Entry
Name
[phosphatase 2A protein]-leucine-carboxy methyltransferase;
leucine carboxy methyltransferase-1;
LCMT1
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[phosphatase 2A protein]-leucine O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
[phosphatase 2A protein]-leucine
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
[phosphatase 2A protein]-leucine methyl ester
Comment
Methylates the C-terminal leucine of phosphatase 2A. A key regulator of protein phosphatase 2A. The methyl ester is hydrolysed by EC
3.1.1.89 (protein phosphatase methylesterase-1). Occurs mainly in the cytoplasm, Golgi region and late endosomes.
History
EC 2.1.1.233 created 2011
Orthology
K18203 [phosphatase 2A protein]-leucine-carboxy methyltransferase
Genes
LLV : 125082669 125090291 125090543 125090545
FCA : 102900324 102901317(LCMT1)
LRUF : 124517743 124518063 124518065
SSC : 100520426 100626661 110255326(LCMT1)
MLF : 102418219(LCMT1) 102435834
MGP : 100538645(LCMT1) 104913486
XLA : 108703202(lcmt1.S) 734508(lcmt1.L)
SANH : 107669194 107692087
CCAR : 109062376 109106244
CAUA : 113056253 113111752
CGIB : 127969549 128025155
CGOB : 115024599(lcmt1) 115024886
DSI : Dsimw501_GD24020(Dsim_GD24020)
MSEX : 115450555 119191568 119192512
CFEL : 113377318 113378206
PMOO : 119586409 119586643
CEL : CELE_B0285.4(lcmt-1)
BMY : BM_BM1736(Bma-lcmt-1)
CME : CYME_CML095C CYME_CML136C
NCS : NCAS_0F01180(NCAS0F01180)
NDI : NDAI_0H01700(NDAI0H01700)
TPF : TPHA_0K00430(TPHA0K00430)
TBL : TBLA_0D01520(TBLA0D01520)
TDL : TDEL_0A04100(TDEL0A04100)
KAF : KAFR_0E03210(KAFR0E03210)
KNG : KNAG_0C03120(KNAG0C03120)
CAL : CAALFM_CR08170CA(CaO19.6377)
CTP : CTRG_03036 CTRG_03048
NTE : NEUTE1DRAFT128865(NEUTE1DRAFT_128865)
BFU : BCIN_07g06610(Bcppm1)
ANG : ANI_1_2090074(An08g07080)
PNO : SNOG_02904(SNOG_02903)
ABP : AGABI1DRAFT56526(AGABI1DRAFT_56526)
ABV : AGABI2DRAFT204952(AGABI2DRAFT_204952)
SCM : SCHCO_01155614(SCHCODRAFT_01155614)
PGR : PGTG_11793 PGTG_22757
MLR : MELLADRAFT_28915 MELLADRAFT_85978
TVA : TVAG_2v0072550 TVAG_2v0221290 TVAG_2v0300800 TVAG_2v0669630
» show all
Taxonomy
Reference
Authors
De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J
Title
Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.
Journal
Sequence
Reference
Authors
Tsai ML, Cronin N, Djordjevic S
Title
The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.233