KEGG   ENZYME: 2.1.1.213Help
Entry
EC 2.1.1.213                Enzyme                                 

Name
tRNA (guanine10-N2)-dimethyltransferase;
PAB1283;
N(2),N(2)-dimethylguanosine tRNA methyltransferase;
Trm-G10;
PabTrm-G10;
PabTrm-m2 2G10 enzyme
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (guanine10-N2)-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + guanine10 in tRNA = 2 S-adenosyl-L-homocysteine + N2-dimethylguanine10 in tRNA (overall reaction);
(1a) S-adenosyl-L-methionine + guanine10 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA;
(1b) S-adenosyl-L-methionine + N2-methylguanine10 in tRNA = S-adenosyl-L-homocysteine + N2-dimethylguanine10 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
guanine10 in tRNA;
N2-methylguanine10 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N2-dimethylguanine10 in tRNA;
N2-methylguanine10 in tRNA
History
EC 2.1.1.213 created 2011 (EC 2.1.1.32 created 1972, part transferred 2011 to EC 2.1.1.213)
Orthology
K07446  tRNA (guanine10-N2)-dimethyltransferase
Genes
SBE: RAAC3_TM7C01G0591
MJA: MJ_0710
MFE: Mefer_1079
MVU: Metvu_1454
MFS: MFS40622_1461
MIF: Metin_0546
MJH: JH146_1190
MIG: Metig_1747
MMP: MMP0149
MMQ: MmarC5_1526
MMD: GYY_00760
MAE: Maeo_0667
MVO: Mvol_1562
MTH: MTH_724
METC: MTCT_0646
MWO: MWSIV6_1099(trmG10)
METE: tca_00694(vspIM)
MST: Msp_1319
MSI: Msm_0352
MRU: mru_1440
MEB: Abm4_0970
MMIL: sm9_0677
MEYE: TL18_03240
MOL: YLM1_0942
METH: MBMB1_0336(trmG10)
MFC: BRM9_1932
MFI: DSM1535_0119(trmG10)
MCUB: MCBB_0309(trmG10)
MFV: Mfer_0515
MKA: MK0894
AFU: AF_1257
FPL: Ferp_2537
GAC: GACE_0300
GAH: GAH_00011
TAC: Ta1417
PTO: PTO0412
FAI: FAD_1651
CDIV: CPM_1388
MARC: AR505_1586
ABI: Aboo_0103
PHO: PH0338(PH0338)
PAB: PAB1283
PFU: PF0400
PFI: PFC_01085
PYN: PNA2_0953
PYS: Py04_0652
TKO: TK0981
TON: TON_0891
TGA: TGAM_1324
TSI: TSIB_0468
THE: GQS_00605
THA: TAM4_1865
THM: CL1_1819
TLT: OCC_04989
THS: TES1_0358
TNU: BD01_0690
TEU: TEU_09025
PPAC: PAP_05445
MAC: MA_0209(trmL)
MBAR: MSBR2_2146
MBAK: MSBR3_2213
MMA: MM_1496
MMAC: MSMAC_3192
METM: MSMTP_3078
MTHE: MSTHC_1296
MTHR: MSTHT_1988
MHOR: MSHOH_3910
MBU: Mbur_1623
MMET: MCMEM_2120
MMH: Mmah_0030
MPY: Mpsy_1912
MTP: Mthe_1006
MCJ: MCON_2920
MHI: Mhar_0314
MHU: Mhun_0125
MLA: Mlab_0420
MEMA: MMAB1_2361(trmL)
MPI: Mpet_0674
MBN: Mboo_1210
MPL: Mpal_2321
MPD: MCP_2859
MEZ: Mtc_0295(trmL)
RCI: RCIX421(trmL)
HAL: VNG_2242C
HSL: OE_4144R(trmG10)
HHB: Hhub_3599(trmG10)
HALH: HTSR_0164
HHSR: HSR6_0160
HMA: rrnAC2834
HHI: HAH_0111
NPH: NP_1066A(trmG10)
NMO: Nmlp_3498(trmG10)
HUT: Huta_1249
HTI: HTIA_1151
HMU: Hmuk_0722
HWA: HQ_3407A(trmG10)
HWC: Hqrw_3933(trmG10)
HVO: HVO_0156(trmG10)
HME: HFX_0158
HLA: Hlac_2630
HTU: Htur_0132
NMG: Nmag_1864(trmG10)
NAT: NJ7G_0583
SALI: L593_02760
APE: APE_1835
ACJ: ACAM_1152
SMR: Smar_1237
IHO: Igni_0619
IIS: EYM_01565
DKA: DKAM_0539
TAG: Tagg_0138
IAG: Igag_0007
HBU: Hbut_0330
STO: STK_09470
SSO: SSO1044
SOL: Ssol_2015
SSOA: SULA_2048
SSOL: SULB_2049
SSOF: SULC_2047
SAI: Saci_1283
SID: M164_1166
SII: LD85_1293
SIH: SiH_1137
SIR: SiRe_1051
SIC: SiL_1060
MSE: Msed_1789
MCN: Mcup_0444
AHO: Ahos_1244
TUZ: TUZN_2058
VDI: Vdis_1816
VMO: VMUT_0257
TPE: Tpen_0700
ASC: ASAC_0193
NMR: Nmar_1775
NCT: NMSP_1692
NDV: NDEV_0030
NEQ: NEQ440
KCR: Kcr_1457
BARC: AOA65_0743
BARB: AOA66_0366
 » show all
Taxonomy
Reference
1  [PMID:15210688]
  Authors
Armengaud J, Urbonavicius J, Fernandez B, Chaussinand G, Bujnicki JM, Grosjean H
  Title
N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota.
  Journal
J Biol Chem 279:37142-52 (2004)
DOI:10.1074/jbc.M403845200
  Sequence
[pab:PAB1283]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.213
IUBMB Enzyme Nomenclature: 2.1.1.213
ExPASy - ENZYME nomenclature database: 2.1.1.213
BRENDA, the Enzyme Database: 2.1.1.213

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