KEGG ENZYME: 2.1.1.184

ENZYME: 2.1.1.184

Entry

EC 2.1.1.184                Enzyme

Name

23S rRNA (adenine2085-N6)-dimethyltransferase;
ErmC' methyltransferase;
ermC methylase;
ermC 23S rRNA methyltransferase;
rRNA:m6A methyltransferase ErmC';
ErmC';
rRNA methyltransferase ErmC'

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:23S rRNA (adenine2085-N6)-dimethyltransferase

Reaction(IUBMB)

2 S-adenosyl-L-methionine + adenine2085 in 23S rRNA = 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA [RN:R10716]

Reaction(KEGG)

R10716

Substrate

S-adenosyl-L-methionine [CPD:C00019];
adenine2085 in 23S rRNA

Product

S-adenosyl-L-homocysteine [CPD:C00021];
N6-dimethyladenine2085 in 23S rRNA

Comment

ErmC is a methyltransferase that confers resistance to the macrolide-lincosamide-streptogramin B group of antibiotics by catalysing the methylation of 23S rRNA at adenine2085.

History

EC 2.1.1.184 created 1976 as EC 2.1.1.48, part transferred 2010 to EC 2.1.1.184

Orthology

K00561

23S rRNA (adenine-N6)-dimethyltransferase

Genes

CIE:	AN232_30680

PCIB:

F9282_16500

PRG:	RB151_016370(ermD)

PMP:	Pmu_02850(erm(42))

BTO:

WQG_970

BTRH:

F543_22890

BTRA:

F544_3050

ATG:	J4G44_12835(erm)

NME:	NMB0066(ermC)

VFG:

C9I84_016

BSUT:

BSUB_10005

BLH:	BaLi_c28970(ermD)

BHA:

BH0380

BCL:

ABC3508

OIH:

OB0921

OJD:	NP439_14310(erm)

OON:	NP440_11095(erm)

GMC:	GY4MC1_0187

PTL:	AOT13_01950

ASED:

IRT44_04780

LYB:	C3943_14160(erm-23S_rRNA)

VIG:	BKP57_12950

VPN:	A21D_00889(ermD)

BTHV:

CQJ30_01485

GRC:	GI584_11570(erm(A))

SCIA:

HUG15_07595(erm)

BOU:	I5818_12075(erm)

SAU:	SA0048(ermA) SA0766(ermA) SA1480(ermA) SA1951(ermA) SA2384(ermA)

SAV:	SAV0052(ermA) SAV1655(ermA)

SAW:	SAHV_0051(ermA) SAHV_1642(ermA)

SAH:	SaurJH1_0039 SaurJH1_1747

SAJ:	SaurJH9_0039 SaurJH9_1713

SAR:	SAR0050(ermA1) SAR1735(ermA2)

SAA:	SAUSA300_pUSA0307(ermC)

SUV:	SAVC_05665

SUK:	SAA6008_00830(ermA) SAA6008_01623(ermA_1)

SUC:

ECTR2_126

SUT:	SAT0131_01756

SUD:	ST398NM01_2897

SUW:	SATW20_00430(ermA1) SATW20_16480(ermA2)

SAUN:

SAKOR_02720

SAUG:

SA268_2515

SAUZ:

SAZ172_0044(ermA1) SAZ172_1667(ermA2)

SAUT:

SAI1T1_2006330(ermA) SAI1T1_2011990(ermA) SAI1T1_2015840(ermA) SAI1T1_2019340(ermA)

SAUJ:

SAI2T2_1006350(ermA) SAI2T2_1012010(ermA) SAI2T2_1015850(ermA) SAI2T2_1019350(ermA)

SAUK:

SAI3T3_1006340(ermA) SAI3T3_1011990(ermA) SAI3T3_1015840(ermA) SAI3T3_1019340(ermA)

SAUQ:

SAI4T8_1006330(ermA) SAI4T8_1012000(ermA) SAI4T8_1015850(ermA) SAI4T8_1019350(ermA)

SAUV:

SAI7S6_1006340(ermA) SAI7S6_1012010(ermA) SAI7S6_1015850(ermA) SAI7S6_1019340(ermA)

SAUW:

SAI5S5_1006300(ermA) SAI5S5_1011960(ermA) SAI5S5_1015790(ermA) SAI5S5_1019280(ermA) SAI5S5_20050(ermC)

SAUX:

SAI6T6_1006310(ermA) SAI6T6_1011970(ermA) SAI6T6_1015800(ermA) SAI6T6_1019290(ermA)

SAUY:

SAI8T7_1006340(ermA) SAI8T7_1012000(ermA) SAI8T7_1015830(ermA) SAI8T7_1019320(ermA)

SUY:	SA2981_0052(ermA) SA2981_1614(ermA)

SAUM:

BN843_16560

SAUC:

CA347_1648(ermA5) CA347_49(ermA5)

SAUR:

SABB_02575(ermA1) SABB_05250(ermA2)

SER:	SERP1220(ermA-1) SERP1343(ermA-2) SERP2510(ermA-3)

SHA:	pSHaeB01(ermC)

SDT:	SPSE_1800(ermA)

SPET:

CEP67_02750 CEP67_07740

MLEN:

H3V22_01745(erm(B)) H3V22_01785(erm(B))

MCL:	MCCL_plsB0042

MACR:

BHM04_10840

SBAC:

BVH56_08720

NMY:	CJ229_004000(erm)

EAUR:

NMQ00_15990(erm(B))

EPF:	OE059_03685(erm)

BAYD:

BSPP4475_00515(erm)

BBOR:

RFB14_22240(erm)

GYM:	GYMC10_1326

PSON:

JI735_30615

POW:	IJ21_00020

PIB:	BBD41_08175

PVO:	PVOR_08690

PLW:	D5F53_22980(erm)

PLUT:

EI981_22720(erm)

PDY:	QJQ58_06400

NTR:	B0W44_01260

TVU:	AB849_011290(erm)

KPUL:

GXN76_07960(erm)

KEB:	GXN75_04125(erm)

SPI:	MGAS10750_Spy1703

SPW:	SPCG_0172 SPCG_1323 SPCG_1327

SPX:	SPG_1241(ermB)

SPNN:

T308_09065

SPV:

SPH_1420

SNC:	HMPREF0837_12197

SNB:	SP670_1166

SNP:	SPAP_0896(erm(TR))

SAGE:

EN72_06990

SSB:	SSUBM407_0952(ermB)

SSUS:

NJAUSS_0669

SSK:	SSUD12_1346 SSUD12_1565

SSQ:	SSUD9_1049

SUI:	SSUJS14_0695

SUO:	SSU12_0879

SOR:	SOR_1880(ermB)

STD:	SPPN_01485

SIU:	SII_0641(ermB)

SANC:

SANR_1363(ermTR)

SOI:	I872_07900

SLU:

KE3_0212

SEQI:

A6J79_00310

SGW:	D7D53_04400(erm(B))

SPAB:

KQ224_08640(erm(B))

STOY:

STYK_17430(ermB)

LJH:

LJP_0027c

LAI:	LAC30SC_10855

LAH:	LA20533_04015

EFA:

EFA0007

EFD:	EFD32_pA0006

EFC:	EFAU004_01593(ermG)

EFAU:

EFAU085_p3012(erm)

EFU:	HMPREF0351_12804(ermA)

EAV:	EH197_00455(erm(B))

ESG:	EsVE80_07090(ermB) EsVE80_p1-00130(ermB)

ECEC:

NCTC12421_01166(erm)

ERAF:

J9537_20525(erm(B))

EDS:	PML78_13385(erm(B))

THL:

TEH_23120

TKR:	C7K43_00275(erm-23S_rRNA)

VAC:	E4Z98_09655(erm(B))

VFV:	K5K99_14655(erm(B))

AUR:	HMPREF9243_0168

ALOY:

CJ190_008495(erm(A))

AMIT:

DBT49_0000585(erm(A))

ABAE:

CL176_05680

GSG:	CYJ72_003480(erm)

FHM:	R0V13_00175(erm(B))

JAR:	G7057_06385(erm(B))

CIA:	BEN51_12270

AOE:

Clos_2851

PROQ:

P6M73_11175(erm)

HSC:	HVS_13755(ermA1)

RUK:	A4V00_10655

CTHD:

CDO33_12400

VFA:	MM35RIKEN_22660(ermB)

VCOP:

MM50RIKEN_19590(ermB)

BLAR:

LC508_17745(erm(B))

HSD:

SD1D_1531

CDF:	CD630_20070(ermB) CD630_20100(ermB1)

PDC:	CDIF630_02225(ermB1) CDIF630_02229(ermB2)

PDF:	CD630DERM_20072(ermB)

PHX:	KGNDJEFE_00529(erm_1) KGNDJEFE_01831(ermC') KGNDJEFE_02272(erm_2)

IBR:	NQ514_13420

DDH:	Desde_1644 Desde_1647

DFG:	B0537_11580

EMT:	CPZ25_016270

INT:	RX717_03635(erm(B))

VPY:	HZI73_25260(erm)

FMS:	M1R53_06000(erm(A))

ETM:	CE91St48_05660(ermB)

HOR:	Hore_16530

HALS:

D7D81_05390 D7D81_13075(erm)

PED:	ING2D1G_1534(ermGT)

CAD:	Curi_c11270

KPAR:

JL105_07480(erm)

ECOU:

M1R54_02815(erm(A)) M1R54_03150(erm(A))

VNK:	VEIT17_15390(ermB)

SELO:

AXE86_11765

AARG:

Aargi30884_28740(ermB)

EBM:	SG0102_07200(ermB)

EHN:	H9Q80_06575(erm(B)) H9Q80_07490(erm(B))

TUR:	AT726_11135

EYY:	EGYY_26800(KsgA)

ERZ:	ER308_08415

EUZ:	DVS28_a1268

MTU:	Rv1988(erm(37))

MTV:

RVBD_1988

MTC:

MT2042

MRA:

MRA_2001

MTF:	TBFG_12019

MTB:	TBMG_02000

MTK:	TBSG_02011

MTZ:	TBXG_001984

MTG:	MRGA327_12240

MTI:	MRGA423_12355

MTE:	CCDC5079_1836

MTUR:

CFBS_2095

MTL:	CCDC5180_1811

MTO:	MTCTRI2_2021

MTD:

UDA_1988

MTN:	ERDMAN_2189

MTJ:	J112_10605

MTUB:

MT7199_2017

MTUC:

J113_13695

MTUE:

J114_10620

MTX:	M943_10315

MTUH:

I917_14015

MTUL:

TBHG_01945

MTUT:

HKBT1_2091

MTUU:

HKBT2_2093

MTQ:	HKBS1_2096

MBO:	BQ2027_MB2010(erm(37))

MBB:

BCG_2004

MBT:

JTY_1999

MBM:	BCGMEX_1986

MBK:	K60_020580

MBX:

BCGT_1798

MAF:

MAF_19990

MMIC:

RN08_2199

MCE:	MCAN_20081

MCQ:	BN44_40271

MCZ:	BN45_50265

MORY:

MO_002081(erm(37))

MYV:	G155_08570

MSM:	MSMEG_1646

MSG:	MSMEI_1608

MFT:	XA26_17170

MVQ:	MYVA_1303(erm(X))

MCHT:

MCHIJ_07850

MMAT:

MMAGJ_45650

MBOK:

MBOE_57580

MSEN:

K3U95_07780(erm)

MKR:	MKOR_26660

MPAK:

MIU77_11050(erm)

MAB:

MAB_2297

CJK:	jk1436(erm(X))

CUR:	cu1922(erm(X))

CUA:	CU7111_1847(erm(X))

CGY:	CGLY_13945(ermA)

CDO:	CDOO_02540

CHM:	B842_00165

CSX:	CSING_13175(ermA)

CMV:	CMUST_04105(ermA)

CFC:	CFLV_12470

CSTR:

CBE89_09900

CAMG:

CAMM_02585

CPRP:

I6I69_04585(erm)

CGLU:

I6J20_08505(erm)

CLUJ:

IAU68_04200(erm)

CJH:	CJEDD_04405(carB1)

CPSP:

L9H27_00215

CMAS:

CMASS_00105(carB)

CHAD:

CHAD_02490(carB1) CHAD_04490(carB2)

CAUI:

CAURIS_09035(carB2)

CAFE:

CAFEL_03935(carB1)

CGOI:

CGOTT_10650(carB2)

CAPP:

CAPP_02335(carB1)

NFA:

NFA_27210

NFR:	ERS450000_01376(rsmA_1)

NCY:	NOCYR_3185(carB)

NBR:	O3I_025710 O3I_028830

NNO:	NONO_c69700

NTP:	CRH09_08515

NOZ:	DMB37_05105(erm)

NOD:	FOH10_07535(erm)

NAH:	F5544_25790(erm)

NAD:	NCTC11293_06190(ermC')

NWL:	NWFMUON74_65270

NIE:	KV110_25405(erm)

NHU:	H0264_15925(erm)

NYA:	LTV02_34005(erm)

NGP:	LTT66_28290(erm)

NSPU:

IFM12276_27630

RHU:	A3Q40_02474(carB_2)

RCR:	NCTC10994_01728(ksgA_2)

RTM:	G4H71_02885(erm)

RGOR:

NMQ04_23200(erm)

GBR:

Gbro_3423

TPR:

Tpau_0528

TSM:	ASU32_02800

TPUL:

TPB0596_05520

DTM:	BJL86_0111

DIZ:	CT688_16390

DPC:	A6048_17085

DKN:	NHB83_18615(erm)

TOY:	FO059_06945(erm)

SCO:	SCO6089(SCBAC1A6.13)

SVL:	Strvi_2357

SRC:	M271_13995

SMAL:

SMALA_5962

SSOI:

I1A49_33645(erm)

SBH:

SBI_03035

SDV:	BN159_2247(ermSF)

SLV:	SLIV_07695(ermSF)

SXI:	SXIM_38360

STRC:

AA958_28040

SAMB:

SAM23877_5636(srm1) SAM23877_5808(ermSF)

SPAV:

Spa2297_25715

STSI:

A4E84_31320

SLS:	SLINC_0256

STRD:

NI25_08920

SNW:	BBN63_06400

SALF:

SMD44_05855(ksgA)

SALJ:

SMD11_1643

SNZ:	DC008_27420

SGE:	DWG14_01987(carB_1)

SQZ:	FQU76_07780(erm)

SAST:

CD934_06025

SNQ:	CP978_26430(erm)

SHAW:

CEB94_31945

SAQU:

EJC51_36560(erm)

SPAC:

B1H29_08255

STSU:

B7R87_07750

SCHA:

CP983_09665(erm)

SGX:	H4W23_25560 H4W23_25565(erm)

SCOE:

CP976_33775(erm(O))

SBAT:

G4Z16_22520(erm)

SSPB:

CP982_28015(erm)

SHAR:

HUT13_18995

SFEU:

IM697_32505(erm)

SVD:	CP969_29465(erm)

SROI:

IAG44_08630(erm)

SMAO:

CAG99_07230

SLF:	JEQ17_11955(erm)

SAOV:

G3H79_11460(erm)

SCAE:

IHE65_08805(erm)

STUB:

MMF93_09910(erm)

SSPN:

LXH13_30765(erm)

SCIR:

STRCI_006338(erm)

SANT:

QR300_11845(erm)

MIX:	AB663_000810

MPAL:

BO218_00270

MWA:	E4K62_06780(erm)

MSED:

E3O41_03110(erm)

MOY:	CVS54_00826(carB_1)

MLZ:	F6J85_06495(erm)

MCHN:

HCR76_14615(erm)

MRN:	K8F61_10335(erm)

MICS:

C1N74_10880(erm-23S_rRNA)

MBIN:

LXM64_10360(erm)

MLIQ:

NMQ05_03430

AARC:

G127AT_06435(erm)

AMAU:

DSM26151_27220(rsmA)

ASOI:

MTP13_06600(erm)

CPHY:

B5808_18090

MHUM:

NNL39_04770(erm)

MDB:	OVN18_04295(erm)

LEU:	Leucomu_03315(erm)

LTR:	EVS81_01550(erm)

LARI:

KI794_07290(erm) KI794_14590(erm)

LALL:

MUN78_03350(erm)

LTN:	KVY00_13050(erm)

AGG:	C1N71_01480(erm)

GMN:	GMOLON4_57(ermA)

ARI:	UM93_13695

GPR:	JQN66_18405(erm)

GNC:	QQS42_17375(erm)

MLY:	CJ228_009490(erm)

MPOR:

KW076_01550(erm) KW076_08905(erm)

NAE:	BHE16_06395

AUL:	DCC27_002790(erm)

AIG:	QDX25_02075(erm)

PALU:

CJ193_003580(erm) CJ193_007655(erm)

BCV:

Bcav_1923

BRX:	BH708_17385

BSAU:

DWV08_00885

BKI:	M4486_00965(erm)

BHH:	Bra3105_16790(erm)

DJJ:	COP05_07550

DHM:	CYJ49_002755(erm)

HMM:	R3I40_10500(erm)

KSE:	Ksed_17860

LMOI:

VV02_04275

BEI:	GCM100_04010

CCEU:

CBR64_12025

CPRT:

FIC82_018035

OEK:	FFI11_009090(erm)

BLIN:

BLSMQ_0384

BLUT:

EW640_10075(erm)

BCAU:

I6G59_05385(erm) I6G59_16080

BSPO:

L1F31_02135(erm)

GEZ:	FE251_15160

HALT:

IM660_17970

RHAL:

LQF10_17760(rlmJ)

RSUA:

LQF12_15200

PPC:	HMPREF9154_2441

ARUB:

J5A65_05065(erm)

PBO:	PACID_32300

AACI:

ASQ49_06035 ASQ49_16540

MPH:

MLP_23220

MIK:	FOE78_01450

MICG:

GJV80_18770

TDF:	H9L22_03800(erm)

BRT:	J4N02_08095(erm)

PROP:

QQ658_06420(erm)

NOY:	EXE57_00825

NANO:

G5V58_24520

NRO:	K8W59_14555

PSIM:

KR76_04810

AER:	AERYTH_15865

MUZ:	H4N58_14510(erm)

KFL:

Kfla_5998

KQI:	F1D05_14645

THAO:

NI17_017960(erm)

TALX:

FOF52_15385(erm)

NDA:

Ndas_2264

NAL:

B005_4554

NGV:	CDO52_15325

NEX:	NE857_15875(erm)

NEC:	KGD82_14690(erm)

NAKE:

KGD83_14230(erm)

NCG:	KGD84_16680(erm)

SNAH:

OUQ99_14115(erm)

SAIU:

J4H86_03440(erm)

TCU:

Tcur_0508

ACTW:

F7P10_28120(erm)

AMAZ:

LUW76_03195(erm)

SRO:

Sros_4551

NOA:	BKM31_35115

NOW:	GBF35_09980(erm)

NCX:	Nocox_09195(carB1)

NGN:	LCN96_10305(erm)

TBI:

Tbis_3490

SEN:	SACE_0733(ermE)

SACG:

FDZ84_11210(erm)

SVI:	Svir_28640

SACC:

EYD13_15795(ermD)

AJA:	AJAP_39985(ermA)

AMQ:	AMETH_5559(ermE)

AMYC:

CU254_19965

AAB:	A4R43_20630

AMYY:

YIM_08965(ermD)

AORI:

SD37_02260

AACD:

LWP59_32270

AROO:

NQK81_23370(erm)

PSEA:

WY02_07165

PSEH:

XF36_07650

PECQ:

AD017_22270

PHH:	AFB00_22305

PAUT:

Pdca_44150

KAL:

KALB_1436

KPHY:

AOZ06_12370

AHM:	TL08_04290

ACTI:

UA75_04315

ACAD:

UA74_04215

AHG:	AHOG_04070(carB1)

ACTA:

C1701_19120(erm-23S_rRNA)

PMAD:

BAY61_24475

SACE:

GIY23_06515(erm)

ACTU:

Actkin_05847(carB_2)

STP:	Strop_3669

SAQ:

Sare_4045

MTUA:

CSH63_31505

MICH:

FJK98_27070(erm)

MTEM:

GCE86_20490(erm)

MCAB:

HXZ27_06190(rosS)

MSAG:

GCM10017556_14360

MENO:

Jiend_39260

MFEU:

H1D33_01380(erm)

MPRN:

Q3V37_12065(erm)

MHAW:

RMN56_16980(erm)

AMS:	AMIS_48830

AFS:

AFR_03150

ACTR:

Asp14428_40630

PLK:	CIK06_23790

PLAB:

C6361_02045

PLAT:

C6W10_19625

PFLA:

Pflav_081920

PSUU:

Psuf_044740

ATL:	Athai_06990

ASER:

Asera_65950

PRY:	Prubr_69530

DVC:	Dvina_34665(erm)

DFU:	Dfulv_26555(erm)

DAUR:

Daura_14940(erm)

DMAT:

Dmats_29490(erm)

NHY:	JQS43_12230

CCAZ:

COUCH_36525(erm)

CAI:

Caci_6125

SNA:

Snas_2596

NAV:	JQS30_00520(erm)

GLY:	K3N28_20195(erm)

TBER:

QPC17_01210(erm)

ATIM:

CYJ17_0009255(erm)

SOO:	FBF35_08030(erm)

FSL:	EJO69_09850(erm)

WNE:	PIG85_07860(erm) PIG85_10605(erm)

GEU:	CJ185_002105(erm)

BKS:

BBKW_0982

BCHO:

BcFMB_02975

GPT:	K9E43_01345

GSW:	K9E37_01815

AEY:	CDG81_11200 CDG81_13135(rsmA)

EKE:	EK0264_06100

CWO:

Cwoe_0389

ATQ:	GH723_14315

IAM:	HC251_10005

IMA:	PO878_05490

DHI:	LH044_20440

TTR:

Tter_2586

FHO:	H9Q81_00315(erm(A))

BUN:	Bun01g_12530(ermC)

BEG:	INE88_02670(ermC)

BSA:	Bacsa_2566

PCOP:

I6J50_02055(erm)

PBT:	ING2E5B_2269(ermF)

PMUC:

ING2E5A_0789(ermFU)

PET:	PEIBARAKI_5223

PSAC:

PSM36_1528(ermF)

PGOL:

K6V26_03560(erm(F))

BVS:	BARVI_12255

COPR:

Cop2CBH44_11580(ermC)

BUY:	D8S85_06020(erm(B))

BFH:	F1611_17325(erm(B))

PCLR:

PC1C4_18810

ALD:	GFH31_01555(erm(F))

ACOU:

A5CBH24_09260

PSN:	Pedsa_1646

SPHE:

GFH32_09105

MALS:

NWE55_16765(erm(F))

OCI:	FEZ18_11405(erm)

RAG:

B739_0033

CNR:	EB819_06990(erm)

PTAN:

CRYO30217_03560(ermD)

TMA:

TM1538

TMM:	Tmari_1546

TMI:	THEMA_06595

TMW:

THMA_1572

TMQ:

THMB_1572

TMX:

THMC_1572

TPT:

Tpet_1254

TNP:

Tnap_1270

TRQ:

TRQ2_1201

TNA:

CTN_1121

THQ:	T2812B_06025

THZ:	CELL2_06590

THR:	TRQ7_07080

TLE:

Tlet_0379

TTA:	Theth_1672

PHY:	AJ81_04635

TME:

Tmel_0667

TAF:

THA_907

THP:	BG95_03920

THER:

Y592_03970

TFE:	JYK00_01715

FNO:

Fnod_0842

FPE:	Ferpe_1056

FIA:	NA23_05360

OCY:	OSSY52_00800

MPZ:	Marpi_0993

MARN:

LN42_05435

DTN:	DTL3_0384 DTL3_1144

ASAC:

ATHSA_0057

SAAL:

L336_0918

SBE:	RAAC3_TM7C01G0614

WWE:	P147_WWE3C01G0221

MIB:	UY43_C0001G1083(ine151)

» show all

Reference

1 [PMID:7543473]

Authors

Zhong P, Pratt SD, Edalji RP, Walter KA, Holzman TF, Shivakumar AG, Katz L

Title

Substrate requirements for ErmC' methyltransferase activity.

Journal

J Bacteriol 177:4327-32 (1995)
DOI:10.1128/JB.177.15.4327-4332.1995

Sequence

[ag:AAA98136]

Reference

2 [PMID:2492520]

Authors

Denoya C, Dubnau D

Title

Mono- and dimethylating activities and kinetic studies of the ermC 23 S rRNA methyltransferase.

Journal

J Biol Chem 264:2615-24 (1989)

Reference

3 [PMID:2440853]

Authors

Denoya CD, Dubnau D

Title

Site and substrate specificity of the ermC 23S rRNA methyltransferase.

Journal

J Bacteriol 169:3857-60 (1987)
DOI:10.1128/JB.169.8.3857-3860.1987

Reference

4 [PMID:9585521]

Authors

Bussiere DE, Muchmore SW, Dealwis CG, Schluckebier G, Nienaber VL, Edalji RP, Walter KA, Ladror US, Holzman TF, Abad-Zapatero C

Title

Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria.

Journal

Biochemistry 37:7103-12 (1998)
DOI:10.1021/bi973113c

Sequence

[ag:AAA98136]

Reference

5 [PMID:10366505]

Authors

Schluckebier G, Zhong P, Stewart KD, Kavanaugh TJ, Abad-Zapatero C

Title

The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism.

Journal

J Mol Biol 289:277-91 (1999)
DOI:10.1006/jmbi.1999.2788

Sequence

[ag:AAA98136]

Reference

6 [PMID:12907737]

Authors

Maravic G, Bujnicki JM, Feder M, Pongor S, Flogel M

Title

Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC' redefines the substrate-binding site and suggests a model for protein-RNA interactions.

Journal

Nucleic Acids Res 31:4941-9 (2003)
DOI:10.1093/nar/gkg666

Sequence

[ag:AAA98136]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.184

IUBMB Enzyme Nomenclature:

2.1.1.184

ExPASy - ENZYME nomenclature database:

2.1.1.184

BRENDA, the Enzyme Database:

2.1.1.184

DBGET integrated database retrieval system