Entry
Name
tRNA (guanine26-N2)-dimethyltransferase;
Trm1p;
TRM1;
tRNA (m22G26)dimethyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (guanine26-N2)-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + guanine26 in tRNA = 2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
guanine26 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
N2-dimethylguanine26 in tRNA
Comment
The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions. In contrast to EC
2.1.1.215 , tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase, this enzyme does not catalyse the methylation of guanine27 in tRNA.
History
EC 2.1.1.216 created 2011 (EC 2.1.1.32 created 1972, part transferred 2011 to EC 2.1.1.216)
Orthology
K00555 tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase
Genes
PPS : 100989807(TRMT1) 100991487
CANG : 105520924(TRMT1) 105524074
XLA : 100158298(trmt1.L) 108703489
SANH : 107691282 107695061
SGH : 107556090(trmt1) 107581597
CAUA : 113055378 113111045
CGIB : 127968649 128022202
SASA : 100380529(trmt1) 106590623
STRU : 115147424 115191194
CCLU : 121554000(trmt1) 123482793
ARUT : 117401987 117971989
DSI : Dsimw501_GD23837(Dsim_GD23837)
AALB : 115265621 115265638
ACER : 107996260 107996295
PXY : 105381762 105392995 105395668
PPOI : 119113815 119114045 119114047
DPTE : 113788692 113791028
CSCU : 111614848 111628362 111628363 111628364
CBR : CBG_04743(Cbr-trm-1)
BMY : BM_BM7373(Bma-trm-1)
PMAX : 117334272 117335197
SHX : MS3_00005870(TRMT1_1)
ATH : AT3G02320 AT3G56330 AT5G15810
ALY : 9309812 9314147 9318289
CRB : 111831609 17884030 17887196
CSAT : 104705865 104712294 104735604 104744301 104763786 104769826 104781533 104791930
EUS : EUTSA_v10005995mg EUTSA_v10013036mg
BRP : 103841541 103842972 103846383 103856163
BNA : 106349208 106350869 106352282 106367969 106368087 106372181 106404184 106424644 106432187 106432374 106433224
BOE : 106307838 106309718 106313184 106331371 106340912
RSZ : 108806281 108814103 108831250 108846951 108848061 108856528
THJ : 104802987 104823883 104824240 104827143
CPAP : 110819396 110820184
CIC : CICLE_v10011357mg CICLE_v10031828mg
MINC : 123193378 123198201 123225275
GRA : 105770416 105801633 105803527
GHI : 107892004 107901433 107904453 107910492 107954895
GAB : 108453755 108461061 108470478
DZI : 111306531 111310038 111314592
EGR : 104422044 104422046 104454457
GMX : 100777825 100788340 100800256
GSJ : 114381439 114400326 114415701
PVU : PHAVU_004G041500g PHAVU_009G142000g
CCAJ : 109797058 109818992
APRC : 113852669 113867140
PSAT : 127080667 127120968
LJA : Lj0g3v0159199.1(Lj0g3v0159199.1) Lj0g3v0302739.1(Lj0g3v0302739.1) Lj1g3v1182040.1(Lj1g3v1182040.1) Lj1g3v1182040.2(Lj1g3v1182040.2)
ADU : 107470216 107471370 107486515 107486580
AIP : 107623370 107623728 107635468
AHF : 112715807 112716541 112744627 112783407 112784026 112797928 112797998
LANG : 109326091 109336434 109347393
PMUM : 103329574 103332883
PAVI : 110745759 110759076
PDUL : 117619507 117623133
MDM : 103404653 103432969 103438303 103438311 103442444
PXB : 103926582 103953757 103953788 103962738
ZJU : 107413964 107414014 107416403
MCHA : 111006460 111015931
CMAX : 111484232 111487439
CMOS : 111447941 111456770
CPEP : 111792243 111804902
HBR : 110648173 110668069 110668099 110672354 110672437 110672440
MESC : 110609098 110619101 110630617
POP : 18107341 7479026 7480595
PEU : 105113940 105115387 105123257
PALZ : 118034464 118042707 118055062
CILL : 122292663 122303020
QSU : 111985068 111990692 112004760 112019694
TWL : 119980105 119993354 120012524
SPEN : 107011639 107023339
SOT : 102584325 102598925 102602420
SSTN : 125847795 125858443 125872100
CANN : 107860425 107874267
NTA : 107760972 107766715 107776095 107829593 107830261 107831243
NSY : 104214318 104233789 104248195
NTO : 104090994 104092993 104115936
NAU : 109212728 109216307 109235314
INI : 109153714 109186684 109189065
ITR : 116000035 116013735 116019774
SIND : 105160800 105167525 105177544
OEU : 111373612 111373613 111379068 111397915
EGT : 105960898 105971568 105977550
SSPL : 121756415 121765739 121768717 121771998
APAN : 127244511 127259544
HAN : 110869035 110879172 110904262
ECAD : 122587070 122603571 122605375
CCAV : 112513159 112513168 112515371 112523361
DCR : 108196587 108211066 108216751
CSIN : 114256378 114257935
CQI : 110703543 110704475 110705782 110723181
NNU : 104593784 104597893 104599725
MING : 122076627 122079354 122090660
TSS : 122654261 122655387 122664584
PSOM : 113275758 113281846 113283713
OSA : 4334353 4338419 4348435
DOSA : Os03t0786700-01(Os03g0786700) Os10t0357800-01(Os10g0357800)
OBR : 102702545 102711619 102711648
OGL : 127753001 127768495 127772892
BDI : 100825731 100832805 100833677 100843496
ATS : 109747522 109762476 109785912
TDC : 119270377 119278512 119285267 119290837 119353277 119362398
TAES : 123043681 123051549 123063382 123072361 123080600 123085438 123092607 123097914 123187476
TUA : 125535642 125535643 125545978
LPER : 127294422 127296022 127333813
SBI : 8055064 8066754 8084941
ZMA : 100274276 100275038 100276957 100382564
SITA : 101755654 101757831 101772693
SVS : 117839515 117850736 117852482
PVIR : 120652853 120665900 120688609 120699120
PHAI : 112877368 112884710
PDA : 103704210 103720406 103722879
EGU : 105057165 105057196 105058114
ZOF : 121969352 121974470 121983808 122020467 122024268 122036968 122055397
DCT : 110094587 110094822 110095593 110106862
NCOL : 116251364 116253967 116259181
SMO : SELMODRAFT_132457 SELMODRAFT_153186 SELMODRAFT_159602
CRE : CHLRE_10g422000v5 CHLRE_10g428100v5
VCN : VOLCADRAFT_42766 VOLCADRAFT_60094
MNG : MNEG_12498 MNEG_15282
OLU : OSTLU_16869 OSTLU_17464
OTA : OT_ostta03g04970 OT_ostta09g03580 OT_ostta11g03270
MIS : MICPUN_68581 MICPUN_98316
MPP : MICPUCDRAFT_35450 MICPUCDRAFT_56104
CME : CYME_CMS136C CYME_CMS167C
NCS : NCAS_0B03760(NCAS0B03760)
NDI : NDAI_0J01300(NDAI0J01300)
TPF : TPHA_0A01730(TPHA0A01730)
TBL : TBLA_0H01440(TBLA0H01440)
TDL : TDEL_0F04010(TDEL0F04010)
KAF : KAFR_0B05430(KAFR0B05430)
KNG : KNAG_0H03160(KNAG0H03160)
CAL : CAALFM_CR00900WA(TRM1)
NTE : NEUTE1DRAFT60425(NEUTE1DRAFT_60425)
BFU : BCIN_01g01230(Bctrm1)
ANG : ANI_1_2058014(An01g00070)
ABP : AGABI1DRAFT97610(AGABI1DRAFT_97610)
ABV : AGABI2DRAFT183183(AGABI2DRAFT_183183)
SCM : SCHCO_081492(SCHCODRAFT_081492)
EHI : EHI_148760(1.t00080)
TET : TTHERM_001166292 TTHERM_00636860
SMIN : v1.2.034519.t1(symbB.v1.2.034519.t1)
AAF : AURANDRAFT_1191 AURANDRAFT_34606
SPAR : SPRG_03801 SPRG_12516
EHX : EMIHUDRAFT_120570 EMIHUDRAFT_464575 EMIHUDRAFT_467307 EMIHUDRAFT_471752 EMIHUDRAFT_51353
GTT : GUITHDRAFT_159001 GUITHDRAFT_40201 GUITHDRAFT_98999
TVA : TVAG_2v0236120 TVAG_2v0481310
SYR : SynRCC307_1690(trm1)
SYX : SynWH7803_1642(trm1)
SYNW : SynWH8103_00781(trm1)
MKA : MK0154(trm1_1) MK0189(trm1_2)
TVO : TVG0752240(TVG0752240)
LOKI : Lokiarch_25110(trm1)
» show all
Taxonomy
Reference
Authors
Constantinesco F, Motorin Y, Grosjean H
Title
Characterisation and enzymatic properties of tRNA(guanine 26, N (2), N (2))-dimethyltransferase (Trm1p) from Pyrococcus furiosus.
Journal
Sequence
Reference
Authors
Constantinesco F, Benachenhou N, Motorin Y, Grosjean H
Title
The tRNA(guanine-26,N2-N2) methyltransferase (Trm1) from the hyperthermophilic archaeon Pyrococcus furiosus: cloning, sequencing of the gene and its expression in Escherichia coli.
Journal
Sequence
Reference
Authors
Liu J, Liu J, Straby KB
Title
Point and deletion mutations eliminate one or both methyl group transfers catalysed by the yeast TRM1 encoded tRNA (m22G26)dimethyltransferase.
Journal
Sequence
Reference
Authors
Liu J, Zhou GQ, Straby KB
Title
Caenorhabditis elegans ZC376.5 encodes a tRNA (m2/2G(26))dimethyltransferance in which (246)arginine is important for the enzyme activity.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.216