KEGG   ENZYME: 2.1.1.145
Entry
EC 2.1.1.145                Enzyme                                 
Name
trans-aconitate 3-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate [RN:R05764]
Reaction(KEGG)
R05764
Substrate
S-adenosyl-L-methionine [CPD:C00019];
trans-aconitate [CPD:C02341]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(E)-2-(methoxycarbonylmethyl)butenedioate [CPD:C11515]
Comment
Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate as the product, that from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.144, trans-aconitate 2-methyltransferase)
History
EC 2.1.1.145 created 2002
Orthology
K22438  trans-aconitate 3-methyltransferase
Genes
ASN102381625
AMJ102569370
PSS102451271
CMY102933461
CPIC101943168
XTR100498610
NPR108800554
DRE555292(zgc:162396)
SRX107733630
SANH107663909
SGH107551942 107568094
CAUA113053218 113108780
PPRM120486788(zgc:162396)
MAMB125270279(zgc:162396)
IPU108266249 108266250 108266251
PHYP113535005 113535006
SMEO124383001 124383099
TFD113646289
AMEX103038316 103038625
EEE113592256
TRU101073886 101079061 115252434
LCO104928317 104936015
NCC104955817
CGOB115026389
ELY117249875 117250211 117251436(zgc:162396)
EFO125885012 125885268 125899955
PLEP121949088(zgc:162396) 121962625 121962958
SLUC116044448(zgc:162396) 116044711
ECRA117939401 117953053(zgc:162396)
ESP116673918 116687495
PFLV114551225 114563992 114563993
GAT120820226 120833789(zgc:162396)
PPUG119223154 119229299(zgc:162396)
MSAM119884027 119887689 119903860(zgc:162396) 119904595(si:ch211-93g23.2)
CUD121506312 121522769(zgc:162396)
ALAT119014933 119014934 119015529 119026322(zgc:162396)
MZE101466574 101467129
ONL100699555 100701305
OAU116325710(zgc:162396) 116332103
OLA101157984 101159172
OML112155144(zgc:162396) 112156639
XMA102229857 102232349
XCO114141210 114148361
XHE116716257 116723317
PRET103460220 103473420
PFOR103148686 103153518
PLAI106956832 106958200
PMEI106916065 106925664
GAF122826850 122840085(zgc:162396)
CVG107084235 107094147
CTUL119780812 119796555(zgc:162396)
GMU124861695 124871276(zgc:162396)
NFU107389394
KMR108238497(zgc:162396)
ALIM106529443
NWH119419027(zgc:162396)
AOCE111563024
MCEP125000598(si:ch211-93g23.2) 125017698(zgc:162396)
POV109631040 109631041
SSEN122785799(zgc:162396)
HHIP117754786(zgc:162396)
HSP118120267(zgc:162396)
LCF108873045(si:ch211-93g23.2) 108887095(zgc:162396)
SDU111218885 111233950
SLAL111665341 111667426
XGL120798272
HCQ109528745
BPEC110170910
BSPL114847555 114847556
SASA106575799 106586297(Y3374) 106586299 106586300(Y3374)
STRU115160878 115160879 115160880 115179683 115196467
OTW112237921 112246667 121846070
OMY110520214 110520215 110520216 110527273 118941089
OGO124018237 124042916 124043957 124043959
ONE115110267
SALP111976662
SNH120058313 120058314
CCLU121536237 121536688
ELS105023182 105026255
SFM108922275 108922288
PKI111851601
LOC102685425 107078729
PSPA121322465
ARUT117426119
PSEX120530755
LCM102367000
RTP109910913 109928000 109929170
BFO118418082 118421340
CIN100175142 100176950 100181852 100182452 100182735 100183251 100186622 101243446
SCLV120326477 120329823 120329826 120329881 120330086 120330443 120331042 120331058 120331215 120331216 120332000 120332861 120334108 120334551 120334553 120335394 120336182 120336815 120337508 120337630 120338111 120338168 120339298 120339302 120339305 120339306 120339307 120339622 120339627 120341097 120341180 120341355 120346028 120346482 120347349 120347785 120347786
SPU100888493 100892755 100893113 100893205
APLC110982107 110982152 110982157 110984568 110984569
SKO100368336 100369162
BTAB109040316
DCI103504902
NLU111057126
CSEC111866386
FCD110841945 110846634 110859337 110862381
DPXDAPPUDRAFT_221341
PJA122246046 122252772 122267778
PCHN125038208
HAME121869100 121871327
PCLA123746667 123767344
PTRU123520302
HAZT108666396 108678825
EAF111696101 111699948
PPOI119093534 119093723 119093800 119094023 119094210
DSV119444192 119445188 119446603 119446604
RSAN119383276 119388732 119389774
TUT107359408 107368944 107369076 107369101
CSCU111619037
PTEP107445017
SDM118197135
HROHELRODRAFT_154743 HELRODRAFT_154744 HELRODRAFT_159849 HELRODRAFT_172299
HRJ124284017
LAK106154626 106158400 106158401 106158442 106168153 106173575 106174760 106180744
TADTRIADDRAFT_60934 TRIADDRAFT_61353
QSU111983315 112005367 112006171 112008094 112009447 112030492 112031305 112031376
SCEYER175C(TMT1)
SEUBDI49_1584
SPAOSPAR_E02490
AGOAGOS_AGR110W
KLAKLLA0_C17864g
KMXKLMA_30285(TMT1)
LTHKLTH0B01936g KLTH0G14212g KLTH0H09460g
VPOKpol_1032p55
ZROZYRO0B11924g ZYRO0B11946g ZYRO0E10032g
CGRCAGL0H00418g CAGL0L12012g
NCSNCAS_0A03100(NCAS0A03100) NCAS_0B04900(NCAS0B04900)
NDINDAI_0B02310(NDAI0B02310) NDAI_0I02680(NDAI0I02680)
TPFTPHA_0A01900(TPHA0A01900)
TBLTBLA_0C01350(TBLA0C01350) TBLA_0C01360(TBLA0C01360) TBLA_0F03870(TBLA0F03870)
TGBHG536_0H02960
TDLTDEL_0G00510(TDEL0G00510) TDEL_0G00520(TDEL0G00520)
KAFKAFR_0B02610(KAFR0B02610) KAFR_0B06440(KAFR0B06440) KAFR_0C00170(KAFR0C00170)
KNGKNAG_0G01930(KNAG0G01930)
ZMKHG535_0C06500 HG535_0G04630
PPAPAS_chr2-1_0815 PAS_chr3_0330
DHADEHA2E06974g DEHA2F04224g
PICPICST_35256(TMT2) PICST_52120(TMT1)
PGUPGUG_01293 PGUG_05542
SPAASPAPADRAFT_58538 SPAPADRAFT_62852
LELLELG_00669 LELG_01712
CALCAALFM_C105830WA(CaO19.2468) CAALFM_C110310WA(CaO19.4902)
CTPCTRG_03323 CTRG_04828
COTCORT_0A06730 CORT_0B08770
CDUCD36_09710
CTENCANTEDRAFT_110574 CANTEDRAFT_112197
CLUCLUG_01304 CLUG_05543
CLUSA9F13_06g01078 A9F13_16g00385
CAURCJI97_002082 CJI97_002948
SLBAWJ20_2280(TMT1)
BNNFOA43_000128
BBRXBRETT_000969
OPAHPODL_01451 HPODL_01656
SLUDSCDLUD_001318 SCDLUD_001328 SCDLUD_002247 SCDLUD_003062 SCDLUD_003794 SCDLUD_004972 SCDLUD_005331
NCRNCU06616
NTENEUTE1DRAFT128461(NEUTE1DRAFT_128461)
SMPSMAC_04742
PANPODANSg09285
TTTTHITE_2120388
MTMMYCTH_107976
TMNUCRPA7_3353 UCRPA7_3581 UCRPA7_4376
SSCKSPSK_02666
FGRFGSG_01823
FVRFVEG_07666 FVEG_11957
FOXFOXG_03914 FOXG_04552 FOXG_06508 FOXG_06756 FOXG_06856 FOXG_07166 FOXG_07188 FOXG_07316 FOXG_10739 FOXG_16154 FOXG_16225 FOXG_16342
NHENECHADRAFT_57800 NECHADRAFT_66244
MAWMAC_01281
MAJMAA_06303
CMTCCM_00874
PLJVFPFJ_06187 VFPFJ_06292
VALVDBG_06574
VDAVDAG_05114 VDAG_07944
CFJCFIO01_01623 CFIO01_04000 CFIO01_07771
CLUPCLUP02_18116
CHIGCH63R_13660
SAPOSAPIO_CDS8452
ELAUCREL1_11728 UCREL1_6587 UCREL1_8188
PFYPFICI_04420 PFICI_10834 PFICI_14068
SSLSS1G_04668 SS1G_13944
BFUBCIN_01g08170 BCIN_15g04430
MBEMBM_06649
PSCOLY89DRAFT_253306 LY89DRAFT_352805 LY89DRAFT_664351 LY89DRAFT_681847 LY89DRAFT_687638 LY89DRAFT_689716
GLZGLAREA_00346 GLAREA_01715 GLAREA_02496
AFMAFUA_2G01390
NFINFIA_033690
ANGANI_1_576054(An06g02170)
ALUCAKAW2_51523A AKAW2_81327A
ACHEACHE_31313S
PCSPc13g06310
PDPPDIP_15440
TRGTRUGW13939_10458 TRUGW13939_10506
ABEARB_00401 ARB_06273
TVETRV_04640 TRV_06396
AJEHCAG_05462
PTEPTT_10228
BZECOCCADRAFT_3024
ZTRMYCGRDRAFT_36084 MYCGRDRAFT_89257
PFJMYCFIDRAFT_70746
FFUCLAFUR5_08336
BCOMBAUCODRAFT_228911
NPAUCRNP2_5952
CNECNM00330
CNBCNBM0330
CNGCNAG_06022
CGICGB_M0310C
TMSTREMEDRAFT_35179
TASAA1Q1_02719 A1Q1_07785
TVSTRAVEDRAFT_22245 TRAVEDRAFT_50314
DSQDICSQDRAFT_134511
PCOPHACADRAFT_259362 PHACADRAFT_259518
SHSSTEHIDRAFT_62535
HIRHETIRDRAFT_241537
ADLAURDEDRAFT_92054
FMEFOMMEDRAFT_164693
GTRGLOTRDRAFT_101860 GLOTRDRAFT_101861 GLOTRDRAFT_108867
LBCLACBIDRAFT_318092 LACBIDRAFT_318110
CCICC1G_01626 CC1G_07293
MRRMoror_3347
MOREE1B28_005795
SCMSCHCO_02638322(SCHCODRAFT_02638322)
CPUTCONPUDRAFT_158898
SLASERLADRAFT_478572
WSEWALSEDRAFT_62375 WALSEDRAFT_67401
WICJ056_002119 J056_002856
UMAUMAG_01201 UMAG_12026
PFPPFL1_01824
PGRPGTG_00467 PGTG_15358 PGTG_16523
MLRMELLADRAFT_64121
 » show all
Reference
1  [PMID:10224113]
  Authors
Cai H, Clarke S
  Title
A novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coli.
  Journal
J Biol Chem 274:13470-9 (1999)
DOI:10.1074/jbc.274.19.13470
Reference
2  [PMID:11329290]
  Authors
Cai H, Strouse J, Dumlao D, Jung ME, Clarke S
  Title
Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases.
  Journal
Biochemistry 40:2210-9 (2001)
DOI:10.1021/bi0022902
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.145
IUBMB Enzyme Nomenclature: 2.1.1.145
ExPASy - ENZYME nomenclature database: 2.1.1.145
BRENDA, the Enzyme Database: 2.1.1.145
CAS: 235107-12-7

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