| Entry |
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| Name |
tRNA (adenine22-N1)-methyltransferase;
TrmK;
YqfN;
Sp1610 (gene name);
tRNA: m1A22 methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:tRNA (adenine22-N1)-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + adenine22 in tRNA = S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
adenine22 in tRNA
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
N1-methyladenine22 in tRNA
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| Comment |
The enzyme specifically methylates adenine22 in tRNA.
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| History |
EC 2.1.1.217 created 2011 (EC 2.1.1.36 created 1972, part transferred 2011 to EC 2.1.1.217)
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| Orthology |
| K06967 | tRNA (adenine22-N1)-methyltransferase |
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| Genes |
| PMUD: | NCTC8068_03498(trmK) |
| PCHP: | C4K32_2337 C4K32_2663 |
| PTAE: | NCTC10697_02751(trmK) |
| PLG: | NCTC10937_01998(trmK) |
| BAZ: | BAMTA208_12920(trmK) |
| BSON: | S101395_01828(trmK) |
| BFD: | NCTC4823_01823(trmK) |
| BLEN: | NCTC4824_01677(trmK) |
| SDP: | NCTC12225_01446(trmK) |
| SPIC: | SAMEA4384060_1388(trmK) |
| SSH: | NCTC13712_01557(trmK) |
| SSIM: | SAMEA4384339_1451(trmK) |
| SSTE: | SAMEA4384403_1202(trmK) |
| MCAK: | MCCS_14970(trmK_1) MCCS_15360(trmK_2) |
| LGZ: | NCTC10812_01404(trmK) |
| GMO: | NCTC11323_00454(trmK) |
| GHA: | NCTC10459_01308(trmK) |
| COHN: | KCTCHS21_41130(trmK) |
| SVB: | NCTC12167_01183(trmK) |
| SMEN: | SAMEA4412692_0956(trmK) |
| SFER: | NCTC12278_00713(trmK) |
| SCAI: | NCTC12191_01424(trmK) |
| SPSU: | NCTC13786_00453(trmK) |
| SPOC: | NCTC10925_00745(trmK) |
| SAUP: | NCTC3168_01866(trmK) |
| SURN: | NCTC13766_01381(trmK) |
| SVF: | NCTC3166_00881(trmK) |
| SMIE: | NCTC11169_00614(trmK) |
| LOR: | AYI71_01325 AYI71_14575 |
| LAH: | LA20533_00070 LA20533_08250 |
| ECEC: | NCTC12421_01182(trmK) |
| CCOH: | SAMEA4530647_1774(trmK) |
| BPRO: | PMF13cell1_04414(trmK) |
| CSCI: | HDCHBGLK_02809(trmK) |
| PHX: | KGNDJEFE_01708(trmK) |
| KME: | H0A61_02594(trmK_1) H0A61_02596(trmK_2) |
| PHAR: | NCTC13077_00943(trmK) |
| PIV: | NCTC13079_00598(trmK) |
| VRM: | 44547418_01271(trmK) |
| VDN: | NCTC11831_00687(trmK) |
| MANA: | MAMMFC1_03512(trmK) |
| PFAC: | PFJ30894_02022(trmK) |
| MMYI: | mycmycITA_00507(trmK) |
| MCAP: | MCCPF38_00595(trmK) |
| MCAR: | MCCPILRI181_00594(trmK) |
| AHK: | NCTC10172_00060(trmK) |
| AAXA: | NCTC10138_01388(trmK) |
| MTAB: | MTABA_v1c02830(trmK) |
| MCOL: | MCOLE_v1c02900(trmK) |
| EML: | EMELA_v1c03860(trmK) |
| EFR: | EFREU_v1c03550(trmK) |
| ELJ: | ELUMI_v1c06420(trmK) |
| ESX: | ESOMN_v1c04040(trmK) |
| SCR: | SCHRY_v1c03310(trmK) |
| SSYR: | SSYRP_v1c03500(trmK) |
| SDI: | SDIMI_v3c05810(trmK) |
| STAI: | STAIW_v1c08190(trmK) |
| SAPI: | SAPIS_v1c06910(trmK) |
| SATR: | SATRI_v1c08820(trmK) |
| SCQ: | SCULI_v1c07260(trmK) |
| SSAB: | SSABA_v1c03240(trmK) |
| SERI: | SERIO_v1c08590(trmK) |
| SLL: | SLITO_v1c02970(trmK) |
| SCJ: | SCANT_v1c07200(trmK) |
| SHJ: | SHELI_v1c06640(trmK) |
| SFZ: | SFLOR_v1c07760(trmK) |
| SCOU: | SCORR_v1c02820(trmK) |
| SPRN: | S100390_v1c03450(trmK) |
| SPIT: | STU14_v1c03450(trmK) |
| STAB: | STABA_v1c07410(trmK) |
| SMOO: | SMONO_v1c05450(trmK) |
| SALX: | SALLE_v1c04350(trmK) |
| SGQ: | SGLAD_v1c06930(trmK) |
| SCHI: | SCHIN_v1c08510(trmK) |
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| Reference |
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| Authors |
Ta HM, Kim KK |
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| Title |
Crystal structure of Streptococcus pneumoniae Sp1610, a putative tRNA methyltransferase, in complex with S-adenosyl-L-methionine. |
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| Journal |
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| Reference |
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| Authors |
Roovers M, Kaminska KH, Tkaczuk KL, Gigot D, Droogmans L, Bujnicki JM |
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| Title |
The YqfN protein of Bacillus subtilis is the tRNA: m1A22 methyltransferase (TrmK). |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.217 |
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