KEGG ENZYME: 2.1.1.145

ENZYME: 2.1.1.145

Entry

EC 2.1.1.145                Enzyme

Name

trans-aconitate 3-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate [RN:R05764]

Reaction(KEGG)

R05764

Substrate

S-adenosyl-L-methionine [CPD:C00019];
trans-aconitate [CPD:C02341]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
(E)-2-(methoxycarbonylmethyl)butenedioate [CPD:C11515]

Comment

Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate as the product, that from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.144, trans-aconitate 2-methyltransferase)

History

EC 2.1.1.145 created 2002

Orthology

K22438

trans-aconitate 3-methyltransferase

Genes

ASN:

102381625

AMJ:

102569370

PSS:

102451271

CMY:

102933461

CPIC:

101943168

XTR:

100498610

NPR:

108800554

DRE:	555292(zgc:162396)

SRX:

107733630

SANH:

107663909

SGH:	107551942 107568094

CAUA:

113053218 113108780

PPRM:

120486788(zgc:162396)

MAMB:

125270279(zgc:162396)

IPU:	108266249 108266250 108266251

PHYP:

113535005 113535006

SMEO:

124383001 124383099

TFD:

113646289

AMEX:

103038316 103038625

EEE:

113592256

TRU:	101073886 101079061 115252434

LCO:	104928317 104936015

NCC:

104955817

CGOB:

115026389

ELY:	117249875 117250211 117251436(zgc:162396)

EFO:	125885012 125885268 125899955

PLEP:

121949088(zgc:162396) 121962625 121962958

SLUC:

116044448(zgc:162396) 116044711

ECRA:

117939401 117953053(zgc:162396)

ESP:	116673918 116687495

PFLV:

114551225 114563992 114563993

GAT:	120820226 120833789(zgc:162396)

PPUG:

119223154 119229299(zgc:162396)

MSAM:

119884027 119887689 119903860(zgc:162396) 119904595(si:ch211-93g23.2)

CUD:	121506312 121522769(zgc:162396)

ALAT:

119014933 119014934 119015529 119026322(zgc:162396)

MZE:	101466574 101467129

ONL:	100699555 100701305

OAU:	116325710(zgc:162396) 116332103

OLA:	101157984 101159172

OML:	112155144(zgc:162396) 112156639

XMA:	102229857 102232349

XCO:	114141210 114148361

XHE:	116716257 116723317

PRET:

103460220 103473420

PFOR:

103148686 103153518

PLAI:

106956832 106958200

PMEI:

106916065 106925664

GAF:	122826850 122840085(zgc:162396)

CVG:	107084235 107094147

CTUL:

119780812 119796555(zgc:162396)

GMU:	124861695 124871276(zgc:162396)

NFU:

107389394

KMR:	108238497(zgc:162396)

ALIM:

106529443

NWH:	119419027(zgc:162396)

AOCE:

111563024

MCEP:

125000598(si:ch211-93g23.2) 125017698(zgc:162396)

POV:	109631040 109631041

SSEN:

122785799(zgc:162396)

HHIP:

117754786(zgc:162396)

HSP:	118120267(zgc:162396)

LCF:	108873045(si:ch211-93g23.2) 108887095(zgc:162396)

SDU:	111218885 111233950

SLAL:

111665341 111667426

XGL:

120798272

HCQ:

109528745

BPEC:

110170910

BSPL:

114847555 114847556

SASA:

106575799 106586297(Y3374) 106586299 106586300(Y3374)

STRU:

115160878 115160879 115160880 115179683 115196467

OTW:	112237921 112246667 121846070

OMY:	110520214 110520215 110520216 110527273 118941089

OGO:	124018237 124042916 124043957 124043959

ONE:

115110267

SALP:

111976662

SNH:	120058313 120058314

CCLU:

121536237 121536688

ELS:	105023182 105026255

SFM:	108922275 108922288

PKI:

111851601

LOC:	102685425 107078729

PSPA:

121322465

ARUT:

117426119

PSEX:

120530755

LCM:

102367000

RTP:	109910913 109928000 109929170

BFO:	118418082 118421340

CIN:	100175142 100176950 100181852 100182452 100182735 100183251 100186622 101243446

SCLV:

120326477 120329823 120329826 120329881 120330086 120330443 120331042 120331058 120331215 120331216 120332000 120332861 120334108 120334551 120334553 120335394 120336182 120336815 120337508 120337630 120338111 120338168 120339298 120339302 120339305 120339306 120339307 120339622 120339627 120341097 120341180 120341355 120346028 120346482 120347349 120347785 120347786

SPU:	100888493 100892755 100893113 100893205

APLC:

110982107 110982152 110982157 110984568 110984569

SKO:	100368336 100369162

BTAB:

109040316

DCI:

103504902

NLU:

111057126

CSEC:

111866386

FCD:	110841945 110846634 110859337 110862381

DPX:	DAPPUDRAFT_221341

PJA:	122246046 122252772 122267778

PCHN:

125038208

HAME:

121869100 121871327

PCLA:

123746667 123767344

PTRU:

123520302

HAZT:

108666396 108678825

EAF:	111696101 111699948

PPOI:

119093534 119093723 119093800 119094023 119094210

DSV:	119444192 119445188 119446603 119446604

RSAN:

119383276 119388732 119389774

TUT:	107359408 107368944 107369076 107369101

CSCU:

111619037

PTEP:

107445017

SDM:

118197135

HRO:	HELRODRAFT_154743 HELRODRAFT_154744 HELRODRAFT_159849 HELRODRAFT_172299

HRJ:

124284017

LAK:	106154626 106158400 106158401 106158442 106168153 106173575 106174760 106180744

TAD:	TRIADDRAFT_60934 TRIADDRAFT_61353

QSU:	111983315 112005367 112006171 112008094 112009447 112030492 112031305 112031376

SCE:	YER175C(TMT1)

SEUB:

DI49_1584

SPAO:

SPAR_E02490

AGO:	AGOS_AGR110W

KLA:	KLLA0_C17864g

KMX:	KLMA_30285(TMT1)

LTH:	KLTH0B01936g KLTH0G14212g KLTH0H09460g

VPO:	Kpol_1032p55

ZRO:	ZYRO0B11924g ZYRO0B11946g ZYRO0E10032g

CGR:	CAGL0H00418g CAGL0L12012g

NCS:	NCAS_0A03100(NCAS0A03100) NCAS_0B04900(NCAS0B04900)

NDI:	NDAI_0B02310(NDAI0B02310) NDAI_0I02680(NDAI0I02680)

TPF:	TPHA_0A01900(TPHA0A01900)

TBL:	TBLA_0C01350(TBLA0C01350) TBLA_0C01360(TBLA0C01360) TBLA_0F03870(TBLA0F03870)

TGB:	HG536_0H02960

TDL:	TDEL_0G00510(TDEL0G00510) TDEL_0G00520(TDEL0G00520)

KAF:	KAFR_0B02610(KAFR0B02610) KAFR_0B06440(KAFR0B06440) KAFR_0C00170(KAFR0C00170)

KNG:	KNAG_0G01930(KNAG0G01930)

ZMK:	HG535_0C06500 HG535_0G04630

PPA:	PAS_chr2-1_0815 PAS_chr3_0330

DHA:	DEHA2E06974g DEHA2F04224g

PIC:	PICST_35256(TMT2) PICST_52120(TMT1)

PGU:	PGUG_01293 PGUG_05542

SPAA:

SPAPADRAFT_58538 SPAPADRAFT_62852

LEL:	LELG_00669 LELG_01712

CAL:	CAALFM_C105830WA(CaO19.2468) CAALFM_C110310WA(CaO19.4902)

CTP:	CTRG_03323 CTRG_04828

COT:	CORT_0A06730 CORT_0B08770

CDU:	CD36_09710

CTEN:

CANTEDRAFT_110574 CANTEDRAFT_112197

CLU:	CLUG_01304 CLUG_05543

CLUS:

A9F13_06g01078 A9F13_16g00385

CAUR:

CJI97_002082 CJI97_002948

SLB:	AWJ20_2280(TMT1)

BNN:	FOA43_000128

BBRX:

BRETT_000969

OPA:	HPODL_01451 HPODL_01656

SLUD:

SCDLUD_001318 SCDLUD_001328 SCDLUD_002247 SCDLUD_003062 SCDLUD_003794 SCDLUD_004972 SCDLUD_005331

NCR:

NCU06616

NTE:	NEUTE1DRAFT128461(NEUTE1DRAFT_128461)

SMP:	SMAC_04742

PAN:	PODANSg09285

TTT:	THITE_2120388

MTM:	MYCTH_107976

TMN:	UCRPA7_3353 UCRPA7_3581 UCRPA7_4376

SSCK:

SPSK_02666

FGR:	FGSG_01823

FVR:	FVEG_07666 FVEG_11957

FOX:	FOXG_03914 FOXG_04552 FOXG_06508 FOXG_06756 FOXG_06856 FOXG_07166 FOXG_07188 FOXG_07316 FOXG_10739 FOXG_16154 FOXG_16225 FOXG_16342

NHE:	NECHADRAFT_57800 NECHADRAFT_66244

MAW:

MAC_01281

MAJ:

MAA_06303

CMT:

CCM_00874

PLJ:	VFPFJ_06187 VFPFJ_06292

VAL:	VDBG_06574

VDA:	VDAG_05114 VDAG_07944

CFJ:	CFIO01_01623 CFIO01_04000 CFIO01_07771

CLUP:

CLUP02_18116

CHIG:

CH63R_13660

SAPO:

SAPIO_CDS8452

ELA:	UCREL1_11728 UCREL1_6587 UCREL1_8188

PFY:	PFICI_04420 PFICI_10834 PFICI_14068

SSL:	SS1G_04668 SS1G_13944

BFU:	BCIN_01g08170 BCIN_15g04430

MBE:

MBM_06649

PSCO:

LY89DRAFT_253306 LY89DRAFT_352805 LY89DRAFT_664351 LY89DRAFT_681847 LY89DRAFT_687638 LY89DRAFT_689716

GLZ:	GLAREA_00346 GLAREA_01715 GLAREA_02496

AFM:	AFUA_2G01390

NFI:	NFIA_033690

ANG:	ANI_1_576054(An06g02170)

ALUC:

AKAW2_51523A AKAW2_81327A

ACHE:

ACHE_31313S

PCS:	Pc13g06310

PDP:	PDIP_15440

TRG:	TRUGW13939_10458 TRUGW13939_10506

ABE:	ARB_00401 ARB_06273

TVE:	TRV_04640 TRV_06396

AJE:	HCAG_05462

PTE:

PTT_10228

BZE:	COCCADRAFT_3024

ZTR:	MYCGRDRAFT_36084 MYCGRDRAFT_89257

PFJ:	MYCFIDRAFT_70746

FFU:	CLAFUR5_08336

BCOM:

BAUCODRAFT_228911

NPA:	UCRNP2_5952

CNE:

CNM00330

CNB:

CNBM0330

CNG:	CNAG_06022

CGI:	CGB_M0310C

TMS:	TREMEDRAFT_35179

TASA:

A1Q1_02719 A1Q1_07785

TVS:	TRAVEDRAFT_22245 TRAVEDRAFT_50314

DSQ:	DICSQDRAFT_134511

PCO:	PHACADRAFT_259362 PHACADRAFT_259518

SHS:	STEHIDRAFT_62535

HIR:	HETIRDRAFT_241537

ADL:	AURDEDRAFT_92054

FME:	FOMMEDRAFT_164693

GTR:	GLOTRDRAFT_101860 GLOTRDRAFT_101861 GLOTRDRAFT_108867

LBC:	LACBIDRAFT_318092 LACBIDRAFT_318110

CCI:	CC1G_01626 CC1G_07293

MRR:	Moror_3347

E1B28_005795

SCM:	SCHCO_02638322(SCHCODRAFT_02638322)

CPUT:

CONPUDRAFT_158898

SLA:	SERLADRAFT_478572

WSE:	WALSEDRAFT_62375 WALSEDRAFT_67401

WIC:	J056_002119 J056_002856

UMA:	UMAG_01201 UMAG_12026

PFP:	PFL1_01824

PGR:	PGTG_00467 PGTG_15358 PGTG_16523

MLR:	MELLADRAFT_64121

» show all

Reference

1 [PMID:10224113]

Authors

Cai H, Clarke S

Title

A novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coli.

Journal

J Biol Chem 274:13470-9 (1999)
DOI:10.1074/jbc.274.19.13470

Reference

2 [PMID:11329290]

Authors

Cai H, Strouse J, Dumlao D, Jung ME, Clarke S

Title

Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases.

Journal

Biochemistry 40:2210-9 (2001)
DOI:10.1021/bi0022902

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.145

IUBMB Enzyme Nomenclature:

2.1.1.145

ExPASy - ENZYME nomenclature database:

2.1.1.145

BRENDA, the Enzyme Database:

2.1.1.145

CAS:	235107-12-7

DBGET integrated database retrieval system