| Entry |
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| Name |
tRNA:m4X modification enzyme;
TRM13;
Trm13p;
tRNA:Xm4 modification enzyme
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:tRNAPro/His/Gly(GCC) (cytidine/adenosine4-2'-O)-methyltransferase
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| Reaction(IUBMB) |
(1) S-adenosyl-L-methionine + cytidine4 in tRNAPro = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAPro;
(2) S-adenosyl-L-methionine + cytidine4 in tRNAGly(GCC) = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAGly(GCC);
(3) S-adenosyl-L-methionine + adenosine4 in tRNAHis = S-adenosyl-L-homocysteine + 2'-O-methyladenosine4 in tRNAHis
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
cytidine4 in tRNAPro;
cytidine4 in tRNAGly(GCC);
adenosine4 in tRNAHis
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
2'-O-methylcytidine4 in tRNAPro;
2'-O-methylcytidine4 in tRNAGly(GCC);
2'-O-methyladenosine4 in tRNAHis
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| Comment |
The enzyme from Saccharomyces cerevisiae 2'-O-methylates cytidine4 in tRNAPro and tRNAGly(GCC), and adenosine4 in tRNAHis.
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| History |
EC 2.1.1.225 created 2011
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| Orthology |
| K15446 | tRNA:m4X modification enzyme |
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| Genes |
| DMER: | 138804449 138817328(Trmt13) |
| LWW: | 102730943(TRMT13) 102736220 |
| SGH: | 107588056 107592707(trmt13) |
| CCAR: | 109047774(trmt13) 109052798 |
| CAUA: | 113064898 113065233 |
| CVE: | 137883797(trmt13) 137888883 |
| ALIM: | 106510934 106519697(trmt13) |
| PTAO: | 133480478 133480885(trmt13) |
| BSPL: | 114850793 114853100(trmt13) |
| LPIC: | 129270875 129270879 |
| DME: | Dmel_CG18048(CG18048) |
| DSI: | Dsimw501_GD19867(Dsim_GD19867) |
| AALB: | 109405368 115255634 |
| CEL: | CELE_Y49A3A.3(Y49A3A.3) |
| MAEA: | 128212870 128213252 |
| SHX: | MS3_00007963(TRMT13_1) |
| CSAT: | 104707920 104713456 104737600 |
| EUS: | EUTSA_v10028644mg EUTSA_v10028645mg |
| BNA: | 106389094 106438647 125574840 |
| HSYR: | 120136788 120165153 |
| CSAV: | 115707541 133031923 |
| PALZ: | 118044511 118050482 |
| CAVE: | 132172294 132172668 |
| NTA: | 107771521 107824039 107829617 |
| SSPL: | 121741785 121790384 |
| SMIL: | 131007263 131007267 131013337 |
| PSOM: | 113321376 113334923 113357962 |
| TAES: | 123087791 123114136 123123625 |
| MFLO: | 136497808 136501365 |
| PVIR: | 120649210 120691533 |
| CGR: | 2887408(GVI51_E01683) |
| NCS: | NCAS_0C04580(NCAS0C04580) |
| NDI: | NDAI_0G03950(NDAI0G03950) |
| TPF: | TPHA_0P01340(TPHA0P01340) |
| TBL: | TBLA_0B08620(TBLA0B08620) |
| TDL: | TDEL_0E00570(TDEL0E00570) |
| KAF: | KAFR_0C01700(KAFR0C01700) |
| KNG: | KNAG_0A01350(KNAG0A01350) |
| LBG: | 92206053(LODBEIA_P08570) |
| CAL: | CAALFM_CR00670CA(CaO19.7460) |
| ASAU: | 88171451(PUMCH_000382) |
| YLI: | 2912777(YALI2_E01219g) |
| SSAO: | 94297201(SS50377_23178) 94297204(SS50377_23181) |
| EHX: | EMIHUDRAFT_200603 EMIHUDRAFT_247952 |
| GTT: | GUITHDRAFT_103306 GUITHDRAFT_110392 |
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| Reference |
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| Authors |
Wilkinson ML, Crary SM, Jackman JE, Grayhack EJ, Phizicky EM |
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| Title |
The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.225 |
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