KEGG   ENZYME: 2.1.1.203Help
Entry
EC 2.1.1.203                Enzyme                                 

Name
tRNA (cytosine34-C5)-methyltransferase;
hTrm4 Mtase;
hTrm4 methyltransferase;
hTrm4 (gene name);
tRNA:m5C-methyltransferase (ambiguous)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (cytosine34-C5)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cytosine34 in tRNA precursor = S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor [RN:R00595]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cytosine34 in tRNA precursor
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5-methylcytosine34 in tRNA precursor
Comment
The human enzyme is specific for C5-methylation of cytosine34 in tRNA precursors. The intron in the human pre-tRNALeu(CAA) is indispensable for the C5-methylation of cytosine in the first position of the anticodon. It is not able to form 5-methylcytosine at positions 48 and 49 of human and yeast tRNA precursors [1].
History
EC 2.1.1.203 created 1976 as EC 2.1.1.29, part transferred 2011 to EC 2.1.1.203
Orthology
K15335  tRNA (cytosine34-C5)-methyltransferase
Genes
HSA: 54888(NSUN2)
PTR: 461711(NSUN2)
PPS: 100978191(NSUN2)
GGO: 101144331(NSUN2)
PON: 100443369(NSUN2)
NLE: 100606775(NSUN2)
MCC: 694987(NSUN2)
MCF: 102125748(NSUN2)
CSAB: 103214972(NSUN2)
RRO: 104672269(NSUN2)
RBB: 108522883(NSUN2)
CJC: 100391414(NSUN2)
SBQ: 101044631(NSUN2)
MMU: 28114(Nsun2)
MCAL: 110307569(Nsun2)
MPAH: 110328757(Nsun2)
RNO: 361191(Nsun2)
MUN: 110550387(Nsun2)
CGE: 100760286(Nsun2)
NGI: 103735347(Nsun2)
HGL: 101714363(Nsun2)
CCAN: 109693822(Nsun2)
OCU: 100350862(NSUN2)
TUP: 102500776(NSUN2)
CFA: 478625(NSUN2)
VVP: 112934270(NSUN2)
AML: 100472688(NSUN2)
UMR: 103679252(NSUN2)
ORO: 101363016(NSUN2)
FCA: 101099103(NSUN2)
PTG: 102952778(NSUN2)
PPAD: 109267837(NSUN2)
AJU: 106971247(NSUN2)
BTA: 516044(NSUN2)
BOM: 102272859(NSUN2)
BIU: 109574872(NSUN2)
BBUB: 102396321(NSUN2)
CHX: 102180428(NSUN2)
OAS: 101106968(NSUN2)
SSC: 100518405(NSUN2)
CFR: 102513890(NSUN2)
CDK: 105094036(NSUN2)
BACU: 102998396(NSUN2)
LVE: 103071447(NSUN2)
OOR: 101275527(NSUN2)
DLE: 111178553(NSUN2)
PCAD: 102980393 102980553(NSUN2)
ECB: 100071458(NSUN2)
EPZ: 103550089(NSUN2)
EAI: 106822986(NSUN2)
MYB: 102260943(NSUN2)
MYD: 102762450(NSUN2)
MNA: 107540527(NSUN2)
HAI: 109376003(NSUN2)
DRO: 112320946(NSUN2)
PALE: 102893514(NSUN2)
RAY: 107518892(NSUN2)
MJV: 108401277(NSUN2)
LAV: 100673463(NSUN2)
TMU: 101347263
MDO: 100018054(NSUN2)
SHR: 100920695(NSUN2)
PCW: 110220444(NSUN2)
OAA: 100092642(NSUN2)
GGA: 420938(NSUN2)
MGP: 100541040(NSUN2)
CJO: 107309500(NSUN2)
NMEL: 110393801(NSUN2)
APLA: 101792480(NSUN2)
ACYG: 106036579(NSUN2)
TGU: 100223811(NSUN2)
LSR: 110479508(NSUN2)
SCAN: 103815426(NSUN2)
GFR: 102039201(NSUN2)
FAB: 101814592(NSUN2)
PHI: 102110302(NSUN2)
PMAJ: 107200160(NSUN2)
CCAE: 111925368(NSUN2)
CCW: 104685923(NSUN2)
ETL: 114055138(NSUN2)
FPG: 101910766(NSUN2)
FCH: 102049337(NSUN2)
CLV: 102086935(NSUN2)
EGZ: 104126189(NSUN2)
NNI: 104018890(NSUN2)
ACUN: 113476068(NSUN2)
PADL: 103915156(NSUN2)
AAM: 106492334(NSUN2)
ASN: 102380740(NSUN2)
AMJ: 102565534(NSUN2)
PSS: 102452913(NSUN2)
CMY: 102940691(NSUN2)
CPIC: 101953716(NSUN2)
ACS: 100555854(nsun2)
PVT: 110080022(NSUN2)
PBI: 103053000 103065582(NSUN2)
PMUR: 107289984(NSUN2)
TSR: 106554497(NSUN2)
PMUA: 114601062(NSUN2)
GJA: 107123742(NSUN2)
XLA: 414460(nsun2.S)
XTR: 548716(nsun2)
NPR: 108795130(NSUN2)
DRE: 325292(nsun2)
SRX: 107711338 107754797(nsun2)
CCAR: 109110846
IPU: 108273268(nsun2)
PHYP: 113543748(nsun2)
AMEX: 103038375(nsun2)
EEE: 113590336(nsun2)
TRU: 101074500(nsun2)
LCO: 104922766(nsun2)
NCC: 104959827 104961211(nsun2)
MZE: 101476280(nsun2)
ONL: 100706204(nsun2)
OLA: 101158463(nsun2)
XMA: 102222973(nsun2)
XCO: 114156397(nsun2)
PRET: 103472067(nsun2)
CVG: 107091822(nsun2)
NFU: 107383181(nsun2)
KMR: 108238711(nsun2)
ALIM: 106532693(nsun2)
AOCE: 111569837(nsun2)
CSEM: 103394106(nsun2)
POV: 109631855(nsun2)
LCF: 108900394(nsun2)
SDU: 111233168(nsun2)
SLAL: 111671483(nsun2)
HCQ: 109519206(nsun2)
BPEC: 110167265(nsun2)
MALB: 109971722(nsun2)
SASA: 106570340(nsun2) 106588694
SALP: 111955838
ELS: 105012406(nsun2)
SFM: 108919300(nsun2)
PKI: 111852626(nsun2)
CMK: 103183195(nsun2)
RTP: 109935655(nsun2)
CIN: 100184803
SPU: 592875
APLC: 110989010
DME: Dmel_CG6133(Nsun2)
DER: 6550971
DSI: Dsimw501_GD16312(Dsim_EG:EG0007.9)
DYA: Dyak_GE16872(Dyak_EG:EG0007.9)
DSR: 110181687
DPE: 6602770
DMN: 108152835
DWI: 6653048
DAZ: 108618573
DNV: 115564950
DHE: 111591881
MDE: 101892384
LCQ: 111684239
AAG: 5579023
AME: 411579
BIM: 100740667
BTER: 100650195
OBB: 114871390
SOC: 105203136
MPHA: 105839289
AEC: 105149871
ACEP: 105621541
PBAR: 105432310
VEM: 105568490
HST: 105182995
DQU: 106746386
CFO: 105258017
LHU: 105668308
PGC: 109855240
OBO: 105287624
PCF: 106787847
NVI: 100116182
CSOL: 105366104
MDL: 103578914
TCA: 662306
DPA: 109535099
ATD: 109605821
NVL: 108557299
BMOR: 101745118
PRAP: 110999001
HAW: 110381723
TNL: 113494141
PXY: 105380786
API: 100169525
DNX: 107167504
AGS: 114124882
RMD: 113556645
BTAB: 109032920
CLEC: 106670829
ZNE: 110829145
FCD: 110858480
PVM: 113830205
TUT: 107368159
PTEP: 107437231
CEL: CELE_Y48G8AL.5(Y48G8AL.5)
CBR: CBG08493
TSP: Tsp_00405
PCAN: 112553222
CRG: 105343718
MYI: 110446873
OBI: 106883416
SHX: MS3_09900
EGL: EGR_03050
EPA: 110245842
ADF: 107338283
AMIL: 114969415
PDAM: 113675748
SPIS: 111335007
DGT: 114532764
HMG: 100214074
CCAV: 112505324
CRE: CHLREDRAFT_114222(TRM4)
DFA: DFA_07613
TAN: TA19955
BBO: BBOV_IV000560(21.m02754)
CPV: cgd7_1630
SMIN: v1.2.013460.t1(symbB.v1.2.013460.t1) v1.2.033994.t1(symbB.v1.2.033994.t1) v1.2.037264.t1(symbB.v1.2.037264.t1)
 » show all
Taxonomy
Reference
1  [PMID:17071714]
  Authors
Brzezicha B, Schmidt M, Makalowska I, Jarmolowski A, Pienkowska J, Szweykowska-Kulinska Z
  Title
Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA).
  Journal
Nucleic Acids Res 34:6034-43 (2006)
DOI:10.1093/nar/gkl765
  Sequence
[hsa:54888]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.203
IUBMB Enzyme Nomenclature: 2.1.1.203
ExPASy - ENZYME nomenclature database: 2.1.1.203
BRENDA, the Enzyme Database: 2.1.1.203

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