KEGG ENZYME: 2.1.1.22

ENZYME: 2.1.1.22

Entry

EC 2.1.1.22 Enzyme

Name

carnosine N-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:carnosine N-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine [RN:R02144]

Reaction(KEGG)

R02144

Substrate

S-adenosyl-L-methionine [CPD:C00019];
carnosine [CPD:C00386]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
anserine [CPD:C01262]

History

EC 2.1.1.22 created 1972

Pathway

ec00340

Histidine metabolism

Orthology

K19787

carnosine N-methyltransferase

K22437

carnosine N-methyltransferase

Genes

HSA:	138199(CARNMT1)

PTR:	472958(CARNMT1)

PPS:	100992790(CARNMT1)

GGO:	101138623(CARNMT1)

PON:	100450734(CARNMT1)

NLE:	100588172(CARNMT1)

MCC:	706229(CARNMT1)

MCF:	102116939(CARNMT1)

CSAB:

103219598(CARNMT1)

RRO:	104682182(CARNMT1)

RBB:	108542642(CARNMT1)

CJC:	100404328(CARNMT1)

SBQ:

101039194

MMU:	67383(Carnmt1)

RNO:	293871(Carnmt1)

CGE:	100765030(Carnmt1)

NGI:	103737705(Carnmt1)

HGL:	101707014 101709582(Carnmt1)

CCAN:

109700890(Carnmt1)

OCU:	100337947(CARNMT1)

TUP:	102471161(CARNMT1)

CFA:	476320(CARNMT1)

AML:	100477516(CARNMT1)

UMR:	103663348(CARNMT1)

ORO:

101364480

FCA:	101092964(CARNMT1)

PTG:	102950954(CARNMT1)

AJU:	106982977(CARNMT1)

BTA:	538441(CARNMT1)

BOM:	102281194(CARNMT1)

BIU:	109562965(CARNMT1)

PHD:	102319832(CARNMT1)

CHX:	102185653(CARNMT1)

OAS:	101122760(CARNMT1)

SSC:	100518712(CARNMT1)

CFR:	102510169(CARNMT1)

CDK:	105106152(CARNMT1)

BACU:

103013271(CARNMT1)

LVE:	103085957(CARNMT1)

OOR:

101270225

ECB:	100064023(CARNMT1)

EPZ:	103558206(CARNMT1)

EAI:	106847289(CARNMT1)

MYB:	102239394(CARNMT1)

MYD:	102757203(CARNMT1)

HAI:	109387012(CARNMT1)

RSS:	109449939(CARNMT1)

PALE:

102896119(CARNMT1)

LAV:	100674138(CARNMT1)

TMU:

101349650

MDO:	100019997(CARNMT1)

SHR:	100917399(CARNMT1)

OAA:	100075277(CARNMT1) 103170638

GGA:	427256(CARNMT1) 771456

MGP:	100541865 104915081(CARNMT1)

CJO:	107306190(CARNMT1) 107317036

APLA:

101795407 101796794(CARNMT1)

ACYG:

106039326 106044151(CARNMT1)

TGU:	100229105(CARNMT1) 100230949

GFR:	102032387(CARNMT1) 102041084

FAB:	101813136(CARNMT1) 101817609

PHI:	102099135(HNMT) 102104175(CARNMT1)

PMAJ:

107207184 107216046(CARNMT1)

CCAE:

111932324 111941545(CARNMT1)

CCW:	104685240(CARNMT1) 104694220

FPG:	101916549(CARNMT1) 101921012

FCH:	102058237 102058741(CARNMT1)

CLV:	102087172 102095931

EGZ:	104123838 104129539

AAM:	106482212 106490920(CARNMT1) 106498446

ASN:	102383634(CARNMT1) 102388422

AMJ:	102563588(HNMT) 102570667(CARNMT1)

PSS:

102450230

CMY:	102942325(CARNMT1)

CPIC:

101931211(CARNMT1)

ACS:	100553037 100561810(carnmt1)

PVT:	110071881(HNMT) 110076004(CARNMT1)

PBI:	103050393(CARNMT1)

GJA:	107107645 107110768(CARNMT1) 107115022

XLA:	108714534 734612(carnmt1.S)

XTR:	100144950(carnmt1)

NPR:	108795304(CARNMT1)

DRE:	503765(carnmt1)

SRX:	107730713 107744489

SANH:

107672718 107673371

SGH:	107592372 107599972

CCAR:

109081603 109083779

IPU:	108256026(carnmt1)

AMEX:

103037894(carnmt1)

TRU:	101064520(carnmt1) 105418550

TNG:	GSTEN00007904G001

LCO:	104917866(carnmt1)

NCC:

104953066

MZE:	101468848(carnmt1)

OLA:	101159445(carnmt1)

XMA:	102234636(carnmt1)

PRET:

103470584(carnmt1)

NFU:	107393681(carnmt1)

KMR:	108236511(carnmt1) 108238488

CSEM:

103398028(carnmt1)

LCF:	108878234(carnmt1)

SDU:	111230043(carnmt1)

HCQ:	109511645(carnmt1)

BPEC:

110169881(carnmt1)

MALB:

109954740(carnmt1)

SASA:

106580071(carnmt1) 106585701

OTW:	112263253(carnmt1)

ELS:	105014474(carnmt1)

SFM:	108938979(carnmt1)

LCM:	102345337(CARNMT1)

CMK:	103182375(carnmt1)

BFO:	BRAFLDRAFT_76676

CIN:

SPU:

APLC:

SKO:

DME:	Dmel_CG11596(CG11596)

DPO:	Dpse_GA11089

DAN:	Dana_GF22187

DER:

6555659

DPE:

6600432

DSE:	Dsec_GM19182

DSI:	Dsimw501_GD16577(Dsim_GD16577)

DWI:

6648437

DYA:	Dyak_GE16224

DGR:	Dgri_GH17892

DMO:	Dmoj_GI21682

DVI:	Dvir_GJ15861

MDE:

101898635

AGA:	AgaP_AGAP007115

AAG:

5571756

CQU:	CpipJ_CPIJ013357

AME:

BIM:

BTER:

SOC:

AEC:

ACEP:

PBAR:

HST:

DQU:

CFO:

LHU:

PGC:

PCF:

NVI:

MDL:

TCA:

DPA:

NVL:

BMOR:

DPL:	KGM_206215 KGM_209093

PMAC:

106715305

PRAP:

111001333

HAW:

110369598

PXY:	105381314 105385096

API:

100163993

DNX:

107169046

CLEC:

106661615

PHU:	Phum_PHUM527210

ZNE:

110829899

FCD:

110843989

DPX:	DAPPUDRAFT_43139

ISC:	IscW_ISCW005249

CEL:	CELE_Y48E1C.2(Y48E1C.2)

CBR:

CBG20781

NAI:	NECAME_18487

BMY:

Bm1_56640

LOA:	LOAG_09552

TSP:

Tsp_07355

HRO:	HELRODRAFT_64289

LGI:	LOTGIDRAFT_158828

CRG:

105323299

MYI:

110446365

OBI:

106876185

LAK:	106156666 106171428

SMM:	Smp_160530

SHX:

MS3_05432

OVI:	T265_07808

EGL:

EGR_07732

NVE:	NEMVE_v1g124563

EPA:

110250200

ADF:

107347240

HMG:

100215396

TAD:	TRIADDRAFT_30505

AQU:

100637183

ALY:	ARALYDRAFT_902263 ARALYDRAFT_902264

CRB:

17889505

CSAT:

104704285 104704287 104753336 104786379

EUS:	EUTSA_v10017571mg

BRP:

103865181

BNA:

106397398

BOE:

106337436

THJ:	104800970 104826162

CPAP:

110821767

CIT:

102617870

CIC:	CICLE_v10011552mg

TCC:

18612248

GRA:

105789553

GHI:

107920534

DZI:	111305660 111314583

EGR:

104425159

GMX:	100791662 100818452

PVU:	PHAVU_006G001800g

VRA:

106776034

VAR:

108342859

CCAJ:

109790494

MTR:	MTR_3g081180

CAM:

101514925

LJA:	Lj6g3v0204730.1(Lj6g3v0204730.1) Lj6g3v0204730.2(Lj6g3v0204730.2)

ADU:	107482441 107482810

AIP:

LANG:

FVE:

PPER:

PMUM:

PAVI:

MDM:	103426012 103441446

PXB:	103964168 103966510

ZJU:

CSV:

CMO:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

POP:	18106070 18108991 7495643

JRE:	108980594 109015456

VVI:

SLY:

SPEN:

SOT:

CANN:

NTA:	107761920 107806745

NSY:

104214606

NTO:	104105084 104119141

INI:

SIND:

OEU:

HAN:

LSV:

CCAV:

DCR:	108210947 108225495

BVG:

SOE:

NNU:

OSA:

DOSA:

Os05t0511300-01(Os05g0511300)

OBR:

102701822

BDI:

100840420

ATS:	109773426(LOC109773426)

SBI:

8080100

ZMA:	100381551(TIDP3405)

SITA:

PDA:

EGU:

MUS:

DCT:

PEQ:

AOF:

ATR:

SMO:	SELMODRAFT_101691 SELMODRAFT_79682

PPP:	112286972 112294818

CRE:	CHLREDRAFT_101034

VCN:	VOLCADRAFT_69374

MNG:

MNEG_9151

OTA:	OT_ostta05g02235

BPG:	Bathy13g01790

MIS:	MICPUN_97395

MPP:	MICPUCDRAFT_3417

CSL:	COCSUDRAFT_37740

CVR:	CHLNCDRAFT_142741

APRO:

F751_6419

GSL:	Gasu_17380

CCP:	CHC_T00006594001 CHC_T00006900001

SCE:

YNL092W

AGO:	AGOS_ACL085C

KLA:	KLLA0_C13750g

KMX:	KLMA_80211

ZRO:	ZYRO0C15532g

CGR:	CAGL0K09856g

TPF:	TPHA_0P00940(TPHA0P00940)

PPA:	PAS_chr4_0928

DHA:	DEHA2A10934g

PIC:	PICST_90967

PGU:	PGUG_01960

SPAA:

SPAPADRAFT_148110

LEL:	LELG_05421

CAL:	CAALFM_CR08040WA(CaO19.592)

CTP:	CTRG_02645

COT:	CORT_0G02080

CDU:	CD36_33670

CTEN:

CANTEDRAFT_110406

YLI:	YALI0D07238g

CLU:	CLUG_02814

CLUS:

CAUR:

SLB:

MGR:

FGR:	FGSG_02250

FPU:	FPSE_00265

FVR:	FVEG_12049

FOX:	FOXG_03807

NHE:	NECHADRAFT_90612

MAW:

MAC_01573

MAJ:

MAA_02409

CMT:

CCM_08297

PLJ:	VFPFJ_02492

VAL:	VDBG_05488

VDA:	VDAG_07139

CFJ:	CFIO01_00749 CFIO01_12314

ELA:

UCREL1_99

PDP:	PDIP_41050

ABE:

ARB_05744

TVE:

TRV_04498

PNO:	SNOG_12539

BZE:	COCCADRAFT_103718

BSC:	COCSADRAFT_36792

BOR:	COCMIDRAFT_39858

AALT:

CC77DRAFT_1020190

ZTR:	MYCGRDRAFT_25801

SPO:	SPBC1778.07

CGI:	CGB_A8270W

TMS:	TREMEDRAFT_30233

TVS:	TRAVEDRAFT_52089 TRAVEDRAFT_60824

DSQ:	DICSQDRAFT_107156 DICSQDRAFT_59823

PCO:	PHACADRAFT_194233 PHACADRAFT_98646

SHS:	STEHIDRAFT_96161

HIR:	HETIRDRAFT_327542 HETIRDRAFT_461401

PSQ:	PUNSTDRAFT_110705 PUNSTDRAFT_71869

ADL:	AURDEDRAFT_134569

FME:	FOMMEDRAFT_108842 FOMMEDRAFT_116646

GTR:	GLOTRDRAFT_112601 GLOTRDRAFT_93785

LBC:	LACBIDRAFT_255655 LACBIDRAFT_256049

MRR:	Moror_10009 Moror_2658

CCI:	CC1G_06836 CC1G_07496

SCM:	SCHCODRAFT_16269

ABP:	AGABI1DRAFT107480(AGABI1DRAFT_107480) AGABI1DRAFT47663(AGABI1DRAFT_47663)

ABV:	AGABI2DRAFT121027(AGABI2DRAFT_121027) AGABI2DRAFT209970(AGABI2DRAFT_209970)

CPUT:

CONPUDRAFT_106078

SLA:	SERLADRAFT_464658

WSE:	WALSEDRAFT_59442

WIC:	J056_002317

UMA:	UMAG_10376

PFP:	PFL1_02940

PGR:	PGTG_01896

MLR:	MELLADRAFT_35280 MELLADRAFT_91697

SRE:	PTSG_11583

DDI:	DDB_G0282239

DFA:	DFA_01813 DFA_12355

EIV:	EIN_118310 EIN_227480

TET:	TTHERM_00670350

PTM:	GSPATT00005551001 GSPATT00024230001

SMIN:

v1.2.001623.t1(symbB.v1.2.001623.t1) v1.2.006227.t1(symbB.v1.2.006227.t1) v1.2.030600.t1(symbB.v1.2.030600.t1)

FCY:	FRACYDRAFT_260947 FRACYDRAFT_263932

AAF:	AURANDRAFT_22773

PIF:	PITG_08675

PSOJ:

PHYSODRAFT_287151

SPAR:

SPRG_13920 SPRG_15803

EHX:	EMIHUDRAFT_356882

GTT:	GUITHDRAFT_112257 GUITHDRAFT_159108 GUITHDRAFT_86800

TBR:	Tb927.4.3350

TCR:

507739.70

NGR:	NAEGRDRAFT_1820

TVA:	TVAG_246220

CHZ:

CHSO_1738

» show all

Reference

Authors

McManus, I.R.

Title

Enzymatic synthesis of anserine in skeletal muscle by N-methylation of carnosine.

Journal

J Biol Chem 237:1207-1211 (1962)

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.22

IUBMB Enzyme Nomenclature:

2.1.1.22

ExPASy - ENZYME nomenclature database:

2.1.1.22

BRENDA, the Enzyme Database:

2.1.1.22

CAS:	37256-93-2

DBGET integrated database retrieval system