440) KAFR_0C00170(KAFR0C00170)

KNG:	KNAG_0G01930(KNAG0G01930)

ZMK:	HG535_0C06500 HG535_0G04630

SLUD:

SCDLUD_001318 SCDLUD_001328 SCDLUD_002247 SCDLUD_003062 SCDLUD_003794 SCDLUD_004972 SCDLUD_005331

DHA:	DEHA2E06974g DEHA2F04224g

PIC:	PICST_35256(TMT2) PICST_52120(TMT1)

PGU:	PGUG_01293 PGUG_05542

SPAA:

SPAPADRAFT_58538 SPAPADRAFT_62852

LEL:	PVL30_000644 PVL30_001684

LBG:	92205637(LODBEIA_P04410) 92207902(LODBEIA_P27060)

CAL:	CAALFM_C105830WA(CaO19.2468) CAALFM_C110310WA(CaO19.4902)

CTP:	CTRG_03323 CTRG_04828

COT:	CORT_0A06730 CORT_0B08770

CDU:	CD36_09710

CTEN:

18246206(PSN45_001898) 18246397(PSN45_002930)

CLU:	CLUG_01304 CLUG_05543

CLUS:

A9F13_06g01078 A9F13_16g00385

CAUR:

CJI96_0000731 CJI96_0005091

ASAU:

88171288(PUMCH_000219) 88174687(PUMCH_003624)

PPA:	PAS_chr2-1_0815 PAS_chr3_0330

BNN:	FOA43_000128

BBRX:

BRETT_000969

OPA:	HPODL_01451 HPODL_01656

SLB:	AWJ20_2280(TMT1)

NCR:

NCU06616

NTE:	NEUTE1DRAFT128461(NEUTE1DRAFT_128461)

SMP:	10803959(SMAC4_04742)

PAN:	PODANSg09285

TTT:	THITE_2120388

MTM:	MYCTH_107976

TMN:	UCRPA7_3353 UCRPA7_3581 UCRPA7_4376

SSCK:

SPSK_02666

FGR:	FGSG_01823

FVR:	FVEG_07666 FVEG_11957

FOX:	FOXG_03914 FOXG_04552 FOXG_06508 FOXG_06756 FOXG_06856 FOXG_07166 FOXG_07188 FOXG_07316 FOXG_10739 FOXG_16154 FOXG_16225 FOXG_16342

NHE:	NECHADRAFT_57800 NECHADRAFT_66244

FFC:	NCS54_00238400 NCS54_01490000

FKR:	NCS57_00233800

MAW:	19245592(TMT1_1)

MAJ:

MAA_06303

MBRN:

26237849(G6M90_00g021420)

PCHM:

VFPPC_05054

CMT:

CCM_00874

AMUS:

LMH87_010222

PLJ:	28888311(PLICBS_003514) 28888416(PLICBS_003611)

PTKZ:

JDV02_000235(TMT1)

VAL:	VDBG_06574

VDA:	VDAG_05114 VDAG_07944

CFJ:	CFIO01_01623 CFIO01_04000 CFIO01_07771

CLUP:

CLUP02_18116

CHIG:

CH63R_13660

CDET:

87947241(CDEST_10741)

SAPO:

SAPIO_CDS8452

ELA:	UCREL1_11728 UCREL1_6587 UCREL1_8188

PFY:	PFICI_04420 PFICI_14068

SSL:	SS1G_04668 SS1G_13944

BFU:	BCIN_01g08170 BCIN_15g04430

MBE:

MBM_06649

PSCO:

LY89DRAFT_253306 LY89DRAFT_352805 LY89DRAFT_664351 LY89DRAFT_681847 LY89DRAFT_689716

GLZ:	GLAREA_00346 GLAREA_01715 GLAREA_02496

AFM:	AFUA_2G01390

NFI:	NFIA_033690

ANG:	An06g02170

ALUC:

AKAW2_51523A AKAW2_81327A

ACHE:

ACHE_31313S

PCS:	N7525_003533

PDP:	PDIP_15440

TRG:	TRUGW13939_10458 TRUGW13939_10506

ABE:	ARB_00401 ARB_06273

TVE:	TRV_04640 TRV_06396

AJE:	HCAG_05462

PTE:

PTT_10228

PTRR:

6349428(PtrM4_072900)

BZE:	COCCADRAFT_3024

ZTR:	MYCGRDRAFT_36084

PFJ:	MYCFIDRAFT_70746

FFU:	CLAFUR5_08336

CBET:

CB0940_04135

BCOM:

BAUCODRAFT_228911

NPA:	UCRNP2_5952

CNE:

CNM00330

CNB:

CNBM0330

CNG:	CNAG_06022

CGI:	CGB_M0310C

CDEU:

CNBG_4760

CDEC:

89993040(IAS62_006272)

CTEG:

91993087(I308_106232)

CBAS:

91986455(I312_106412)

KNE:	92181874(IAR55_004616)

TMS:	TREMEDRAFT_35179

TASA:

A1Q1_02719 A1Q1_07785

CCAC:

CcaHIS019_0201010(TMT1)

TVS:	TRAVEDRAFT_22245 TRAVEDRAFT_50314

DSQ:	DICSQDRAFT_134511

PCO:	PHACADRAFT_259362 PHACADRAFT_259518

SHS:	STEHIDRAFT_62535

HIR:	HETIRDRAFT_241537

ADL:	AURDEDRAFT_92054

FME:	FOMMEDRAFT_164693

GTR:	GLOTRDRAFT_101860 GLOTRDRAFT_101861 GLOTRDRAFT_108867

RSX:	RhiXN_09209

LBC:	LACBIDRAFT_318092 LACBIDRAFT_318110

CCI:	CC1G_01626 CC1G_07293

MRR:	Moror_3347

E1B28_005795

SCM:	SCHCO_02638322(SCHCODRAFT_02638322)

CPUT:

CONPUDRAFT_158898

SLA:	SERLADRAFT_478572

WSE:	WALSEDRAFT_62375 WALSEDRAFT_67401

WIC:	J056_002119 J056_002856

UMA:	UMAG_12026

PFP:	PFL1_01824

SGRA:

EX895_005104

PGR:	PGTG_00467 PGTG_15358 PGTG_16523

MLR:	MELLADRAFT_64121

» show all

Reference

1 [PMID:10224113]

Authors

Cai H, Clarke S

Title

A novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coli.

Journal

J Biol Chem 274:13470-9 (1999)
DOI:10.1074/jbc.274.19.13470

Reference

2 [PMID:11329290]

Authors

Cai H, Strouse J, Dumlao D, Jung ME, Clarke S

Title

Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases.

Journal

Biochemistry 40:2210-9 (2001)
DOI:10.1021/bi0022902

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.145

IUBMB Enzyme Nomenclature:

2.1.1.145

ExPASy - ENZYME nomenclature database:

2.1.1.145

BRENDA, the Enzyme Database:

2.1.1.145

CAS:	235107-12-7

All links

Gene (28)   
   MGENES (10)   
   RefGene (18)   
Protein sequence (79)   
   UniProt (65)   
   SWISS-PROT (2)   
   RefSeq(pep) (11)   
   PDBSTR (1)   
DNA sequence (47)   
   RefSeq(nuc) (20)   
   GenBank (14)   
   EMBL (13)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   InterPro (3)   
All databases (158)   

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