KEGG   ENZYME: 2.1.1.22
Entry
EC 2.1.1.22                 Enzyme                                 
Name
carnosine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:carnosine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine [RN:R02144]
Reaction(KEGG)
R02144
Substrate
S-adenosyl-L-methionine [CPD:C00019];
carnosine [CPD:C00386]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
anserine [CPD:C01262]
History
EC 2.1.1.22 created 1972
Pathway
ec00340  Histidine metabolism
ec01100  Metabolic pathways
Orthology
K19787  carnosine N-methyltransferase
K22437  carnosine N-methyltransferase
Genes
HSA138199(CARNMT1)
PTR472958(CARNMT1)
PPS100992790(CARNMT1)
GGO101138623(CARNMT1)
PON100450734(CARNMT1)
NLE100588172(CARNMT1)
MCC706229(CARNMT1)
MCF102116939(CARNMT1)
CSAB103219598(CARNMT1)
CATY105584191
PANU101014722(CARNMT1)
TGE112608713(CARNMT1)
RRO104682182(CARNMT1)
RBB108542642(CARNMT1)
TFN117098456(CARNMT1)
PTEH111543356(CARNMT1)
CJC100404328(CARNMT1)
SBQ101039194
CSYR103276910(CARNMT1)
MMUR105868707(CARNMT1)
OGA100943391(CARNMT1)
MMU67383(Carnmt1)
MCAL110285538(Carnmt1)
MPAH110331667(Carnmt1)
RNO293871(Carnmt1)
MCOC116103642(Carnmt1)
MUN110558149(Carnmt1)
CGE100765030(Carnmt1)
PLEU114696923(Carnmt1)
NGI103737705(Carnmt1)
HGL101707014 101709582(Carnmt1)
CPOC100735755(Carnmt1)
CCAN109700890(Carnmt1)
DORD105987195
DSP122095108(Carnmt1)
NCAR124964344
OCU100337947(CARNMT1)
OPI101529716 101531525
TUP102471161(CARNMT1)
CFA476320(CARNMT1)
VVP112922101(CARNMT1)
VLG121482879(CARNMT1)
AML100477516(CARNMT1)
UMR103663348(CARNMT1)
UAH113269844(CARNMT1)
UAR123781525(CARNMT1)
ELK111153653
LLV125082834
MPUF101692030
ORO101364480
EJU114202323(CARNMT1)
ZCA113934385(CARNMT1)
MLX118026283(CARNMT1)
FCA101092964(CARNMT1)
PYU121013617(CARNMT1)
PBG122475209(CARNMT1)
PTG102950954(CARNMT1)
PPAD109275380(CARNMT1)
AJU106982977(CARNMT1)
HHV120221849(CARNMT1)
BTA538441(CARNMT1)
BOM102281194(CARNMT1)
BIU109562965(CARNMT1)
BBUB102410158(CARNMT1)
CHX102185653(CARNMT1)
OAS101122760(CARNMT1)
ODA120874011(CARNMT1)
CCAD122452892(CARNMT1)
SSC100518712(CARNMT1)
CFR102510169(CARNMT1)
CBAI105067281
CDK105106152(CARNMT1)
VPC102527404(CARNMT1)
BACU103013271(CARNMT1)
LVE103085957(CARNMT1)
OOR101270225
DLE111174585(CARNMT1)
PCAD102982608(CARNMT1)
PSIU116756016(CARNMT1)
ECB100064023(CARNMT1)
EPZ103558206(CARNMT1)
EAI106847289(CARNMT1)
MYB102239394(CARNMT1)
MYD102757203(CARNMT1)
MMYO118667450(CARNMT1)
MLF102421249(CARNMT1)
MNA107544969(CARNMT1)
PKL118716475(CARNMT1)
HAI109387012(CARNMT1)
DRO112300275(CARNMT1)
SHON118976053(CARNMT1)
AJM119045579(CARNMT1)
PDIC114504745(CARNMT1)
PHAS123819744(CARNMT1)
MMF118629829(CARNMT1)
RFQ117032258(CARNMT1)
PALE102896119(CARNMT1)
PGIG120586604(CARNMT1)
PVP105304003(CARNMT1)
RAY107511652(CARNMT1)
MJV108401237(CARNMT1)
TOD119230475(CARNMT1)
SARA101556723
LAV100674138(CARNMT1)
TMU101349650
DNM101414265(CARNMT1)
MDO100019997(CARNMT1)
GAS123233423(CARNMT1)
SHR100917399(CARNMT1)
PCW110223169(CARNMT1)
OAA100075277(CARNMT1) 103170638
GGA427256(CARNMT1) 771456
PCOC116227293 116234648(CARNMT1)
MGP100541865 104915081
CJO107306190(CARNMT1) 107317036
NMEL110390380(CARNMT1) 110400388
APLA101795407 101796794(CARNMT1) 113844155
ACYG106039326 106044151(CARNMT1)
AFUL116490659 116490923 116501052(CARNMT1)
TGU100229105(CARNMT1) 100230949
LSR110476509(CARNMT1) 110480616
SCAN103814271 103821003(CARNMT1)
PMOA120498240 120506924(CARNMT1)
OTC121338439 121345386(CARNMT1)
PRUF121356563 121365359(CARNMT1)
GFR102032387(CARNMT1) 102041084
FAB101813136(CARNMT1) 101817609
PHI102099135(HNMT) 102104175(CARNMT1)
PMAJ107207184 107216046(CARNMT1)
CCAE111932324 111941545(CARNMT1)
CCW104685240(CARNMT1) 104694220
ETL114057698 114058710(CARNMT1)
ZAB102061733(CARNMT1) 102075357
FPG101916549(CARNMT1) 101921012
FCH102058237 102058741(CARNMT1)
CLV102087172 102095931
EGZ104123838 104129539
NNI104009733 104009762 104011391
ACUN113482039 113490075(CARNMT1)
TALA104356151 104366315
PADL103912631 103920372
ACHC115336690(CARNMT1) 115343270 121232783
AAM106482212 106490920(CARNMT1) 106498446
AROW112974911 112977070
NPD112948592 112958200(CARNMT1)
DNE112983255(CARNMT1) 112997438
ASN102383634(CARNMT1) 102388422
AMJ102563588(HNMT) 102570667(CARNMT1)
CPOO109323218 109323492(CARNMT1)
GGN109297583(CARNMT1) 109301352
PSS102450230
CPIC101931211(CARNMT1)
TST117878760(CARNMT1)
CABI116828649
MRV120407907(CARNMT1)
ACS100553037 100561810(carnmt1)
PVT110071881(HNMT) 110076004(CARNMT1)
SUND121918548 121923268(CARNMT1)
PBI103050393(CARNMT1)
PMUR107286160(CARNMT1)
TSR106539677(CARNMT1)
PGUT117661432(CARNMT1)
VKO123027472 123031222(CARNMT1)
PMUA114604668 114606699(CARNMT1)
ZVI118076888(CARNMT1) 118092526
GJA107110768(CARNMT1) 107115022
XLA108714534 734612(carnmt1.S)
XTR100144950(carnmt1)
NPR108795304(CARNMT1)
RTEM120943077(CARNMT1)
BBUF120989148(CARNMT1)
BGAR122923214(CARNMT1)
DRE503765(carnmt1)
SRX107730713 107744489
SANH107672718 107673371
SGH107592372 107599972
CCAR109081603 109083779
CAUA113049879 113091364
IPU108256026(carnmt1)
PHYP113542607(carnmt1)
SMEO124380350(carnmt1)
TFD113639039(carnmt1)
AMEX103037894(carnmt1)
EEE113588633(carnmt1)
TRU101064520(carnmt1)
TNGGSTEN00007904G001
LCO104917866(carnmt1)
NCC104953066
CGOB115013510(carnmt1)
ELY117252084(carnmt1)
PLEP121944484(carnmt1)
SLUC116062603(carnmt1)
PFLV114555659(carnmt1)
GAT120830742(carnmt1)
PPUG119225205(carnmt1)
MSAM119891471(carnmt1)
CUD121510389(carnmt1)
MZE101468848(carnmt1)
ONL100711835(carnmt1)
OAU116323772(carnmt1)
OLA101159445(carnmt1)
OML112148840(carnmt1)
XMA102234636(carnmt1)
XCO114155026(carnmt1)
XHE116729516(carnmt1)
PRET103470584(carnmt1)
PFOR103146525 103146543
PLAI106934442 106950452
PMEI106905713 106933822
GAF122828837(carnmt1)
CVG107092735(carnmt1)
CTUL119784932(carnmt1)
GMU124877412(carnmt1)
NFU107393681(carnmt1)
KMR108236511(carnmt1)
ALIM106520102(carnmt1)
NWH119413630(carnmt1)
AOCE111582193(carnmt1)
CSEM103398028(carnmt1)
POV109633605(carnmt1)
SSEN122769098 122769100
HHIP117768277(carnmt1)
LCF108878234(carnmt1)
SDU111230043(carnmt1)
SLAL111644997(carnmt1)
XGL120804749(carnmt1)
HCQ109511645(carnmt1)
BPEC110169881(carnmt1)
MALB109954740(carnmt1)
SASA106580071(carnmt1) 106585701
OTW112263253(carnmt1)
OMY110535794(carnmt1)
OGO124036078(carnmt1)
ONE115139800(carnmt1)
SALP111957987(carnmt1) 111974496
SNH120063091(carnmt1)
ELS105014474(carnmt1)
SFM108938979(carnmt1)
PKI111839355(carnmt1)
AANG118237486(carnmt1)
LOC102689976(carnmt1)
PSPA121299174(carnmt1)
ARUT117408695(carnmt1)
LCM102345337(CARNMT1)
CMK103182375(carnmt1)
RTP109928630(carnmt1)
BFO118410804 118418615
BBEL109464794
CIN100177315
SCLV120335154 120335155
SPU100887880
APLC110987808
SKO102802420
DMEDmel_CG11596(CG11596)
DER6555659
DSE6616059
DSIDsimw501_GD16577(Dsim_GD16577)
DYADyak_GE16224
DAN6504853
DSR110184174
DPODpse_GA11089
DPE6600432
DMN108164589
DWI6648437
DGR6569340
DMODmoj_GI21682
DAZ108619443
DNV108657147
DHE111598126
DVI6634639
CCAT101455810
BOD106619326
MDE101898635
SCAC106083018
LCQ111677127
AGAAgaP_AGAP007115
ACOZ120949871
AARA120893395
AAG110680789 5571756
AALB109416703 109419441 115268934 115271118
CQUCpipJ_CPIJ013357
CPII120419413
CNS116348358
AME551439
ACER107998752
ALAB122710973
BIM100746914
BBIF117208099
BVK117243453
BVAN117155530
BTER100649116
BPYO122574537
CCAL108627923
OBB114874216
MGEN117226457
NMEA116427003
CGIG122401974
SOC105195013
MPHA105837824
AEC105144359
ACEP105621686
PBAR105426372
VEM105566794 105570972
HST105186116
DQU106745351
CFO105256888
FEX115240923
LHU105670365
PGC109852071
OBO105284503
PCF106786449
PFUC122526296
VPS122630322
NVI100117153
CSOL105364345
TPRE106652744
MDL103580204
CGLO123268683
FAS105265677
DAM107040876
AGIF122852143
CCIN107268839
TCA662054
DPA109543539
SOY115885398
ATD109605280
CSET123308145
AGB108904691
LDC111513646
NVL108566317
APLN108741386
PPYR116159465
OTU111418804
BMOR101744680
BMAN114241872
MSEX115441599
DPLKGM_206215 KGM_209093
BANY112050028 112052976
PMAC106715305
PPOT106101906
PXU106124459
PRAP111001333
ZCE119836452
HAW110369598
TNL113504123
OFU114353315
PXY105381314 105385096
API100163993
DNX107169046
AGS114128372
RMD113559381
BTAB109035790
DCI103516943
CLEC106661615
HHAL106678284
NLU111053405
PHUPhum_PHUM527210
FOC113208981
ZNE110829899
CSEC111874727
FCD110843989
DPXDAPPUDRAFT_43139
DMK116930336
PVM113816903
PJA122265246
PCHN125030410 125030637
HAME121860122
PCLA123747928 123755452 123769634
PTRU123511220
HAZT108682124
EAF111713588
ISCIscW_ISCW005249
DSV119455585
RSAN119393985 119394825
RMP119172729
VDE111248270
VJA111271700
DPTE113790346 113792326
DFR124492955
PTEP107449829
SDM118193867
CELCELE_Y48E1C.2(Y48E1C.2)
CBRCBG_20781
BMYBM_BM6660(Bm6660)
LOALOAG_09552
TSPTsp_07355
HROHELRODRAFT_64289
LGILOTGIDRAFT_158828
PCAN112556200
BGT106057917
GAE121373339
HRF124113201 124131709
HRJ124256456 124256490
CRG105323299 117687888
MYI110446365
PMAX117315055
MMER123542699
OBI106876185
OSN115214956
LAK106156666 106171428
SMMSmp_160530
SHXMS3_0020031
OVIT265_07808
EGLEGR_07732
NVE5506172
EPA110250200
ATEN116307019
ADF107347240
AMIL114975972
PDAM113685044
SPIS111344277
DGT114537936
XEN124440907
HMG100215396
TADTRIADDRAFT_30505
AQU100637183
ATHAT2G32160 AT2G32170
ALY9315434 9315435
CRB17888228 17889505
CSAT104704285 104704287 104753336 104786379 104786382
EUSEUTSA_v10017571mg
BRP103865181
BNA106397398 106447080
BOE106337436
RSZ108849468
THJ104800970 104826162
CPAP110821767
CIT102617870
CICCICLE_v10011552mg
PVY116114396
MINC123195772
TCC18612248
GRA105789553
GHI107920534 121232127
GAB108471718
DZI111305660 111314583
EGR104425159
GMX100791662 100818452
GSJ114382638 114403295
PVUPHAVU_006G001800g
VRA106776034
VAR108342859
VUN114189158
CCAJ109790494
APRC113855709
MTRMTR_3g081180
CAM101514925
LJALj6g3v0204730.1(Lj6g3v0204730.1) Lj6g3v0204730.2(Lj6g3v0204730.2)
ADU107482441
AIP107638305
AHF112740878 112795599
LANG109344400 109350674
FVE101309077
RCN112188827
PPER18783696
PMUM103329018
PAVI110768750
PDUL117621443
MDM103426012 103441446
PXB103964168 103966510
ZJU107423585
MNT21400696
CSV101207614
CMO103502495
BHJ120085925
MCHA111008126
CMAX111477044
CMOS111442769
CPEP111796670
RCU8270530
JCU105634437
HBR110636579
MESC110622623
POP18106070 18108991 7495643
PEU105110956 105113889 105118609
PALZ118033114 118052934
JRE108980594
QSU111983947 112030213
QLO115986652
TWL120016519 120016521
VVI100852521
VRI117906565
SLY101266222
SPEN107018683
SOT102600462
CANN107851301
NTA107761920 107806745
NSY104214606
NTO104119141
NAU109208157
INI109179120
ITR116013039
SIND105176090
OEU111410587
EGT105964868
SSPL121759932 121763508
HAN110910534
ECAD122585184
LSV111888622
CCAV112503588
DCR108210947 108225495
CSIN114284311
BVG104902698
SOE110785351
CQI110691926 110701982
NNU104588623
MING122085452
TSS122640898
PSOM113287275 113294720
NCOL116256886
OSA4339287
DOSAOs05t0511300-01(Os05g0511300)
OBR102701822
BDI100840420
ATS109773426
TDC119286606 119348960
TAES123062555 123139760 123182598
SBI8080100
ZMA100381551
SITA101764292
SVS117847548
PVIR120664961 120666238 120698155 120699519
PHAI112886370
PDA103709836
EGU105033202
MUS103990970
DCT110091779
PEQ110021767
AOF109834653
ATR18443048
SMOSELMODRAFT_101691 SELMODRAFT_79682
PPP112286972 112294818
CRECHLRE_03g188950v5
VCNVOLCADRAFT_69374
MNGMNEG_9151
CSLCOCSUDRAFT_37740
CVRCHLNCDRAFT_142741
APROF751_6419
OLUOSTLU_38469
OTAOT_ostta05g02235
BPGBathy13g01790
MISMICPUN_97395
MPPMICPUCDRAFT_3417
GSLGasu_17380
CCPCHC_T00006594001 CHC_T00006900001
SCEYNL092W
AGOAGOS_ACL085C
KLAKLLA0_C13750g
KMXKLMA_80211
ZROZYRO0C15532g
CGRCAGL0K09856g
TPFTPHA_0P00940(TPHA0P00940)
PPAPAS_chr4_0928
DHADEHA2A10934g
PICPICST_90967
PGUPGUG_01960
SPAASPAPADRAFT_148110
LELLELG_05421
CALCAALFM_CR08040WA(CaO19.592)
CTPCTRG_02645
COTCORT_0G02080
CDUCD36_33670
CTENCANTEDRAFT_110406
YLIYALI0D07238g
CLUCLUG_02814
CLUSA9F13_07g00143
CAURCJI97_000102
SLBAWJ20_665
PKZC5L36_0B04180
BNNFOA43_001020
BBRXBRETT_003689
NCRNCU03692
NTENEUTE1DRAFT77104(NEUTE1DRAFT_77104)
SMPSMAC_02553
PANPODANSg9064
TTTTHITE_2108189
MTMMYCTH_2302026
CTHRCTHT_0068100
MGRMGG_09217
TMNUCRPA7_1556
SSCKSPSK_05253
FGRFGSG_01856
FPUFPSE_09983
FVRFVEG_07400
FOXFOXG_04279
NHENECHADRAFT_96857
TRETRIREDRAFT_66222
TRRM419DRAFT_86035
MAWMAC_05627
MAJMAA_03288
CMTCCM_05641
PLJVFPFJ_02966
VALVDBG_09433
VDAVDAG_04669
CFJCFIO01_13515
SAPOSAPIO_CDS0535
ELAUCREL1_4045
PFYPFICI_07777
SSLSS1G_12537
BFUBCIN_10g04100
MBEMBM_00239
PSCOLY89DRAFT_609495
GLZGLAREA_05453
ANIAN0865.2
AFMAFUA_1G15210
ACTACLA_020120
NFINFIA_010210
AORAO090005001199
ANGANI_1_3248014(An01g13460)
AFVAFLA_004022
ALUCAKAW2_10289A
ACHEACHE_30659A
APUUAPUU_50947A
PCSPc06g00980
PDPPDIP_05670
TMFPMAA_064850
TRGTRUGW13939_09089
CIMCIMG_03215
CPWCPC735_009540
UREUREG_07073
PBLPAAG_02139
PBNPADG_00755
TVETRV_06809
AJEHCAG_06766
BGHBDBG_03075
PNOSNOG_02321
PTEPTT_10419
BZECOCCADRAFT_41506
BSCCOCSADRAFT_103326
BORCOCMIDRAFT_98263
AALTCC77DRAFT_1021984
ZTRMYCGRDRAFT_37396
PFJMYCFIDRAFT_39838
BCOMBAUCODRAFT_282873
SPOSPBC1778.07
CNECNA07180
CNBCNBA6980
CGICGB_A8270W
TMSTREMEDRAFT_30233
TASAA1Q1_06987
TVSTRAVEDRAFT_60824
DSQDICSQDRAFT_59823
PCOPHACADRAFT_194233
SHSSTEHIDRAFT_96161
HIRHETIRDRAFT_327542
PSQPUNSTDRAFT_110705
ADLAURDEDRAFT_134569
FMEFOMMEDRAFT_108842
GTRGLOTRDRAFT_112601
LBCLACBIDRAFT_255655
MRRMoror_10009
CCICC1G_07496
SCMSCHCODRAFT_16269
ABPAGABI1DRAFT107480(AGABI1DRAFT_107480)
ABVAGABI2DRAFT121027(AGABI2DRAFT_121027)
CPUTCONPUDRAFT_106078
SLASERLADRAFT_464658
WSEWALSEDRAFT_59442
WICJ056_002317
UMAUMAG_10376
PFPPFL1_02940
MRTMRET_2153
MSYMMSY001_2811
PGRPGTG_01896
MLRMELLADRAFT_35280
MBRMONBRDRAFT_14285
SREPTSG_11583
DDIDDB_G0282239
DFADFA_01813 DFA_12355
EHIEHI_011930(72.t00002)
EDIEDI_227600
EIVEIN_118310
PFAPF3D7_0309300
PFDPFDG_02055
PFHPFHG_01092
PREIPRSY57_0308600
PYOPY17X_0409900
PCBPCHAS_040840(PC403406.00.0)
PBEPBANKA_0407500
PVVPVVCY_0400820
PKNPKNH_0833400
PVXPVX_119580
PCYPCYB_084010
TANTA12795
TPVTP02_0368
TOTTOT_020001055
BEQBEWA_021080
BBOBBOV_III006290(17.m07559)
BMICBmR1_04g07775
BBIGBBBOND_0308520
CPVcgd4_1420
CHOChro.40162
TGOTGME49_241150 TGME49_301000
TETTTHERM_00670350
PTMGSPATT00005551001 GSPATT00024230001
SMINv1.2.001623.t1(symbB.v1.2.001623.t1)
FCYFRACYDRAFT_263932
AAFAURANDRAFT_22773
PIFPITG_08675
SPARSPRG_13920 SPRG_15803
EHXEMIHUDRAFT_356882
GTTGUITHDRAFT_112257 GUITHDRAFT_120282 GUITHDRAFT_159108 GUITHDRAFT_86800
TBRTb927.4.3350
TBGTbgDal_IV3360
TCR506435.430 507739.70
LMALMJF_34_1020
LIFLINJ_34_1090
LDOLDBPK_341090
LMILMXM_33_1020
LBZLBRM_20_0990
LPANLPMP_201030
NGRNAEGRDRAFT_1820
TVATVAG_246220
 » show all
Reference
1
  Authors
McManus, I.R.
  Title
Enzymatic synthesis of anserine in skeletal muscle by N-methylation of carnosine.
  Journal
J Biol Chem 237:1207-1211 (1962)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.22
IUBMB Enzyme Nomenclature: 2.1.1.22
ExPASy - ENZYME nomenclature database: 2.1.1.22
BRENDA, the Enzyme Database: 2.1.1.22
CAS: 37256-93-2

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