KEGG   ENZYME: 2.1.1.20
Entry
EC 2.1.1.20                 Enzyme                                 
Name
glycine N-methyltransferase;
glycine methyltransferase;
S-adenosyl-L-methionine:glycine methyltransferase;
GNMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:glycine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine [RN:R00367]
Reaction(KEGG)
R00367
Substrate
S-adenosyl-L-methionine [CPD:C00019];
glycine [CPD:C00037]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
sarcosine [CPD:C00213]
Comment
This enzyme is thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. It is inhibited by 5-methyltetrahydrofolate pentaglutamate [4]. Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3, sarcosine dehydrogenase.
History
EC 2.1.1.20 created 1972, modified 2005
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
Orthology
K00552  glycine N-methyltransferase
Genes
HSA27232(GNMT)
PTR462703(GNMT)
PPS100993237(GNMT)
GGO101143848(GNMT)
PON100432507(GNMT)
NLE100603199(GNMT)
MCC697722(GNMT)
MCF102133929(GNMT)
CSAB103221484(GNMT)
CATY105591544(GNMT)
PANU101008718(GNMT)
TGE112622332(GNMT)
RRO104667328(GNMT)
RBB108533480(GNMT)
TFN117087242(GNMT)
PTEH111543055(GNMT)
CJC100413047(GNMT)
SBQ101053276(GNMT)
CSYR103268550(GNMT)
MMUR105875835(GNMT)
OGA100950716(GNMT)
MMU14711(Gnmt)
MCAL110284012(Gnmt)
MPAH110335591
RNO25134(Gnmt)
MCOC116075524(Gnmt)
MUN110550343(Gnmt)
CGE100769585
PLEU114705340(Gnmt)
NGI103730804(Gnmt)
HGL101697457(Gnmt)
CPOC100717389
CCAN109682081(Gnmt)
DSP122101636
OCU100009512(GNMT)
OPI101517330(GNMT)
TUP102501380(GNMT)
CFA474905(GNMT)
VVP112913997(GNMT)
VLG121490377(GNMT)
AML100477196(GNMT)
UMR103664079(GNMT)
UAH113261284(GNMT)
UAR123794585(GNMT)
ELK111147599 111147995
LLV125102116
MPUF101680816(GNMT)
ORO101377523(GNMT)
EJU114204495(GNMT)
ZCA113926507(GNMT)
MLX118000555(GNMT)
FCA101083006(GNMT)
PYU121029468(GNMT)
PBG122489532(GNMT)
PTG102965502(GNMT)
PPAD109271639(GNMT)
AJU106973967(GNMT)
HHV120231230(GNMT)
BTA112443696 538212(GNMT)
BOM102287446(GNMT)
BIU109577223(GNMT)
BBUB102395585(GNMT)
CHX102170645(GNMT)
OAS101111134(GNMT)
ODA120870113(GNMT)
CCAD122429153(GNMT)
SSC397444(GNMT)
CFR102506340(GNMT)
CBAI105083787(GNMT)
CDK105088648(GNMT)
VPC102544214(GNMT)
BACU103001201(GNMT)
LVE103077097(GNMT)
OOR101270773(GNMT)
DLE111178834(GNMT)
PCAD102994709(GNMT)
PSIU116761635(GNMT)
ECB100067145(GNMT)
EPZ103548169(GNMT)
EAI106828715(GNMT)
MYB102250180(GNMT)
MYD102760706(GNMT)
MMYO118660030(GNMT)
MLF102442398(GNMT)
MNA107536922(GNMT)
PKL118705248(GNMT)
HAI109382878
DRO112302127(GNMT)
SHON118991685(GNMT)
AJM119041338 119056163(GNMT)
PDIC114494172(GNMT)
PHAS123821630(GNMT)
MMF118621513(GNMT)
RFQ117020130(GNMT)
PALE102898977(GNMT)
PGIG120596148(GNMT)
PVP105288454(GNMT)
RAY107501992(GNMT)
MJV108395057(GNMT)
TOD119252477(GNMT)
SARA101543105(GNMT)
LAV100660725(GNMT)
TMU101355018
DNM101434952(GNMT)
MDO100010632(GNMT)
GAS123245665(GNMT)
SHR100925098
PCW110201291(GNMT)
OAA100092827(GNMT)
GGA769542(GNMT)
PCOC116231565(GNMT)
MGP100540940(GNMT)
CJO107310908(GNMT)
NMEL110395296(GNMT)
APLA113842961
AFUL116488118(GNMT)
TGU100231507(GNMT)
LSR110472810(GNMT)
SCAN103821310
PMOA120500924(GNMT)
OTC121346383(GNMT)
PRUF121353917(GNMT)
FAB101818171(GNMT)
PHI102109993(GNMT)
PMAJ107202337(GNMT)
CCAE111922583
CCW120411694(GNMT)
ETL114066770(GNMT)
ZAB102074891(GNMT)
FCH102046712
CLV102096572
EGZ104128772(GNMT)
NNI104015806(GNMT)
TALA116962039(GNMT)
ACHC115349946(GNMT)
AAM106494152(GNMT)
AROW112973557(GNMT)
NPD112949349
DNE112985529(GNMT)
ASN102386281
AMJ102566047(GNMT)
CPOO109319031
GGN109304209
PSS102460961
CMY102938095(GNMT)
CPIC101948133
TST117874136(GNMT)
CABI116824871(GNMT)
MRV120400901(GNMT)
ACS100552842(gnmt)
PVT110087012(GNMT)
SUND121919446(GNMT)
PBI103067312(GNMT)
PMUR107297201(GNMT)
TSR106538009(GNMT)
PGUT117671591(GNMT)
VKO123023227(GNMT)
PMUA114594784(GNMT)
ZVI118083074(GNMT)
GJA107123075(GNMT)
XLA108716567 108717630
XTR116410885(gnmt)
NPR108803755
RTEM120921851(GNMT)
BBUF120984424
BGAR122923284
DRE403338(gnmt)
SRX107706413 107748599
SANH107697528(gnmt) 107703804
SGH107553737 107566124
CCAR109106978
CAUA113051607 113117001
IPU108270118(gnmt)
PHYP113545046(gnmt)
SMEO124390082(gnmt)
AMEX103028138
EEE113572147(gnmt)
TRU101067368 115246826
TNGGSTEN00016922G001
LCO104932648(gnmt)
NCC104954782(gnmt)
CGOB115027654(gnmt)
ELY117267179(gnmt)
PLEP121953867(gnmt)
SLUC116042433(gnmt)
ECRA117935637(gnmt)
PFLV114546486(gnmt)
GAT120832577(gnmt)
PPUG119228166(gnmt)
MSAM119910871(gnmt)
CUD121526476(gnmt)
MZE101484870(gnmt)
ONL100706279(gnmt)
OAU116311098(gnmt)
OLA101154832(gnmt)
OML112144840(gnmt)
XMA102219353(gnmt)
XCO114134382(gnmt)
XHE116708699 116726160
PFOR103154189(gnmt)
PLAI106937322(gnmt)
PMEI106904043(gnmt)
GAF122845739(gnmt)
CVG107084845(gnmt)
CTUL119781787
GMU124855913(gnmt)
NFU107389170 107392578(gnmt)
KMR108246999(gnmt)
ALIM106521247(gnmt)
NWH119427916(gnmt)
AOCE111562587(gnmt)
CSEM103380842(gnmt)
POV109628164(gnmt)
SSEN122759962(gnmt)
HHIP117756209(gnmt)
LCF108898000(gnmt)
SDU111226206(gnmt)
SLAL111668120(gnmt)
XGL120795580(gnmt)
HCQ109530231(gnmt)
BPEC110155508(gnmt)
MALB109973687(gnmt)
SASA106561891(gnmt)
OTW112263437(gnmt)
OMY110506251(gnmt)
OGO124035938(gnmt)
ONE115113437(gnmt)
SALP111969168(gnmt)
SNH120025133(gnmt)
ELS105006939(gnmt)
SFM108923148(gnmt)
PKI111834432(gnmt)
AANG118215023(gnmt)
LOC102697278(gnmt)
PSPA121316224 121317350
ARUT117402945 117411412
LCM102360222(GNMT)
CMK103187634(gnmt)
RTP109919411
BFO118403902 118421975
BBEL109464842 109487980
SPU105438157 105439109 575025 579000 579441 580044 589953 752758
APLC110974275 110981790
SKO100378448
DMEDmel_CG6188(Gnmt)
DER6553637
DSE6606629
DSIDsimw501_GD18854(Dsim_GD18854)
DYADyak_GE26214
DAN6499903
DSR110186710
DPODpse_GA19423
DPE113566232
DMN108156785
DWI6651484
DGR6567519
DMODmoj_GI10501
DAZ108608851
DNV115561966
DHE111598317
DVI6630429
CCAT101463471
BOD106622609
MDE101892983
SCAC106093742
LCQ111682604
AGAAgaP_AGAP002198
ACOZ120949558
AARA120896517
AAG5576784
AALB109405766 109430495
CQUCpipJ_CPIJ015956
CPII120417520
CNS116348230
AME552832
ACER107995953
ALAB122718069
BIM100742588
BBIF117213847
BVK117231350
BVAN117156595
BTER100647936
BPYO122572858
CCAL108624035
OBB114880987
MGEN117230028
NMEA116434800
CGIG122397194
SOC105193482
MPHA105837902
AEC105154304
ACEP105618894
PBAR105430839
VEM105561988
HST105191076
DQU106745158
CFO105256576
FEX115235867
LHU105675201
PGC109860071
OBO105277551
PCF106788778
PFUC122524825
VPS122631351
NVI100121709 100122726
CSOL105367921
TPRE106649165
MDL103577735 103578163 103578164 103578165 103578166 103578167
CGLO123262576
FAS105269615
DAM107040411
AGIF122860626
CCIN107264219
TCA662005 662371
DPA109541622
SOY115888275
ATD109598594
CSET123310143
AGB108910330
LDC111511342
NVL108569224
PPYR116168959
OTU111414017
BMOR101738705 101738844
BMAN114249996 114249997
MSEX115442024
DPLKGM_204745
BANY112050222
PMAC106708644
PPOT106105794
PXU106113478
PRAP110995024
ZCE119833301
HAW110374194
TNL113506686 113508201
OFU114356235
PXY105387574
FOC113213148
ZNE110837685
CSEC111874971
FCD110843745
DPXDAPPUDRAFT_230833
PVM113822744
PJA122254528
HAME121864322
PCLA123771322
PTRU123507075
HAZT108664465 108664466
EAF111710249
ISCIscW_ISCW020587
DSV119465876 119465877
RSAN119374547
RMP119167501
VDE111253606
VJA111266853
CSCU111617666
PTEP107452716
SDM118202486
LAK106167602
NVE5504443
EPA110240485
ATEN116294365
ADF107351994 107351995
AMIL114967239
PDAM113684111
SPIS111338256
DGT114520307
HMG100206590
TADTRIADDRAFT_59780
 » show all
Reference
1  [PMID:13971907]
  Authors
BLUMENSTEIN J, WILLIAMS GR.
  Title
Glycine methyltransferase.
  Journal
Can J Biochem Physiol 41:201-10 (1963)
Reference
2  [PMID:9597750]
  Authors
Ogawa H, Gomi T, Takusagawa F, Fujioka M.
  Title
Structure, function and physiological role of glycine N-methyltransferase.
  Journal
Int J Biochem Cell Biol 30:13-26 (1998)
DOI:10.1016/S1357-2725(97)00105-2
Reference
3  [PMID:10608809]
  Authors
Yeo EJ, Briggs WT, Wagner C.
  Title
Inhibition of glycine N-methyltransferase by 5-methyltetrahydrofolate pentaglutamate.
  Journal
J Biol Chem 274:37559-64 (1999)
DOI:10.1074/jbc.274.53.37559
Reference
4  [PMID:10833353]
  Authors
Martinov MV, Vitvitsky VM, Mosharov EV, Banerjee R, Ataullakhanov FI.
  Title
A substrate switch: a new mode of regulation in the methionine metabolic pathway.
  Journal
J Theor Biol 204:521-32 (2000)
DOI:10.1006/jtbi.2000.2035
Reference
5  [PMID:12859184]
  Authors
Takata Y, Huang Y, Komoto J, Yamada T, Konishi K, Ogawa H, Gomi T, Fujioka M, Takusagawa F.
  Title
Catalytic mechanism of glycine N-methyltransferase.
  Journal
Biochemistry 42:8394-402 (2003)
DOI:10.1021/bi034245a
  Sequence
[rno:25134]
Reference
6  [PMID:15340920]
  Authors
Pakhomova S, Luka Z, Grohmann S, Wagner C, Newcomer ME
  Title
Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes.
  Journal
Proteins 57:331-7 (2004)
DOI:10.1002/prot.20209
  Sequence
[hsa:27232] [mmu:14711]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.20
IUBMB Enzyme Nomenclature: 2.1.1.20
ExPASy - ENZYME nomenclature database: 2.1.1.20
BRENDA, the Enzyme Database: 2.1.1.20
CAS: 37228-72-1

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