KEGG ENZYME: 2.1.1.22

ENZYME: 2.1.1.22

Entry

EC 2.1.1.22 Enzyme

Name

carnosine N-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:carnosine N-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine [RN:R02144]

Reaction(KEGG)

R02144

Substrate

S-adenosyl-L-methionine [CPD:C00019];
carnosine [CPD:C00386]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
anserine [CPD:C01262]

History

EC 2.1.1.22 created 1972

Pathway

ec00340

Histidine metabolism

ec01100

Metabolic pathways

Orthology

K19787

carnosine N-methyltransferase

K22437

carnosine N-methyltransferase

Genes

HSA:	138199(CARNMT1)

PTR:	472958(CARNMT1)

PPS:	100992790(CARNMT1)

GGO:	101138623(CARNMT1)

PON:	100450734(CARNMT1)

NLE:	100588172(CARNMT1)

MCC:	706229(CARNMT1)

MCF:	102116939(CARNMT1)

CSAB:

103219598(CARNMT1)

RRO:	104682182(CARNMT1)

RBB:	108542642(CARNMT1)

CJC:	100404328(CARNMT1)

SBQ:

101039194

MMU:	67383(Carnmt1)

MCAL:

110285538(Carnmt1)

MPAH:

110331667(Carnmt1)

RNO:	293871(Carnmt1)

MUN:	110558149(Carnmt1)

CGE:	100765030(Carnmt1)

NGI:	103737705(Carnmt1)

HGL:	101707014 101709582(Carnmt1)

CCAN:

109700890(Carnmt1)

OCU:	100337947(CARNMT1)

TUP:	102471161(CARNMT1)

CFA:	476320(CARNMT1)

VVP:	112922101(CARNMT1)

AML:	100477516(CARNMT1)

UMR:	103663348(CARNMT1)

UAH:	113269844(CARNMT1)

ORO:

101364480

ELK:

111153653

FCA:	101092964(CARNMT1)

PTG:	102950954(CARNMT1)

PPAD:

109275380(CARNMT1)

AJU:	106982977(CARNMT1)

BTA:	538441(CARNMT1)

BOM:	102281194(CARNMT1)

BIU:	109562965(CARNMT1)

BBUB:

102410158(CARNMT1)

CHX:	102185653(CARNMT1)

OAS:	101122760(CARNMT1)

SSC:	100518712(CARNMT1)

CFR:	102510169(CARNMT1)

CDK:	105106152(CARNMT1)

BACU:

103013271(CARNMT1)

LVE:	103085957(CARNMT1)

OOR:

101270225

DLE:	111174585(CARNMT1)

PCAD:

102982608(CARNMT1)

ECB:	100064023(CARNMT1)

EPZ:	103558206(CARNMT1)

EAI:	106847289(CARNMT1)

MYB:	102239394(CARNMT1)

MYD:	102757203(CARNMT1)

MNA:	107544969(CARNMT1)

HAI:	109387012(CARNMT1)

DRO:	112300275(CARNMT1)

PALE:

102896119(CARNMT1)

RAY:	107511652(CARNMT1)

MJV:	108401237(CARNMT1)

LAV:	100674138(CARNMT1)

TMU:

101349650

MDO:	100019997(CARNMT1)

SHR:	100917399(CARNMT1)

PCW:	110223169(CARNMT1)

OAA:	100075277(CARNMT1) 103170638

GGA:	427256(CARNMT1) 771456

MGP:	100541865 104915081

CJO:	107306190(CARNMT1) 107317036

NMEL:

110390380(CARNMT1) 110400388

APLA:

101795407 101796794(CARNMT1) 113844155

ACYG:

106039326 106044151(CARNMT1)

TGU:	100229105(CARNMT1) 100230949

LSR:	110476509(CARNMT1) 110480616

SCAN:

103814271 103821003(CARNMT1)

GFR:	102032387(CARNMT1) 102041084

FAB:	101813136(CARNMT1) 101817609

PHI:	102099135(HNMT) 102104175(CARNMT1)

PMAJ:

107207184 107216046(CARNMT1)

CCAE:

111932324 111941545(CARNMT1)

CCW:	104685240(CARNMT1) 104694220

ETL:	114057698 114058710(CARNMT1)

FPG:	101916549(CARNMT1) 101921012

FCH:	102058237 102058741(CARNMT1)

CLV:	102087172 102095931

EGZ:	104123838 104129539

NNI:	104009733 104009762 104011391

ACUN:

113482039 113490075(CARNMT1)

PADL:

103912631 103920372

AAM:	106482212 106490920(CARNMT1) 106498446

ASN:	102383634(CARNMT1) 102388422

AMJ:	102563588(HNMT) 102570667(CARNMT1)

PSS:

102450230

CMY:	102942325(CARNMT1)

CPIC:

101931211(CARNMT1)

ACS:	100553037 100561810(carnmt1)

PVT:	110071881(HNMT) 110076004(CARNMT1)

PBI:	103050393(CARNMT1)

PMUR:

107286160(CARNMT1)

TSR:	106539677(CARNMT1)

PMUA:

114606699(CARNMT1)

GJA:	107110768(CARNMT1) 107115022

XLA:	108714534 734612(carnmt1.S)

XTR:	100144950(carnmt1)

NPR:	108795304(CARNMT1)

DRE:	503765(carnmt1)

SRX:	107730713 107744489

SANH:

107672718 107673371

SGH:	107592372 107599972

CCAR:

109081603 109083779

IPU:	108256026(carnmt1)

PHYP:

113542607(carnmt1)

AMEX:

103037894(carnmt1)

EEE:	113588633(carnmt1)

TRU:	101064520(carnmt1)

TNG:	GSTEN00007904G001

LCO:	104917866(carnmt1)

NCC:

104953066

MZE:	101468848(carnmt1)

ONL:	100711835(carnmt1)

OLA:	101159445(carnmt1)

XMA:	102234636(carnmt1)

XCO:	114155026(carnmt1)

PRET:

103470584(carnmt1)

CVG:	107092735(carnmt1)

NFU:	107393681(carnmt1)

KMR:	108236511(carnmt1)

ALIM:

106520102(carnmt1)

AOCE:

111582193(carnmt1)

CSEM:

103398028(carnmt1)

POV:	109633605(carnmt1)

LCF:	108878234(carnmt1)

SDU:	111230043(carnmt1)

SLAL:

111644997(carnmt1)

HCQ:	109511645(carnmt1)

BPEC:

110169881(carnmt1)

MALB:

109954740(carnmt1)

SASA:

106580071(carnmt1) 106585701

OTW:	112263253(carnmt1)

SALP:

111957987(carnmt1) 111974496

ELS:	105014474(carnmt1)

SFM:	108938979(carnmt1)

PKI:	111839355(carnmt1)

LCM:	102345337(CARNMT1)

CMK:	103182375(carnmt1)

RTP:	109928630(carnmt1)

BFO:	118410804 118418615

CIN:

SPU:

APLC:

SKO:

DME:	Dmel_CG11596(CG11596)

DER:

6555659

DSE:

6616059

DSI:	Dsimw501_GD16577(Dsim_GD16577)

DYA:	Dyak_GE16224

DAN:

6504853

DSR:

110184174

DPO:	Dpse_GA11089

DPE:

6600432

DMN:

108164589

DWI:

6648437

DGR:	Dgri_GH17892

DMO:	Dmoj_GI21682

DAZ:

DNV:

DHE:

DVI:

MDE:

LCQ:

AGA:	AgaP_AGAP007115

AAG:	110680789 5571756

AALB:

109416703 109419441 115268934 115271118

CQU:	CpipJ_CPIJ013357

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:	105566794 105570972

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:

DPA:

ATD:

NVL:

BMOR:

BMAN:

DPL:	KGM_206215 KGM_209093

PMAC:

PRAP:

HAW:

TNL:

PXY:	105381314 105385096

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM527210

ZNE:

110829899

FCD:

110843989

DPX:	DAPPUDRAFT_43139

PVM:

113816903

ISC:	IscW_ISCW005249

DPTE:

113790346 113792326

PTEP:

107449829

CEL:	CELE_Y48E1C.2(Y48E1C.2)

CBR:

CBG20781

BMY:

Bm1_56640

LOA:	LOAG_09552

TSP:

Tsp_07355

HRO:	HELRODRAFT_64289

LGI:	LOTGIDRAFT_158828

PCAN:

CRG:

MYI:

OBI:

LAK:	106156666 106171428

SMM:	Smp_160530

SHX:

MS3_05432

OVI:	T265_07808

EGL:

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

TAD:	TRIADDRAFT_30505

AQU:

100637183

ATH:	AT2G32160 AT2G32170

ALY:	9315434 9315435

CRB:	17888228 17889505

CSAT:

104704285 104704287 104753336 104786379 104786382

EUS:	EUTSA_v10017571mg

BRP:

103865181

BNA:	106397398 106447080

BOE:

106337436

RSZ:

108849468

THJ:	104800970 104826162

CPAP:

110821767

CIT:

102617870

CIC:	CICLE_v10011552mg

TCC:

GRA:

GHI:

GAB:

DZI:	111305660 111314583

EGR:

104425159

GMX:	100791662 100818452

GSJ:	114382638 114403295

PVU:	PHAVU_006G001800g

VRA:

VAR:

VUN:

CCAJ:

MTR:	MTR_3g081180

CAM:

101514925

LJA:	Lj6g3v0204730.1(Lj6g3v0204730.1) Lj6g3v0204730.2(Lj6g3v0204730.2)

ADU:

AIP:

LANG:

FVE:

RCN:

PPER:

PMUM:

PAVI:

MDM:	103426012 103441446

PXB:	103964168 103966510

ZJU:

CSV:

CMO:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:	18106070 18108991 7495643

PEU:	105110956 105113889 105118609

JRE:

108980594

QSU:	111983947 112030213

VVI:

SLY:

SPEN:

SOT:

CANN:

NTA:	107761920 107806745

NSY:

NTO:

NAU:

INI:

SIND:

OEU:

HAN:

LSV:

CCAV:

DCR:	108210947 108225495

BVG:

104902698

SOE:

110785351

CQI:	110691926 110701982

NNU:

104588623

PSOM:

113287275 113294720

OSA:

4339287

DOSA:

Os05t0511300-01(Os05g0511300)

OBR:

102701822

BDI:

100840420

ATS:	109773426(LOC109773426)

SBI:

8080100

ZMA:	100381551(TIDP3405)

SITA:

PDA:

EGU:

MUS:

DCT:

PEQ:

AOF:

ATR:

SMO:	SELMODRAFT_101691 SELMODRAFT_79682

PPP:	112286972 112294818

CRE:	CHLREDRAFT_101034

VCN:	VOLCADRAFT_69374

MNG:

MNEG_9151

CSL:	COCSUDRAFT_37740

CVR:	CHLNCDRAFT_142741

APRO:

F751_6419

OLU:	OSTLU_38469

OTA:	OT_ostta05g02235

BPG:	Bathy13g01790

MIS:	MICPUN_97395

MPP:	MICPUCDRAFT_3417

GSL:	Gasu_17380

CCP:	CHC_T00006594001 CHC_T00006900001

SCE:

YNL092W

AGO:	AGOS_ACL085C

KLA:	KLLA0_C13750g

KMX:	KLMA_80211

ZRO:	ZYRO0C15532g

CGR:	CAGL0K09856g

TPF:	TPHA_0P00940(TPHA0P00940)

PPA:	PAS_chr4_0928

DHA:	DEHA2A10934g

PIC:	PICST_90967

PGU:	PGUG_01960

SPAA:

SPAPADRAFT_148110

LEL:	LELG_05421

CAL:	CAALFM_CR08040WA(CaO19.592)

CTP:	CTRG_02645

COT:	CORT_0G02080

CDU:	CD36_33670

CTEN:

CANTEDRAFT_110406

YLI:	YALI0D07238g

CLU:	CLUG_02814

CLUS:

A9F13_07g00143

CAUR:

CJI97_000102

SLB:

AWJ20_665

PKZ:	C5L36_0B04180

SMP:	SMAC_02553

PAN:	PODANSg9064

TTT:	THITE_2108189

MTM:	MYCTH_2302026

CTHR:

CTHT_0068100

MGR:

MGG_09217

TMN:	UCRPA7_1556

SSCK:

SPSK_05253

FGR:	FGSG_01856

FPU:	FPSE_09983

FVR:	FVEG_07400

FOX:	FOXG_04279

NHE:	NECHADRAFT_96857

TRE:	TRIREDRAFT_66222

TRR:	M419DRAFT_86035

MAW:

MAC_05627

MAJ:

MAA_03288

CMT:

CCM_05641

PLJ:	VFPFJ_02966

VAL:	VDBG_09433

VDA:	VDAG_04669

CFJ:	CFIO01_13515

SAPO:

SAPIO_CDS0535

ELA:	UCREL1_4045

PFY:	PFICI_07777

SSL:	SS1G_12537

BFU:	BCIN_10g04100

MBE:

MBM_00239

PSCO:

LY89DRAFT_609495

GLZ:	GLAREA_05453

ACT:	ACLA_020120

NFI:	NFIA_010210

AOR:	AO090005001199

ANG:	ANI_1_3248014(An01g13460)

PCS:	Pc06g00980

PDP:	PDIP_05670

TMF:	PMAA_064850

CIM:	CIMG_03215

CPW:	CPC735_009540

PBL:	PAAG_02139

PBN:	PADG_00755

URE:	UREG_07073

AJE:	HCAG_06766

BGH:	BDBG_03075

PNO:	SNOG_02321

PTE:

PTT_10419

BZE:	COCCADRAFT_41506

BSC:	COCSADRAFT_103326

BOR:	COCMIDRAFT_98263

AALT:

CC77DRAFT_1021984

ZTR:	MYCGRDRAFT_37396

PFJ:	MYCFIDRAFT_39838

BCOM:

BAUCODRAFT_282873

SPO:	SPBC1778.07

CNE:

CNA07180

CNB:

CNBA6980

CGI:	CGB_A8270W

TMS:	TREMEDRAFT_30233

TASA:

A1Q1_06987

TVS:	TRAVEDRAFT_60824

DSQ:	DICSQDRAFT_59823

PCO:	PHACADRAFT_194233

HIR:	HETIRDRAFT_327542

PSQ:	PUNSTDRAFT_110705

ADL:	AURDEDRAFT_134569

FME:	FOMMEDRAFT_108842

GTR:	GLOTRDRAFT_112601

LBC:	LACBIDRAFT_255655

MRR:	Moror_10009

CCI:	CC1G_07496

SCM:	SCHCODRAFT_16269

ABP:	AGABI1DRAFT107480(AGABI1DRAFT_107480)

ABV:	AGABI2DRAFT121027(AGABI2DRAFT_121027)

CPUT:

CONPUDRAFT_106078

SLA:	SERLADRAFT_464658

WSE:	WALSEDRAFT_59442

WIC:	J056_002317

UMA:	UMAG_10376

PFP:	PFL1_02940

MRT:

MRET_2153

MSYM:

MSY001_2811

PGR:	PGTG_01896

MLR:	MELLADRAFT_35280

MBR:	MONBRDRAFT_14285

SRE:	PTSG_11583

DDI:	DDB_G0282239

DFA:	DFA_01813 DFA_12355

EHI:	EHI_011930(72.t00002)

EDI:	EDI_227600

EIV:	EIN_118310 EIN_227480

PYO:	PY17X_0409900

PCB:	PCHAS_040840(PC403406.00.0)

PBE:	PBANKA_0407500

PVX:	PVX_119580

TAN:

TA12795

TPV:

TP02_0368

TOT:	TOT_020001055

BEQ:	BEWA_021080

BBO:	BBOV_III006290(17.m07559)

BMIC:

BmR1_04g07775

CPV:

cgd4_1420

CHO:	Chro.40162

TGO:	TGME49_241150 TGME49_301000

TET:	TTHERM_00670350

PTM:	GSPATT00005551001 GSPATT00024230001

SMIN:

v1.2.001623.t1(symbB.v1.2.001623.t1)

FCY:	FRACYDRAFT_260947 FRACYDRAFT_263932

AAF:	AURANDRAFT_22773

PIF:	PITG_08675

SPAR:

SPRG_13920 SPRG_15803

EHX:	EMIHUDRAFT_356882

GTT:	GUITHDRAFT_112257 GUITHDRAFT_120282 GUITHDRAFT_159108 GUITHDRAFT_86800

TBR:	Tb927.4.3350

TBG:	TbgDal_IV3360

TCR:

507739.70

LMA:	LMJF_34_1020

LIF:	LINJ_34_1090

LDO:	LDBPK_341090

LMI:	LMXM_33_1020

LBZ:	LBRM_20_0990

LPAN:

LPMP_201030

NGR:	NAEGRDRAFT_1820

TVA:	TVAG_246220

CPI:

Cpin_1270

CHZ:

CHSO_1738

» show all

Reference

Authors

McManus, I.R.

Title

Enzymatic synthesis of anserine in skeletal muscle by N-methylation of carnosine.

Journal

J Biol Chem 237:1207-1211 (1962)

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.22

IUBMB Enzyme Nomenclature:

2.1.1.22

ExPASy - ENZYME nomenclature database:

2.1.1.22

BRENDA, the Enzyme Database:

2.1.1.22

CAS:	37256-93-2

DBGET integrated database retrieval system