Entry
Name
precorrin-6A synthase (deacetylating);
precorrin-6X synthase (deacetylating);
CobF
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)
Reaction(IUBMB)
S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate [RN:
R05219 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, which participates in the aerobic (late cobalt insertion) cobalamin biosythesis pathway, catalyses two reactions -the methylation of carbon C1 of precorrin-5, and its deacetylation, forming precorrin-6A. See EC
2.1.1.195 , cobalt-precorrin-5B (C1)-methyltransferase, for the C1-methyltransferase that participates in the anaerobic cobalamin biosynthesis pathway.
History
EC 2.1.1.152 created 2004
Pathway
Orthology
Genes
PCQ : PcP3B5_15360(sumT_1)
PVD : CFBP1590__2569(cobF)
PPRC : PFLCHA0_c23110(cobF)
PMUD : NCTC8068_01955(cobF)
PFW : PF1751_v1c21430(cobF)
PPUU : PputUW4_03212(cobF)
PTRT : HU722_0012260(cobF)
HAAH : HALA3H3_800147(cobF)
PVAC : HC248_02548(cysG_2)
MESP : C1M53_22885 C1M53_23370
MESU : LHFGNBLO_003204(cobF)
SMEL : SM2011_c03194(cobF)
SFD : USDA257_c53980(cobF)
SAME : SAMCFNEI73_Ch3354(cobF)
REC : RHECIAT_PA0000379(cobF)
REL : REMIM1_PD00479(cobF)
REP : IE4803_PA00415(cobF)
REI : IE4771_PC00428(cobF)
RTR : RTCIAT899_PC06985(cobF)
RHL : LPU83_pLPU83d0188(cobF)
RGA : RGR602_PC01217(cobF)
RPHA : AMC79_PB00388(cobF)
RLW : RlegWSM1455_31605(cobF)
BSEP : HAP48_0032410(cobF)
BCAN : BcanWSM471_15600(cobF)
MTUN : MTUNDRAET4_2509(cobF)
FIL : BN1229_v1_3164(cobF)
FIY : BN1229_v1_2758(cobF)
RLI : RLO149_c006280(cobF)
SINL : DSM14862_03161(cobI_1)
PMAU : CP157_03014(cobI_2)
GEH : HYN69_05215 HYN69_20030
MHEK : JMUB5695_01173(cobF)
MKY : IWGMT90018_52610(cobF)
MPHL : MPHLCCUG_00906(cysG_1)
MTHN : 4412656_03793(cobI_2)
MGO : AFA91_12930 AFA91_20070
CDIP : ERS451417_00729(cobI)
COI : CPCIP5297_03315(cobF)
CUN : Cul210932_0709(cobF)
CUQ : Cul210931_0677(cobF)
CUJ : CUL131002_0686(cobF)
NSPU : IFM12276_05150(cobF)
RPY : Y013_10485 Y013_14605
RCR : NCTC10994_03362(cbiL)
SAMB : SAM23877_6460(cobF)
SLE : sle_08880(sle_08880)
SALF : SMD44_07530(cobF) SMD44_07531(cobF)
SGOB : test1122_13320(cobF)
ICA : Intca_0163 Intca_0799
PAK : HMPREF0675_4977(cobF)
CGRN : 4412665_00095(cbiL)
TEZ : BKM78_01595 BKM78_14765
TLA : TLA_TLA_00323 TLA_TLA_02971
TEJ : KDB89_08130(cobF) KDB89_12090(cobF)
TLS : QH948_02230(cobF) QH948_05995(cobF)
BROO : brsh051_09570(cobF)
NAQU : ENKNEFLB_00261 ENKNEFLB_01612(cobI)
AEB : C6I20_00075 C6I20_00430
» show all
Taxonomy
Reference
Authors
Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F
Title
Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans.
Journal
Reference
Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
Title
The biosynthesis of adenosylcobalamin (vitamin B12).
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.152