KEGG   ENZYME: 2.1.1.218
Entry
EC 2.1.1.218                Enzyme                                 
Name
tRNA (adenine9-N1)-methyltransferase;
Trm10p (ambiguous);
tRNA(m1G9/m1A9)-methyltransferase;
tRNA(m1G9/m1A9)MTase;
TK0422p (gene name);
tRNA m1A9-methyltransferase;
tRNA m1A9 Mtase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:tRNA (adenine9-N1)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + adenine9 in tRNA = S-adenosyl-L-homocysteine + N1-methyladenine9 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenine9 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N1-methyladenine9 in tRNA
Comment
The enzyme from Sulfolobus acidocaldarius specifically methylates adenine9 in tRNA [1]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of guanine9 in tRNA (cf. EC 2.1.1.221, tRNA (guanine9-N1)-methyltransferase).
History
EC 2.1.1.218 created 2011 (EC 2.1.1.36 created 1972, part transferred 2011 to EC 2.1.1.218)
Orthology
K15566  tRNA (adenine9-N1/guanine9-N1)-methyltransferase
Genes
SCHISCHIN_v1c06060
TAMTheam_0430
DTEDester_0946
MTEEMTTB_10690
METZMETMT2_0324
MKAMK1026
AFUAF_0031
AFGAFULGI_00000290
APOArcpr_0444
AVEArcve_1658
ASTAsulf_00271
FPLFerp_2241
GACGACE_1058
GAHGAH_01558
PFUPF0678
PFIPFC_02550
PHOPH0711(PH0711)
PABPAB0880
PYNPNA2_1359
PYAPYCH_07940
PYSPy04_0749
PYCTQ32_04170
TKOTK0422
TONTON_0675
TGATGAM_0680
TSITSIB_0970
TBATERMP_00715
THEGQS_01580
THATAM4_954
THMCL1_2027
TLTOCC_05461
THSTES1_0839
TNUBD01_0565
TEUTEU_09285
TGYX802_06960
THVADU37_CDS08810
TCHCHITON_1103
TPEPA0127_02185
TPIEA7C91_09480
TGGA3K92_05160
TCEA3L02_03975
TBSA3L01_04150
THHCDI07_04045
TSLA3L11_08190
TTDA3L14_05990
TPRFA3L09_06445
TRLA3L10_02450
TPAFA3L08_07670
THYA3L12_04930
TICFH039_07735
TCQTIRI35C_1075
THEMFPV09_01680
THEIK1720_08035
PPACPAP_07635
APEAPE_0498
ACJACAM_0386
IHOIgni_0721
IISEYM_07625
IAGIgag_1267
HBUHbut_0079
PFMPyrfu_0146
PDLPyrde_0625
STOSTK_08530
SOHD1869_04710
SSOSSO1087
SOLSsol_2061
SSOASULA_2093
SSOLSULB_2094
SSOFSULC_2092
SSHIJ5U23_02392
SCASSACC_09790
SAISaci_1677
SACNSacN8_08140
SACRSacRon12I_08150
SACSSUSAZ_07945
SISLS215_1235
SIAM1425_1138
SIMM1627_1202
SIDM164_1128
SIYYG5714_1134
SINYN1551_1724
SIILD85_1255
SIHSiH_1099
SIRSiRe_1012
SICSiL_1021
SULABFU36_01095
SULEGFS03_06515
SULOGFS33_11925
SULLEWF20_05755
MSEMsed_1469
MEMJMJ1HA_1683
MCNMcup_0756
MHKDFR87_11375
MPRUDFR88_10965
MTENGWK48_00910
MJNMjAS7_2563
AHOAhos_0922
AMANB6F84_08465
ABRIDFR85_11875
ASULDFR86_07475
AAMBD1866_12520
ACIHHS5_22990
SAZOD1868_10880
CSTYKN1_14840
STEPIC006_0815
PAIPAE0001
PISPisl_0031
PCLPcal_0647
PASPars_1096
PYRP186_0834
POGPogu_1177
TNETneu_0946
PYWPYWP30_01088
CMACmaq_1633
TTNTTX_0355
TUZTUZN_0832
VDIVdis_0727
VMOVMUT_1574
VSOVsou_13860
ASCASAC_0477
ACIASE86_03265
CLGCalag_0035
NEQNEQ005
NAANps_02650
 » show all
Reference
1  [PMID:20525789]
  Authors
Kempenaers M, Roovers M, Oudjama Y, Tkaczuk KL, Bujnicki JM, Droogmans L
  Title
New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA.
  Journal
Nucleic Acids Res 38:6533-43 (2010)
DOI:10.1093/nar/gkq451
  Sequence
[sai:Saci_1677] [tko:TK0422]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.218
IUBMB Enzyme Nomenclature: 2.1.1.218
ExPASy - ENZYME nomenclature database: 2.1.1.218
BRENDA, the Enzyme Database: 2.1.1.218

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