KEGG ENZYME: 2.1.1.20

ENZYME: 2.1.1.20

Entry

EC 2.1.1.20                 Enzyme

Name

glycine N-methyltransferase;
glycine methyltransferase;
S-adenosyl-L-methionine:glycine methyltransferase;
GNMT

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:glycine N-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine [RN:R00367]

Reaction(KEGG)

R00367

Substrate

S-adenosyl-L-methionine [CPD:C00019];
glycine [CPD:C00037]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
sarcosine [CPD:C00213]

Comment

This enzyme is thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. It is inhibited by 5-methyltetrahydrofolate pentaglutamate [4]. Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3, sarcosine dehydrogenase.

History

EC 2.1.1.20 created 1972, modified 2005

Pathway

ec00260

Glycine, serine and threonine metabolism

ec00270

Cysteine and methionine metabolism

ec00670

One carbon pool by folate

ec01100

Metabolic pathways

Orthology

K00552

glycine N-methyltransferase

Genes

HSA:	27232(GNMT)

PTR:	462703(GNMT)

PPS:	100993237(GNMT)

GGO:	101143848(GNMT)

PON:	100432507(GNMT)

PPYG:

129039544(GNMT)

NLE:	100603199(GNMT)

HMH:	116460460(GNMT)

SSYN:

129473062(GNMT)

MCC:	697722(GNMT)

MCF:	102133929(GNMT)

MTHB:

126952406

MNI:	105489583(GNMT)

CSAB:

103221484(GNMT)

CATY:

105591544(GNMT)

PANU:

101008718(GNMT)

TGE:	112622332(GNMT)

MLEU:

105544315(GNMT)

RRO:	104667328(GNMT)

RBB:	108533480(GNMT)

TFN:	117087242(GNMT)

PTEH:

111543055(GNMT)

CANG:

105524930(GNMT)

CJC:	100413047(GNMT)

SBQ:	101053276(GNMT)

CIMI:

108317109(GNMT)

ANAN:

105714643(GNMT)

CSYR:

103268550(GNMT)

MMUR:

105875835(GNMT)

LCAT:

123631892(GNMT)

PCOQ:

105807466(GNMT)

OGA:	100950716(GNMT)

MMU:	14711(Gnmt)

MCAL:

110284012

MPAH:

110335591

RNO:	25134(Gnmt)

MCOC:

116075524(Gnmt)

ANU:

117722363

ASYL:

127692103(Gnmt)

MUN:	110550343(Gnmt)

CGE:

100769585

MAUA:

101825665(Gnmt)

PROB:

127236611(Gnmt)

PLEU:

114705340(Gnmt)

MORG:

121450802(Gnmt)

MFOT:

126488896

AAMP:

119823462(Gnmt)

NGI:	103730804(Gnmt)

HGL:	101697457(Gnmt)

CPOC:

100717389

CCAN:

109682081(Gnmt)

DSP:

122101636

PLOP:

125352575(Gnmt)

NCAR:

124988152

MMMA:

107143924(Gnmt)

ITI:	101964621(Gnmt)

OCU:

100009512

OPI:	101517330(GNMT)

TUP:	102501380(GNMT)

GVR:	103585755(GNMT)

CFA:	474905(GNMT)

CLUD:

112641604(GNMT)

VVP:	112913997(GNMT)

VLG:	121490377(GNMT)

NPO:	129512905(GNMT)

AML:	100477196(GNMT)

UMR:	103664079(GNMT)

UAH:	113261284(GNMT)

UAR:	123794585(GNMT)

ELK:	111147599 111147995

LLV:

125102116

MPUF:

101680816(GNMT)

MNP:	132018050(GNMT)

MLK:	131833992(GNMT)

NVS:	122908333(GNMT)

ORO:	101377523(GNMT)

EJU:	114204495(GNMT)

ZCA:	113926507(GNMT)

MLX:	118000555(GNMT)

NSU:	110582195(GNMT)

LWW:	102741887(GNMT)

FCA:	101083006(GNMT)

PYU:	121029468(GNMT)

PCOO:

112862016(GNMT)

PBG:	122489532(GNMT)

PVIV:

125165691(GNMT)

LRUF:

124528630

LGF:	123608393(GNMT)

AJU:

106973967

PTG:	102965502(GNMT)

PPAD:

109271639(GNMT)

PUC:

125938222

PLEZ:

122219927(GNMT)

HHV:	120231230(GNMT)

BTA:	112443696 538212(GNMT)

BOM:	102287446(GNMT)

BIU:	109577223(GNMT)

BBUB:

102395585(GNMT)

BBIS:

105005232(GNMT)

CHX:

102170645

OAS:	101111134(GNMT)

BTAX:

128055977(GNMT)

CSUM:

138098044(GNMT)

ODA:	120870113(GNMT)

CCAD:

122429153(GNMT)

MREE:

136151769(GNMT)

OVR:	110150960(GNMT)

MBEZ:

129543209(GNMT)

SSC:	397444(GNMT)

CFR:	102506340(GNMT)

CBAI:

105083787(GNMT)

CDK:	105088648(GNMT)

VPC:	102544214(GNMT)

BACU:

103001201(GNMT)

BMUS:

118903492

LVE:	103077097(GNMT)

OOR:	101270773(GNMT)

LALB:

132527341(GNMT)

DLE:	111178834(GNMT)

PCAD:

102994709(GNMT)

PSIU:

116761635(GNMT)

NASI:

112414009(GNMT)

ECB:	100067145(GNMT)

EPZ:	103548169(GNMT)

EAI:	106828715(GNMT)

MYB:	102250180(GNMT)

MYD:	102760706(GNMT)

MMYO:

118660030(GNMT)

MLF:	102442398(GNMT)

MDT:	132237315(GNMT)

MYUM:

139012510(GNMT)

PKL:	118705248(GNMT)

EFUS:

103296654(GNMT)

MNA:	107536922(GNMT)

DRO:	112302127(GNMT)

SHON:

118991685(GNMT)

AJM:	119041338 119056163(GNMT)

PDIC:

114494172(GNMT)

PHAS:

123821630(GNMT)

MMF:	118621513(GNMT)

PPAM:

129067461(GNMT)

HAI:

109382878

RFQ:	117020130(GNMT)

PALE:

102898977(GNMT)

PGIG:

120596148(GNMT)

PVP:	105288454(GNMT)

RAY:	107501992(GNMT)

MJV:	108395057(GNMT)

TOD:	119252477(GNMT)

SARA:

101543105(GNMT)

SFUM:

130034460(GNMT)

SETR:

125995981(GNMT)

LAV:	100660725(GNMT)

TMU:

101355018

ETF:	101641334(GNMT)

DNM:	101434952(GNMT)

MDO:	100010632(GNMT)

GAS:	123245665(GNMT)

SHR:

100925098

AFZ:

127561759

PCW:	110201291(GNMT)

TVP:

118856606

PBRV:

138144592(GNMT)

OAA:	100092827(GNMT)

TACU:

119940611(GNMT)

GGA:	769542(GNMT)

PCOC:

116231565(GNMT)

MGP:	100540940(GNMT)

CJO:	107310908(GNMT)

TPAI:

128077306(GNMT)

LMUT:

125689496(GNMT)

NMEL:

110395296(GNMT)

APLA:

113842961(GNMT) 119716560

ACYG:

125184663(GNMT)

CATA:

118253563(GNMT)

AFUL:

116488118(GNMT)

TGU:	100231507(GNMT)

LSR:	110472810(GNMT)

SCAN:

103821310

PMOA:

120500924(GNMT)

OTC:	121346383(GNMT)

PRUF:

121353917(GNMT)

ATRC:

139586163(GNMT)

FAB:	101818171(GNMT)

OMA:	130251190(GNMT)

PHI:	102109993(GNMT)

PMAJ:

107202337(GNMT)

CCAE:

111922583

CCW:	120411694(GNMT)

CBRC:

103617483

ACOE:

138107677(GNMT)

ETL:	114066770(GNMT)

ZAB:	102074891(GNMT)

ZLE:	135446102(GNMT)

ACHL:

103799528(GNMT)

SVG:	106862738(GNMT)

MMEA:

130581316(GNMT)

HRT:	120751305(GNMT)

SATI:

136359786(GNMT)

CCIC:

134042311(GNMT)

FCH:

102046712

CCRI:

104169554(GNMT)

NNT:	104405885(GNMT)

SHAB:

115613655(GNMT)

TALA:

116962039(GNMT)

ACHC:

115349946(GNMT)

HLE:	104838232(GNMT)

AGEN:

126052632

HHAR:

128150516(GNMT)

GCL:

127014806

CSTI:

104553735(GNMT)

LDI:	104349264(GNMT)

MNB:	103773754(GNMT)

DPUB:

104300901(GNMT)

PPUS:

135186694(GNMT)

AVIT:

104279738(GNMT)

EGZ:

104128772

NNI:	104015806(GNMT)

AFOR:

103893486

FGA:	104073594(GNMT)

CLV:

102096572

PLET:

104617980(GNMT)

CUCA:

104060738(GNMT)

TEO:	104376891(GNMT)

ACAR:

104519526

CPEA:

104395327(GNMT)

CVF:	104295130(GNMT)

RTD:	128906809(GNMT)

AAM:	106494152(GNMT)

AROW:

112973557(GNMT)

NPD:

112949349

TGT:	104570050(GNMT)

DNE:	112985529(GNMT)

ASN:

102386281

AMJ:	102566047(GNMT)

CPOO:

109319031

GGN:

109304209

PSS:

102460961

CMY:	102938095(GNMT)

CCAY:

125633270(GNMT)

DCC:	119853338(GNMT)

CPIC:

101948133

TST:	117874136(GNMT)

CABI:

116824871(GNMT)

MRV:	120400901(GNMT)

ACS:	100552842(gnmt)

ASAO:

132761523(GNMT)

PVT:	110087012(GNMT)

SUND:

121919446(GNMT)

PBI:	103067312(GNMT)

PMUR:

107297201(GNMT)

CTIG:

120299559(GNMT)

TSR:	106538009(GNMT)

PGUT:

117671591(GNMT)

APRI:

131189179(GNMT)

PTEX:

113433360(GNMT)

NSS:	113422928(GNMT)

VKO:	123023227(GNMT)

PMUA:

114594784(GNMT)

PRAF:

128411262(GNMT)

ZVI:	118083074(GNMT)

HCG:	128352865(GNMT)

GJA:	107123075(GNMT)

STOW:

125424889(GNMT)

EMC:	129333114(GNMT)

XLA:	108716567 108717630

XTR:	116410885(gnmt)

NPR:

108803755

RTEM:

120921851(GNMT)

BBUF:

120984424

BGAR:

122923284

PWL:	138296916(GNMT)

MUO:	115465289(GNMT)

GSH:	117357772(GNMT)

DRE:	403338(gnmt)

SRX:	107706413 107748599

SANH:

107697528(gnmt) 107703804

SGH:	107553737 107566124

CCAR:

109106978

CAUA:

113051607 113117001

CGIB:

127975850 128031492

PTET:

122334893 122334896

LROH:

127179542(gnmt)

OMC:	131523170(gnmt)

PPRM:

120494925(gnmt)

RKG:	130088929(gnmt)

MAMB:

125268364(gnmt)

CIDE:

127498492

CERY:

137006136(gnmt)

MASI:

127410990

TROS:

130549548(gnmt)

TDW:	130437074(gnmt)

PDAB:

135727298(gnmt) 135765271

IPU:

108270118

IFU:	128612581(gnmt)

PHYP:

113545046(gnmt)

SMEO:

124390082(gnmt)

TFD:	113659593(gnmt)

TVC:	132852183(gnmt)

CGAR:

128536380(gnmt)

NGRA:

132894627(gnmt)

TRN:	134325820(gnmt)

AMEX:

103028138(gnmt)

CMAO:

118823180(gnmt)

EEE:	113572147(gnmt)

CHAR:

105888545(gnmt)

SPIL:

134067277(gnmt)

TRU:	101067368 115246826

TFS:	130540187(gnmt)

TNG:	GSTEN00016922G001

LCO:	104932648(gnmt)

NCC:	104954782(gnmt)

TBEN:

117486745(gnmt)

CGOB:

115027654(gnmt)

PGEO:

117467818(gnmt)

GACU:

117558521(gnmt)

EMAC:

134881525(gnmt)

ELY:	117267179(gnmt)

EFO:	125900391(gnmt)

PLEP:

121953867(gnmt)

SLUC:

116042433(gnmt)

ECRA:

117935637(gnmt)

ESP:	116669936(gnmt)

PFLV:

114546486(gnmt)

GAT:	120832577(gnmt)

PPUG:

119228166(gnmt)

AFB:	129103685(gnmt)

CLUM:

117751385(gnmt)

PSWI:

130205839(gnmt)

CANA:

137787935(gnmt)

CVE:	137877643(gnmt)

MSAM:

119910871(gnmt)

SCHU:

122861874(gnmt)

CUD:	121526476(gnmt)

SPUL:

138591575(gnmt)

LMIX:

132993075(gnmt)

ALAT:

119005000(gnmt)

ASTR:

137610749(gnmt)

MZE:	101484870(gnmt)

ONL:	100706279(gnmt)

OAU:	116311098(gnmt)

OLA:	101154832(gnmt)

OML:	112144840(gnmt)

CSAI:

133462264(gnmt)

XMA:	102219353(gnmt)

XCO:	114134382(gnmt)

XHE:	116708699 116726160

PFOR:

103154189(gnmt)

PLAI:

106937322(gnmt)

PMEI:

106904043(gnmt)

GAF:	122845739(gnmt)

PPRL:

129374881(gnmt)

CVG:	107084845(gnmt)

CTUL:

119781787

GMU:	124855913(gnmt)

NFU:	107389170 107392578(gnmt)

KMR:	108246999(gnmt)

ALIM:

106521247(gnmt)

NWH:	119427916(gnmt)

AOCE:

111562587(gnmt)

EJA:	138212172(gnmt)

BFRE:

138614610(gnmt)

MCEP:

125023941(gnmT)

CSEM:

103380842(gnmt)

POV:	109628164(gnmt)

SSEN:

122759962(gnmt)

HHIP:

117756209(gnmt)

HSP:	118116217(gnmt)

PPLT:

128450454(gnmt)

SMAU:

118285912(gnmt)

LCF:

108898000

SDU:	111226206(gnmt)

SLAL:

111668120(gnmt)

XGL:	120795580(gnmt)

HCQ:	109530231(gnmt)

SSCV:

125981326(gnmt)

SBIA:

133513460(gnmt)

PEE:	133413175(gnmt)

PTAO:

133487795(gnmt)

BPEC:

110155508(gnmt)

MALB:

109973687(gnmt)

BSPL:

114848273(gnmt)

SJO:	128375518(gnmt)

SSCO:

134000373(gnmt)

GMH:	115535976(gnmt)

SASA:

106561891(gnmt)

STRU:

115202816(gnmt)

OTW:	112263437(gnmt)

OMY:	110506251(gnmt)

OGO:	124035938(gnmt)

ONE:	115113437(gnmt)

OKI:	109895585(gnmt)

OKE:	118402591(gnmt)

OMM:	135506116(gnmt)

SALP:

111969168(gnmt)

SNH:	120025133(gnmt)

CCLU:

121539682(gnmt)

ELS:	105006939(gnmt)

SFM:	108923148(gnmt)

PKI:	111834432(gnmt)

AANG:

118215023(gnmt)

AROT:

135235798(gnmt)

CCOG:

133130054(gnmt)

LOC:	102697278(gnmt)

PSPA:

121316224 121317350

ARUT:

117402945 117411412

PSEX:

120526399(gnmt)

LCM:	102360222(GNMT)

CMK:	103187634(gnmt)

RTP:	109919411(gnmt)

CPLA:

122548511(gnmt)

HOC:	132836767(gnmt)

LERI:

129697634(gnmt)

PMRN:

116948385(GNMT)

LRJ:	133352627(GNMT)

BFO:	118403902 118421975

BBEL:

109464842 109487980

SPU:	105438157 105439109 575025 579000 579441 580044 589953 752758

LPIC:

129263263 129263534 129263541 129263666 129264872 129265454 129282198 129283305 129283548 129283549

APLC:

110974275 110981790

ARUN:

117291639

AJC:

117111684

SKO:

100378448

PFLL:

139150434

DME:	Dmel_CG6188(Gnmt)

DER:

6553637

DSE:

6606629

DSI:	Dsimw501_GD18854(Dsim_GD18854)

DYA:	Dyak_GE26214

DAN:

6499903

DSR:

110186710

DPO:

4800872

DPE:

113566232

DMN:

108156785

DWI:

6651484

DGR:

6567519

DMO:	Dmoj_GI10501

DAZ:

108608851

DNV:

115561966

DHE:

111598317

DVI:	6630429(Gnmt)

CCAT:

101463471

BOD:

106622609

BDR:

105228244

RZE:

108378670

AOQ:

129235731

TDA:

119684616

MDE:

101892983

SCAC:

106093742

LCQ:

111682604

LSQ:

119605752

CVJ:	135962801(Gnmt)

GFS:

119639614

ECOE:

129938851

CLON:

129614242

HIS:	119659359 119660372 119660404 119660432

AGA:

3290580

ACOZ:

120949558

AARA:

120896517

AMER:

121588250

ASTE:

118504598

AFUN:

125765977

AMOU:

128298290

AALI:

118456659

AAG:

5576784

AALB:

109405766 109430495

ASUA:

134224462

CQU:	CpipJ_CPIJ015956

CPII:

120417520

CNS:

116348230

BCOO:

119084046

LLL:

129787872

PPAP:

129809767

AME:

552832

ACER:

107995953

ALAB:

122718069

ADR:

102676389

AFLR:

100870573

BIM:

100742588

BBIF:

117213847

BVK:

117231350

BVAN:

117156595

BHUN:

126863512

BTER:

100647936

BAFF:

126917710

BPYO:

122572858

BPAS:

132907498

FVI:

122535046

CCAL:

108624035

OBB:

114880987

OLG:

117601881

MGEN:

117230028

NMEA:

116434800

CGIG:

122397194

SOC:

105193482

MPHA:

105837902

AEC:

105154304

ACEP:

105618894

PBAR:

105430839

VEM:

105561988

COBS:

139106443(Gnmt)

HST:

105191076

DQU:

106745158

CFO:

105256576

FEX:

115235867

PMEC:

138938808(Gnmt)

LHU:	105675201(Gnmt)

PGC:

109860071

OBO:

105277551

PCF:

106788778

PFUC:

122524825

VPS:

122631351

VCRB:

124425994

VVE:

124951566

NVI:	100121709 100122726

CSOL:

105367921

TPRE:

106649165

LHT:

122501485

LBD:

127278592

MDL:	103577735 103578163 103578164 103578165 103578166 103578167

CGLO:

123262576

FAS:

105269615

DAM:

107040411

AGIF:

122860626

CINS:

118068278

VCAN:

122415567

CCIN:

107264219

DSM:

124413084

NPT:	124221571(Gnmt)

NFB:

124184869

NLO:

107227225

NVG:

124307106

AROA:

105693397

TCA:	662005 662371

TMOL:

138131394 138132600(Gnmt)

DPA:

109541622

ESIM:

136408436(Gnmt)

EFOR:

136342790(Gnmt)

SOY:

115888275

AGRG:

126738531

ATD:

109598594

CSET:

123310143

HAXR:

123684239

AGB:

108910330

LDC:

111511342

DVV:

114342981

NVL:

108569224

PPYR:

116168959

OTU:

111414017

BMOR:

101738705 101738844

BMAN:

114249996 114249997

MSEX:

115442024

DPL:	KGM_204745

BANY:

112050222

MJU:

123866497

NIQ:

126768155

VCD:

124544373

MCIX:

123669973

PMAC:

106708644

PPOT:

106105794

PXU:

106113478

BPHI:

137928828(Gnmt)

PRAP:

110995024

PBX:

123711496

PNAP:

125059240

ZCE:

119833301

CCRC:

123691736

LSIN:

126977108

AAGE:

121728930

HAW:

110374194

HZE:

124632507

TNL:	113506686 113508201

SLIU:

111358440

OFU:

114356235

ATRA:

106139443

GMW:

113514885

PXY:

105387574

PGW:

126366323

LGLY:

125229058

CSTB:

134741313

CFEL:

113384692 113384693 113385227

CCRN:

123292343

FOC:

113213148

TPAL:

117647128

ZNE:

110837685

CSEC:

111874971

SGRE:

126291779

BROR:

134534343

IEL:

124153495

FCD:

110843745

DPX:	DAPPUDRAFT_230833

PVM:

113822744

PJA:

122254528

PCHN:

125035817

PMOO:

119594178

HAME:

121864322

PCLA:

123771322(Gnmt)

CQD:	128704780(Gnmt)

PTRU:

123507075

ESN:

126987890

MNZ:

135223868

MRJ:	136839392(Gnmt)

PORN:

139761862(Gnmt)

HAZT:

108664465 108664466

EAF:

111710249

LSM:

121118087

PPOI:

119093211 119093213

ISC:

8035074

DSV:

119465877

RSAN:

119374547

RMP:

119167501

VDE:

111253606

VJA:

111266853

CSCU:

111617666

CVS:	136979317(Gnmt)

PTEP:

107452716

ABRU:

129958300

UDV:

129220437

SDM:

118202486

LPOL:

106457816

LJP:

135475347

LAK:

106167602

LLON:

135484419

NVE:

5504443

EPA:

110240485

ATEN:

116294365

ADF:	107351994 107351995

AMIL:

114967239

MCAZ:

138027039 138027810

MFOO:

137979474

PDAM:

113684111

SPIS:

111338256

DGT:

114520307

HMG:

100206590

HSY:

130656521

RES:

135689241

TAD:	TRIADDRAFT_59780

» show all

Reference

1 [PMID:13971907]

Authors

BLUMENSTEIN J, WILLIAMS GR.

Title

Glycine methyltransferase.

Journal

Can J Biochem Physiol 41:201-10 (1963)

Reference

2 [PMID:9597750]

Authors

Ogawa H, Gomi T, Takusagawa F, Fujioka M.

Title

Structure, function and physiological role of glycine N-methyltransferase.

Journal

Int J Biochem Cell Biol 30:13-26 (1998)
DOI:10.1016/S1357-2725(97)00105-2

Reference

3 [PMID:10608809]

Authors

Yeo EJ, Briggs WT, Wagner C.

Title

Inhibition of glycine N-methyltransferase by 5-methyltetrahydrofolate pentaglutamate.

Journal

J Biol Chem 274:37559-64 (1999)
DOI:10.1074/jbc.274.53.37559

Reference

4 [PMID:10833353]

Authors

Martinov MV, Vitvitsky VM, Mosharov EV, Banerjee R, Ataullakhanov FI.

Title

A substrate switch: a new mode of regulation in the methionine metabolic pathway.

Journal

J Theor Biol 204:521-32 (2000)
DOI:10.1006/jtbi.2000.2035

Reference

5 [PMID:12859184]

Authors

Takata Y, Huang Y, Komoto J, Yamada T, Konishi K, Ogawa H, Gomi T, Fujioka M, Takusagawa F.

Title

Catalytic mechanism of glycine N-methyltransferase.

Journal

Biochemistry 42:8394-402 (2003)
DOI:10.1021/bi034245a

Sequence

[rno:25134]

Reference

6 [PMID:15340920]

Authors

Pakhomova S, Luka Z, Grohmann S, Wagner C, Newcomer ME

Title

Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes.

Journal

Proteins 57:331-7 (2004)
DOI:10.1002/prot.20209

Sequence

[hsa:27232] [mmu:14711]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.20

IUBMB Enzyme Nomenclature:

2.1.1.20

ExPASy - ENZYME nomenclature database:

2.1.1.20

BRENDA, the Enzyme Database:

2.1.1.20

CAS:	37228-72-1

DBGET integrated database retrieval system