Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy

S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase

S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate [RN:R05764]

R05764
Reaction

S-adenosyl-L-methionine [CPD:C00019];
trans-aconitate [CPD:C02341]

Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate as the product, that from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.144, trans-aconitate 2-methyltransferase)

EC 2.1.1.145 created 2002

1  [PMID:10224113]

Cai H, Clarke S

A novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coli.

J Biol Chem 274:13470-9 (1999)
DOI:10.1074/jbc.274.19.13470

2  [PMID:11329290]

Cai H, Strouse J, Dumlao D, Jung ME, Clarke S

Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases.

Biochemistry 40:2210-9 (2001)
DOI:10.1021/bi0022902