KEGG   ENZYME: 2.1.1.233
Entry
EC 2.1.1.233                Enzyme                                 
Name
[phosphatase 2A protein]-leucine-carboxy methyltransferase;
leucine carboxy methyltransferase-1;
LCMT1
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[phosphatase 2A protein]-leucine O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[phosphatase 2A protein]-leucine
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[phosphatase 2A protein]-leucine methyl ester
Comment
Methylates the C-terminal leucine of phosphatase 2A. A key regulator of protein phosphatase 2A. The methyl ester is hydrolysed by EC 3.1.1.89 (protein phosphatase methylesterase-1). Occurs mainly in the cytoplasm, Golgi region and late endosomes.
History
EC 2.1.1.233 created 2011
Orthology
K18203  [phosphatase 2A protein]-leucine-carboxy methyltransferase
Genes
HSA51451(LCMT1)
PTR467930(LCMT1)
PPS100987316(LCMT1)
GGO101148281(LCMT1)
PON100443208(LCMT1)
NLE100606762(LCMT1)
HMH116471156(LCMT1)
MCC702050(LCMT1)
MCF102124303(LCMT1)
MTHB126944395
MNI105485039(LCMT1)
CSAB103229986(LCMT1)
CATY105585880(LCMT1)
PANU101017255(LCMT1)
TGE112614250(LCMT1)
MLEU105545152(LCMT1)
RRO104661764(LCMT1)
RBB108538865(LCMT1)
TFN117087472(LCMT1)
PTEH111526907(LCMT1)
CANG105520729(LCMT1)
CJC100397919(LCMT1)
SBQ101042382(LCMT1)
CIMI108308545(LCMT1)
CSYR103273024(LCMT1)
MMUR105879704(LCMT1)
LCAT123632497(LCMT1)
PCOQ105810883(LCMT1)
OGA100947802(LCMT1)
MMU30949(Lcmt1)
MCAL110298422(Lcmt1)
MPAH110326778(Lcmt1)
RNO361643(Lcmt1)
MCOC116102924(Lcmt1)
ANU117698293(Lcmt1)
MUN110559474(Lcmt1)
CGE100762400(Lcmt1)
MAUA101827198(Lcmt1)
PROB127228309(Lcmt1)
PLEU114692214(Lcmt1)
MORG121457788(Lcmt1)
MFOT126502345
AAMP119805292(Lcmt1)
NGI103746920(Lcmt1)
HGL101699863(Lcmt1)
CPOC100719646(Lcmt1)
CCAN109699800(Lcmt1)
DORD105981992(Lcmt1)
DSP122116148(Lcmt1)
NCAR124970502
OCU100350737
OPI101525355(LCMT1)
TUP102491269(LCMT1)
GVR103587068(LCMT1)
CFA608360(LCMT1)
CLUD112640220(LCMT1)
VVP112929171(LCMT1)
VLG121486338(LCMT1)
AML100464868(LCMT1)
UMR103657800(LCMT1)
UAH113267594(LCMT1)
UAR123778061(LCMT1)
ELK111162303
LLV125082669 125090291 125090543 125090545
MPUF101680087(LCMT1)
NVS122895795(LCMT1)
ORO101386951(LCMT1)
EJU114214502(LCMT1)
ZCA113933596(LCMT1)
MLX117999681(LCMT1)
NSU110589777(LCMT1)
LWW102740482(LCMT1)
FCA102900324 102901317(LCMT1)
PBG122472077(LCMT1)
LRUF124517743 124518063 124518065
PTG102951671(LCMT1)
PPAD109256482
PUC125936193
HHV120233289(LCMT1)
BTA618021(LCMT1)
BOM102268025(LCMT1)
BIU109578134(LCMT1)
BBUB102403203(LCMT1)
BBIS104986590(LCMT1)
CHX102174529(LCMT1)
OAS101107755(LCMT1)
ODA120876330(LCMT1)
CCAD122433277(LCMT1)
SSC100520426 100626661 110255326(LCMT1)
CFR102503513(LCMT1)
CBAI105073661(LCMT1)
CDK105094842(LCMT1)
VPC102528416(LCMT1)
BACU103015136(LCMT1)
LVE103069896(LCMT1)
OOR101279381(LCMT1)
DLE111182223(LCMT1)
PCAD102993657(LCMT1)
PSIU116740806(LCMT1)
ECB100061739(LCMT1)
EPZ103564488(LCMT1)
EAI106826671(LCMT1)
MYB102239060(LCMT1)
MYD102773182(LCMT1)
MMYO118656455(LCMT1)
MLF102418219(LCMT1) 102435834
MNA107544791(LCMT1)
PKL118731541(LCMT1)
HAI109386551(LCMT1)
DRO112304876(LCMT1)
SHON118990424(LCMT1)
AJM119035913(LCMT1)
PDIC114505352(LCMT1)
PHAS123825543(LCMT1)
MMF118642609(LCMT1)
RFQ117019372(LCMT1)
PALE102879909(LCMT1)
PGIG120584526(LCMT1)
PVP105302469(LCMT1)
RAY107508840(LCMT1)
MJV108395318(LCMT1)
TOD119241813(LCMT1)
SARA101547036(LCMT1)
LAV100673711(LCMT1)
TMU101348585
ETF101651581(LCMT1)
DNM101425348(LCMT1)
MDO100014639(LCMT1)
GAS123231875(LCMT1)
SHR100923755(LCMT1)
AFZ127541944
PCW110214571(LCMT1)
OAA100074396(LCMT1)
GGA416565(LCMT1)
PCOC116237449(LCMT1)
MGP100538645(LCMT1) 104913486
CJO107320771(LCMT1)
NMEL110405874(LCMT1)
APLA101789500(LCMT1)
ACYG106046047(LCMT1)
AFUL116495421(LCMT1)
TGU100231820(LCMT1)
LSR110480970(LCMT1)
SCAN103817803(LCMT1)
PMOA120513180(LCMT1)
OTC121334620(LCMT1)
PRUF121365813(LCMT1)
GFR102041579(LCMT1)
FAB101820295(LCMT1)
PHI102104644(LCMT1)
PMAJ107211153(LCMT1)
CCAE111936197(LCMT1)
CCW104684990(LCMT1)
CBRC103615518(LCMT1)
ETL114064328(LCMT1)
ZAB102065302(LCMT1)
ACHL103805747(LCMT1)
SVG106859277(LCMT1)
FPG101920570(LCMT1)
FCH102054412(LCMT1)
CLV102090659(LCMT1)
EGZ104134540(LCMT1)
NNI104015274(LCMT1)
PLET104626610(LCMT1)
PCRI104035660(LCMT1)
PCAO104043215(LCMT1)
ACUN113485940(LCMT1)
TALA104363184(LCMT1)
PADL103921913(LCMT1)
AFOR103905054(LCMT1)
ACHC115335848(LCMT1)
HALD104325856(LCMT1)
HLE104833659(LCMT1)
AGEN126034093
GCL127022400
CCRI104159029(LCMT1)
CSTI104556989(LCMT1)
EHS104507907(LCMT1)
CMAC104480539(LCMT1)
MUI104545835(LCMT1)
FGA104080540(LCMT1)
GSTE104253503(LCMT1)
LDI104342495(LCMT1)
MNB103779728(LCMT1)
OHA104338296(LCMT1)
NNT104409007(LCMT1)
SHAB115606186(LCMT1)
DPUB104300283(LCMT1)
PGUU104458741(LCMT1)
ACAR104524365(LCMT1)
CPEA104393135(LCMT1)
AVIT104272903(LCMT1)
CVF104295357(LCMT1)
CUCA104064594(LCMT1)
TEO104377703(LCMT1)
BRHI104498680(LCMT1)
AAM106486210(LCMT1)
AROW112975276(LCMT1)
NPD112959903(LCMT1)
TGT104573957(LCMT1)
DNE112985374(LCMT1)
SCAM104138900(LCMT1)
ASN102368372
AMJ102572102(LCMT1)
CPOO109314603(LCMT1)
GGN109294419(LCMT1)
PSS102449721(LCMT1)
CMY102929388(LCMT1)
CPIC101952389(LCMT1)
TST117883782(LCMT1)
CABI116817886(LCMT1)
MRV120372953(LCMT1)
ACS100557653(lcmt1)
PVT110085038(LCMT1)
SUND121937513(LCMT1)
PBI103062236(LCMT1)
PMUR107296216(LCMT1)
CTIG120310836(LCMT1)
TSR106550943(LCMT1)
PGUT117667324(LCMT1)
VKO123028142(LCMT1)
PMUA114584255(LCMT1)
ZVI118092904(LCMT1)
GJA107110581(LCMT1)
STOW125431578(LCMT1)
XLA108703202(lcmt1.S) 734508(lcmt1.L)
XTR548787(lcmt1)
NPR108791006(LCMT1)
RTEM120943294(LCMT1)
BBUF121007856(LCMT1)
BGAR122945150(LCMT1)
DRE447907(lcmt1)
SRX107731431 107734249
SANH107669194 107692087
SGH107584116 107594185
CCAR109062376 109106244
CAUA113056253 113111752
CGIB127969549 128025155
PPRM120475053(lcmt1)
MAMB125255584(lcmt1)
CIDE127524066
MASI127427036
IPU100528205(lcmt1)
PHYP113527085(lcmt1)
SMEO124389058(lcmt1)
TFD113637195(lcmt1)
EEE113574896(lcmt1)
TRU101066473(lcmt1)
TNGGSTEN00024199G001
LCO104918937(lcmt1)
CGOB115024599(lcmt1) 115024886
ELY117246684(lcmt1)
EFO125880269(lcmt1)
PLEP121958805(lcmt1)
SLUC116044308(lcmt1)
ECRA117936918(lcmt1)
ESP116671820(lcmt1)
PFLV114548212(lcmt1)
GAT120819452(lcmt1)
PPUG119212956(lcmt1)
MSAM119916232(lcmt1)
CUD121528403(lcmt1)
ALAT119009508(lcmt1)
MZE101468727(lcmt1)
ONL100704848(lcmt1)
OAU116327290(lcmt1)
OLA101171444(lcmt1)
OML112154680(lcmt1)
XMA102230867(lcmt1)
XCO114160124(lcmt1)
XHE116727553(lcmt1)
PRET103481011(lcmt1)
PFOR103132315(lcmt1)
PLAI106964153(lcmt1)
PMEI106910244(lcmt1)
GAF122823449(lcmt1)
CVG107086261(lcmt1)
CTUL119775901(lcmt1)
GMU124874721(lcmt1)
NFU107388130(lcmt1)
KMR108237078(lcmt1)
ALIM106525145(lcmt1)
NWH119423351(lcmt1)
AOCE111582406(lcmt1)
MCEP125022980(lcmt1)
CSEM103382315(lcmt1)
POV109626636(lcmt1)
SSEN122759131(lcmt1)
HHIP117753047(lcmt1)
HSP118100890(lcmt1)
LCF108890779
SDU111220064(lcmt1)
SLAL111656425(lcmt1)
XGL120793910(lcmt1)
HCQ109508176(lcmt1)
SSCV125990895
BPEC110159694(lcmt1)
MALB109969158(lcmt1)
BSPL114846340(lcmt1)
SASA100196453(lcmt1)
STRU115201355(lcmt1)
OTW112224431(lcmt1)
OMY110499172(lcmt1)
OGO124039316(lcmt1)
ONE115144205(lcmt1)
SALP111967922(lcmt1)
SNH120029543(lcmt1)
CCLU121547496(lcmt1)
ELS105031147(lcmt1)
SFM108939947(lcmt1)
PKI111842546(lcmt1)
AANG118219508(lcmt1)
LOC102682449(lcmt1)
PSPA121300594(lcmt1)
ARUT117431290(lcmt1)
PSEX120542258(lcmt1)
LCM102365484(LCMT1)
CMK103178665(lcmt1)
RTP109923702(lcmt1)
BFO118429644
BBEL109463296
CIN100186621
SCLV120335482
SPU584645
APLC110989479
AJC117104104
SKO100376437
DMEDmel_CG3793(CG3793)
DER6541397
DSE6611393
DSIDsimw501_GD24020(Dsim_GD24020)
DYADyak_GE21133
DAN6497736
DSR110185591
DPO4816447
DPE6603394
DMN108163416
DWI6643977
DGR6566496
DMODmoj_GI13964
DAZ108610942
DNV115563216
DHE111600431
DVI6633933
CCAT101453160
BOD106619870
RZE108360896
MDE101894021
SCAC106090686
LCQ111684357
LSQ119615584
HIS119651071
AGAAgaP_AGAP008768
ACOZ120958366
AARA120901835
ASTE118511714
AAG5565351
AALB109400337
CQUCpipJ_CPIJ016450
CPII120417360
CNS116336934
BCOO119075625
AME409320
ACER107994134
ALAB122713317
BIM100740367
BBIF117207818
BVK117238210
BVAN117160013
BTER100651839
BPYO122570884
CCAL108632161
OBB114874038
MGEN117225159
NMEA116429970
CGIG122404042
SOC105200553
MPHA105838447
AEC105149520
ACEP105622441
PBAR105429881
VEM105562927
HST105188089
DQU106746175
CFO105251585
FEX115241391
LHU105667309
PGC109854607
OBO105276469
PCF106788231
PFUC122517701
VPS122637658
NVI100118221
CSOL105368264
TPRE106659459
MDL103574468
CGLO123261714
FAS105263421
DAM107047819
AGIF122855671
CINS118069611
LHT122497683
CCIN107274927
TCA103315159
DPA109535976
SOY115888293
ATD109600379
CSET123319127
AGB108904391
LDC111504196
NVL108562734
APLN108740887
PPYR116164705
OTU111420666
BMOR101743540
BMAN114241043
MSEX115450555 119191568 119192512
DPLKGM_210609
BANY112050751
NIQ126771366
PMAC106710887
PXU106123956
PRAP110996060
PBX123714149
PNAP125059560
ZCE119829433
CCRC123694363
HAW110380630
HZE124631258
TNL113500944
SLIU111353175
OFU114364293
CFEL113377318 113378206
API100163289
DNX107163947
AGS114121038
RMD113556526
BTAB109042686
DCI103507315
CLEC106668668
HHAL106691569
NLU111051844
PHUPhum_PHUM617740
FOC113204614
TPAL117652638
ZNE110832872
CSEC111868788
SGRE126351382
FCD110852810
DPXDAPPUDRAFT_301561
DMK116932027
DPZ124350716
PVM113812279
PJA122266028
PCHN125039557
PMOO119586409 119586643
HAME121854860
PCLA123754111
PTRU123518456
HAZT108678900
EAF111699466 111709355
LSM121121442
PPOI119097145
ISCIscW_ISCW006147
DSV119443102
RSAN119388226
RMP119185203
VDE111250336
VJA111267850
TUT107366960
DFR124492261
CSCU111626934
PTEP107444491
SDM118186824
CELCELE_B0285.4(lcmt-1)
CBRCBG_18087
BMYBM_BM1736(Bma-lcmt-1)
LOALOAG_11076
NAINECAME_04312
TSPTsp_08223
HROHELRODRAFT_189998
LGILOTGIDRAFT_116132
PCAN112555215
BGT106066691
GAE121367501
HRF124139560
HRJ124273264
CRG105343554
MYI110467257
PMAX117341583
MCAF127738036
MMER123553761
DPOL127833860
OBI106874329
OSN115211798
LAK106158578 106177558
SMMSmp_124860
EGLEGR_04095
NVE5503885
EPA110241094
ATEN116291463
AMIL114959469
PDAM113679339
SPIS111321645
DGT114529162
XEN124447768
HMG100200532
TADTRIADDRAFT_20408
AQU100636740
QSU111991249 112040003
CMECYME_CML095C CYME_CML136C
SCEYDR435C(PPM1)
SEUBDI49_0603
SPAOSPAR_D06180
AGOAGOS_ADR178W
ERCEcym_4082
KLAKLLA0_B01089g
KMXKLMA_40597(PPM1)
LTHKLTH0G04224g
VPOKpol_1023p87
ZROZYRO0D13002g
CGRCAGL0F03201g
NCSNCAS_0F01180(NCAS0F01180)
NDINDAI_0H01700(NDAI0H01700)
TPFTPHA_0K00430(TPHA0K00430)
TBLTBLA_0D01520(TBLA0D01520)
TGBHG536_0A05650
TDLTDEL_0A04100(TDEL0A04100)
KAFKAFR_0E03210(KAFR0E03210)
KNGKNAG_0C03120(KNAG0C03120)
ZMKHG535_0D05130
PPAPAS_chr2-2_0234
DHADEHA2E06094g
PICPICST_28852(PPM1)
PGUPGUG_05577
SPAASPAPADRAFT_59315
LELLELG_03082
CALCAALFM_CR08170CA(CaO19.6377)
CTPCTRG_03036 CTRG_03048
COTCORT_0G02390
CDUCD36_33800
CTENCANTEDRAFT_129620
YLIYALI0D12881g
CLUCLUG_02893
CLUSA9F13_18g00110
CAURCJI97_003919
SLBAWJ20_4436(PPM1)
PKZC5L36_0C09250
BNNFOA43_000403
BBRXBRETT_003013
OPAHPODL_03497
NCRNCU07993
NTENEUTE1DRAFT128865(NEUTE1DRAFT_128865)
SMPSMAC_01830
PANPODANSg7392
TTTTHITE_23764
MTMMYCTH_2298631
CTHRCTHT_0034300
MGRMGG_01758
PPEIPpBr36_01274
TMNUCRPA7_2978
SSCKSPSK_04246
FGRFGSG_05090
FPUFPSE_11304
FVRFVEG_06075
FOXFOXG_08595
NHENECHADRAFT_34349
TRETRIREDRAFT_74693
MAJMAA_06485
CMTCCM_05360
PLJVFPFJ_00995
CFJCFIO01_05371
CHIGCH63R_04694
SAPOSAPIO_CDS7311
ELAUCREL1_11059
PFYPFICI_04240
SSLSS1G_01313
BFUBCIN_07g06610(Bcppm1)
MBEMBM_01610
PSCOLY89DRAFT_781998
ANIAN9438.2
AFMAFUA_1G13930
ACTACLA_021530
NFINFIA_011540
ANGANI_1_2090074(An08g07080)
ALUCAKAW2_30376A(PPM1)
ACHEACHE_30538S(PPM1)
APUUAPUU_11278A(PPM1)
PCSPc16g12400
PDPPDIP_67190
TMFPMAA_066880
CIMCIMG_03375
CPWCPC735_008350
PBLPAAG_02194
PBNPADG_11158
PNOSNOG_02904(SNOG_02903)
PTEPTT_16481
BSCCOCSADRAFT_179854
AALTCC77DRAFT_1023866
ZTRMYCGRDRAFT_100580
PFJMYCFIDRAFT_46445
FFUCLAFUR5_08890
BCOMBAUCODRAFT_71209
TMLGSTUM_00006721001
SPOSPBP8B7.08c
CNECNB04800
CNBCNBB0940
CNGCNAG_03994
CGICGB_A1190W
TMSTREMEDRAFT_65596
TASAA1Q1_07020
TVSTRAVEDRAFT_154317
DSQDICSQDRAFT_92147
PCOPHACADRAFT_163699
SHSSTEHIDRAFT_81997
HIRHETIRDRAFT_332300
PSQPUNSTDRAFT_71852
ADLAURDEDRAFT_91138
FMEFOMMEDRAFT_74455
GTRGLOTRDRAFT_121431
LBCLACBIDRAFT_296365
CCICC1G_14237
ABPAGABI1DRAFT56526(AGABI1DRAFT_56526)
ABVAGABI2DRAFT204952(AGABI2DRAFT_204952)
PCUBJR316_0002485
MRRMoror_17800
MOREE1B28_010197
SCMSCHCO_01155614(SCHCODRAFT_01155614)
CPUTCONPUDRAFT_165903
SLASERLADRAFT_414442
WSEWALSEDRAFT_32598
WICJ056_000131
UMAUMAG_12293
PFPPFL1_01613
MGLMGL_0125
MRTMRET_1192
MSYMMSY001_0510
PGRPGTG_11793 PGTG_22757
MLRMELLADRAFT_28915 MELLADRAFT_85978
MBRMONBRDRAFT_22106
SREPTSG_02743
FCYFRACYDRAFT_269772
AAFAURANDRAFT_60685
SPARSPRG_09071
GTTGUITHDRAFT_81242
TBGTbgDal_X5490
LIFLINJ_36_0090
LDOLDBPK_360090
LMILMXM_36_0080
LBZLBRM_35_0150
LPANLPMP_350080
TVATVAG_2v0072550 TVAG_2v0221290 TVAG_2v0300800 TVAG_2v0669630
GLAGL50803_0010516
 » show all
Reference
1  [PMID:10600115]
  Authors
De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J
  Title
Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.
  Journal
Biochemistry 38:16539-47 (1999)
DOI:10.1021/bi991646a
  Sequence
[hsa:51451]
Reference
2  [PMID:21206058]
  Authors
Tsai ML, Cronin N, Djordjevic S
  Title
The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A.
  Journal
Acta Crystallogr D Biol Crystallogr 67:14-24 (2011)
DOI:10.1107/S0907444910042204
  Sequence
[hsa:51451]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.233
IUBMB Enzyme Nomenclature: 2.1.1.233
ExPASy - ENZYME nomenclature database: 2.1.1.233
BRENDA, the Enzyme Database: 2.1.1.233

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