KEGG   ENZYME: 2.1.1.204
Entry
EC 2.1.1.204                Enzyme                                 
Name
tRNA (cytosine38-C5)-methyltransferase;
hDNMT2 (gene name);
DNMT2 (gene name);
TRDMT1 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cytosine38 in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA [RN:R00595]
Reaction(KEGG)
R00595
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cytosine38 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5-methylcytosine38 in tRNA
Comment
The eukaryotic enzyme catalyses methylation of cytosine38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease [3].
History
EC 2.1.1.204 created 1976 as EC 2.1.1.29, part transferred 2011 to EC 2.1.1.204
Orthology
K15336  tRNA (cytosine38-C5)-methyltransferase
Genes
HSA1787(TRDMT1)
PTR738954(TRDMT1)
PPS100994021(TRDMT1)
GGO101139244(TRDMT1)
PON100444503(TRDMT1)
NLE100605724(TRDMT1)
MCC699758(TRDMT1)
MCF102122839(TRDMT1)
MTHB126963238
CSAB103237951(TRDMT1)
CATY105583838(TRDMT1)
PANU101024705(TRDMT1)
TGE112631516(TRDMT1)
RRO104655337(TRDMT1)
RBB108527744(TRDMT1)
TFN117082094(TRDMT1)
PTEH111550004(TRDMT1)
CJC100407322(TRDMT1)
SBQ101045369(TRDMT1)
CSYR103258678(TRDMT1)
MMUR105865305(TRDMT1)
LCAT123625631(TRDMT1)
OGA100961833(TRDMT1)
MMU13434(Trdmt1)
MCAL110289783(Trdmt1)
MPAH110319156(Trdmt1)
RNO291324(Trdmt1)
MCOC116089721(Trdmt1)
MUN110540833
CGE100773025(Trdmt1)
MAUA101833089(Trdmt1)
PLEU114693940(Trdmt1)
MORG121432717(Trdmt1)
MFOT126503259
AAMP119817936(Trdmt1)
NGI103734824(Trdmt1)
HGL101719891(Trdmt1)
CPOC100720839(Trdmt1)
CCAN109700440(Trdmt1)
DORD105984442(Trdmt1)
DSP122113302(Trdmt1)
NCAR124962204 124992575
OCU100346643
OPI101535517(TRDMT1)
TUP102491382(TRDMT1)
GVR103598489(TRDMT1)
CFA487116(TRDMT1)
CLUD112659092(TRDMT1)
VVP112932974(TRDMT1)
VLG121497608(TRDMT1)
AML100463906(TRDMT1)
UMR103664205(TRDMT1)
UAH113241369(TRDMT1)
UAR123785740(TRDMT1)
ELK111155600
LLV125107283
MPUF101670836(TRDMT1)
ORO101381218(TRDMT1)
EJU114217258(TRDMT1)
ZCA113922868(TRDMT1)
MLX118021534(TRDMT1)
NSU110586483(TRDMT1)
LWW102742350(TRDMT1)
FCA101091708(TRDMT1)
PYU121014760(TRDMT1)
PBG122473867(TRDMT1)
LRUF124502153
PTG102964129(TRDMT1)
PPAD109273684(TRDMT1)
AJU106979876(TRDMT1)
HHV120240974(TRDMT1)
BTA353353(TRDMT1)
BOM102282714(TRDMT1)
BIU109567981(TRDMT1)
BBUB102389413(TRDMT1)
BBIS105003046(TRDMT1)
CHX102180682(TRDMT1)
OAS101110692(TRDMT1)
ODA120869570(TRDMT1)
CCAD122447982(TRDMT1)
SSC100302362(TRDMT1)
CFR102512226(TRDMT1)
CBAI105078332(TRDMT1)
CDK105099236(TRDMT1)
VPC102529548(TRDMT1)
BACU103017247
LVE103089631
OOR101283176(TRDMT1)
DLE111178104(TRDMT1)
PCAD102989767(TRDMT1)
PSIU116749374(TRDMT1)
ECB100068465(TRDMT1)
EPZ103544036(TRDMT1)
EAI106834425(TRDMT1)
MYB102242384(TRDMT1)
MYD102768922(TRDMT1)
MMYO118674309(TRDMT1)
MLF102418367(TRDMT1)
MNA107537250(TRDMT1)
PKL118730842(TRDMT1)
HAI109393562(TRDMT1)
DRO112318603(TRDMT1)
SHON118997140(TRDMT1)
AJM119061308(TRDMT1)
PDIC114492362(TRDMT1)
PHAS123831164(TRDMT1)
MMF118623969(TRDMT1)
RFQ117019164(TRDMT1)
PALE102879724(TRDMT1)
PGIG120614641(TRDMT1)
PVP105294908(TRDMT1)
RAY107513676(TRDMT1)
MJV108406156(TRDMT1)
TOD119244723(TRDMT1)
SARA101552168(TRDMT1)
LAV100674519(TRDMT1)
TMU101351605
ETF101646013(TRDMT1)
DNM101440485(TRDMT1)
MDO100026881(TRDMT1)
GAS123248866(TRDMT1)
SHR100933240(TRDMT1)
PCW110194492(TRDMT1)
OAA100091400(TRDMT1)
GGA420520(TRDMT1)
PCOC116243204(TRDMT1)
MGP100547420(TRDMT1)
CJO107309025(TRDMT1)
NMEL110393946(TRDMT1)
APLA101794189(TRDMT1)
ACYG106030352(TRDMT1)
AFUL116486161(TRDMT1)
TGU100230580(TRDMT1)
LSR110482440(TRDMT1)
SCAN103812792(TRDMT1)
PMOA120503492(TRDMT1)
OTC121338179(TRDMT1)
PRUF121365745(TRDMT1)
GFR102032424(TRDMT1)
FAB101814992(TRDMT1)
PHI102108198(TRDMT1)
PMAJ107200477(TRDMT1)
CCAE111924171(TRDMT1)
CCW104689209(TRDMT1)
CBRC103612335(TRDMT1)
ETL114066711(TRDMT1)
ZAB102072575(TRDMT1)
ACHL103798620(TRDMT1)
FPG101918245(TRDMT1)
FCH102059325(TRDMT1)
CLV102087351(TRDMT1)
EGZ104135615(TRDMT1)
NNI104013326(TRDMT1)
PLET104622928(TRDMT1)
PCRI104030738(TRDMT1)
PCAO104039461(TRDMT1)
ACUN113477237(TRDMT1)
TALA104364308(TRDMT1)
PADL103922459(TRDMT1)
AFOR103895985(TRDMT1)
ACHC115338747(TRDMT1)
HALD104315028(TRDMT1)
HLE104837538(TRDMT1)
AGEN126037650
GCL127012735
CCRI104165566(TRDMT1)
CSTI104550839(TRDMT1)
EHS104513757(TRDMT1)
CMAC104474569(TRDMT1)
MUI104541971(TRDMT1)
FGA104082854(TRDMT1)
GSTE104251885(TRDMT1)
LDI104347002(TRDMT1)
MNB103777251(TRDMT1)
OHA104332529(TRDMT1)
NNT104408593(TRDMT1)
DPUB104302291(TRDMT1)
PGUU104471327(TRDMT1)
ACAR104520425(TRDMT1)
CPEA104394069(TRDMT1)
AVIT104267388(TRDMT1)
CVF104288326(TRDMT1)
CUCA104057667(TRDMT1)
TEO104381497(TRDMT1)
BRHI104492838(TRDMT1)
AAM106483601(TRDMT1)
AROW112976181(TRDMT1)
NPD112947341(TRDMT1)
TGT104580261(TRDMT1)
DNE112982344(TRDMT1)
SCAM104143287(TRDMT1)
ASN102376738(TRDMT1)
AMJ102565207(TRDMT1)
CPOO109308241(TRDMT1)
GGN109291356(TRDMT1)
PSS102443731
CMY102942823(TRDMT1)
CPIC101948080(TRDMT1)
TST117872165(TRDMT1)
CABI116829431
MRV120399166(TRDMT1)
ACS100562684(trdmt1)
PVT110085994(TRDMT1)
SUND121935019(TRDMT1)
PBI103065020(TRDMT1)
PMUR107283327(TRDMT1)
TSR106543573(TRDMT1)
PGUT117654884(TRDMT1)
VKO123020676(TRDMT1)
ZVI118092174(TRDMT1)
GJA107120970(TRDMT1)
STOW125441036(TRDMT1)
XLA379360(trdmt1.L)
XTR448379(trdmt1)
NPR108793079(TRDMT1)
RTEM120939977(TRDMT1)
BBUF121002876(TRDMT1)
BGAR122939027(TRDMT1)
DRE449878(trdmt1)
SRX107712773 107732079(trdmt1)
SANH107657754(trdmt1) 107677147
SGH107555384 107599711
CCAR109101215
CAUA113042544 113042564 113045037
PPRM120488308(trdmt1)
MAMB125257989(trdmt1)
IPU108271445(trdmt1)
PHYP113534002(trdmt1)
SMEO124384523(trdmt1)
TFD113644238(trdmt1)
AMEX103043215(trdmt1)
EEE113580612(trdmt1)
TRU101068212 105419160
TNGGSTEN00006202G001
LCO104939607(trdmt1)
NCC104946236
CGOB115025488(trdmt1)
ELY117264312(trdmt1)
EFO125881999(trdmt1)
PLEP121960619(trdmt1)
SLUC116050111(trdmt1)
ECRA117938139(trdmt1)
ESP116685852(trdmt1)
PFLV114549148(trdmt1)
GAT120811352 120812006 120813215 120814357 120815236
PPUG119198790(trdmt1)
MSAM119905701(trdmt1)
CUD121527348(trdmt1)
ALAT119008829(trdmt1)
MZE101477362(trdmt1)
ONL100703654(trdmt1)
OAU116329228(trdmt1)
OLA101155097(trdmt1)
OML112139048(trdmt1)
XMA102227471(trdmt1)
XCO114149998(trdmt1)
XHE116712287(trdmt1)
PRET103482231(trdmt1)
PFOR103130730(trdmt1)
PLAI106942339(trdmt1)
PMEI106904909(trdmt1)
GAF122824510(trdmt1)
CTUL119772020(trdmt1)
GMU124857804(trdmt1)
NFU107382625(trdmt1)
KMR108234666(trdmt1)
ALIM106528573(trdmt1)
NWH119426813(trdmt1)
AOCE111589194(trdmt1)
MCEP125024381(trdmt1)
CSEM103376850(trdmt1)
POV109638401(trdmt1)
SSEN122770126(trdmt1)
HHIP117753629(trdmt1)
HSP118098657(trdmt1)
LCF108874197 108898777(trdmt1)
SDU111236374(trdmt1)
SLAL111669681(trdmt1)
XGL120787902 120789719(trdmt1)
HCQ109519514(trdmt1)
BPEC110174636(trdmt1)
MALB109968781(trdmt1)
BSPL114853668(trdmt1)
SASA106578517(trdmt1)
STRU115153366(trdmt1)
OTW112215558(trdmt1)
OMY110535514(trdmt1)
OGO123991168(trdmt1)
ONE115105074(trdmt1)
SALP111973047(trdmt1)
SNH120027724(trdmt1)
CCLU121549926(trdmt1)
ELS105027107(trdmt1)
SFM108918892(trdmt1)
PKI111832851(trdmt1)
AANG118225490(trdmt1)
LOC102696522(trdmt1)
PSPA121312697(trdmt1)
ARUT117400256(trdmt1)
PSEX120530103(trdmt1)
LCM102356211(TRDMT1)
CMK103181574(trdmt1)
RTP109930014(trdmt1)
BFO118428057
BBEL109481640
CIN100183289
SCLV120340730
SPU115918932 764431
APLC110987477 110987752
AJC117124245
SKO102802258
DMEDmel_CG10692(Mt2)
DER6541112
DSE6617712
DSIDsimw501_GD23816(Dsim_Mt2)
DYADyak_GE18570
DSR110187293
DPO4817726
DPE6595410
DMN108163418
DWI6646604
DGR6562395
DMODmoj_GI17066
DAZ108609715
DNV108649777
DHE111602447
DVI26531744
CCAT101449142
BOD106622787
RZE108371874
MDE101899369
SCAC106085525
LCQ111677743
LSQ119612038
HIS119657227
AGAAgaP_AGAP004101 AgaP_AGAP012836
ACOZ120953932
AARA120899796
ASTE118502910
AAG5567564
AALB109413800
CQUCpipJ_CPIJ017186
CPII120413277
CNS116344819
BCOO119070074
AME410512
ACER107998678
ALAB122711336
BIM100741608
BBIF117208163
BVK117243236
BVAN117155504
BTER100651101
BPYO122574732
CCAL108629767
OBB114877238
MGEN117225924 117226280 117228257
NMEA116427092
CGIG122396419
SOC105195023
MPHA105836342
AEC105154851
ACEP105620783
PBAR105429247
VEM105561492
HST105180694
DQU106749195
CFO105256853
FEX115240864
LHU105676696
PGC109862018
OBO105282939
PCF106785402
PFUC122524884
VPS122631386
NVI100117910
CSOL105366184
TPRE106656881
MDL103574114
CGLO123268572
FAS105267840
DAM107038740
AGIF122857718
CINS118065195
LHT122509329
CCIN107268235
TCA663081(Dnmt2)
DPA109538977
SOY115883430
ATD109598241
CSET123317035
LDC111508753
NVL108566736
APLN108744132
PPYR116179337
OTU111426508
BMOR692480(Dnmt2)
BMAN114242235
MSEX115441190
DPLKGM_212925
BANY112051749
NIQ126774439
PMAC106718334
PPOT106109802
PXU106121484
PRAP111003452
PBX123714893
PNAP125057571
ZCE119840914
CCRC123694693
HAW110382440
HZE124634937
TNL113498003
SLIU111358983
OFU114351176
PXY105382564 105392645
CFEL113386682
API100167127
DNX107164163
AGS114125940
RMD113548168
BTAB109039667
DCI103506315 103507728
CLEC106666303
HHAL106687306
NLU111063298
PHUPhum_PHUM591830
FOC113206577
TPAL117649673
ZNE110837652
CSEC111870022
SGRE126335535
FCD110844434
DPXDAPPUDRAFT_187425(DNMT2)
DMK116920303
DPZ124337097
PVM113814108
PJA122256038
PCHN125031838
HAME121855108
PCLA123745885
PTRU123505643
HAZT108681722
EAF111705964
LSM121123658
PPOI119091491
ISCIscW_ISCW023659
DSV119457588
RSAN119373899
RMP119167078
VDE111248231
VJA111271568
DPTE113798271
DFR124495316
CSCU111627952
PTEP107449649
SDM118184499
NAINECAME_08542
TSPTsp_05801
HROHELRODRAFT_89038
LGILOTGIDRAFT_114987
PCAN112560287
BGT106079224
GAE121382065 121391375
HRJ124267676
CRG105344617
MYI110459962
PMAX117336130
MMER123536432
OBI106871816
OSN115214157
LAK106175283 112041635
SMMSmp_145390 Smp_198180
SHXMS3_00007655(TRDMT1_1)
OVIT265_14186
EGLEGR_07014
NVE5503664
EPA110254156
ATEN116306454
ADF107336965 107343937
AMIL114964238
PDAM113684145
SPIS111329616
DGT114518164
XEN124452739
TADTRIADDRAFT_49657
AQU100638692
ATHAT5G25480(DNMT2)
ALY9310332
CRB17883675
CSAT104706869 104736574 104771030
EUSEUTSA_v10004397mg
BRP103874407
BNA106348535 106367782 106407360
BOE106303640
RSZ108851875
THJ104799221
CPAP110811345
CIT102609884
CICCICLE_v10008576mg
PVY116115717 116115730
MINC123193906
TCC18588980
GRA105792840
GHI107907768
GAB108468090
DZI111303368
EGR104437064
GMX100778223 100792567
GSJ114386437 114424615
PVUPHAVU_006G205000g
VRA106775135
VAR108341182
VUN114187080
CCAJ109803623
APRC113850210
MTR11433867
CAM101491158
PSAT127084478
LJALj6g3v2204760.1(Lj6g3v2204760.1)
ADU107468720 107492391
AIP107623462
AHF112714835 112785319 112805245
LANG109333630
FVE101293747
RCN112172879 112182323
PPER18789470
PMUM103320079
PAVI110769100
PDUL117613876
MDM103441974 103456178
PXB103927558 103937104
ZJU107421223
MNT21389072
CSV101219472
CMO103488282
BHJ120075376
MCHA111005184
CMAX111491952
CMOS111462432
CPEP111805612
RCU8278568
JCU105637669
HBR110637304 110652843
MESC110604034
POP7495763
PEU105120066 105122392
PALZ118050305
JRE109001811
QSU111990419 112003961
QLO115974994
TWL120004788
VVI100259391 109121395
VRI117912626
SLY101263628
SPEN107029004
SOT102596409
SSTN125842238
CANN107839049
NTA107814185 107829352
NSY104233117
NTO104108135
NAU109234042
INI109174645
ITR115996491
SIND105166670
EGT105967272
SSPL121796601
APAN127243523
HAN110898533
ECAD122585786
LSV111883157
CCAV112521000 112521001
DCR108206371
CSIN114306634
BVG104887679
SOE110776057
CQI110704513 110723143
NNU104595329
MING122073883
TSS122653047
PSOM113341041 113361076
OSA9268926
DOSAOs01t0612000-01(Os01g0612000)
OBR102707736
BDI100822436
ATS109746509
TDC119268360 119276248
TAES100859954 123061457 123070101
TUA125544022
LPER127342907
SBI8054375
ZMA542067
SITA101758674
SVS117859303
PVIR120707386
PHAI112894919
PDA103721236
EGU105047774
MUS103994888
ZOF122000868 122005162
DCT110115622
PEQ110039202
AOF109820601
NCOL116250677
ATR18431727
SMOSELMODRAFT_105635 SELMODRAFT_98974
PPP112289487
CRECHLRE_12g484600v5
VCNVOLCADRAFT_63767
CSLCOCSUDRAFT_28375
APROF751_1528
OLUOSTLU_16070(DMT3502) OSTLU_87597(DMT3501)
OTAOT_ostta06g03670 OT_ostta07g01440
BPGBathy02g04340
MISMICPUN_79083 MICPUN_84170
MPPMICPUCDRAFT_45851 MICPUCDRAFT_57303
SPOSPBC19C2.02(pmt1)
TVSTRAVEDRAFT_160146
DSQDICSQDRAFT_73086
PCOPHACADRAFT_167754
SHSSTEHIDRAFT_151280
HIRHETIRDRAFT_306746
PSQPUNSTDRAFT_94229
ADLAURDEDRAFT_132442
FMEFOMMEDRAFT_83315
GTRGLOTRDRAFT_31030
LBCLACBIDRAFT_243521
CCICC1G_13191
ABPAGABI1DRAFT123710(AGABI1DRAFT_123710)
ABVAGABI2DRAFT198459(AGABI2DRAFT_198459)
MPRMPER_14201
MRRMoror_1271
MOREE1B28_010799
SCMSCHCO_01194045(SCHCODRAFT_01194045)
CPUTCONPUDRAFT_148326
SLASERLADRAFT_453499
MBRMONBRDRAFT_1464
SREPTSG_05624 PTSG_11488
DDIDDB_G0288047(dnmA)
DPPDICPUDRAFT_153508
DFADFA_08535(dnmA)
EHIEHI_069140(32.t00050)
EDIEDI_128870
EIVEIN_135110
ACANACA1_180000
CPVcgd5_2100
SMINv1.2.011495.t1(symbB.v1.2.011495.t1) v1.2.012243.t1(symbB.v1.2.012243.t1) v1.2.025625.t1(symbB.v1.2.025625.t1) v1.2.030523.t1(symbB.v1.2.030523.t1)
PTIPHATRDRAFT_16674
FCYFRACYDRAFT_139371
TPSTHAPSDRAFT_22139
EHXEMIHUDRAFT_310514 EMIHUDRAFT_44391
GTTGUITHDRAFT_107597 GUITHDRAFT_137189
NGRNAEGRDRAFT_63302
PRZGZH47_31845
PIRVN12_08925(hpaIIM)
RULUC8_46610(banIM)
AHELQ31a_08890(hhaIM)
 » show all
Reference
1  [PMID:16424344]
  Authors
Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, Golic KG, Jacobsen SE, Bestor TH
  Title
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.
  Journal
Science 311:395-8 (2006)
DOI:10.1126/science.1120976
  Sequence
[hsa:1787]
Reference
2  [PMID:18567810]
  Authors
Jurkowski TP, Meusburger M, Phalke S, Helm M, Nellen W, Reuter G, Jeltsch A
  Title
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism.
  Journal
RNA 14:1663-70 (2008)
DOI:10.1261/rna.970408
Reference
3  [PMID:20679393]
  Authors
Schaefer M, Pollex T, Hanna K, Tuorto F, Meusburger M, Helm M, Lyko F
  Title
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.
  Journal
Genes Dev 24:1590-5 (2010)
DOI:10.1101/gad.586710
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.204
IUBMB Enzyme Nomenclature: 2.1.1.204
ExPASy - ENZYME nomenclature database: 2.1.1.204
BRENDA, the Enzyme Database: 2.1.1.204

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