KEGG ENZYME: 2.1.1.225

ENZYME: 2.1.1.225

Entry

EC 2.1.1.225 Enzyme

Name

tRNA:m4X modification enzyme;
TRM13;
Trm13p;
tRNA:Xm4 modification enzyme

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:tRNAPro/His/Gly(GCC) (cytidine/adenosine4-2'-O)-methyltransferase

Reaction(IUBMB)

(1) S-adenosyl-L-methionine + cytidine4 in tRNAPro = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAPro;
(2) S-adenosyl-L-methionine + cytidine4 in tRNAGly(GCC) = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAGly(GCC);
(3) S-adenosyl-L-methionine + adenosine4 in tRNAHis = S-adenosyl-L-homocysteine + 2'-O-methyladenosine4 in tRNAHis

Substrate

S-adenosyl-L-methionine [CPD:C00019];
cytidine4 in tRNAPro;
cytidine4 in tRNAGly(GCC);
adenosine4 in tRNAHis

Product

S-adenosyl-L-homocysteine [CPD:C00021];
2'-O-methylcytidine4 in tRNAPro;
2'-O-methylcytidine4 in tRNAGly(GCC);
2'-O-methyladenosine4 in tRNAHis

Comment

The enzyme from Saccharomyces cerevisiae 2'-O-methylates cytidine4 in tRNAPro and tRNAGly(GCC), and adenosine4 in tRNAHis.

History

EC 2.1.1.225 created 2011

Orthology

K15446

tRNA:m4X modification enzyme

Genes

HSA:	54482(TRMT13)

PTR:	742372(TRMT13)

PPS:	100972211(TRMT13)

GGO:	101148351(TRMT13)

PON:	100456893(TRMT13)

NLE:	100580575(TRMT13)

MCC:	711396(TRMT13)

MCF:	102137915(TRMT13)

CSAB:

103224368(TRMT13)

CATY:

105590146(TRMT13)

RRO:	104673250(TRMT13)

RBB:	108524171(TRMT13)

TFN:	117075117(TRMT13)

CJC:	100391711(TRMT13)

SBQ:	101047705(TRMT13)

MMUR:

105862368(TRMT13)

MMU:	229780(Trmt13)

MCAL:

110291171(Trmt13)

MPAH:

110320352(Trmt13)

RNO:	499697(Trmt13)

MCOC:

116093685(Trmt13)

MUN:	110551862(Trmt13)

CGE:

100760563

PLEU:

114707424(Trmt13)

NGI:

103743348

HGL:	101721354(Trmt13)

CCAN:

109688165(Trmt13)

OCU:	100347251(TRMT13)

TUP:	102488274(TRMT13)

CFA:	479930(TRMT13)

VVP:	112918469(TRMT13)

AML:	100480930(TRMT13)

UMR:	103669334(TRMT13)

UAH:	113254356(TRMT13)

ORO:	101372186(TRMT13)

ELK:

111143265

MPUF:

101691311

EJU:	114207879(TRMT13)

FCA:	101086829(TRMT13)

PTG:	102961454(TRMT13)

PPAD:

109271918(TRMT13)

AJU:	106976410(TRMT13)

BTA:	614311(TRMT13)

BOM:	102272220(TRMT13)

BIU:	109556020(TRMT13)

BBUB:

102398971(TRMT13)

CHX:	102177115(TRMT13)

OAS:	101112862(TRMT13)

SSC:	102167932(TRMT13)

CFR:	102516817(TRMT13)

CDK:	105084984(TRMT13)

BACU:

103003812(TRMT13)

LVE:	103086778(TRMT13)

OOR:	101282936(TRMT13)

DLE:	111180121(TRMT13)

PCAD:

102996420(TRMT13)

ECB:	100050460(TRMT13)

EPZ:	103541514(TRMT13)

EAI:	106837784(TRMT13)

MYB:	102251850(TRMT13)

MYD:	102753968(TRMT13)

MMYO:

118673553(TRMT13)

MNA:	107530676(TRMT13)

HAI:	109374612(TRMT13)

DRO:	112313769(TRMT13)

SHON:

118990637(TRMT13)

AJM:	119054970(TRMT13)

MMF:	118637452(TRMT13)

PALE:

102881835(TRMT13)

RAY:	107504332(TRMT13)

MJV:	108397647 108404763(TRMT13)

LAV:	100657527(TRMT13)

TMU:

101348709

MDO:	100032957(TRMT13)

SHR:	100913690(TRMT13)

PCW:	110217473(TRMT13)

OAA:	100081774(TRMT13)

GGA:	424470(TRMT13)

MGP:	100550808(TRMT13)

CJO:	107317455(TRMT13)

NMEL:

110402430(TRMT13)

APLA:

101790226(TRMT13)

ACYG:

106039449(TRMT13)

TGU:	100230227(TRMT13)

LSR:	110467820(TRMT13)

SCAN:

103814865(TRMT13)

GFR:	102042132(TRMT13)

FAB:	101821407(TRMT13)

PHI:	102105730(TRMT13)

PMAJ:

107208061(TRMT13)

CCAE:

111932562(TRMT13)

CCW:	104695571(TRMT13)

ETL:	114061663(TRMT13)

FPG:	101911980(TRMT13)

FCH:	102055641(TRMT13)

CLV:	102092758(TRMT13)

EGZ:	104134029(TRMT13)

NNI:	104015603(TRMT13)

ACUN:

113482929(TRMT13)

PADL:

103925180(TRMT13)

AAM:	106499749(TRMT13)

ASN:	102374605(TRMT13)

AMJ:	102560657(TRMT13)

PSS:	102444671(TRMT13)

CMY:	102929911(TRMT13)

CPIC:

101948973(TRMT13)

ACS:	100563797(trmt13)

PVT:	110076503(TRMT13)

PBI:	103056354(TRMT13)

PMUR:

107302489(TRMT13)

PMUA:

114598709(TRMT13)

GJA:	107112252(TRMT13)

XLA:	443770(trmt13.L)

XTR:	100379916(trmt13)

NPR:	108791472(TRMT13)

DRE:	541496(trmt13)

SRX:	107757496(trmt13)

SANH:

107669842(trmt13)

SGH:	107588056 107592707(trmt13)

CCAR:

109047774 109052833

IPU:	108271181(trmt13)

PHYP:

113536521(trmt13)

AMEX:

103035609(trmt13)

EEE:	113574544(trmt13)

TRU:	101064514(trmt13)

TNG:	GSTEN00008272G001

LCO:	104936348(trmt13)

MZE:	101468812(trmt13)

ONL:	100691203(trmt13)

OLA:	101161965(trmt13)

XMA:	102231464(trmt13)

XCO:	114141394(trmt13)

PRET:

103463270(trmt13)

CVG:	107100511(trmt13)

NFU:	107395230(trmt13)

KMR:	108228797(trmt13)

ALIM:

106510934 106519697(trmt13)

AOCE:

111564524(trmt13)

CSEM:

103398595(trmt13)

POV:	109647782(trmt13)

LCF:	108874169(trmt13)

SDU:	111236204(trmt13)

SLAL:

111668190(trmt13)

HCQ:	109506849(trmt13)

BPEC:

110162795(trmt13)

MALB:

109965270(trmt13)

SASA:

106573941(trmt13)

OTW:	112252091(trmt13)

SALP:

111952645(trmt13)

ELS:	105011372(trmt13)

SFM:	108919082(trmt13)

PKI:	111844650(trmt13)

LCM:	102357633(TRMT13)

CMK:	103184743(trmt13)

RTP:	109930860(trmt13)

BFO:

118432406

SPU:

575954

SKO:

102802454

DME:	Dmel_CG18048(CG18048)

DER:

6553246

DSE:

6614101

DSI:	Dsimw501_GD19867(Dsim_GD19867)

DYA:	Dyak_GE10212

DSR:

110176630

DPO:	Dpse_GA14776

DPE:

6587946

DMN:

108157169

DWI:

6650285

DGR:	Dgri_GH14041

DMO:	Dmoj_GI24415

DAZ:

DNV:

DHE:

DVI:

MDE:

LCQ:

AGA:	AgaP_AGAP000681

AAG:

5574527

AALB:

109405368 115255634

CQU:	CpipJ_CPIJ009806

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:

DPA:

ATD:

NVL:

BMOR:

BMAN:

DPL:	KGM_204636

PMAC:

PRAP:

HAW:

TNL:

PXY:

ZNE:

FCD:

DPX:	DAPPUDRAFT_313492

PVM:

113809719

ISC:	IscW_ISCW018578

CSCU:

111624546

PTEP:

107447235

CEL:	CELE_Y49A3A.3(Y49A3A.3)

CBR:

CBG04631

BMY:

Bm1_32655

LOA:	LOAG_00110

HRO:	HELRODRAFT_77676

LGI:	LOTGIDRAFT_102700

PCAN:

CRG:

MYI:

OBI:

LAK:

SMM:	Smp_156030 Smp_196960

OVI:	T265_13063

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:	100209000 100214801

TAD:	TRIADDRAFT_57802

AQU:	105314578 105315862

ATH:

AT4G01880

ALY:

9311022

CRB:

17883442

CSAT:

104707920 104713456 104737600

EUS:	EUTSA_v10028644mg EUTSA_v10028645mg

BRP:

103858799

BNA:	106389094 106438647

BOE:

106331382

RSZ:	108845758 108845759

THJ:

104801320

CPAP:

110820615

CIT:

102630836

CIC:	CICLE_v10001046mg

TCC:

GRA:

GHI:

GAB:

DZI:

EGR:	104428969 104456606

GMX:

100793810

GSJ:

114419277

PVU:	PHAVU_003G019300g

VRA:

VAR:

VUN:

CCAJ:

MTR:	MTR_1g032120

CAM:

101513602

LJA:	Lj0g3v0339199.1(Lj0g3v0339199.1) Lj0g3v0339199.2(Lj0g3v0339199.2)

ADU:

AIP:

LANG:

FVE:

RCN:

PPER:

PMUM:

PAVI:

MDM:

PXB:	103953085 103964908

ZJU:

CSV:

CMO:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:	110640927 110661741

MESC:

POP:

PEU:

JRE:

QSU:

VVI:

SLY:

SPEN:

SOT:

NTA:	107771521 107824039 107829617

NSY:

NTO:

NAU:

INI:

SIND:

OEU:

HAN:	110871381 110892877 110899447

LSV:

CCAV:

DCR:

BVG:

SOE:

CQI:	110732962 110734221

NNU:

104611248

PSOM:

113321376 113334923 113357962

OSA:

9267457

DOSA:

Os03t0833200-01(Os03g0833200)

OBR:

BDI:

ATS:

SBI:

ZMA:

SITA:

PDA:

EGU:

MUS:

DCT:

PEQ:

AOF:

ATR:

SMO:	SELMODRAFT_427800

PPP:

112274211

CRE:	CHLREDRAFT_151570

VCN:	VOLCADRAFT_117653

CSL:	COCSUDRAFT_48390

CVR:	CHLNCDRAFT_52958

APRO:

F751_2767

OLU:	OSTLU_24121

MIS:	MICPUN_107426(CHP1)

MPP:	MICPUCDRAFT_5259

CCP:	CHC_T00000204001

SCE:	YOL125W(TRM13)

AGO:	AGOS_ADL163W

ERC:

Ecym_2047

KLA:	KLLA0_E07547g

KMX:	KLMA_40390(TRM13)

LTH:	KLTH0F18832g

VPO:	Kpol_1076p3

ZRO:	ZYRO0C02640g

CGR:	CAGL0E01903g

NCS:	NCAS_0C04580(NCAS0C04580)

NDI:	NDAI_0G03950(NDAI0G03950)

TPF:	TPHA_0P01340(TPHA0P01340)

TBL:	TBLA_0B08620(TBLA0B08620)

TDL:	TDEL_0E00570(TDEL0E00570)

KAF:	KAFR_0C01700(KAFR0C01700)

ZMK:	HG535_0F02160

PPA:	PAS_chr2-1_0523

DHA:	DEHA2E17446g

PIC:	PICST_32922

PGU:	PGUG_03255

SPAA:

SPAPADRAFT_70629

LEL:	LELG_00231

CAL:	CAALFM_CR00670CA(CaO19.7460)

CTP:	CTRG_01011

COT:	CORT_0A02530

CDU:	CD36_25770

CTEN:

CANTEDRAFT_111474

YLI:	YALI0E27137g

CLU:	CLUG_03052

CLUS:

A9F13_12g00682

CAUR:

CJI97_001628

SLB:	AWJ20_904(TRM13)

PKZ:	C5L36_0C03910

BNN:	FOA43_002443

BBRX:

BRETT_000240

SPO:	SPAC1805.03c(trm13)

MBR:	MONBRDRAFT_27936

SRE:	PTSG_00880

DDI:	DDB_G0293682

DPP:	DICPUDRAFT_148568

DFA:

DFA_09068

EHI:	EHI_083130(38.t00028)

EDI:	EDI_077820

EIV:	EIN_221870

ACAN:

ACA1_180610

CPV:

cgd1_2810

CHO:	Chro.10316

TET:	TTHERM_00083540

PTM:	GSPATT00016685001

SMIN:

v1.2.021497.t1(symbB.v1.2.021497.t1) v1.2.021499.t1(symbB.v1.2.021499.t1)

PTI:	PHATRDRAFT_47468

FCY:	FRACYDRAFT_260308

TPS:	THAPSDRAFT_5079

PIF:	PITG_04858

PSOJ:

PHYSODRAFT_533448

SPAR:

SPRG_19285

EHX:	EMIHUDRAFT_200603 EMIHUDRAFT_247952

GTT:	GUITHDRAFT_103306 GUITHDRAFT_110392

TBR:	Tb927.4.4030

TBG:	TbgDal_IV4140

TCR:

509237.50

LMA:	LMJF_31_0520

LIF:	LINJ_31_0540

LDO:	LDBPK_310540

LMI:	LMXM_30_0520

LBZ:	LBRM_31_0680

LPAN:

LPMP_310500

» show all

Reference

1 [PMID:17242307]

Authors

Wilkinson ML, Crary SM, Jackman JE, Grayhack EJ, Phizicky EM

Title

The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4.

Journal

RNA 13:404-13 (2007)
DOI:10.1261/rna.399607

Sequence

[sce:YOL125W]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.225

IUBMB Enzyme Nomenclature:

2.1.1.225

ExPASy - ENZYME nomenclature database:

2.1.1.225

BRENDA, the Enzyme Database:

2.1.1.225

All links

Gene (2488)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (437)   
   KEGG MGENES (208)   
   RefGene (1842)   
Protein sequence (2032)   
   UniProt (2006)   
   SWISS-PROT (12)   
   RefSeq(pep) (14)   
DNA sequence (22)   
   RefSeq(nuc) (16)   
   GenBank (5)   
   EMBL (1)   
Protein domain (6)   
   InterPro (6)   
All databases (4548)   

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