KEGG   ENZYME: 2.1.1.206
Entry
EC 2.1.1.206                Enzyme                                 
Name
tRNA (cytidine56-2'-O)-methyltransferase;
aTrm56;
tRNA ribose 2'-O-methyltransferase aTrm56;
PAB1040 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:tRNA (cytidine56-2'-O)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cytidine56 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cytidine56 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
2'-O-methylcytidine56 in tRNA
Comment
The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts.
History
EC 2.1.1.206 created 2011
Orthology
K07254  tRNA (cytidine56-2'-O)-methyltransferase
Genes
MJAMJ_1385
MFEMefer_0592
MVUMetvu_0176
MFSMFS40622_0541
MIFMetin_0231
MJHJH146_0372
MESGMLAUSG7_0296
MESAMLASG1_1381
MIGMetig_1799
MMPMMP1425
MMQMmarC5_0153
MMXMmarC6_1248
MMZMmarC7_0670
MMDGYY_07960
MMAKMMKA1_16490
MMAOMMOS7_15320
MMADMMJJ_14140
MAEMaeo_1410
MVNMevan_0736
MVOMvol_1037
MOKMetok_0792
METFCFE53_00130
MTHMTH_1113
MMGMTBMA_c14970
MWOMWSIV6_1505
MTEEMTTB_02990
METCMTCT_1007
METEtca_01069
METZMETMT2_1133
METKFVF72_06015
MTHMFZP57_07200
METJFZP68_03475
MSTMsp_1167
METBAW729_09920
MEISPXD04_01795
MRUmru_1893
MSIMsm_0932
MEBAbm4_0323
MMILsm9_1882
MEYETL18_08850
MOLYLM1_1348
MAROMarbSA_15820
METVK4897_06815
MELMetbo_0385
MEWMSWAN_2023
METHMBMB1_1643
MFCBRM9_0897
MFIDSM1535_0864
MCUBMCBB_1950
MSUBBK009_07225
METNBK008_02870
METTCIT01_03460
METOCIT02_09670
MEMEHYG87_04755
MFEGGCM10025860_02290
MFVMfer_0122
MKAMK0803
AFUAF_0751
AFGAFULGI_00008320
APOArcpr_0987
AVEArcve_1584
ASTAsulf_01684
FPLFerp_1796
GACGACE_0721
GAHGAH_02047
PFUPF0461
PFIPFC_01420
PHOPH0461(PH0461)
PABPAB1040
PYNPNA2_1092
PYAPYCH_18720
PYSPy04_0643
PYCTQ32_02215
TKOTK0060
TONTON_1167
TGATGAM_1164
TSITSIB_1085
TBATERMP_01227
THEGQS_09740
THATAM4_2086
THMCL1_1536
TLTOCC_07621
THSTES1_1266
TNUBD01_1130
TEUTEU_11540
TGYX802_07940
THVADU37_CDS08890
TCHCHITON_1288
TPEPA0127_03590
TPIEA7C91_01275
TGGA3K92_02410
TCEA3L02_08790
TBSA3L01_06495
THHCDI07_06475
TSLA3L11_10745
TTDA3L14_08925
TPRFA3L09_04035
TRLA3L10_00045
TPAFA3L08_09705
THYA3L12_03570
TICFH039_09520
TCQTIRI35C_1626
THEMFPV09_00200
THEIK1720_08555
PPACPAP_07235
MBAMbar_A3187
MBYMSBRM_2288
MBWMSBRW_1550
MBARMSBR2_0124
MBAKMSBR3_0181
MACMA_3241
MMAMM_0086
MMAZMmTuc01_0095
MMJMSMAS_1244
MMACMSMAC_2592
MVCMSVAZ_1623
MEKMSKOL_1552
MLSMSLAZ_1587
METMMSMTP_1231
MEFMSWH1_2025
MEQMSWHS_3044
MSJMSSAC_1183
MSZMSSIH_2778
MSWMSSIT_2810
MTHRMSTHT_0155
MTHEMSTHC_0573
MHORMSHOH_2090
MFZAOB57_001680
MBUMbur_0256
MMETMCMEM_0873
MELOJ7W08_02605
MMHMmah_1277
MHAZBHR79_07155
MEVMetev_0683
MZHMzhil_0676
MPYMpsy_0110
MZIHWN40_05875
MMAVRE476_02545
MSEBRE474_12385
MHZMetho_1155
MEHFMmiHf6_06130
MEESMmiEs2_03910
MTPMthe_1667
MCJMCON_3465
MHIMhar_0634
MHUMhun_2799
MRTJKHC33_02905
MLAMlab_0456
MEMMemar_1522
MBGBN140_3042
MEMAMMAB1_2390
MCHKMchiMG62_16880
MSUMOH143_01820
MRCR6Y96_08050
MPIMpet_1609
MENDL6E24_01865
MEFWF1737_03795
MAQERJ40_00290
MOUOU421_01045
MESBL1S32_01955
MANQL1994_05315
MBNMboo_1277
MFOMetfor_2030
MPLMpal_2011
MPDMCP_1507
MEZMtc_1741
RCILRC271
HALVNG_0755C
HSLOE_2117F(trm56)
HANRLJ422_03125
HDLHALDL1_08190
HHBHhub_1875(trm56)
HAGSJT689_04400
HABOJRZ79_02900
HNOLT974_04310
HLULT972_08550
HALHHTSR_1132
HHSRHSR6_1167
HSUHLASF_1177
HSFHLASA_1165
HAHSHSRCO_1393
SALRFQU85_10930
HALREFA46_008115
HJEHacjB3_11305
HDOMUK72_09060
HALXM0R89_16510
HAXZM0R88_17060
HAYCNGM10_14395
HAXYNGM07_02925
SALIL593_09495
SAIMK0C01_00485
HARAAArcS_0924
HMArrnAC0857
HHIHAH_1495
HHNHISP_07640
HABSG26_15470
HTABVU17_07265
HALJG9465_11905
HSINKDQ40_05990
NPHNP_4110A(trm56)
NMONmlp_1943(trm56)
NHOHWV23_05450
NSALHWV07_05135
HUTHuta_0284
HTIHTIA_0466
HALAHrd1104_05730
HASVSVXHr_1299(atrm56)
HABNHBNXHr_1283(atrm56)
HMUHmuk_2326
HALZE5139_14765
HALLLC1Hm_1493(atrm56)
HAZPGBQ70_14780
HALIBV210_14520
HSNDV733_08295
HDSHSR122_2094
HRRHZS55_16130
HPELHZS54_18855
HLTI7X12_19780
HARCHARCEL1_02315
SSAIN0B31_03485
HAADMW046_10120
HWAHQ_2492A(trm56)
HWCHqrw_2788(trm56)
HVOHVO_1173(trm56)
HMEHFX_1186
HGIABY42_05745
HALEG3A49_09080
HLSKU306_10580
HLNSVXHx_1126(trm56)
HBOHbor_20680
HAQDU484_08785
HAJDU500_08825
HAERDU502_06110
HRAEI982_04785
HLMDV707_11140
HALMFCF25_13875
HLAHlac_1701
HALPDOS48_08510
HALBEKH57_14925
HEZZEO776_11385
HALQHrr1229_011765
HSSJ7656_04860
HSAIHPS36_10130
HAZZKI388_09785
SRUBC2R22_07475
HAEhalTADL_0858
HALNB4589_004015
HALGHUG10_06490
HALUHUG12_10585
HMPK6T50_05380
HREK6T36_05095 K6T36_16395
HRMK6T25_10845
HACBHbl1158_11225
HDFAArcSl_0328
HAHHalar_2519
HTUHtur_0969
HSALJMJ58_04095
HAKZJ0X25_11910
NMGNmag_3160(trm56)
HXAHalxa_2543
NATNJ7G_3541
NPENatpe_2672
NVRFEJ81_12335
NPLFGF80_11985
NAYHYG81_15520
HALYHYG82_20495
HJTDVR14_03340
HLOJ0X27_16775
NGENatgr_0523
HRUHalru_1278
SAWLNGM29_18195
HALVNGM15_09365
NOUNatoc_1132
HLRHALLA_09300
HLCCHINAEXTREME18705
NAJB1756_02900
NAGAArcMg_1377
NANAArc1_2240
NARAQQ977_04110
NBGDV706_02730
NASGCU68_10815
HDABB347_03560
NACAQV86_02070
MEAMMU439_06315
MEAEQEN48_03830
TACTa0931
TVOTVG1129508(TVG1129508)
PTOPTO0696
FACFACI_IFERC01G0561
FAIFAD_1482
CDIVCPM_1236
TARTALC_01531
MAXMMALV_16540
MERMMINT_17500
MEARMpt1_c13980
MEUZKRP56_00100
ABIAboo_0493
ACFAciM339_0550
APEAPE_2006.1
ACJACAM_1260
SMRSmar_0917
SHCShell_1548
IHOIgni_1123
IISEYM_02835
IPCIPA_03690
DKADKAM_1271
DFDDesfe_1372
DMUDesmu_1262
TAGTagg_1277
IAGIgag_0104
THGTCELL_0275
HBUHbut_1137
PDLPyrde_1218
PABIPABY_10630
PAREPYJP_04690
STOSTK_03330
SOHD1869_01275
SSOSSO0267
SOLSsol_1245
SSOASULA_1286
SSOLSULB_1287
SSOFSULC_1285
SSHIJ5U23_03199
SCASSACC_01980
SAISaci_0653
SACNSacN8_03155
SACRSacRon12I_03145
SACSSUSAZ_02945
SISLS215_1972
SIAM1425_1863
SIMM1627_1950
SIDM164_1880
SIYYG5714_1949
SINYN1551_0973
SIILD85_2092
SIHSiH_1809
SIRSiRe_1729
SICSiL_1723
SULEGFS03_10250
SULOGFS33_02065
SULLEWF20_02725
MSEMsed_2278
MEMJMJ1HA_2603
MCNMcup_2024
MHKDFR87_06875
MPRUDFR88_06805
MTENGWK48_05280
MJNMjAS7_0572
ABRIDFR85_07360
SACDHS1genome_0362
SAZOD1868_02015
CSTYKN1_18970
STEPIC006_1763
SMETRQ359_000079
SAHSHS7_08150
TPETpen_0709
THBN186_04900
TCBTCARB_0041
THFMA03_06215
THELIG193_04215
ASCASAC_0292
ACIASE86_02260
CLGCalag_1284
FFOFFONT_0828
NMRNmar_1606
NIRNSED_08695
NKRNKOR_08735
NIDNPIRD3C_0448
NINNADRNF5_0279
NIWNisw_05860
NCLC5F47_08420
NOXC5F49_08305
NUEC5F50_11680
NIPNsoK4_00235
NZTNZOSNM25_000178
NCTNMSP_1548
NICDSQ20_09330
NGANgar_c34950
NVNNVIE_018330
NEVNTE_00448
TAANMY3_03713
NFNNFRAN_1002
NCVNCAV_0128
CSYCENSYa_1737
CSUCSUB_C1670
NBVT478_1324
TAHSU86_005110
NIUDSQ19_00930
NDVNDEV_1964
BARCAOA65_2251
BARBAOA66_0957
MARHMia14_0749
FLTSv326_1102
NCONLC1Nh_0240(atrm56)
AGWQT03_C0001G1078
ARGQT11_C0001G0013
 » show all
Reference
1  [PMID:15987815]
  Authors
Renalier MH, Joseph N, Gaspin C, Thebault P, Mougin A
  Title
The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP.
  Journal
RNA 11:1051-63 (2005)
DOI:10.1261/rna.2110805
  Sequence
[pab:PAB1040]
Reference
2  [PMID:18068186]
  Authors
Kuratani M, Bessho Y, Nishimoto M, Grosjean H, Yokoyama S
  Title
Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA.
  Journal
J Mol Biol 375:1064-75 (2008)
DOI:10.1016/j.jmb.2007.11.023
  Sequence
[pho:PH0461]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.206
IUBMB Enzyme Nomenclature: 2.1.1.206
ExPASy - ENZYME nomenclature database: 2.1.1.206
BRENDA, the Enzyme Database: 2.1.1.206

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