KEGG ENZYME: 2.1.1.213

ENZYME: 2.1.1.213

Entry

EC 2.1.1.213                Enzyme

Name

tRNA (guanine10-N2)-dimethyltransferase;
PAB1283;
N(2),N(2)-dimethylguanosine tRNA methyltransferase;
Trm-G10;
PabTrm-G10;
PabTrm-m2 2G10 enzyme

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:tRNA (guanine10-N2)-dimethyltransferase

Reaction(IUBMB)

2 S-adenosyl-L-methionine + guanine10 in tRNA = 2 S-adenosyl-L-homocysteine + N2-dimethylguanine10 in tRNA (overall reaction);
(1a) S-adenosyl-L-methionine + guanine10 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA;
(1b) S-adenosyl-L-methionine + N2-methylguanine10 in tRNA = S-adenosyl-L-homocysteine + N2-dimethylguanine10 in tRNA

Substrate

S-adenosyl-L-methionine [CPD:C00019];
guanine10 in tRNA;
N2-methylguanine10 in tRNA

Product

S-adenosyl-L-homocysteine [CPD:C00021];
N2-dimethylguanine10 in tRNA;
N2-methylguanine10 in tRNA

History

EC 2.1.1.213 created 2011 (EC 2.1.1.32 created 1972, part transferred 2011 to EC 2.1.1.213)

Orthology

K07446

tRNA (guanine10-N2)-dimethyltransferase

Genes

PPM:	PPSC2_05755(rumA)

PPO:	PPM_1083(rumA)

PPOL:

X809_05760

PPOY:

RE92_06130

PTA:	HPL003_13815

PPEO:

ABE82_05860

PVO:	PVOR_28994

PBAC:

HUB98_23105

CBZ:

Cbs_5041

CBEI:

LF65_05719

CSR:	Cspa_c57580

CBV:

U729_2969

CBUT:

ATN24_01095

CDY:	F3K33_25850

CALE:

FDN13_13510

MBJ:	KQ51_00080

MJA:

MJ_0710

MFE:	Mefer_1079

MVU:	Metvu_1454

MFS:	MFS40622_1461

MIF:	Metin_0546

MJH:	JH146_1190

MESG:

MLAUSG7_0857(trmG)

MESA:

MLASG1_0918

MIG:	Metig_1747

MMP:

MMP0149

MMQ:	MmarC5_1526

MMX:	MmarC6_0801

MMZ:	MmarC7_1149

MMD:

GYY_00760

MMAK:

MMKA1_01540

MMAO:

MMOS7_01800

MMAD:

MMJJ_09360

MAE:

Maeo_0667

MVN:	Mevan_1154

MVO:

Mvol_1562

MOK:	Metok_1400

METF:

CFE53_02650

MTH:

MTH_724

MMG:	MTBMA_c11200

MWO:	MWSIV6_1099(trmG10)

MTEE:

MTTB_07780

METC:

MTCT_0646

METE:

tca_00694(vspIM)

METZ:

METMT2_0571

METK:

FVF72_07920

MTHM:

FZP57_05210

METJ:

FZP68_00995

MST:

Msp_1319

METB:

AW729_08945

MRU:

mru_1440

MSI:

Msm_0352

MEB:

Abm4_0970

MMIL:

sm9_0677

MEYE:

TL18_03240

MOL:

YLM1_0942

MARO:

MarbSA_03580

METV:

K4897_02270

MEL:	Metbo_2365

MEW:	MSWAN_0291

METH:

MBMB1_0336(trmG10)

MFC:

BRM9_1932

MFI:	DSM1535_0119(trmG10)

MCUB:

MCBB_0309(trmG10)

MSUB:

BK009_11860

METN:

BK008_07500

METT:

CIT01_01345

METO:

CIT02_05165

MEME:

HYG87_02905

MFV:

Mfer_0515

MKA:

MK0894

AFU:

AF_1257

AFG:	AFULGI_00013550

APO:	Arcpr_1299

AVE:	Arcve_0093

AST:	Asulf_00856

FPL:

Ferp_2537

GAC:

GACE_0300

GAH:

GAH_00011

PFU:

PF0400

PFI:

PFC_01085

PHO:	PH0338(PH0338)

PAB:

PAB1283

PYN:

PNA2_0953

PYA:	PYCH_18020

PYS:

Py04_0652

PYC:	TQ32_03620

TKO:

TK0981

TON:

TON_0891

TGA:

TGAM_1324

TSI:

TSIB_0468

TBA:	TERMP_00282

THE:

GQS_00605

THA:

TAM4_1865

THM:

CL1_1819

TLT:

OCC_04989

THS:

TES1_0358

TNU:

BD01_0690

TEU:

TEU_09025

TGY:	X802_09795

THV:	ADU37_CDS03990

TCH:	CHITON_1165

TPEP:

A0127_00245

TPIE:

A7C91_10630

TGG:	A3K92_03910

TCE:	A3L02_02975

TBS:	A3L01_05130

THH:	CDI07_05070

TSL:	A3L11_09295

TTD:	A3L14_07470

TPRF:

A3L09_05870

TRL:	A3L10_01515

TPAF:

A3L08_08385

THY:	A3L12_07345

TIC:	FH039_06660

TCQ:	TIRI35C_1316(trmG)

THEM:

FPV09_02790

THEI:

K1720_05460

PPAC:

PAP_05445

MBA:	Mbar_A1330

MBY:	MSBRM_0234

MBW:	MSBRW_3395

MBAR:

MSBR2_2146

MBAK:

MSBR3_2213

MAC:	MA_0209(trmL)

MMA:

MM_1496

MMAZ:

MmTuc01_1551

MMJ:	MSMAS_3172

MMAC:

MSMAC_3192

MVC:	MSVAZ_0234

MEK:	MSKOL_0227

MLS:	MSLAZ_0124

METM:

MSMTP_3078

MEF:	MSWH1_0145

MEQ:	MSWHS_0144

MSJ:	MSSAC_0182

MSZ:	MSSIH_0168

MSW:	MSSIT_0172

MTHR:

MSTHT_1988

MTHE:

MSTHC_1296

MHOR:

MSHOH_3910

MFZ:	AOB57_009260

MBU:

Mbur_1623

MMET:

MCMEM_2120

MELO:

J7W08_09565

MMH:

Mmah_0030

MHAZ:

BHR79_03315

MEV:	Metev_0088

MZH:	Mzhil_0084

MPY:

Mpsy_1912

MZI:	HWN40_12645

MHZ:	Metho_0141

MTP:

Mthe_1006

MCJ:

MCON_2920

MHI:

Mhar_0314

MHU:

Mhun_0125

MRTJ:

KHC33_13585

MLA:

Mlab_0420

MEM:	Memar_1059

MBG:	BN140_1828

MEMA:

MMAB1_2361(trmL)

MCHK:

MchiMG62_11920

MSUM:

OH143_12020

MPI:

Mpet_0674

MBN:

Mboo_1210

MFO:	Metfor_1651

MPL:

Mpal_2321

MPD:

MCP_2859

MEZ:	Mtc_0295(trmL)

RCI:	RCIX421(trmL)

HAL:

VNG_2242C

HSL:	OE_4144R(trmG10)

HDL:	HALDL1_02260

HHB:	Hhub_3599(trmG10)

HAGS:

JT689_10395

HABO:

JRZ79_08770

HNO:	LT974_00030

HLU:	LT972_13520

HANR:

LJ422_09045

HJE:	HacjB3_02115

HALH:

HTSR_0164

HHSR:

HSR6_0160

HSU:	HLASF_2052

HSF:	HLASA_2086

SALR:

FQU85_04115

HALR:

EFA46_003460

HAAD:

MW046_08615

HALX:

M0R89_05055

HAXZ:

M0R88_05040

SALI:

L593_02760

SAIM:

K0C01_07590

HARA:

AArcS_0165(trm11)

HMA:

rrnAC2834

HHI:

HAH_0111

HHN:	HISP_00630

HTA:	BVU17_00525

HALJ:

G9465_02075

HSIN:

KDQ40_12860

NPH:	NP_1066A(trmG10)

NMO:	Nmlp_3498(trmG10)

NHO:	HWV23_11050

NSAL:

HWV07_11815

HUT:

Huta_1249

HTI:

HTIA_1151

HALA:

Hrd1104_09770

HMU:

Hmuk_0722

HALZ:

E5139_06790

HALL:

LC1Hm_3234(trmG10)

HAZP:

GBQ70_06785

HALI:

BV210_09895

HSN:	DV733_00520

HDS:	HSR122_2314(trm11)

HRR:	HZS55_03205

HPEL:

HZS54_02885

HLT:	I7X12_09280

HARC:

HARCEL1_01645

HDO:	MUK72_03215

SSAI:

N0B31_13395

HWA:	HQ_3407A(trmG10)

HWC:	Hqrw_3933(trmG10)

HVO:	HVO_0156(trmG10)

HME:

HFX_0158

HGI:	ABY42_00740

HALE:

G3A49_01185

HBO:	Hbor_00050

HAQ:	DU484_01165

HAJ:	DU500_01730

HAER:

DU502_17210

HRA:	EI982_13805

HLM:	DV707_00940

HALM:

FCF25_07425

HLA:

Hlac_2630

HALP:

DOS48_13190

HALB:

EKH57_10770

HALQ:

Hrr1229_007435

HSS:	J7656_01885

HSAI:

HPS36_07420

HAZZ:

KI388_13025

SRUB:

C2R22_19475

HAE:	halTADL_1734

HALN:

B4589_010590

HALG:

HUG10_12425

HALU:

HUG12_03245

HMP:	K6T50_09090

HRE:	K6T36_08860

HRM:	K6T25_07030

HACB:

Hbl1158_01005

HDF:	AArcSl_2334

HAH:	Halar_2967

HTU:

Htur_0132

HDA:	BB347_14935

HSAL:

JMJ58_08655

HLO:	J0X27_09740

HAKZ:

J0X25_07165

NMG:	Nmag_1864(trmG10)

HXA:	Halxa_1252

NAT:

NJ7G_0583

NPE:	Natpe_0114

NVR:	FEJ81_00600

NPL:	FGF80_00515

NAY:	HYG81_10080

HALY:

HYG82_14025

HJT:	DVR14_09975

NGE:	Natgr_1800

HRU:	Halru_0525

HALV:

NGM15_11825

NOU:	Natoc_3966

HLR:	HALLA_18860

HLC:	CHINAEXTREME05265

NAJ:	B1756_06710

NAG:	AArcMg_0313

NAN:	AArc1_0322

NBG:	DV706_05880

NAS:	GCU68_05635

SAWL:

NGM29_02195

NAC:	AQV86_02120

MELU:

MTLP_08430

MEAM:

MU439_05595

TAC:

Ta1417

PTO:

PTO0412

FAC:	FACI_IFERC01G0757

FAI:

FAD_1651

CDIV:

CPM_1388

TAR:	TALC_00274

MAX:	MMALV_02580

MER:	MMINT_05950

MEAR:

Mpt1_c10930

MEUZ:

KRP56_01375

MARC:

AR505_1586

ABI:

Aboo_0103

ACF:	AciM339_0947

APE:

APE_1835

ACJ:

ACAM_1152

SMR:

Smar_1237

SHC:	Shell_1218

IHO:

Igni_0619

IIS:

EYM_01565

DKA:

DKAM_0539

DFD:	Desfe_0585

DMU:	Desmu_0588

TAG:

Tagg_0138

IAG:

Igag_0007

THG:	TCELL_0071

HBU:

Hbut_0330

PFM:	Pyrfu_1793

PDL:	Pyrde_0349

STO:

STK_09470

SOH:	D1869_06575

SSO:

SSO1044

SOL:

Ssol_2015

SSOA:

SULA_2048

SSOL:

SULB_2049

SSOF:

SULC_2047

SSHI:

J5U23_02439

SCAS:

SACC_09250

SAI:

Saci_1283

SACN:

SacN8_06260

SACR:

SacRon12I_06255

SACS:

SUSAZ_06125

SIS:	LS215_1274

SIA:	M1425_1177

SIM:	M1627_1241

SID:

M164_1166

SIY:	YG5714_1173

SIN:	YN1551_1678

SII:

LD85_1293

SIH:

SiH_1137

SIR:

SiRe_1051

SIC:

SiL_1060

SULA:

BFU36_01290

SULE:

GFS03_06710

SULO:

GFS33_12120

SULL:

EWF20_07805

MSE:

Msed_1789

MEMJ:

MJ1HA_2043

MCN:

Mcup_0444

MHK:	DFR87_09690

MPRU:

DFR88_09265

MTEN:

GWK48_02580

MJN:	MjAS7_2941

AHO:

Ahos_1244

AMAN:

B6F84_10515

ABRI:

DFR85_11195

ASUL:

DFR86_09005

AAMB:

D1866_01120

ACIH:

HS5_26390

SACD:

HS1genome_0984

SAZO:

D1868_00245

CSTY:

KN1_15380

STEP:

IC006_0862

SAHS:

HS7_19810

PIS:

Pisl_1659

PCL:

Pcal_0592

TNE:

Tneu_0686

PYW:	PYWP30_00726

TTN:

TTX_1476

VDI:

Vdis_1816

VMO:

VMUT_0257

TPE:

Tpen_0700

THB:	N186_04660

TCB:	TCARB_1959

THEL:

IG193_03970

ASC:

ASAC_0193

ACIA:

SE86_01750

CLG:	Calag_1453

FFO:	FFONT_0990

NMR:

Nmar_1775

NIR:	NSED_09510

NKR:	NKOR_09445

NID:	NPIRD3C_0231

NIN:	NADRNF5_0092

NIW:	Nisw_05135

NCL:	C5F47_09190

NOX:	C5F49_09075

NUE:	C5F50_12510

NIP:	NsoK4_09425

NZT:	NZOSNM25_000029

NCT:

NMSP_1692

NIC:	DSQ20_10080

CSU:	CSUB_C1072

TAH:	SU86_006100

NIU:	DSQ19_10385

NDV:

NDEV_0030

CCAI:

NAS2_0115

KCR:

Kcr_1457

BARC:

AOA65_0743

BARB:

AOA66_0366

NEQ:

NEQ440

NCON:

LC1Nh_0244(trmG10)

» show all

Reference

1 [PMID:15210688]

Authors

Armengaud J, Urbonavicius J, Fernandez B, Chaussinand G, Bujnicki JM, Grosjean H

Title

N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota.

Journal

J Biol Chem 279:37142-52 (2004)
DOI:10.1074/jbc.M403845200

Sequence

[pab:PAB1283]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.213

IUBMB Enzyme Nomenclature:

2.1.1.213

ExPASy - ENZYME nomenclature database:

2.1.1.213

BRENDA, the Enzyme Database:

2.1.1.213

All links

Gene (3498)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (389)   
   KEGG MGENES (2414)   
   RefGene (694)   
Protein sequence (698)   
   UniProt (364)   
   SWISS-PROT (5)   
   RefSeq(pep) (329)   
DNA sequence (707)   
   RefSeq(nuc) (491)   
   GenBank (117)   
   EMBL (99)   
Protein domain (5)   
   InterPro (5)   
All databases (4908)   

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