23S rRNA (adenosine1067-2'-O)-methyltransferase;
23S rRNA A1067 2'-methyltransferase;
Transferring one-carbon groups;
S-adenosyl-L-methionine:23S rRNA (adenosine1067-2'-O)-methyltransferase
S-adenosyl-L-methionine + adenosine1067 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA
adenosine1067 in 23S rRNA
2'-O-methyladenosine1067 in 23S rRNA
The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton .
EC 126.96.36.199 created 2011
K05926 23S rRNA (adenosine1067-2'-O)-methyltransferase
Genes » show all
Bechthold A, Floss HG
Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2'-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA.
Thompson J, Schmidt F, Cundliffe E
Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton.
J Biol Chem 257:7915-7 (1982)
Thompson, J. and Cundliffe, E.
Purification and properties of an RNA methylase produced by Streptomyces azureus and involved in resistance to thiostrepton.
J Gen Microbiol 124:291-297 (1981)
Yang H, Wang Z, Shen Y, Wang P, Jia X, Zhao L, Zhou P, Gong R, Li Z, Yang Y, Chen D, Murchie AI, Xu Y
Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus.
ExPASy - ENZYME nomenclature database: 188.8.131.52